DNA glycosylases remove aberrant DNA nucleobases as the first enzymatic step of the base excision repair (BER) pathway. The alkyl‐DNA glycosylases AlkC and AlkD adopt a unique structure based on α‐helical HEAT repeats. Both enzymes identify and excise their substrates without a base‐flipping mechanism used by other glycosylases and nucleic acid processing proteins to access nucleobases that are otherwise stacked inside the double‐helix. Consequently, these glycosylases act on a variety of cationic nucleobase modifications, including bulky adducts, not previously associated with (...) BER. The related non‐enzymatic HEAT‐like repeat (HLR) proteins, AlkD2, and AlkF, have unique nucleic acid binding properties that expand the functions of this relatively new protein superfamily beyond DNA repair. Here, we review the phylogeny, biochemistry, and structures of the HLR proteins, which have helped broaden our understanding of the mechanisms by which DNA glycosylases locate and excise chemically modified DNA nucleobases. (shrink)

Ben shu jie shao le gong zi zhen, wei yuan, yan fu, kang you wei, tan si tong, liang qi chao, chen tian hua, zhang bing lin deng wan qing si xiang jia de zhe xue si xiang.

本书共九章,内容包括现代性的哲学奠基、现代性哲学的四种言路、海德格尔的现代性病理学诊断、德里达与现代性哲学的解构等。.

本书介绍了“三个代表”重要思想是新世纪“指导自己前进的真理”;“三个代表”重要思想是对马克思主义的新发展;“三个代表”重要思想的科学内涵和内在关联;继续为实现党的基本路线和历史任务面奋斗等。.

唯识学种子说通过在微分、刹那层面探讨深层心识的构造活动和存在的本质，论证了佛教缘起性空的非本体立场，属于一种“非本体”的本体诠释。但是，由于受到中国固有思维的影响，中国佛学不再侧重强调法性即空性的“非 本体”立场，而是把法性和心性主体结合起来，倾向于设立一种“实体化”的本体，形成了“心性本体论”。由非本体的本体诠释逐渐转向心性本体的本体诠释是印度唯识学在心识哲学层面中国化的基本趋势。.

Airuijiena is a medieval philosophy in the ninth century AD, the rise of a peak, it is the essence of mystical experience with God or with God, God included two adults and people of God into history. This article focuses on the Gospel of John describes Airuijiena Introduction sermons, also known as "Eagle Spirit Music," which contains the secret Qisi think, to be explored, but also involves its philosophy, theology and intellectual history of some of the relevant problem. This article (...) will first discuss the Airuijiena inherited traditions, such as the Irish spirit, Seven Arts in humanities education, Augustine Xing Greek Fathers, etc., and in "On the distinction between natural" will include them in a large integrated system. His "Gospel of St. John preaching preamble", or "Eagle Spirit Music," is a delicate little synthesis, which contains a wealth of secret Qisi want. This article will focus on St. John that he admired the mystical soul, show the people must continue to run away, until all finite things out, into the infinite God. This is a "self out of the" meaning of "extrapolation" of the most extreme, the most profound example. Then this paper to discuss Airuijiena by Zhu Zhong Jing's knowledge of God, to God and experience God together with their philosophical significance, particularly to understand the basis of the theory of divine light and darkness, which indicates not only the Word is the light itself, and all things even one grain of sand stone, they are the beacon. However, their theory of the divine darkness, God is also revealed that he is the ultimate person. In short, Airuijiena extrapolation of ideas and filled with the spirit of comparison, the system's deep and majestic, worthy I inspired. In the development of mediaeval philosophy, Johannes Scotus Eriugena stood like a "lofty rock in the midst of a plain", as Copleston puts it. His mysticism emphasized the union of God and Man in the double process of incarnation and deification. This paper will focus on his mysticism and its philosophical and historical implications in his Homily on the Prologue to the Gospel of St. John, also know as Vox Spiritualis Aquilae. We will discuss, first of all, what Eriugena had received from his Irish tradition, Neo-Platonism as interpreted by Greek fathers and St. Augustine and how he synthesized them into his Periphyseon. His Homily, as a marvelous work of synthesis in miniature, is very rich of mystic insights. We'll focus fist on his understanding of St. John's speculative mind, as a mind always going beyond itself that finally reaches the divine and thereby becomes deified in order to know God in himself. For me this is an extreme case of strangification. Then we will proceed to discuss Eriugena's mystic and philosophical concept of gnosis and theosis, and also his understanding of Logos as Light and that all things, even so tiny and low, are lights too. By contrast, his notion of Darkness of God leads us to the concept of God as totally Other , or the Ultimate Other. In sum, Eriugena's system of mystical philosophy is always deep and magnanimous, enough to inspire more generations to come. (shrink)

全书分五十个专题,涉及战斗精神、军事变革、历史使命、根本职能、理想信念等,每个专题从不同的角度分为两课,基本覆盖了部队经常性思想教育方方面面的内容。.

本书对早期中国经典中的身体观,作了思想与修行相交融的通盘观照;并在两希传统和印度传统身体观的考察基础上,展开跨文化比较与对话。.

本书在透过“现代性”和“审美教育”这一视角,采用文化学、心理学和美学相结合的方法,透过有关现代性和审美教育言说的复杂性和矛盾,既以现代性和审美教育的言说为基础,又要跳出已有的言说:既体会西方现代性论者 和审美教育论者的言内言外之意,又超越西方学者用以进行表述的西文的局限,力图从丰富、复杂、矛盾的现代性言说和审美教育言说的迷宫里清理出其内在意识中所欲表达的东西.

Ninety-year-old Master Nan Huaijin and his students' ten-day course, the essence of his life is all in his life. The recording of the class in 2008 was formally compiled and published today. Nanshi has explained the essentials of practice with nearly a hundred years of experience and reminded the quick way to get started. Study case study for each person, reminding the key points of study, it is enough for later reference. Introduce the content and history of Dharma Sutra and (...) Dao Di Sutra repeatedly, and use the essence of Langa Sutra, Deep Secret Sutra, Middle Theory, Guan Zi and other books to illustrate internal cultivation Theories and methods for external use. The study of traditional Chinese mind, body, life and life, including Zen, Taoism. (shrink)

本书内容包括:社区与精神文明、城市社区精神文明建设的历史考察、社区服务与城市社区精神文明建设、社区文化与城市社区精神文明建设、社区环境与城市社区精神文明建设、社区精神与城市社区精神文明建设等.

本书选取了典籍、语言、器物、文学、艺术、哲学等六个主要方面,各为一章,以及海外的中国文化热,共七章。.