The dangers presented by antibiotic resistance have now established themselves as a global health security issue. From an international policy perspective, three key pillars have been established: responsible access, conservation, and innovation. These pillars are intrinsically linked, meaning that any attempt to address one must take into account the implications for the other two.An urgent need exists to address the innovation failure in ABR. In the field of anti-bacterials, the pipeline remains anemic in terms of therapeutics with novel mechanisms of (...) action, new drug classes and strategies involving radically different, innovative approaches. The key reasons for this failure have already been well established. The slow development of new antibiotics is the result of a poor and uncertain commercial market and scientific challenges in research and development. (shrink)

This ambitious critical history of the variety of disciplines we group together as the social sciences argues that the defining characteristic of social science, both historically and in the present, is ideology. Based originally on a flawed ideal of science, the 'social sciences' have incorporated and refined a set of assumptions about the nature of state and society, assumptions which have been institutionalized with the growth of modern universities. The book is in three main parts. It deals firstly with the (...) history of certain key ides from the early modern period, before exploring the institutional and social features which have shaped the emergence of modern social science. Manicas goes on to reveal the ideological component of mainstream social science, concluding by suggesting and alternative realist philosophy for the future. Rigorous in scholarship and engaging in presentation, the book offers a brilliant combination of wide-ranging historical scholarship and a firm location in the current theoretical dilemmas of the social sciences. (shrink)

Este artículo se propone analizar las prácticas sociales y culturales de dos colectivos de migrantes en dos países latinoamericanos: el caso de los inmigrantes argentinos en Chile y de los inmigrantes senegaleses en Argentina. Comprendemos que estas prácticas tienen como trasfondo el encuentro entre compatriotas y apelan a la creatividad y espontaneidad en el contexto de integración a la sociedad de destino, contribuyendo a formar redes y lazos sociales quizás antes no existentes. Estas actividades creativas y re-creativas contribuyen a la (...) configuración de la identidad nacional en un contexto migratorio, a la vez que tienen en común surgir de manera espontánea, sin planificación previa, e ir configurando una red de relaciones que consolidan tanto la “identidad argentina” como la “identidad senegalesa” en el contexto migratorio de recepción. (shrink)

Boundary Images investigates the political, material, and visual work that images do to cross and blur the boundaries between the technological and biological and between humans, machines, and nature. Exploring the limits of the visual and beyond what can be seen, Boundary Images posits these boundaries as starting points for the production of new and radically different ways of knowing about the world.

There is a spectrum of identities: from the mathematical, through cases where specific criteria matter, to the complex or intuitive cases where we can recognize identity but don't know what the criteria should be. In a series of essays by senior figures in the sciences and humanities, this book examines what identity means across a number of academic disciplines. Topics range from mathematics, through the rules of recognition in biology and the law, to comprehending the individual in the visual, performing (...) and literary arts, and ultimately to notions of the philosophy of existence. Using the theme of identity to make new interdisciplinary connections, the contributors offer interested readers a glimpse into their specialist subjects and suggest new ways for students and scholars to think about identity in relation to their own work. (shrink)

From the perspective of a realist philosophy of social science, the recent explosion of criticisms of mainstream economics, including reinvigorated Austrian criticism, provides what seems like a rich opportunity to join what are too often disjoined disciplinary interests and inquirers, and also to extend the arguments not only as regards the realist theory of social science, but also as regards the implications of this approach for economics. I begin with a minimum sketch of key features of realist philosophy of science (...) as I understand it. The central difference turns on the role and nature of explanation and of theory, between what is frequently termed ‘deductivism’, and on an alternative in which explanation requires the articulation of a causal mechanism, for example, the mechanism provided by molecular chemistry that gives us an understanding of oxidation. I take the position that in social science, explanation requires social causal mechanisms. I consider the Austrian contribution from this point of view and conclude with some hints regarding how the foregoing bears on our understanding of capitalism and socialism. (shrink)

