We investigated spectral resting-state EEG in persons with chronic stroke-induced aphasia to determine its reliability, sensitivity, and relationship to functional behaviors. Resting-state EEG has not yet been characterized in this population and was selected given the demonstrated potential of resting-state investigations using other neuroimaging techniques to guide clinical decision-making. Controls and persons with chronic stroke-induced aphasia completed two EEG recording sessions, separated by approximately 1 month, as well as behavioral assessments of language, sensorimotor, and cognitive domains. Power in the classic (...) frequency bands was examined via spectral analysis of resting-state EEG data. Results suggest that power in the theta, alpha, and beta bands is reliable for use as a repeated measure. Significantly greater theta and lower beta power was observed in persons with aphasia than controls. Finally, in PWAs theta power negatively correlated with performance on a discourse informativeness measure, while alpha and beta power positively correlated with performance on the same measure. This indicates that spectral rsEEG slowing observed in PWAs in the chronic stage is pathological and suggests a possible avenue for directly altering brain activation to improve behavioral function. Taken together, these results suggest that spectral resting-state EEG holds promise for sensitive measurement of functioning and change in persons with chronic aphasia. Future studies investigating the utility of these measures as biomarkers of frank or latent aphasic deficits and treatment response in chronic stroke-induced aphasia are warranted. (shrink)

Building on more than two decades offeminist analysis of the family, this article takes a neoinstitutionalist approach to examine some of the ways that sex, gender, and sexual orientation intersect in lesbianheaded two-parent families, affecting how they construct their roles as mothers. Institutionalist theory tends to de-emphasize how actors deliberately construct social arrangements such as parenting roles within the family. The authors' analysis of interviews from 14 lesbian mothers remedies this deficiency by focusing both on how they draw upon and (...) transform institutionalized scripts, practices, and understandings of family roles and relations. Their findings reveal how these mothers reinscribed gendered understandings while simultaneously challenging heteronormative ones in their efforts to construct and maintain socially viable two-parent families. (shrink)

This essay presents an argument for reconceptualizing subjectivity as orientational rather than foundational in nature. My focus is on the work of Emmanuel Levinas and Immanuel Kant. I begin by summarizing Levinas''s theory of ethical subjectivity as a theory of the self where the internal and the external are in constant play. Then I turn to two works of Kant for resources to understand better the meaning of Levinas''s theory of the self. In "What is Orientation in Thinking?" Kant presents (...) a model for orientation in thought that I make use of as a basic framework for a model of orientational subjectivity. Then I analyze two feelings described by Kant in the third Critique which I argue can be understood as orientational feelings within such a model of orientational subjectivity: the feeling of sensus communis and the feeling of vocation. (shrink)

Glycosylation refers to the co‐ and post‐translational modification of protein and lipids by monosaccharides or oligosaccharide chains. The surface of mammalian cells is decorated by a heterogeneous and highly complex array of protein and lipid linked glycan structures that vary significantly between different cell types, raising questions about their roles in development and disease pathogenesis. This review will begin by focusing on recent findings that define roles for cell surface protein and lipid glycosylation in pluripotent stem cells and their functional (...) impact during normal development. Then, we will describe how patient derived induced pluripotent stem cells are being used to model human diseases such as congenital disorders of glycosylation. Collectively, these studies indicate that cell surface glycans perform critical roles in human development and disease. (shrink)

Descartes’s work as a philosopher was inspired by three dreams he had on November 10, 1619, and yet the philosophy that Descartes produced in response to this inspiration included an argument that all dreams are deceptive. This particular incongruity is indicative of a more general ambivalence and anxiety in Descartes’s thought concerning images, which creates a tension that is never fully resolved. In this essay I focus primarily on one side of that tension: the part of Descartes’s philosophy that is (...) distrustful of images. To do this I first reconstruct Descartes’s theory of images, drawing from several of his lesser-known writings on optics, and then I consider how that theory of images leads Descartes to conceptualize true vision as a matter of “insight” rather than “eyesight” and to argue that the blind actually see better than those with working eyes. In the final part of the essay I briefly consider some of the consequences of Descartes’s theory of vision and the suspicion of images that animates it. (shrink)

Descartes’s work as a philosopher was inspired by three dreams he had on November 10, 1619, and yet the philosophy that Descartes produced in response to this inspiration included an argument that all dreams are deceptive. This particular incongruity is indicative of a more general ambivalence and anxiety in Descartes’s thought concerning images, which creates a tension that is never fully resolved. In this essay I focus primarily on one side of that tension: the part of Descartes’s philosophy that is (...) distrustful of images. To do this I first reconstruct Descartes’s theory of images, drawing from several of his lesser-known writings on optics, and then I consider how that theory of images leads Descartes to conceptualize true vision as a matter of “insight” rather than “eyesight” and to argue that the blind actually see better than those with working eyes. In the final part of the essay I briefly consider some of the consequences of Descartes’s theory of vision and the suspicion of images that animates it. (shrink)

