DNA glycosylases remove aberrant DNA nucleobases as the first enzymatic step of the base excision repair (BER) pathway. The alkyl‐DNA glycosylases AlkC and AlkD adopt a unique structure based on α‐helical HEAT repeats. Both enzymes identify and excise their substrates without a base‐flipping mechanism used by other glycosylases and nucleic acid processing proteins to access nucleobases that are otherwise stacked inside the double‐helix. Consequently, these glycosylases act on a variety of cationic nucleobase modifications, including bulky adducts, not previously associated with (...) BER. The related non‐enzymatic HEAT‐like repeat (HLR) proteins, AlkD2, and AlkF, have unique nucleic acid binding properties that expand the functions of this relatively new protein superfamily beyond DNA repair. Here, we review the phylogeny, biochemistry, and structures of the HLR proteins, which have helped broaden our understanding of the mechanisms by which DNA glycosylases locate and excise chemically modified DNA nucleobases. (shrink)

本书侧重分析中华民族哲学智慧的个性及其对人类哲学文明发展的特殊贡献。中华文明从未间断并发展下来的哲学原因是中华民族不断开发不断完善的直观智慧,中华民族的哲学精神为人类简单明了地指出了走出民族冲突与宗教 冲突困惑的思路。.

This article aims to explore a more suitable prediction method for tourism complex environment, to improve the accuracy of tourism prediction results and to explore the development law of China’s domestic tourism so as to better serve the domestic tourism management and tourism decision-making. This study uses grey system theory, BP neural network theory, and the combination model method to model and forecast tourism demand. Firstly, the GM model is established based on the introduction of grey theory. The regular data (...) series are obtained through the transformation of irregular data series, and the prediction model is established. Secondly, in the structure algorithm of the BP neural network, the BP neural network model is established using the data series of travel time and the number of people. Then, combining BP neural network with the grey model, the grey neural network combination model is established to forecast the number of tourists. The prediction accuracy of the model is analyzed by the actual time series data of the number of tourists. Finally, the experimental analysis shows that the combination forecasting makes full use of the information provided by each forecasting model and obtains the combination forecasting model and the best forecasting result so as to improve the forecasting accuracy and reliability. (shrink)

Background: Cognitive impairment is one of the core symptoms of schizophrenia, which is considered to be significantly correlated to prognosis. In recent years, many studies have suggested that metabolic disorders could be related to a higher risk of cognitive defects in a general setting. However, there has been limited evidence on the association between metabolism and cognitive function in patients with early-stage schizophrenia.Methods: In this study, we recruited 172 patients with early-stage schizophrenia. Relevant metabolic parameters were examined and cognitive function (...) was evaluated by using the MATRICS Consensus Cognitive Battery (MCCB) to investigate the relationship between metabolic disorder and cognitive impairment.Results: Generally, the prevalence of cognitive impairment among patients in our study was 84.7% (144/170), which was much higher than that in the general population. Compared with the general Chinese setting, the study population presented a higher proportion of metabolic disturbance. Patients who had metabolic disturbance showed no significant differences on cognitive function compared with the other patients. Correlation analysis showed that metabolic status was significantly correlated with cognitive function as assessed by the cognitive domain scores (p < 0.05), while such association was not found in further multiple regression analysis.Conclusions: Therefore, there may be no association between metabolic disorder and cognitive impairment in patients with early-stage schizophrenia.Trial Registration: Clinicaltrials.gov, NCT02880462. Registered August 26, 2016. (shrink)

