Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

In the Mon. Ancyr. II. 2–11 Augustus makes four statements: He carried out a lectio senatus on three occasions. He held a census in his sixth consulship with Agrippa as his colleague, and completed the lustrum after an interval of forty-two years, the number of citizens registered being four millions and sixty-three thousand. He completed a second lustrum in 8 B.C. invested with the consular imperium and without a colleague, the number of citizens having increased by one hundred and seventy (...) thousand. He completed a third lustrum in 14 A.D. again invested with the consular imperium, but with Tiberius as his colleague, the number of citizens having again increased by seven hundred and four thousand. (shrink)

In this paper, the structure of a southeastern Spanish population was studied for the first time with respect to its inbreeding patterns and its relationship with demographic and geographic factors. Data on consanguineous marriages from 1900 to 1969 were taken from ecclesiastic dispensations. Our results confirm that the patterns and trends of inbreeding in the study area are consistent with those previously observed in most non-Cantabrian Spanish populations. The rate of consanguineous marriages was apparently stable between 1900 and 1935 and (...) then sharply decreased since 1940, which coincides with industrialization in Spain. A marked departure from Hardy-Weinberg expectations in the ratio of first cousin to second cousin marriages in the study population was observed. The high levels of endogamy and its significant steadiness throughout the twentieth century is noteworthy. Accordingly, our results show that exogamous marriages were not only poorly represented but also that this reduced mobility suggests that the choice of a mate was preferentially local. We found higher mobility in M22 with respect to M33 cousin mating. The relationships between population size and consanguinity rates and inbreeding fit power-law distributions. A significant positive correlation was observed between inbreeding and elevation. Many Spanish populations have experienced a prolonged and considerable isolation across generations, which has led to high proportions of historical and local endogamy that is associated, in general, with high \ values. Thus, assessing genomic inbreeding using runs of homozygosity in current Spanish populations could be an additional pertinent strategy for obtaining a more refined perspective regarding the population history inferred from the extent and frequency of ROH regions. (shrink)

A study of the analogies between alchemy, Christian dogma, and psychological symbolism. Revised translation, with new bibliography and index.

The concept of 'Archteypes' and the hypothesis of 'A Collective Unconscious' are two of Jung's better known and most exciting ideas. In this volume - taken from the Collected Works and appearing in paperback for the first time - Jung describes and elaborates the two concepts. Three essays establish the theoretical basis which are then followed by essays on specific archetypes. The relation of these to the process of individuation is examined in the last section. _The Archetypes and the Collective (...) Unconscious_ is one of Jung's central works. There are many illustrations in full colour. (shrink)

This book is parapsychological study of the meaningful coincidence of events, extrasensory perception, and similar phenomena.

