Results for 'Mei-Ling Chen'

999 found
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  1.  92
    Evaluating the immediate and delayed effects of psychological need thwarting of online teaching on Chinese primary and middle school teachers’ psychological well-being.I.-Hua Chen, Xiu-mei Chen, Xiao-Ling Liao, Ke-Yun Zhao, Zhi-Hui Wei, Chung-Ying Lin & Jeffrey Hugh Gamble - 2022 - Frontiers in Psychology 13.
    Recent studies on the effects of mandatory online teaching, resulting from the COVID-19 pandemic, have widely reported low levels of satisfaction, unwillingness to continue online teaching, and negative impacts on the psychological well-being of teachers. Emerging research has highlighted the potential role of psychological need thwarting, in terms of autonomy, competence, and relatedness thwarting, resulting from online teaching. The aim of this study was to evaluate the immediate and delayed effects of PNT of online teaching on teachers’ well-being, intention to (...)
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  2.  37
    Self-State of Nurses in Caring for Sars Survivors.Hsien-Hsien Chiang, Mei-Bih Chen & I.-Ling Sue - 2007 - Nursing Ethics 14 (1):18-26.
    The aim of this study was to analyze nurses' experiences of role strain when taking care of patients with severe acute respiratory syndrome (SARS). We adopted an interpretive/constructivist paradigm. Twenty-one nurses who had taken care of SARS patients were interviewed in focus groups. The data were analyzed using thematic analysis. The self-state of nurses during the SARS outbreak evolved into that of professional self as: (1) self-preservation; (2) self-mirroring; and (3) self-transcendence. The relationship between self-state and reflective practice is discussed.
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  3. Xin ling de chong tu yu he xie: lun li yu shen mei.Wangheng Chen - 1992 - [Wuhan shi]: Hubei sheng Xin hua shu dian jing xiao.
    Discussing the relations between ethics and aesthetic judgement.
     
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  4. Guiguzi cai tian di ling qi ji mei rong yang yan mi jue.Yinglue Chen - 1979 - [Taibei]: Guigu xian shi ji nian tang.
     
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  5.  41
    Simulating effects of signage, groups, and crowds on emergent evacuation patterns.Mei Ling Chu, Paolo Parigi, Jean-Claude Latombe & Kincho H. Law - 2015 - AI and Society 30 (4):493-507.
  6. The Effect of Corporate Social Performance on Financial Performance: The Moderating Effect of Ownership Concentration.Chih-Wei Peng & Mei-Ling Yang - 2014 - Journal of Business Ethics 123 (1):171-182.
    The purpose of this study is to extend prior research on this topic by investigating whether the impact of ownership concentration moderates the link between corporate social performance and financial performance. This study uses a set of unique, hand-collected pollution control data to measure CSP, based on a sample of Taiwanese listed companies during the period from 1996 to 2006. The results of the empirical analysis provide firm support for the idea that the divergence between control rights and the cash (...)
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  7.  11
    Assessing Students’ Translation Competence: Integrating China’s Standards of English With Cognitive Diagnostic Assessment Approaches.Huan Mei & Huilin Chen - 2022 - Frontiers in Psychology 13.
    While translation competence assessment has been playing an increasingly facilitating role in translation teaching and learning, it still failed to offer fine-grained diagnostic feedback based on certain reliable translation competence standards. As such, this study attempted to investigate the feasibility of providing diagnostic information about students’ translation competence by integrating China’s Standards of English with cognitive diagnostic assessment approaches. Under the descriptive parameter framework of CSE translation scales, an attribute pool was established, from which seven attributes were identified based on (...)
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  8.  16
    Working Memory Maintenance Modulates Serial Dependence Effects of Perceived Emotional Expression.Gaoxing Mei, Shiyu Chen & Bo Dong - 2019 - Frontiers in Psychology 10.
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  9.  44
    When and How Does Psychological Voice Climate Influence Individual Change Readiness? The Mediating Role of Normative Commitment and the Moderating Role of Work Engagement.Chun-Hsien Lee, Mei-Ling Wang & Min-Shi Liu - 2017 - Frontiers in Psychology 8.
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  10.  13
    The impacts of Covid-19 on foreign domestic workers in Hong Kong.Wong Mei Ling May - 2021 - Asian Journal of Business Ethics 10 (2):357-370.