Our research aimed to investigate the effectiveness of auditory, visual, and audiovisual warning signals for capturing the attention of the pilot, and how stimulus onset asynchronies in audiovisual stimuli affect pilots perceiving the bimodal warning signals under different perceptual load conditions. In experiment 1 of the low perceptual load condition, participants discriminated the location of visual targets preceded by five different types of warning signals. In experiment 2 of high perceptual load, participants completed the location task identical to a low (...) load condition and a digit detection task in a rapid serial visual presentation stream. The main effect of warning signals in two experiments showed that visual and auditory cues presented simultaneously could effectively and efficiently arouse the attention of the pilots in high and low load conditions. Specifically, auditory, AV, and visual preceding auditory stimulus by 100 ms increased the spatial orientation to a valid position in low load conditions. With the increase in visual perceptual load, auditory preceding the visual stimulus by 100 ms and A warning signals had stronger spatial orientation. The results are expected to theoretically support the optimization design of the cockpit display interface, contributing to immediate flight crew awareness. (shrink)

The "Wanzhang" chapter in the Mencius has this famously quoted passage:1.

本书收集了邢贲思的作品,都是在探讨如何建立与社会主义市场经济相适应的社会主义道德体系,这与当前的精神文明建设有着十分密切的关系。.

Interval time-varying delay is common in control process, e.g., automatic robot control system, and its stability analysis is of great significance to ensure the reliable control of industrial processes. In order to improve the conservation of the existing robust stability analysis method, this paper considers a class of linear systems with norm-bounded uncertainty and interval time-varying delay as the research object. Less conservative robust stability criterion is put forward based on augmented Lyapunov-Krasovskii functional method and reciprocally convex combination. Firstly, the (...) delay interval is partitioned into multiple equidistant subintervals, and a new Lyapunov-Krasovskii functional comprising quadruple-integral term is introduced for each subinterval. Secondly, a novel delay-dependent stability criterion in terms of linear matrix inequalities is given by less conservative Wirtinger-based integral inequality approach. Three numerical comparative examples are given to verify the superiority of the proposed approach in reducing the conservation of conclusion. For the first example about closed-loop control systems with interval time-varying delays, the proposed robust stability criterion could get MADB about 0.3 more than the best results in the previous literature; and, for two other uncertain systems with interval time-varying delays, the MADB results obtained by the proposed method are better than those in the previous literature by about 0.045 and 0.054, respectively. All the example results obtained in this paper clearly show that our approach is better than other existing methods. (shrink)

Significant challenges confronting China include reducing carbon emissions, dealing with the resulting problems, and meeting various requirements for long-term economic growth. As a result, the shift in industrial structure best reflects how human society utilizes resources and impacts the environment. To meet China's 2050 net-zero emissions target, we look at how technological innovations, financial development, renewable energy investment, population age, and the economic complexity index all play a role in environmental sustainability in China. Analyzing short- and long-term relationships using ARDL (...) bounds testing, we used historical data spanning 1990–2018. According to the study's findings, the cointegration between CO2 emissions and their underlying factors was found. The deterioration of the environment directly results from financial development, increasing economic complexity, and population aging. Technical advancements, investments in renewable energy sources, and changes to the industrial structure all contribute to lower CO2 emissions. Granger causality results were also reliably obtained in this study. According to our findings in the fight against environmental problems, a key tool for meeting long-term sustainability goals is policy prescriptions that use technological innovations, renewable energy investment, and industrial structure. (shrink)

The construction projects in Pakistan have inherent problems of erroneous planning and schedule development. This dilemma has led to the failure of the majority of construction projects in Pakistan. Earlier researches have tried to curtail the increasing spectrum of inaccurate planning and schedule development. But not many research studies have shed light on the major factor of 2D CAD drawings interpretation problems, which are playing a key role in defective planning and scheduling. Moreover, the role of BIM, i.e., Building Information (...) Modeling with respect to efficient planning, has not been also discussed in detail. This study has concluded a positive impact of BIM on effective planning and scheduling in the construction industry of Pakistan. About 210 responses were obtained from experienced construction professionals of Pakistan and tested via regression analysis in order to validate this argument. It has been analyzed that 2D CAD drawings are now getting primitive and 3D technology BIM is taking its place. BIM is an efficient tool for planning and scheduling. With the start of CPEC and Multi-Billion Dollar investment on infrastructure, construction industry of Pakistan needs to uplift its existing standard in order to meet with international requirements. For this purpose, BIM has been recommended. It will not only assist in attaining flawless planning but will also increase the success rate of CPEC projects in Pakistan. (shrink)

