With the ever‐increasing lifespan along with societal changes, women can marry and procreate later than in previous centuries. However, pathogenic genetic variants segregating in the population can lead to female subfertility or infertility well before the average age of normal menopause, leading to counter‐selection of such deleterious alleles. In reviewing this field, we speculate that a logical consequence would be the later occurrence of menopause and the extension of women's reproductive lifespan. We illustrate this point with a simple model that (...) applies to other variants that contribute to female infertility, including epigenetic variation. We also consider the effect of medical interventions and lifestyle. (shrink)

西洋哲学に対峙した日本の二人の思索者は無や直観、時間や場所などの主題をめぐり何を共有し、どうすれ違ったのか。明晰な最新研究。.

One important function of emotions is to guide decision making and behaviors for survival in complex environments. In the context of such reasoning, the somatic marker hypothesis (Damasio, 1994) has argued that bodily states are represented in specific brain regions, such as the insula, and would play critical roles in decision making. However, it still remains unclear what causal roles bodily states would play in decision making, and how the bodily states would change accompanying decision making. Thus, the aim of (...) this article is to reconsider aspects of the brain and bodily states in decision making based on recent findings. Questions for future research are proposed based on such findings. (shrink)

This is a study of 288 Korean and 323 Japanese Business executives. The result indicates that, (1) the business executives believe basically in higher level business ethics, but (2) they occasionally have to make unethical business decisions which conflict with their personal values, because of prevailing business practices. (3) However, they think higher ethical standards is useful for long-term profit and for improving workers' attitudes, and the standards can be improved, and (4) to improve ethical standards, model setting by superiors (...) is the most important and clear-cut company policies and code of ethics are essential. (shrink)

The epistemology of Richard of Saint-Victor is characterised through a detailed analysis of contemplatio, the highest mode of human knowledge. Contemplatio culminates in an ecstasy, in which man reaches the highest object of his knowledge, God himself, and is fulfilled by true spiritual pleasure. This plenitude of spiritual pleasure is not just the fruit of knowledge, but fed by love. Richard distinguishes three paths of knowledge in accordance with the growth of the love between God and man. The love of (...) God gives an orientation to human knowledge. Through the love of God human knowledge is structured from disoriented cogitatio to oriented meditatio as a spiritual ascent to the divine things supported by virtues, then finally to contemplatio, which culminates in ecstasy with true spiritual pleasure. So the essence of true spiritual pleasure reflects the structural key of the highest knowledge, contemplatio, namely the love of God. (shrink)

We study the system IFP of intuitionistic fixed point logic, an extension of intuitionistic first-order logic by strictly positive inductive and coinductive definitions. We define a realizability interpretation of IFP and use it to extract computational content from proofs about abstract structures specified by arbitrary classically true disjunction free formulas. The interpretation is shown to be sound with respect to a domain-theoretic denotational semantics and a corresponding lazy operational semantics of a functional language for extracted programs. We also show how (...) extracted programs can be translated into Haskell. As an application we extract a program converting the signed digit representation of real numbers to infinite Gray code from a proof of inclusion of the corresponding coinductive predicates. (shrink)

Families of children with mental health challenges may have been particularly vulnerable to emotional distress during the COVID-19 pandemic. This cross-sectional study surveyed 81 parents of children ages 6–17 years receiving mental health treatment in an outpatient clinic during the pandemic. We sought to characterize the impact of the pandemic on family relationships and parental well-being. Additionally, regression and ANCOVA models examined associations between four potentially protective factors—parents’ psychological resilience, perceived social support, positive family experiences during the pandemic, and children’s (...) use of cognitive or behavioral coping strategies—with family relationships and parental well-being. Findings suggest that families of children with mental health conditions experienced remarkable challenges to family relationships, parental well-being, and parents’ perceived capacity to support their children’s mental health. Nearly 80% of parents reported a negative impact of the pandemic on their own well-being, and 60% reported reduced ability to support their children’s mental health. Simultaneously, protective factors appeared to mitigate the negative impact of the pandemic. Particularly, support within the family and from external sources were associated with better self-reported well-being for parents and their capacity to support their children. Children’s use of coping tools, likely enhanced by mental health treatment, was also positively related to better family relationships and parental ability to support children with mental health challenges. Our findings highlight the need for enhancing supports for families at multiple levels including individual skill-building, family-based/parenting support, and community-based support. (shrink)