El presente artículo intentará atravesar una pequeña parte de la cartografía afectiva spinozista. Nos detendremos en la idea de imitación afectiva, momento en el que la categoría de otro - expresión de la exterioridad - se presenta como un desconocido de quien, a pesar de no haber tenido un encuentro específico, podemos sentirnos afectados. Desandar los caminos de la mimesis afectiva nos permite establecer un origen social afectivo que como tal descubrirá la importancia que tienen los afectos en la vida (...) en común de los hombres. En otros términos, mostraremos el rol esencial que posee la vida afectiva en el origen de la comunidad a partir de una primera unión producto de un afecto común. (shrink)

There are immense differences in the social sciences both as regards what is to be explained and how it is to be explained. I make an initial distinction between the understanding, construed roughly as acquiring a grasp of the generative mechanisms and structures at work in the world, natural and social, and explanation, which I construe as causal. I clarify several candidates for the objects of explanation and reject the idea that the “explanation of behavior”—if that means the acts of (...) concrete situated persons—is ever the proper object of explanation. Critical to my account is the idea of a typical actor, created for purposes of explanation. I conclude by applying this analysis to the explanation of crime. (shrink)

Ayda Ignez Arruda was a key figure in the development of the Brazilian school of Paraconsistent logic and the first person to write a historical survey of the field. Despite her importa...

Este artigo apresenta o conceito de ideologia em A ideologia alemã, de Marx e Engels, a partir da relação entre a inversão real gerada pela divisão do trabalho e a inversão ideológica, considerando o problema de a ideologia ser caracterizada como a inversão da realidade das relações de produção ao mesmo tempo que a expressão dessas mesmas relações. Por meio da análise do conceito procura-se reavaliar a importância dos manuscritos inacabados de “I. Feuerbach”, tendo em vista que a discussão bibliográfica (...) mais recente atribui ao texto um caráter menor se comparado ao capítulo dedicado a Stirner. (shrink)

This introduction to the philosophy of social science provides an original conception of the task and nature of social inquiry. Peter Manicas discusses the role of causality seen in the physical sciences and offers a reassessment of the problem of explanation from a realist perspective. He argues that the fundamental goal of theory in both the natural and social sciences is not, contrary to widespread opinion, prediction and control, or the explanation of events. Instead, theory aims to provide an understanding (...) of the processes which, together, produce the contingent outcomes of experience. Offering a host of concrete illustrations and examples of critical ideas and issues, this accessible book will be of interest to students of the philosophy of social science, and social scientists from a range of disciplines. (shrink)

The aim of this paper is to investigate the role of water stress on plants production. We propose a mathematical model for the dynamics growth of plants that takes into account the concentration of available water in the soil, water stress, plant production and plants compensation. Sensitivity analysis of the model has been performed in order to determine the impact of related parameters on the dynamics growth of plants. We present the theoretical analysis of the model with and without water (...) stress. More precisely, we show that the full model is well-posedness. For each model, we compute the trivial equilibria and derive two thresholds parameters that determine the outcome of water stress within a plantation. Further, we perform numerical simulation on the case of banana-plantain simulations to support the theory. We found that the Hopf bifurcation occurs for a specific value of the water absorption rate of unstressed plants. The impact of the water stress on the banana-plantain production is also numerically investigated. After, the role of the water stress on the plant production is numerically investigated. We found that the water stress can cause about 68.16% of loss of banana-plantain production within a plantation with 1600 rejets initially planted. This suggests that climate change plays a detrimental role on banana-plantains production. (shrink)

Resumo O propósito deste texto é mostrar que os problemas enfrentados por Merleau-Ponty, ao longo de seu percurso de pensamento, decorrem dos pressupostos dicotômicos dos quais ele parte. Assim, procuramos trazer à tona outras consequências de se assumir tal pressuposto, o do primado de uma experiência perceptiva muda como solo natal de todas as outras modalidades da experiência. Para tanto, tomam-se em consideração tanto a primeira como a segunda fase do pensamento de Merleau-Ponty.Our purpose is to show that the problems (...) faced by Merleau-Ponty throughout his path of thought arise from the dichotomous assumptions from which he begins. Thus, we seek to shed light on the other consequences of assuming a presumption such as the primacy of a mute perceptual experience as the native soil of all other experience’s modes. Therefore, the first as well as the second phases of Merleau-Ponty’s thought are taken into account. (shrink)