Since our visual perception of physical things essentially involves our identifying objects by their colours, any theory of visual perception must contain some account of the colours of things. The central problem with colour has to do with relating our normal, everyday colour perceptions to what science, i.e. physics, teaches us about physical objects and their qualities. Although we perceive colours as categorical surface properties of things, colour perceptions are explained by introducing physical properties like reflectance profiles or dispositions to (...) cause certain experiences in normal human perceivers. Hence, it seems as if colours as they are experienced by us have no place in the physical world, because they are fundamentally different from the properties which we ascribe to physical objects in scientific accounts of colour perceptions. This special issue on perspectives on colour perception presents new suggestions to solve to this major problem. (shrink)

Everyone knows that the investigation and transcription of characters directly determine the meaning of textual materials. As in the case of the Guodian Chu slips, the publication of the transcriptions of the Chu slips is the basis for scholars to understand and do research on the Guodian Chu slips. However, making public transcriptions of any type of excavated textual material will always stir up a broad range of controversy concerning issues in the investigation and transcription of characters. The significance of (...) some of these issues lies primarily in the nature of philology itself; but there are also problems that fundamentally affect the understanding of a whole text or a whole cache of textual material. This paper attempts to give a critical account of the paleographical issues and their significance, as seen in Guodian Chu slip research. (shrink)

Contemporary scholarship, such as Professor Li Xueqin's work on the formative stage of the "first classic," helps us better understand not only "the first of all Chinese classics," but also the philosophical and cultural continuum between the Shang and Zhou dynasties. By reexamining several perplexing issues, going from the authenticity of the Guicang to the interpretation of "King Wen of Zhou developed the Zhouyi," I argue that archaeological evidence is of critical importance in the study of the preclassics era.

The Chinese traditional culture includes three systems of thought: Confucianism, Daoism and Buddhism. The first two are Chinese culture, and Buddhism is a foreign religion introduced from India. Although there had been conflicts among the three systems of thoughts, but integration is the mainstream in the development of Chinese cultural thought. Thus, Chinese culture has developed into a system by uniting the three religions into one with Confucianism at the centre supported by Daoism and Buddhism. For over 2,000 years, Buddhism (...) has interacted with all levels of Chinese culture such as literature, philosophy, morality, arts, architecture and religions. As a result, Buddhism has successfully integrated into the traditional Chinese culture and has become one of the three pillars. In this paper, I will discuss the Buddhist impact on Chinese culture from the following four points: (1) philosophy and moral teaching; (2) religions and popular beliefs; (3) language and literature; and (4) art and architecture. (shrink)

Cyberloafing is prevalent in the workplace and research has increasingly focused on its antecedents. This study aims to extend the cyberloafing literature from the perspective of perceived overqualification among civil servants. Drawing on equity theory, we examined the effect of POQ on cyberloafing, along with the mediating role of harmonious passion on the POQ–cyberloafing relationship and the moderating role of the need for achievement on strengthening the link between POQ and harmonious passion. Using time-lagged data from a sample of 318 (...) civil servants in China, we found that POQ was positively related to cyberloafing; harmonious passion mediated this relationship; the need for achievement moderated the effect of POQ on harmonious passion as well as the indirect effect of POQ on cyberloafing via harmonious passion. Based on the findings, we discussed theoretical and managerial implications and provided future research avenues. (shrink)

“Moral capital” is a concept emerged in the China ethical community at the end of the 20th century. The issue of moral capital arises from discussions about economy and ethics. The controversial point in this concept consists in that morality is a kind of capital. Will morality become a capital? I think it is possible. The interpretation of the concept “capital” should go back to the logical starting point of economics, namely, “rational-economic man.” From the perspective of moral philosophy, every (...) economic activity is committed to morality. The maximization of self-interest is only a part of rationality. Rationality should also cover the acquisition of no self-interest valuable goals. People’s economic behaviors may also be connected with culture, ethics, intelligence, aesthetic appreciation or emotions. I think it is time to radically reform rationality. The issue of moral capital reinterprets capital by basing on humanity. The core of moral capital consists in the revealing of capital’s property of value; this value functions against the background of the socialist market economy system. It is the issue of economic justice in the context of contemporary China. (shrink)