Humans recognise reddish-coloured faces as angry. However, does facial colour also affect “implicit” facial expression perception of which humans are not explicitly aware? In this study, we investigated the effects of facial colour on implicit facial expression perception. The experimental stimuli were “hybrid faces”, in which the low-frequency component of the neutral facial expression image was replaced with the low-frequency component of the facial expression image of happiness or anger. In Experiment 1, we confirmed that the hybrid face stimuli were (...) perceived as neutral and, therefore, supported implicit facial expression perception. In Experiment 2, the hybrid face stimuli were adjusted to natural and reddish facial colours, and their friendliness ratings were compared. The results showed that the expression of happiness was rated as more friendly than the expression of anger. In addition, the expression of happiness was rated as friendlier when the low-frequency happy component was red, but the friendliness rating of the expression of anger did not change when it was presented in red. In Experiment 3, we affirmed the implicit facial expression perception even in reddish colours. These results suggest that facial colour modulates the perception of implicit facial expressions in hybrid facial stimuli. (shrink)

狂信的な国粋主義者か、はたまた魂の尊厳を問うた求道者か。民俗学と国粋主義の親和性とは。多角的な視点からファシズムを再考する。.

Este trabalho apresenta a experiência de uma abordagem interdisciplinar, desenvolvida na modalidade de pesquisa-ação, no atendimento ambulatorial a um grupo de 20 pacientes em tratamento da hepatite C. As especialidades envolvidas no projeto foram: assistência social, enfermagem, gastroenterologia, ..

Online experimental methods are used in psychological studies investigating the perceptions and impressions of facial photographs, even without substantial evidence supporting their reliability and validity. Although, the quality of visual stimuli is more difficult to control remotely, the methods might allow us to obtain a large amount of data. Then the statistical analysis of a larger volume of data may reduce errors and suggest significant difference in the stimuli. Therefore, we analyzed the reliability and validity of online surveys in investigating (...) the perceptions and impressions of facial photographs created from averaged faces with skin tones modified using computer graphics. In this study, we conducted online and laboratory experiments with well-controlled conditions. For each experiment, 50 participants completed the same questionnaire regarding their impressions of the same 28 CG facial photographs. The results showed significant correlations between the two experiments for all 19 items in the questionnaire. SD in the Online1 compared to the Control from the stimuli and individual differences were 56–84 and 88–104% in each questionnaire items, respectively. Moreover, the rates of mismatching perceptual evaluations to the corresponding physical features demonstrated in the photographs were 4.9–9.7% on average in an additional online survey of another 2,000 participants. These results suggest that online surveys can be applied to experiments to investigate impressions from CG facial photographs instead of general laboratory experiment by obtaining an appropriate number of participants to offset larger statistical errors that may result from the increased noise in the data from conducting the experiment online. (shrink)

Freezing of gait is a common symptom in the late stages of Parkinson’s disease and related disorders. Videos are the gold standard method to conduct FOG scoring; however, the measurement accuracy of FOG scoring based on videos has not been formally assessed, despite its use in previous studies. This study aimed to calculate the measurement accuracy of video-based FOG scoring. Three evaluators scored the FOG based on 157 video data points collected from 21 patients using an annotation tool. One evaluator (...) measured the intra-rater reliability of the retest. The total duration of observed FOG, percentage of the time spent with FOG during the walking task, and FOG phenotypes were evaluated. Intraclass correlation coefficients were used to determine the intra- and inter-rater reliabilities. The duration of FOG and %FOG showed good measurement accuracy for both intra-rater and inter-rater reliabilities. However, the FOG phenotypes showed poor measurement accuracy in inter-rater reliability. These results indicate that the temporal characteristics of FOG can be scored with a high degree of measurement accuracy, even with different evaluators; conversely, the FOG phenotypes need to be scored by several evaluators. (shrink)