    This paper is to inform the recent situations of work by the foreign domestic workers (FDWs) in Hong Kong through the lens of Covid-19. Through the interviews with seven informants — two employers and five FDWs, stories describing the changes in their working conditions, rights and entitlement, and the contextual environment related to the impacts of Covid-19 were collected. They were analysed through three theoretical tools — visibility/invisibility, mobility/immobility, and work boundary. The findings show that under the Covid-19 crisis, the (...)
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  11.  25
    The Effect of Religion on Psychological Resilience in Healthcare Workers During the Coronavirus Disease 2019 Pandemic.Mei-Chung Chang, Po-Fei Chen, Ting-Hsuan Lee, Chao-Chin Lin, Kwo-Tsao Chiang, Ming-Fen Tsai, Hui-Fang Kuo & For-Wey Lung - 2021 - Frontiers in Psychology 12.
    Background: Healthcare workers in the front line of diagnosis, treatment, and care of patients with coronavirus disease 2019 are at great risk of both infection and developing mental health symptoms. This study aimed to investigate the following: whether healthcare workers in general hospitals experience higher mental distress than those in psychiatric hospitals; the role played by religion and alexithymic trait in influencing the mental health condition and perceived level of happiness of healthcare workers amidst the stress of the COVID-19 pandemic; (...)
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  12.  12
    Corrigendum: An Extensive Knowledge Mapping Review of Measurement and Validity in Language Assessment and SLA Research.Vahid Aryadoust, Azrifah Zakaria, Mei Hui Lim & Chaomei Chen - 2021 - Frontiers in Psychology 11.
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  13. An Extensive Knowledge Mapping Review of Measurement and Validity in Language Assessment and SLA Research.Vahid Aryadoust, Azrifah Zakaria, Mei Hui Lim & Chaomei Chen - 2020 - Frontiers in Psychology 11.
    This study set out to investigate intellectual domains as well as the use of measurement and validation methods in language assessment research and second language acquisition published in English in peer-reviewed journals. Using Scopus, we created two datasets: a dataset of core journals consisting of 1,561 articles published in four language assessment journals, and a dataset of general journals consisting of 3,175 articles on language assessment published in the top journals of SLA and applied linguistics. We applied document co-citation analysis (...)
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  14.  28
    The Impact of Inclusive Leadership on Employees’ Innovative Behaviors: The Mediation of Psychological Capital.Yang-Chun Fang, Jia-Yan Chen, Mei-Jie Wang & Chao-Ying Chen - 2019 - Frontiers in Psychology 10:471532.
    Employee innovation is the cornerstone of the organization, and the motivation for employee innovative behavior largely depends on the leadership style of the leader. With the economic development of society, the traditional authoritative style of leadership can no longer adapt to the psychological characteristics of employees, who use new-era work concepts, techniques, and social rules (hereafter, new generation workers). Inclusive leadership is based on the concept of “fully inclusive and equitable” in traditional Chinese culture, and it can adapt to the (...)
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  15.  35
    IJEPA: Gray Area for Health Policy and International Nurse Migration.Ferry Efendi, Timothy Ken Mackey, Mei-Chih Huang & Ching-Min Chen - 2017 - Nursing Ethics 24 (3):313-328.
    Indonesia is recognized as a nurse exporting country, with policies that encourage nursing professionals to emigrate abroad. This includes the country’s adoption of international principles attempting to protect Indonesian nurses that emigrate as well as the country’s own participation in a bilateral trade and investment agreement, known as the Indonesia–Japan Economic Partnership Agreement that facilitates Indonesian nurse migration to Japan. Despite the potential trade and employment benefits from sending nurses abroad under the Indonesia–Japan Economic Partnership Agreement, Indonesia itself is suffering (...)
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  16.  33
    Is early visual processing attention impenetrable?Su-Ling Yeh & I.-Ping Chen - 1999 - Behavioral and Brain Sciences 22 (3):400-400.
    Pylyshyn's effort in establishing the cognitive impenetrability of early vision is welcome. However, his view about the role of attention in early vision seems to be oversimplified. The allocation of focal attention manifests its effect among multiple stages in the early vision system, it is not just confined to the input and the output levels.
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  17.  42
    Quality assurance of complex ChEBI concepts based on number of relationship types.Hasan Yumak, Ling Zheng, Ling Chen, Michael Halper, Yehoshua Perl & Gareth Owen - 2019 - Applied ontology 14 (3):199-214.
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  18. School as a place to have a career.Milbrey Wallin McLaughlin & Sylvia Mei-Ling Yee - 1988 - In Ann Lieberman (ed.), Building a Professional Culture in Schools. Teachers College Press.