本书介绍了“三个代表”重要思想是新世纪“指导自己前进的真理”;“三个代表”重要思想是对马克思主义的新发展;“三个代表”重要思想的科学内涵和内在关联;继续为实现党的基本路线和历史任务面奋斗等。.

本书从时代特征出发,通过大量生动的事实,以及马克思、恩格斯、列宁、毛泽东、邓小平和江泽民同志的著作,论述了马克思主义不断发展的理论。.

A novel fuzzy control scheme with adaptation algorithms is developed for robot manipulators’ system. At the beginning, one adjustable parameter is introduced in the fuzzy logic system, the robot manipulators system with uncertain nonlinear terms as the master device and a reference model dynamic system as the slave robot system. To overcome the limitations such as online learning computation burden and logic structure in conventional fuzzy logic systems, a parameter should be used in fuzzy logic system, which composes fuzzy logic (...) system with updated parameter laws, and can be formed for a new fashioned adaptation algorithms controller. The error closed-loop dynamical system can be stabilized based on Lyapunov analysis, the number of online learning computation burdens can be reduced greatly, and the different kinds of fuzzy logic systems with fuzzy rules or without any fuzzy rules are also suited. Finally, effectiveness of the proposed approach has been shown in simulation example. (shrink)

The aim of the study was to use an clustering analysis method to classify and identify native and foreign basketball players into similar groups based on game-related statistics; use the Pearson’s Chi-square test to identify the key clusters that affect whether a team enters the playoffs; and use the classification tree analysis to stimulate the prediction of team ability and the construction of the team roster. The sample consisted of 422 foreign players and 1,775 native players across 9 seasons from (...) 2011 to 2019. The clustering process allowed for the identification of nine native and six foreign player performance profiles. In addition, two clusters of native players and one cluster of foreign players were identified that had a significant impact on team ability. These results provide alternative references for basketball staff concerning the process of evaluating native and foreign player performance in the Chinese Basketball Association. (shrink)

This study investigates how managers in firms that have committed fraud strategically use socially responsible activities in coordination with their fraudulent financial reporting practices. Using propensity score matching to select control firms that have a similar probability of fraud in the pre-fraud benchmark period, we find that the corporate social responsibility performance of fraudulent firms in the fraud-committing period is significantly higher compared with the CSR performance of non-fraudulent control firms during this period, and compared with that during their own (...) pre-fraud benchmark periods. This higher CSR performance by fraudulent firms is achieved by means of investing in both stakeholder and third-party CSR categories and by improving in CSR strengths. Furthermore, the increase in CSR performance is more pronounced for fraudulent firms with a weak governance environment, and for firms located in high-religiosity states. Overall, our findings suggest that fraudulent firms strategically adjust their CSR performance to coordinate with their fraudulent financial activities. (shrink)

To establish the evaluation index system of urbanization innovation level and ecological efficiency, the entropy method is applied to measure the comprehensive index of urbanization innovation level and ecological efficiency, the VAR model is established, and empirical measurement is used to study the internal relationship and dynamic development between urbanization innovation level and ecological efficiency. The empirical results show the following: The overall development of the innovation level in 30 cities in China is uneven, there is a large gap between (...) the urban innovation level in backwards areas and economically developed areas, and there is a certain coupling effect between the urban innovation level and ecological efficiency. There is a long-term dynamic equilibrium relationship between the urban innovation level and ecological efficiency, which will exert certain pressure on the ecological environment in the process of urbanization. However, the continuous improvement of urbanization will have a positive impact on the improvement of the ecological environment. The improvement of ecological efficiency will also promote the improvement of the urban innovation level. Therefore, this paper puts forwards policy suggestions to promote the harmonious development of urbanization and the ecological environment and provides a reference for realizing the balanced development of urbanization and ecological efficiency in China. (shrink)