Considerando retrospectivamente os desdobramentos da filosofia, é possível observar que, antes de reconhecer e reafirmar as singularidades de seu exercício, o discurso filosófico tem sua origem intimamente associada à poesia. Evidenciando alguns momentos de cisão e outros momentos de contato entre o discurso poético e o discurso filosófico, o presente ensaio visa abordar e refletir sobre o diálogo entre esses dois discursos ao longo do tempo. Nesse horizonte, consideraremos estrategicamente os trabalhos de autores como Homero, Platão, Goethe, F. Schlegel e (...) Schelling, a fim de evidenciar as oscilações e salientar alguns movimentos específicos dentro desse longo diálogo. (shrink)

Este ensaio debate os conceitos de afeto e vontade no trabalho docente e seus vínculos com o “voluntarismo pedagógico” presente em diversas concepções e políticas sobre a educação de crianças. Utiliza-se da doutrina espinosana dos afetos e também da noção de trabalho estranhado nos Manuscritos Econômico-Filosóficos de Marx para uma meditação sobre o perfil sociológico dos professores da educação básica brasileira. Suas considerações finais ressaltam a importância de Espinosa na crítica do “domínio absoluto dos afetos” e análise das atuais condições (...) nas quais se realiza o trabalho docente, apresentando pontos de convergência – e uma possível divergência – com relação a ideias de Mészáros na busca de uma educação “para além do capital”. (shrink)

Argentina fue el primer país del mundo en establecer que los organismos que resulten de nuevas técnicas de edición genética (GE, en sus siglas en inglés) no estarán alcanzados por la normativa para Organismos Genéticamente Modificados (OGM), siempre y cuando una primera evaluación concluya que no incluye ADN de otra especie. Esto es relevante porque las evaluaciones para comercializar un OGM son tan extensas y costosas que solo son accesibles para unas pocas empresas multinacionales, que monopolizan la innovación fundamental, las (...) licencias y los productos derivados. Esta simplificación regulatoria coincide con el descubrimiento de técnicas como CRISPR-Cas9, mucho más baratas y simples que las previas, y con potencial para desarrollarse con reducidos presupuestos de investigación. Este trabajo indaga cómo el Estado argentino utiliza la legislación sobre biotecnología para fomentar la investigación, el desarrollo y la innovación (I+D+i), indagando en los límites y posibilidades de esta estrategia. Para ello se basa en la legislación y las políticas públicas competentes; observaciones en reuniones y conferencias biotecnológicas; y en entrevistas semi-estructuradas realizadas durante 2019 a científicos y empresarios que trabajaban con CRISPR. Así, encuentra que la legislación opera como fomento para los desarrollos locales, pero las ventajas que ofrecen las nuevas técnicas de edición genética dependen de una serie de acciones y estrategias geopolíticas. Entendiendo por regulación al conjunto de acciones y omisiones de los actores interesados, a escala mundial y con intereses contrapuestos, la investigación concluye que es esta regulación geopolítica la que condiciona la innovación biotecnológica en Argentina. Así, la posibilidad de aprovechar esa “ventana de oportunidad” que habilitan las nuevas técnicas descansa en una serie de variables que configuran nuevas relaciones de interdependencia global. (shrink)

« Rythmes et Croyances au Moyen-Âge » Journée d'études organisée par Marie Formarier et Jean-Claude Schmitt 23 juin 2012 – Paris Présentation : Cette journée d'études a eu pour objectif de faire dialoguer les diverses disciplines concernées par le rapport entre rythmes et croyances au Moyen-Âge. Elle a accueilli des historiens, des anthropologues, des sociologues, des philologues et des linguistes. Présents dans la langue latine et les langues vernaculaires, dans la rhétorique du sermon, la prière et (...) - Histoire – (...) NOUVELLE JOURNÉE d'ÉTUDES. (shrink)