     
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  19.  9
    Exploring Consumers’ Interest in Choosing Sustainable Food.Shih-Yun Hsu, Huai-Chen Wang, Juei-Ling Ho & Ho-Cheng Chen - 2020 - Frontiers in Psychology 11.
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  20.  23
    Self-perceived misattributed culpability or incompetence at work.Robin Stanley Snell, Almaz Man-Kuen Chak, May Mei-Ling Wong & Sandy Suk-Kwan Hui - 2021 - Asian Journal of Business Ethics 10 (1):103-128.
    Employees with self-perceived misattributed culpability or incompetence are on the receiving end of complaints, reprimands, or accusations which, from their perspective, incorrectly assume that that they have fallen short of required standards or outcomes. We analyzed an archive of 23 personal stories featuring SMCI, which had been provided by 16 Hong Kong Chinese employees. The stories indicated that the most severe impacts on employee morale had arisen from punitive and targeted feedback based on misrepresentations by superiors, who had engaged in (...)
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  21.  82
    An Investigation of College Students' Perceptions of Academic Dishonesty, Reasons for Dishonesty, Achievement Goals, and Willingness to Report Dishonest Behavior.Shu Ching Yang, Chiao-Ling Huang & An-Sing Chen - 2013 - Ethics and Behavior 23 (6):501-522.
    This study investigated students? perceptions of their own and their peers? academic dishonesty (AD), their reasons for this dishonesty, their achievement goals, and their willingness to report AD (WRAD) within a Chinese cultural context. The results identified students? belief that their peers had a greater likelihood of engaging in AD and had more motivation to do so than did the students themselves. Gender and academic major did not affect students? WRAD. However, students were significantly more willing to report classmates than (...)
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  22.  13
    Distinct mechanisms subserve location- and object-based visual attention.Wei-Lun Chou, Su-Ling Yeh & Chien-Chung Chen - 2014 - Frontiers in Psychology 5.
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  23.  13
    A Novel Automatic Generation Control Method Based on the Ecological Population Cooperative Control for the Islanded Smart Grid.Lei Xi, Yudan Li, Yuehua Huang, Ling Lu & Jianfeng Chen - 2018 - Complexity 2018:1-17.
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  24. The Joint Moderating Impact of Moral Intensity and Moral Judgment on Consumer’s Use Intention of Pirated Software.Mei-Fang Chen, Ching-Ti Pan & Ming-Chuan Pan - 2009 - Journal of Business Ethics 90 (3):361 - 373.
    Moral issues have been included in the studies of consumer misbehavior research, but little is known about the joint moderating effect of moral intensity and moral judgment on the consumer’s use intention of pirated software. This study aims to understand the consumer’s use intention of pirated software in Taiwan based on the theory of planned behavior (TPB) proposed by Ajzen (Organizational Behavior and Human Decision Processes, 50, 179, 1991). In addition, moral intensity and moral judgment are adopted as a joint (...)
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  25.  30
    The Joint Moderating Impact of Moral Intensity and Moral Judgment on Consumer’s Use Intention of Pirated Software.Mei-Fang Chen, Ching-Ti Pan & Ming-Chuan Pan - 2009 - Journal of Business Ethics 90 (3):361-373.
    Moral issues have been included in the studies of consumer misbehavior research, but little is known about the joint moderating effect of moral intensity and moral judgment on the consumer's use intention of pirated software. This study aims to understand the consumer's use intention of pirated software in Taiwan based on the theory of planned behavior proposed by Ajzen. In addition, moral intensity and moral judgment are adopted as a joint moderator to examine their combined influence on the proposed research (...)
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  26.  16
    The "visual word form area" is involved in successful memory encoding of both words and faces.L. Mei, G. Xue, C. Chen, F. Xue, M. Zhang & Q. Dong - unknown
    Previous studies have identified the critical role of the left fusiform cortex in visual word form processing, learning, and memory. However, this so-called visual word form area's other functions are not clear. In this study, we used fMRI and the subsequent memory paradigm to examine whether the putative VWFA was involved in the processing and successful memory encoding of faces as well as words. Twenty-two native Chinese speakers were recruited to memorize the visual forms of faces and Chinese words. Episodic (...)
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  27.  42
    Look into my eyes and I will see you: Unconscious processing of human gaze.Yi-Chia Chen & Su-Ling Yeh - 2012 - Consciousness and Cognition 21 (4):1703-1710.