Background Performance evaluation is vital for IRB operations. As the number of IRBs and their responsibilities in reviewing and supervising clinical research grow in China, there is a significant need to evaluate their performances. To date, little research has examined IRB performance within China. The aim of this study was to ascertain the perspectives and experiences of IRB employees and researchers to understand the current status of IRBs; compare collected results with those of other countries; and identify shortcomings to improve (...) IRB performance. Methods This study was conducted in China from October 2020 to September 2021, using an online survey with the IRB-researcher assessment tool-Chinese version. Results 757 respondents were included in the analysis and classified into IRB employees, researchers, or those who are both IRB employees and researchers. Overall, the score for an ideal IRB was significantly higher than that of an actual IRB. Compared to the US National Validation study, Chinese participants and American participants both agree and differ in their perspectives on the most and least important ideal items. Conclusion This investigation provides a benchmark of the perceived performance of actual IRBs in China. IRBs in China can be precisely adjusted by targeting identified areas of weakness to improve their performances. (shrink)

The form of higher plants is largely dependent upon cell division and expansion patterns. Taking a genetic approach, Takahashi et al.(1) have identified a regulatory molecule in Arabidopsis thaliana called DIMINUTO (DIM), which is involved in determining the degree and direction of plant cell expansion. Their extensive characterization of a dim mutant suggested a direct involvement of the DIM gene in regulating cell elongation, perhaps by modulating the expression of structural genes which determine the orientation and elasticity of the cell (...) wall. (shrink)

作為現代新儒家第二代的重鎮，牟宗三著力凸顯“現代性在中國”的民族文化特質，並與西方現代性展開“吸收”與“批判”的雙向互動。本書將牟宗三哲學置於“古今”“中西”的交會點上，探析他立足儒家思想建構“中國現 代性”的哲學思考，揭示其積極貢獻與內在問題。以牟宗三這一個案審視現代新儒家應對全球化及現代化的理論思考，其意義在於一方面以現代哲學的話語對傳統儒學予以詮釋和重構，另一方面以儒家價值為西方現代性補偏救弊 。.

Dewey’s philosophy of education was heavily criticized by the Chinese Communist Party in the 1950s, which led many to believe that Dewey’s education was in complete opposition to that of the CCP. However, this study intends to prove that Dewey had a tremendous influence on the early CCP members of the 1920s. Dewey’s Chinese visit closely coincided highly with the time of the reception of Marxism in China and the eventual establishment of the CCP. Both founders of the CCP had (...) close personal relationships with Dewey, and Chen even tried to practice Dewey’s educational ideas in Southern China. As a graduate of a normal school, Mao Zedong also read and practiced Dewey’s educational philosophy. Many other CCP members read Dewey in the 1920s and then became left-wing revolutionaries. Though Dewey himself did not stand with Marxism, his idea that education is an agent of social reform paved the way for Marxism in China in theoretical and practical aspects. When an educational theory is spread abroad, it is often not accepted in a fundamentalist way, but rather in a process of collision and integration with the local tradition. (shrink)

Drawing from the grounded theory of work engagement, this research aims to explore three essential yet previously unexamined pathways—work meaningfulness, emotion regulation, and job competence in simultaneously transmitting the effects of mindfulness training to employee experience of work engagement. We employed a six-wave quasi-experimental design and recruited 129 employees to participate in the quasi-experiment, and tested our simultaneous mediating models using the structural equation modeling. Results showed that mindfulness facilitated employees’ work meaningfulness, emotion regulation, and job competence, which in turn (...) enhanced employee work engagement. By doing so, we add to the mindfulness literature by showing that the three essential psychological states are important machanims that link mindfulness to work engagement. Practicially, this research reveals that mindfulness training is an effective tool to influence employees’ psychological states, which ultimately develop their work engagement in the workplace. (shrink)