In Thus Spoke Zarathustra Nietzsche explores the nature of teaching and learning and concludes that a teacher can do more harm than good in a student's life if she allows her students to become her ‘disciples’. A disciple assigns too much authority to a teacher and thus loses the ability to think independently; this is what Zarathustra means when he warns his students, ‘Beware that you are not killed by a statue!’ In this article I argue that Zarathustra's solution to (...) this problem is to undermine his own authority by performing several different variations of the Liar's Paradox in parts 2 and 3 of Thus Spoke Zarathustra. (shrink)

I argue for an approach to Philosophical Fragments that allows it to be philosophical and fragmentary, and that pays particular attention to the fragments, or crumbs, that seem least important. One such overlooked crumb is the theory of merely human education in the book—education that does not enlist God as the teacher, where humans simply try to teach and learn from each other. I argue that Philosophical Fragments defends this theory of education with several reductio ad absurdum proofs that are (...) especially useful because they clarify why merely human education so often fails. Finally I apply the theory of merely human education in Philosophical Fragments to Kierkegaard’s authorship as a whole and argue that it gives us a paradigm for understanding all of Kierkegaard’s texts that is more fundamental than the distinction between direct and indirect communication. (shrink)

This book is an attempt to write about Kierkegaard's philosophy in the style of Kierkegaard's philosophy: energetic, playful, free spirited, surprising, and joyous. It is a deliberately crumby book in the sense that it seeks out the fragments, scraps, and crumbs of philosophical arguments that are generally ignored or swept away, like so much rubbish, but that are actually the most interesting parts of the meal. The Anti-Assistant-Professor Method that this book follows adopts Kierkegaard's many excellent jokes about assistant professors (...) as a guide to how not to write about Kierkegaard's philosophy; specifically: - Don't cease to be human. - Don't be a parasite, merely feeding off other people's creations and never creating anything new. - Don't reduce or simplify or systematize Kierkegaard's ideas in order to make life easier for everyone (because that was never the point). - Don't kill Kierkegaard's philosophy by lecturing on it, thereby turning it into a collection of dead ideas for nonhumans rather than subjective truths that need to be lived. Following these guidelines, the book attempts to extend and amplify some of Kierkegaard's most important ideas in a way that combats the persistent problem of nihilism--a disease that even Kierkegaard succumbed to at the end of his life. (shrink)

This essay argues that Kant's explanation of the purposiveness-without-a-purpose of beauty (in the third Critique) can help to make sense of Nancy's theory of the inoperative community.

In this dissertation I outline a theory of non-cognitive ethics--a theory of how ethics is possible in response to feeling rather than to concepts--that is drawn from the ethical philosophy of Emmanuel Levinas and the aesthetic thought of Immanuel Kant. In general I argue that in the work of Levinas we can find a description of non-cognitive ethics in which community and subjectivity are still meaningful, and that Kant's third Critique can contribute to this project by providing some of the (...) transcendental conditions for such an ethics. ;I begin with a discussion of the general nature of Levinas's ethical project, and the three principal axes of that thought: the singular Other before whom we are obligated, the community of others to which we also belong, and the nature of the subject that must respond to both. Next, I focus on the contribution that Kant's third Critique can make to a Levinasian theory of non-cognitive ethics. After arguing that this contribution is rooted in a general affiliation between Kant's approach to aesthetics and Levinas's approach to ethics, I address three particular connections between Levinasian ethics and the third Critique. These connections involve the sublime and the fact of obligation, the beautiful and non-purposive communities, and finally orientation and ethical subjectivity. (shrink)

In an interview with Philippe Nemo, Emmanuel Levinas makes a very revealing comment about what he was trying to accomplish in his ethical philosophy. In response to a question about the ‘starting-point’ of his ethics, Levinas protests: ‘My task does not consist in constructing ethics; I only try to find its meaning … One can without doubt construct an ethics in function of what I have just said [in describing his philosophy up to this point in the interview], but this (...) is not my own theme’. (shrink)