    This study examines whether human gaze lacking the confounding factor of eye whites can be processed unconsciously and explores the critical aspects for such process. Utilizing the continuous flash suppression paradigm, a schematic face—with direct or averted gaze, and with neutral, fearful or happy expressions—was presented to one eye while dynamic masks rendered it invisible to the other eye. Schematic faces were used to avoid unwanted influence from salient eye whites. Participants’ detection time of anything other than the masks was (...)
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  28.  65
    Time-Dependent Effects of Acute Exercise on University Students’ Cognitive Performance in Temperate and Cold Environments.Ling-Yu Ji, Xiao-Ling Li, Yang Liu, Xiu-Wen Sun, Hui-Fen Wang, Long Chen & Liang Gao - 2017 - Frontiers in Psychology 8.
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  29.  39
    Does Gender Make a Difference in Deception? The Effect of Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex.Mei Gao, Xiaolan Yang, Jinchuan Shi, Yiyang Lin & Shu Chen - 2018 - Frontiers in Psychology 9.
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  30.  23
    Nurses’ perspectives on moral distress.Pei-Pei Chen, Hsiao-Lu Lee, Shu-He Huang, Ching-Ling Wang & Chiu-Mieh Huang - forthcoming - Nursing Ethics:096973301666497.
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  31.  75
    The Neural Correlates of Effortful Cognitive Processing Deficits in Schizophrenia: An ERP Study.Chen-Guang Jiang, Jun Wang, Xiao-Hong Liu, Yan-Ling Xue & Zhen-He Zhou - 2021 - Frontiers in Human Neuroscience 15.
    Background: Individuals’ information processing includes automatic and effortful processes and the latter require sustained concentration or attention and larger amounts of cognitive “capacity.” Event-related potentials reflect all neural activities that are related to a certain stimulus. Investigating ERP characteristics of effortful cognitive processing in people with schizophrenia would be helpful in further understanding the neural mechanism of schizophrenia.Methods: Both schizophrenia patients and health controls completed ERP measurements during the performance of the basic facial emotion identification test and the face-vignette task. (...)
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  32.  23
    First-time mothers’ experiences of pregnancy and birth following assisted reproductive technology treatment in Taiwan.Mei-Zen Huang, Yi-Chin Sun, Meei-Ling Gau, Shuby Puthussery & Chien-Huei Kao - 2019 - Journal of Health, Population and Nutrition 38 (1):10.
    Assisted reproductive technology treatment tends to involve significant physical and emotional commitments that can impact maternal, infant, and family health and well-being. An in-depth understanding of experiences is necessary to provide adequate support for women and their families during pregnancy and transition to parenthood following ART treatment. The aim of this study was to explore first-time mothers’ experiences of pregnancy and transition to parenthood following successful ART treatment in Taiwan. Twelve first-time mothers who conceived and gave live birth using ART (...)
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  33.  11
    An Online Career Intervention for Promoting Chinese High School Students’ Career Readiness.Shi Chen, Huaruo Chen, Hairong Ling & Xueying Gu - 2022 - Frontiers in Psychology 12.
    To assist Chinese high school students in improving their career readiness and tackling career decision-making difficulties, we designed a synchronous online career intervention based on the Cognitive Information Processing theory during the Covid-19 pandemic. The online career intervention consisted of a series of career courses to develop high school students’ knowledge and skills in career planning, career assessments for exploring their vocational interests and academic self-concept, and a database providing basic information about university majors. To evaluate the intervention’s effectiveness, 957 (...)
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  34.  41
    Misattributing the Source of Self-Generated Representations Related to Dissociative and Psychotic Symptoms.Chui-De Chiu, Mei-Chih Meg Tseng, Yi-Ling Chien, Shih-Cheng Liao, Chih-Min Liu, Yei-Yu Yeh & Hai-Gwo Hwu - 2016 - Frontiers in Psychology 7.
  35.  13
    Proposal Allocation Ratio as a Moderator of Interpersonal Responsibility Effects on Hostile Decision-Making in the Ultimatum Game.Xinyu Gong, Ling-Xiang Xia, Yanlin Sun, Lei Guo, Vanessa C. Carpenter, Yuan Fang & Yunli Chen - 2017 - Frontiers in Psychology 8:280503.