Miguel de Cervantes, no último capítulo de sua obra O engenhoso fidalgo Dom Quixote de La Mancha, retrata o falecimento de seu protagonista, decorrente de uma profunda tristeza. O cavaleiro, depois de vencido, sente-se obrigado a retornar ao seu povoado e a renunciar à cavalaria andante, o que lhe causa a transformação de sua realidade e de seu estado mental - da loucura à cordura -, além do seu direcionamento à morte. Assim como faz Cervantes no início do século XVII, (...) Espinosa, ao final do mesmo século, também parece estabelecer analogias entre as ideias de transformação e morte, ao apontar, em sua Ética, a relação entre a natureza do ser e sua proporção de movimento e repouso, responsável pelas inconstâncias humanas. A partir de tais considerações, este trabalho pretende aproximar o último capítulo da obra Dom Quixote à proposição 39 da Quarta Parte da Ética espinosana, de forma a ressaltar as devidas semelhanças entre o conceito de morte como transformação, retratado tanto pelo escritor espanhol quanto pelo filósofo holandês, uma vez que a morte, para ambos, demonstra estar vinculada à mesma ideia. (shrink)

The author problematizes the current socio-religious landscape in critical dialogue with the philosopher Gianni Vattimo — who praises the joyful harmony between a God devoid of his all-powerfulness and a secularization that is both the essence of modernity and the outgrowth of Christianity. The author agrees with the philosopher’s positions to (a) refute the thought that totality cannot be fashioned as a sole transcendent heteronomy and (b) validate a decisive relation to the world, the human body and human agency. However, (...) in strong demarcation with Vattimo, the author calls upon Žižek in order to refute a totality constructed as powerfulness. There are in the secularization process some disengaged matters that need to be validated as such. There is no humanity without excess — excess produced by life and reality, not softened. To exist implies infraction, interruption and thus subversion, internally, from the world and through bodies. The article stands as a reflection on the current socio-cultural scene as well as on Christianity — involving the avatars, temptations and challenges that are nowadays his own — and cross-examines simultaneously the internal sublimation within. (shrink)

A definition of the concept of "Intuitionist Modal Analogue" is presented and motivated through the existence of a theorem preserving translation from MIPC to a bimodal S₄-S₅ calculus.

Departing from and closing with reflections on issues regarding teaching practices of philosophy of mathematics, I propose a comparison between the main features of the Leibnizian notion of symbolic knowledge and some passages from the Tractatus on arithmetic. I argue that this reading allows (i) to shed a new light on the specificities of the Tractarian definition of number, compared to those of Frege and Russell; (ii) to highlight the understanding of the nature of mathematical knowledge as symbolic or formal (...) knowledge that Wittgenstein mobilizes in his book; (iii) to offer reasons for the claim that Wittgenstein can be considered the philosopher of mathematical practice avant la lettre. The paper ends with an overview, a return to the initial reflection on the connections between research and teaching, and a defense of the reading key used here in terms of its potential for the research in philosophy of mathematics. (shrink)

O texto fornece distinções conceituais engendradas desde uma perspectiva para o ensino de filosofia que contempla, em seu horizonte, o projeto a construção de uma didática mínima da lógica para o ensino médio. Após a apresentação de alguns aspectos positivos da referida perspectiva são indicadas duas maneiras usuais de compreender e praticar o ensino de lógica. O objetivo central do texto é mostrar como, desde a perspectiva inicialmente esboçada, os esclarecimentos conceituais propostos podem sugerir caminhos interdisciplinares para a didática da (...) lógica sem perda da especificidade da disciplina. The text provides some conceptual distinctions generated from a perspective on teaching philosophy according to which the project of a "didactica minima" for logic in high schools is contemplated. After a brief presentation of some positive aspects of the perspective from which the distinctions are proposed, two common ways of teaching logic are considered. The aim of the paper is to show how the perspective proposed can clarify some topics on the issue of teaching logic in an interdisciplinary way, without losing the specifics of the discipline. (shrink)