In lieu of an abstract, here is a brief excerpt of the content:RUSSELL AND G. H. HARDY: A STUDY OF THEIR RELATIONSHIP I. GRATTAN-GUINNESS Faculty of Science, Engineering and Mathematics Middlesex Polytechnic Enfield, Middlesex EN3 45F, England I. INTRODUCTION Prom time to time the name of Hardy turns up in Russell's career: a common interest in set theory and the philosophy of mathematics, similar political and religious sentiments, and certain matters of mutual concern arising at Trinity College Cambridge and in (...) the university in general. However, there is no connected account of their contacts. The purpose of this article is to fill a gap in the literature on both men. After enduring private instruction at home, Bertrand Russell gained a minor scholarship in mathematics at Trinity College in 1890; he took Part I of the Mathematical Tripos until 1893 and then Part II of the Moral Sciences Tripos in the following year. In 1895 he gained a Prize Fellowship, which he held until 1901; in 19IO.he was awarded a college lectureship which he lost six years later under circumstances noted in section IV below. Much of the intervening time was spent in Oxford or London; however, he spent part of each year in Cambridge.1 The later years are brieHy recorded in section IV. Born into an intellectual family ofmodest means in 1877 (five years younger than Russell, therefore), Godfrey Harold Hardy won a scholarship to Winchester College and then went to Trinity College in I Standard biographical information on Russell is easily available; see, for example, R. W. Clark, The Life ofBertrand Russel~ specific phases and events are dealt with in succeeding footnotes. The Autobiography ofBertrand Russell is of lower quality than one might imagine; for example, Hardy is not mentioned at all! rus.ell: the Journal of the Bertrand Russell Archives McMasrer Unive~ity Library Press noS. 11 (wimer 1991-92): 165-79 ISSN 0036-01631 166 I. GRATTAN-GUINNESS 1896, just after Russell had gained his fellowship. He was elected to the Apostles (the "Society") in 1898, the year after Russell "took wings" after five years' active membership; he seems to have been less active than Russell as a speaker during his own three years there.2 At some stage he also joined the Cambridge University Moral Sciences Club, which Russell had joined in. 1891; a surprising contribution will be described in section IV.3 Graduating as fourth wrangler in Part I of the Mathematical Tripos in 1898 and gaining a high place in Part II in 1900, Hardy received at once a Prize Fellowship (like Russell). Upon its termination six years later, he obtained a colleg~ lectureship, which he held until 1919. He was elected a Fellow of the Royal Society of London in 1910 (two years after Russell),4 and in the following year he began his life-long collaboration with his younger colleague ]. E. Littlewood (1885-1977), also a Trinity College graduate and then Fellow, and also a friend of Russell.5 The next stages of Hardy's career will be described in section IV: his personality is assessed in a concluding section v. 1 On Russell'~ and Hardy's roles in the Apostles, see passim in P. Levy, Moore: G. E Moore and the Cambridge Apostles (London: Weidenfeld and Nicolson, 1979). 3 The chief obituary of Hardy is by E. C. Titchmarsh, published in slightly different forms in Obituary Notices ofthe Royal Society ofLondon, 6 (1949); 447-61, and Journal ofthe London Mathematical Society, 25 (1950): 81-101 (followed by more technical surveys of his mathematics by Titchmarsh and eight other authors on pp. 102-38). The first version is reprinted with a few changes in Hardy's Collected Papers, 7 vols. (Oxford: Clarendon P., 1966-79), I: 1-12. No major study has been written on him since. 4 Hardy was n~minated for a Royal Sociery fellowship in 1907 by A. R. Forsyth, seconded by J. W L. Glaisher, and supported "on personal knowledge" by W Burnside, E. W Hobson, P. A. MacMahon, A. N. Whitehead, A. E. H. Love, E. B. Elliott and T.]. d'A. Bromwich; the proposal was "suspended" (put up for voring) in 1908, 1909 and 1910 (Royal Sociery Cettificates, 12: foJ. 311). Although Russell was... (shrink)

"From The collected works of C.G. Jung, volumes 4, 8, 12, 16"--P. [i].

This bibliography records the initial publication of each original work by C.G. Jung, each translation, and significant revisions and expansions of both, up to 1975. In nearly every case, the compilers have examined the publications in German, French and English. Translations are recorded in Danish, Dutch, English, Finnish, French, Greek Hebrew, Hungarian, Italian, Japanese, Norwegian, Portuguese, Russian, Serbo-Croatian, Slovenian, Spanish, Swedish and Turkish. It is arranged according to language, with German and English first, publications being listed chronologically in each language. (...) The _General Bibliography_ lists the contents of the respective volumes of the_ Collected Works_ and the _Gesammelte Werke_, published in Switzerland, and shows the interrelation of the two editions. It also lists Jung's seminars and provides, where possible, information about the origin of works that were first conceived as lectures. An index is provided of all the titles in English and German, and all original works in the other languages. Three specialist indexes, of personal names, organizations and societies and periodicals, complete the work. The publication of the _General Bibliography_, together with the _General Index_, complete the publication of the _Collected Works of C.G. Jung _in English. (shrink)

This chapter contains section titled: Extension and Extended Substance? Bodies and Extended Substances Bodies, Space, and the Ontology of Everyday Life Acknowledgments References and Further Reading.