    Interpersonal responsibility is an indigenous Chinese personality construct, which is regarded to have positive social functions. Two studies were designed to explore the relationship among interpersonal responsibility, proposal allocation ratio, and responders’ hostile decisions in an ultimatum game. Study 1 was a scenario study using a hypothetical ultimatum game with a valid sample of 551 high school students. Study 2 was an experimental study which recruited 54 undergraduate students to play the incentivized ultimatum game online. The results of the two (...)
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  36. Self-Construal Priming Modulates Ensemble Perception of Multiple-Face Identities.Shenli Peng, Ling Zhang, Runzhou Xu, Chang Hong Liu, Wenfeng Chen & Ping Hu - 2019 - Frontiers in Psychology 10.
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  37.  32
    Agency practitioners' perceptions of professional ethics in taiwan.Amber Wenling Chen & Jeanne Mei-Chyi Liu - 1998 - Journal of Business Ethics 17 (1):15-23.
    A survey was conducted on the advertising practitioners in Taiwan concerning their experiences of ethical challenges at work. Among 120 respondents, while 32.5 percent responded that ethical problems did not exist, 67.5 percent admitted that ethical problem was a commonplace at work. According to these respondents, the most frequently mentioned ethical problems area representing unethical products or services, the message of advertisements, agency-client relationship, the creditability of research, undertable rebate, and the quality of service. Suggestions for international advertising managers were (...)
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  38.  14
    The Nondualistic Aesthetics of Qi 氣 in Antoni Tàpies' Holistic Conception of Art.Mei-Hsin Chen - 2020 - Philosophy East and West 70 (1):84-115.
    Antoni Tàpies’ essays and interviews display how his conception of art is impregnated with an Oriental nondualistic aesthetics.1 I argue that, among them, the Chinese aesthetics of qi 氣 plays the most pivotal role and leaves an indelible imprint in his corpus. Tàpies’ encounter with this Asian thinking probably came through the translated writings of Laozi 老子, Confucius 孔子, Mencius 孟子, Zhuangzi 莊子, Mozi 墨子, and Lin Yutang 林語堂, among others, thanks to the publications of different Western-based Sinologists.2 However, instead (...)
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  39.  33
    Using discrete choice experiment to elicit doctors' preferences for the report card design of diabetes care in Taiwan – a pilot study.Tsung-Tai Chen, Kuo-Piao Chung, Heng-Chiang Huang, Lao-Nga Man & Mei-Shu Lai - 2010 - Journal of Evaluation in Clinical Practice 16 (1):14-20.
  40.  31
    Flexible Intimacies in the Global Intimate Economy: Evidence from Taiwan's Cross-Border Marriages.Mei-Hua Chen & Hong-zen Wang - 2021 - Feminist Studies 47 (2):258-275.
    In lieu of an abstract, here is a brief excerpt of the content:258 Feminist Studies 47, no. 2. © 2021 by Feminist Studies, Inc. Mei-Hua Chen and Hong-zen Wang Flexible Intimacies in the Global Intimate Economy: Evidence from Taiwan’s Cross-Border Marriages When Lin Ping was interviewed by the first author of this article at a detention center in the southern city of Tainan, Taiwan, in September 2006, she was forty-three. At that time, she had been married to a Taiwanese (...)
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  41.  27
    Delayed Pseudoaneurysm after PCI Treated by Ultrasound-Guided Manual Radial Artery Compression: A Case Report.Ling Chen, Chun-yu Wang, Bing Wu, San-wu Wu & You-en Zhang - 2018 - Journal of Clinical Research and Bioethics 9 (3).
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  42.  13
    Effects of Blue Light on Dynamic Vision.Hung-Wen Chen & Su-Ling Yeh - 2019 - Frontiers in Psychology 10.
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  43.  30
    Prediction of Freezing of Gait in Parkinson’s Disease Using a Random Forest Model Based on an Orthogonal Experimental Design: A Pilot Study.Zhonelue Chen, Gen Li, Chao Gao, Yuyan Tan, Jun Liu, Jin Zhao, Yun Ling, Xiaoliu Yu, Kang Ren & Shengdi Chen - 2021 - Frontiers in Human Neuroscience 15.
    PurposeThe purpose of this study was to introduce an orthogonal experimental design to improve the efficiency of building and optimizing models for freezing of gait prediction.MethodsA random forest model was developed to predict FOG by using acceleration signals and angular velocity signals to recognize possible precursor signs of FOG. An OED was introduced to optimize the feature extraction parameters.ResultsThe main effects and interaction among the feature extraction hyperparameters were analyzed. The false-positive rate, hit rate, and mean prediction time were 27%, (...)
