In nature, cells face a variety of stresses that cause physical damage to the plasma membrane and cell wall. It is well established that evolutionarily conserved cell cycle checkpoints monitor various cellular perturbations, including DNA damage and spindle misalignment. However, the ability of these cell cycle checkpoints to sense a damaged plasma membrane/cell wall is poorly understood. To the best of our knowledge, our recent paper described the first example of such a checkpoint, using budding yeast as a model. In (...) this review, we will discuss this important question as well as provide hypothetical explanations to be tested in the future. (shrink)

Personnalité et irrationalité chez Merleau-PontyUne personnalité est l’ensemble des traits et des qualités propres à une personne spécifique. Il s’agit d’un être humain concret, considéré dans sa totalité et distinct des autres individus. Merleau-Ponty s’est peu intéressé au concept de “personnalité”. Mais il fait référence au concept de totalité pour un individu lorsqu’il parle d’ “existence” ou d’ “être humain”. Grâce à la clarification du concept merleau-pontien de personnalité, je voudrais démontrer ce qui suit : la philosophie merleau-pontienne de la (...) structure caractérise la personnalité humaine comme un tout. Cette idée est héritée du “personnalisme” de la psychologie française inauguré par Ribot. La personnalité ainsi définie possède une rationalité téléologique (un objet visé). Cependant, lorsque Merleau-Ponty propose plus tard le concept d’“institution”, il souligne que toute signification de l’expérience humaine se fonde sur une expérience particulière et sur un point de vue concret ayant valeur de dimension, de niveau, ou encore sur un critère qui donne un sens à l’expérience suivante. S’il en est ainsi, les êtres humains doivent posséder une irrationalité fondamentale au coeur de leur personnalité ; irrationalité désigne une attitude attachée à une expérience particulière ou à un point de vue singulier. Les hommes peuvent “ré-instituer” leur expérience, c’est-à-dire abolir et transformer une dimension, un niveau ou un critère de l’expérience en y intégrant d’autres points de vue à travers leurs relations intersubjectives. Ils gagnent ainsi en nuance et en objectivité. Cependant, ils ne parviennent jamais à une rationalité totale si celle-ci se définit par une pensée totalement objective, universelle et non située, capable de voir le monde de nulle part. La ré-institution pourrait aussi entraîner une rupture dans la personnalité de quelqu’un et la rendre complexe et multiple, sans être pathologique pour autant.Personalità e irrazionalità in Merleau-PontyLa personalità è l’insieme delle qualità e dei tratti peculiari di una certa persona. È un essere umano concreto, preso nella sua interezza e distinto dagli altri individui. Merleau-Ponty non si è mai occupato molto del concetto di “personalità”. Ma si è riferito a tale concetto di totalità di un individuo sotto i nomi di “esistenza” o “essere umano”. Chiarendo la concezione merleau-pontiana della “personalità”, intendo sostenere che la filosofia della struttura di Merleau-Ponty caratterizza la personalità umana come un tutto unificato. Quest’idea è un’eredità del “personalismo” della psicologia francese inaugurata da Ribot. La personalità definita come tale ha una razionalità teleologica (orientata ad un obiettivo). Tuttavia, quando Merleau-Ponty propose più tardi il concetto di “istituzione”, sottolineò più di quanto avesse fatto precedentemente che perché ogni esperienza umana abbia un significato occore stabilire una particolare esperienza ed un punto di vista concreto quale dimensione, livello, o criterio che dia significato all’esperienza successiva. Se così è, gli esseri umani devono avere una fondamentale irrazionalità nel profondo della loro personalità, intendendo con irrazionalità un atteggiamento che è legato ad una particolare esperienza o punto di vista. Gli esseri umani possono “re-istituire” la loro esperienza, ovvero, riconsiderare una dimensione, un livello, o un criterio dell’esperienza attraverso l’integrazione degli altri punti di vista grazie alle loro relazioni intersoggettive. Guadagnano, così, sfumature e obiettività. Tuttavia, non possono mai realizzare la razionalità completa se per razionalità s’intende il pensiero completamente oggettivo, universale, imparziale, che guarda il mondo da nessun luogo. E la re-istituzione potrebbe creare una fessura decisiva nell’identità personale di un uomo, e rendere tale personalità complessa e “multipla,” anche se non necessariamente patologica. (shrink)

The paper is based on a review of research on media selection and related topics on the one hand and on an explorative pilot survey on the other. In summarising the review, the authors propose that the factors explaining media choice be grouped into five categories: (1) the properties of the media itself affect its choice, (2) properties of the user affect media choice, (3) the communication situation plays an important role, (4) macro factors explain media choice, and (5) media (...) choice can be explained as the outcome of a dynamic multiparty negotiation process. The pilot survey compares Japanese and Finnish students’ preference of media in various communication situations. The survey results encourage reserving, local macro factors or culture, a certain amount of explanatory force in explaining media choice. (shrink)

Until recently, many of Japan's medical and bioethical communities had ignored the issue of conflicts of interest . This is no longer the case. Discussion on the economic and ethical problems defined by CIs is now apparent in academic, political, and even industrial spheres. In June 2004, this debate was sparked by a scandal involving AnGes MG, Inc., a bioventure company set up by a faculty member at Osaka University Graduate School of Medicine. AnGes MG developed a gene therapy using (...) the Hepatic Growth Factor for obstructive blood vessel disease. Japanese newspapers reported that “several physicians involved with clinical trials for AnGes obtained unlisted shares of stock. One physician allegedly received 32 million yen after AnGes MG went public on the ‘Mothers’ stock exchange”. (shrink)

While some studies suggest cultural differences in visual processing, others do not, possibly because the complexity of their tasks draws upon high-level factors that could obscure such effects. To control for this, we examined cultural differences in visual search for geometric figures, a relatively simple task for which the underlying mechanisms are reasonably well known. We replicated earlier results showing that North Americans had a reliable search asymmetry for line length: Search for long among short lines was faster than vice (...) versa. In contrast, Japanese participants showed no asymmetry. This difference did not appear to be affected by stimulus density. Other kinds of stimuli resulted in other patterns of asymmetry differences, suggesting that these are not due to factors such as analytic/holistic processing but are based instead on the target-detection process. In particular, our results indicate that at least some cultural differences reflect different ways of processing early-level features, possibly in response to environmental factors. (shrink)

On April 5 2000, the Diet elected Yoshiro Mori as Japan's 55th prime minister. His predecessor, Keizo Obuchi, had suffered a stroke and became unable to carry out his official responsibility. Mori, who was the former Secretary General of the ruling Liberal Democratic Party (LDP), inherited the three party coalition between the LDP, the new Komei Party and the Conservative Party, and reappointed all of Obuchi's cabinet members. Yohei Kono was reposted as the Minister of Foreign Affairs; Hideo Usui (...) as Justice; Kiichi Miyazawa as Finance; Hirofumi Nakasone as Education, Science and Technology; Yuya Niwa as Health and Welfare; Tokuichiro Tanazawa as Agriculture, Forestry and Fisheries; Takeshi Fukaya as International Trade and Industry; Toshihiro Nikai as Transport; Eita Yashiro as Posts and Telecommunications; Takamori Makino as Labor; Masaaki Nakayama as Construction; Kosuke Hori as Home Affairs, Mikio Aoki as Chief Cabinet Secretary; Kunihiro Tsuzuki as Management and Coordination; Tsutomu Kawara as Defense; Taichi Sakaiya as Economic Planning; Kayoko Shimizu as environment; and Sadakazu Tanigaki as Financial Reconstruction. (shrink)