I argue that Kierkegaard’s Journals and Notebooks deserve to be read as works of philosophy and not just used as supplements to bring order and respectability to Kierkegaard’s other writings. There are at least three specific philosophical values in Kierkegaard’s journals – three ways in which the journals create philosophy within their own pages and therefore deserve to be read as independent works of philosophy and not just as supplements to Kierkegaard’s other writing: (1) The journals demonstrate what a true (...) work of existential philosophy looks like. (2) The journals contribute to Kierkegaard’s theory of indirect communication. (3) The journals create new philosophical concepts. All three of these are best understood as philosophical performances or a kind of philosophical theatre. The idea that philosophy can be a kind of theatre is inspired by the work of Gilles Deleuze and Felix Guattari, particularly their book What is Philosophy? I draw from Deleuze and Guattari especially in section (3) to argue that Kierkegaard’s Journals create new philosophical concepts. (shrink)

This essay argues that, in the first Critique, the need for unity leads Kant to re-inscribe the subject in a situation of multiplicity and undecidability. The result, however, is not a relativization that negates the meaning of the subject’s existence, but rather a contextualization that makes meaning possible. This reading clarifies some of the connections between Kant and contemporary postmodernism, especially the work of Jacques Derrida.

Multimodal prehabilitation is increasingly recognized as an important component of the pre-operative pathway in oncology. It aims to optimize physical and psychological health through delivery of a series of tailored interventions including exercise, nutrition, and psychological support. At the core of this prescription is a need for considerable health behavior change, to ensure that patients are engaged with and adhere to these interventions and experience the associated benefits. To date the prehabilitation literature has focused on testing the efficacy of devised (...) exercise and nutritional interventions with a primary focus on physiological and mechanistic outcomes with little consideration for the role of behavioral science, supporting individual behavior change or optimizing patient engagement. Changing health behavior is complex and to maximize success, prehabilitation programs should draw on latest insights from the field of behavioral science. Behavioral science offers extensive knowledge on theories and models of health behavior change to further advance intervention effectiveness. Similarly, interventions developed with a person-centered approach, taking into consideration individual needs and preferences will increase engagement. In this article, we will provide an overview of the extent to which the existing prehabilitation literature incorporates behavioral science, as well as studies that have explored patient's attitudes toward prehabilitation. We will go on to describe and critique ongoing trials in a variety of contexts within oncology prehabilitation and discuss how current scientific knowledge may be enhanced from a behavioral science perspective. We will also consider the role of “surgery schools” and detail practical recommendations that can be embedded in existing or emerging clinical settings. (shrink)

ObjectiveBreast cancer may profoundly affect a couple’s sex life. The present study examines whether patient-, partner- and relationship-related characteristics are associated with sexual activity of couples following breast cancer diagnosis in the treatment phase and over time.MethodsWomen with breast cancer and their male cohabiting partners participated in a longitudinal study in Denmark. Logistic regression was used to examine associations of patient-, partner- and relationship-related characteristics at baseline with couples’ sexual activity at baseline, 5 and 12 months later. The longitudinal analyses (...) were stratified for couples’ sexual activity status at baseline.ResultsA total of 722, 533 and 471 couples were included in the analyses at baseline, 5- and 12-months follow-up, respectively. Older age, depressive symptoms and lower vitality of patients were associated with lower odds of couples’ sexual activity at baseline; chemotherapy treatment and older age of patients were associated with lower odds at 5-months follow-up in couples who were not sexually active at baseline. Higher ratings of emotional closeness, affectionate behavior and satisfaction with dyadic coping were associated with higher odds for sexual activity at baseline and over time in couples who were sexually active at baseline.ConclusionSexual counseling during cancer treatment and rehabilitation should include a couple perspective. Relationship-related variables may be a protective factor for remaining sexually active after breast cancer diagnosis. Interventions could focus on strengthening these factors. Health professionals also need to consider the patients’ breast cancer treatment, vitality, and emotional distress in counselling on sexuality. (shrink)

A review of volume 11, part 1 of _Kierkegaard’s Journals and Notebooks._.

International food aid has long been known to be motivated by domestic and foreign policy objectives as well as humanitarian concerns. The policy objectives sometimes complicate delivery of emergency food, and lead to situations that result in adverse effects on the economic and agricultural systems of recipient countries. Despite the long history and extensive documentation of such effects, they were observed to occur once again during the 1992 Somalia intervention. This intervention encountered many frequently described barriers to effective use of (...) emergency food aid. It also set a new precedent; for the first time, troops were deployed to enforce the safe delivery of food. This action led to the creation of an army of occupation engaged in military conflict with the very people it had come to serve and, eventually, to further deterioration of the country's food economy. The Somalia intervention provided further evidence for the need to uncouple humanitarian food aid from other policy objectives, and to design and manage emergency and long-term food aid programs to maximize benefits, minimize adverse consequences, and strengthen local agricultural production and marketing systems. (shrink)