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  44.  7
    Variations in Static Force Control and Motor Unit Behavior with Error Amplification Feedback in the Elderly.Yi-Ching Chen, Linda L. Lin, Yen-Ting Lin, Chia-Ling Hu & Ing-Shiou Hwang - 2017 - Frontiers in Human Neuroscience 11.
  45.  6
    Varieties of Global Capital and the Paradox of Local Upgrading in China.Ling Chen - 2014 - Politics and Society 42 (2):223-252.
    Over the past two decades, China has launched a nationwide endeavor to push domestic firms up the value chain. This article explores why, in some localities, Chinese firms had significant success in upgrading, while in other localities, firms were paradoxically trapped in a race-to-the-bottom competition. Drawing on national economic census data, a firm-level survey, and in-depth interviews, the article conducts a controlled comparison of China’s largest electronics manufacturing bases in the Yangtze and the Pearl River Deltas. It argues that the (...)
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  46.  55
    Costs and Utilities Perspective of Consumers' Intentions to Engage in Online Music Sharing: Consumers' Knowledge Matters.Mei-Fang Chen & Ya-Hui Yen - 2011 - Ethics and Behavior 21 (4):283 - 300.
    Online music sharing, deemed illegal for invading intellectual property rights under current laws, has become a crucial issue for the music industry in the modern digital age, but few have investigated the potential costs and utilities for individuals involved in such online misbehavior. This study aimed to fill in this gap to predict consumers' intentions to engage in online music sharing and further consider consumers' online music sharing knowledge as a moderator in the research model. The results of repeated measures (...)
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  47.  41
    Identification of the Features of Emotional Dysfunction in Female Individuals With Methamphetamine Use Disorder Measured by Musical Stimuli Modulated Startle Reflex.Xi-Jing Chen, Chun-Guang Wang, Wang Liu, Monika Gorowska, Dong-Mei Wang & Yong-Hui Li - 2018 - Frontiers in Human Neuroscience 12.
  48.  16
    The Lattice Structures of Approximation Operators Based on L-Fuzzy Generalized Neighborhood Systems.Qiao-Ling Song, Hu Zhao, Juan-Juan Zhang, A. A. Ramadan, Hong-Ying Zhang & Gui-Xiu Chen - 2021 - Complexity 2021:1-10.
    Following the idea of L -fuzzy generalized neighborhood systems as introduced by Zhao et al., we will give the join-complete lattice structures of lower and upper approximation operators based on L -fuzzy generalized neighborhood systems. In particular, as special approximation operators based on L -fuzzy generalized neighborhood systems, we will give the complete lattice structures of lower and upper approximation operators based on L -fuzzy relations. Furthermore, if L satisfies the double negative law, then there exists an order isomorphic mapping (...)
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  49.  8
    Global trends of research on depression in breast cancer: A bibliometric study based on VOSviewer.Ling Chen, Tingting Ren, Yun Tan & Hong Li - 2022 - Frontiers in Psychology 13.
    BackgroundDepression is common psychiatric morbidity in breast cancer survivors, seriously affecting patients’ quality of life and mental health. A growing body of research has investigated depression in breast cancer. However, no visual bibliometric analysis was conducted in this field. This study aimed to visualize the literature to identify hotspots and frontiers in research on breast cancer and depression.MethodsThe publications related to depression in breast cancer were retrieved in the Web of Science Core Collection between 1 January 2002 and 17 March (...)
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  50.  8
    How signaling pathways link extracellular mechano‐environment to proline biosynthesis: A hypothesis.Keng Chen, Ling Guo & Chuanyue Wu - 2021 - Bioessays 43 (9):2100116.
    We propose a signaling pathway in which cell‐extracellular matrix (ECM) adhesion components PINCH‐1 and kindlin‐2 sense mechanical signals from ECM and link them to proline biosynthesis, a vital metabolic pathway for macromolecule synthesis, redox balance, and ECM remodeling. ECM stiffening promotes PINCH‐1 expression via integrin signaling, which suppresses dynamin‐related protein 1 (DRP1) expression and mitochondrial fission, resulting in increased kindlin‐2 translocation into mitochondria and interaction with Δ1‐pyrroline‐5‐carboxylate (P5C) reductase 1 (PYCR1). Kindlin‐2 interaction with PYCR1 protects the latter from proteolytic degradation, (...)
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