Reprint. Originally published: 1959; 1st Princeton/Bollingen pbk. ed. published: 1970.

Der hier erstmals ver]ffentlichte Briefwechsel zwischen dem Psychiater C.G. Jung und dem Nobelpreistr{ger der Physik Wolfgang Pauli ist ein geistesgeschichtliches Dokument ersten Ranges. Ein privates Schicksal hat sie zusammengef}hrt, und daraus ist ein vorwissenschaftlicher Dialog erwachsen, in dem versucht wird, naturwissenschaftliches und psychologischesDenken zu vereinheitlichen. Die Briefe verdeutlichen, da~ es weder f}r den Psychologen zul{ssig ist, die methodischen Einsichten der Physik, noch f}r den Physiker, die Erfahrungen im Umgang mit dem Psychischenzu vernachl{ssigen.

This book presents a (new) attempt to apply the notion of an underlying logic to Aristotle’s Organon and certain passages of the Metaphysics. The author situates his approach as part of a ‘deductio...

The concept of masculinity was crucial not only to Jung's revolutionary theories of the human psyche, but also to his own personal development. If, as Jung believed, "modern man is already so darkened that nothing beyond the light of his own intellect illuminates his world," then it is essential to show every man the limits of his understanding and how to overcome them. In _Aspects of the Masculine_ Jung does this by revealing his most significant insights concerning the nature and (...) motivations of masculinity, both conscious and unconscious, and explaining how this affects the development of the personality. Offering a unique perspective on the masculine, based upon both his personal and clinical experiences, Jung asks questions that remain as insistent as ever. He offers answers that--whether they surprise, shock or edify--challenge us to re-examine our contemporary understanding of masculinity. (shrink)

In this book, C. G. Prado addresses the difficult question of when and whether it is rational to end one's life in order to escape devastating terminal illness. He specifically considers this question in light of the impact of multiculturalism on perceptions and judgements about what is right and wrong, permissible and impermissible. Prado introduces the idea of a 'coincidental culture' to clarify the variety of values and commitments that influence decision. He also introduces the idea of a 'proxy premise' (...) to deal with reasoning issues that are raised by intractably held beliefs. Primarily intended for medical ethicists, this book will be of interest to anyone concerned about the ability of modern medicine to keep people alive, thereby forcing people to choose between living and dying. In addition, Prado calls upon medical ethicists and practitioners to appreciate the value of a theoretical basis for their work. (shrink)

This one-volume edition allows the general reader to appreciate Jung's ideas and personality, as they reveal themselves in his comments to his colleagues and to those who approached him with genuine problems of their own, as well as in his communication with personal friends. The correspondence supplies a variety of insights into the genesis of Jung's theories and a running commentary on their development. Originally published in 1984. The Princeton Legacy Library uses the latest print-on-demand technology to again make available (...) previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

The Cratylus’ main concern is to outline and evaluate the competing views of language held by two characters, Hermogenes and Cratylus, who disagree about whether convention or nature (respectively) are the source of onomastic correctness. Hermogenes has been thought to hold two radically different views by different scholars, one extreme conventionalism whereby all names are correct relative to their speakers, and another modest conventionalism according to which distinct naming actions – establishment and employment – explain why some names are correct (...) and others are not, depending on the speaker. In this paper I argue that, though Hermogenes ultimately endorses a conventionalism of the latter kind, it is a mistake to assign him this position from the outset. Rather, to understand the structure of the conversation about conventionalism, we must view Hermogenes’ position, and Socrates’ understanding of it, as developing instead of settled. For it is only by discussing the matter that Hermogenes comes to express a moderate conventionalist view and Socrates comes to appreciate the position Hermogenes actually holds. (shrink)