Search results for '*Receptor Binding' (try it on Scholar)

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  1. N. Galldiks, A. Thiel, C. Haense, G. R. Fink & R. Hilker (2008). 11 C-Flumazenil Positron Emission Tomography Demonstrates Reduction of Both Global and Local Cerebral Benzodiazepine Receptor Binding in a Patient with Stiff Person Syndrome. Journal of Neurology 255 (9).score: 57.0
    Stiff Person Syndrome (SPS) is a rare autoimmune disorder associated with antibodies against glutamic acid decarboxylase (GAD-Ab), the key enzyme in γ -aminobutyric acid synthesis (GABA). In order to investigate the role of cerebral benzodiazepinereceptor binding in SPS, we performed [ 11 C]flumazenil (FMZ) positron emission tomography (PET) in a female patient with SPS compared to nine healthy controls. FMZ is a radioligand to the postsynaptic (...)
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  2. G. Ballard Clive, A. Jennifer, Piggott Margaret, Johnson Mary, O'Brien John, McKeith Ian, Clive Holmes, Peter Lantos, Evelyn Jaros & Robert Perry (2002). Disturbances of Consciousness in Dementia with Lewy Bodies Associated with Alteration in Nicotinic Receptor Binding in the Temporal Cortex. Consciousness and Cognition 11 (3).score: 45.0
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  3. Richard J. Katz (1983). Stone's Revised Aminergic Hypothesis and the Functional Significance of Receptor Binding Sensitivity. Behavioral and Brain Sciences 6 (4):555.score: 45.0
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  4. J. Murray‐Rust, A. N. McLeod, T. L. Blundell & S. P. Wood (1992). Structure and Evolution of Insulins: Implications for Receptor Binding. Bioessays 14 (5):325-331.score: 45.0
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  5. Caryn S. Ross-Innes, Rory Stark, Andrew E. Teschendorff, Kelly A. Holmes, H. Raza Ali, Mark J. Dunning, Gordon D. Brown, Ondrej Gojis, Ian O. Ellis & Andrew R. Green (2012). Differential Oestrogen Receptor Binding is Associated with Clinical Outcome in Breast Cancer. In Jeffrey Kastner (ed.), Nature. Mit Press. 389-393.score: 45.0
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  6. Fias Wim (2012). Threshold for Visual Awareness is Associated with Striatal Dopamine D2 Receptor Binding. Frontiers in Human Neuroscience 6.score: 45.0
  7. Colin W. Ward, John G. Menting & Michael C. Lawrence (2013). The Insulin Receptor Changes Conformation in Unforeseen Ways on Ligand Binding: Sharpening the Picture of Insulin Receptor Activation. Bioessays 35 (11):945-954.score: 42.0
  8. Lynn C. Robertson (2003). Binding, Spatial Attention and Perceptual Awareness. Nature Reviews Neuroscience 4 (2):93-102.score: 39.0
  9. Clive Ballard (2002). Disturbances of Conscious in Dementia with Lewy Bodies Assocated with Alterantion in Nicotonic Receoptor Binding in the Temporal Cortex. Consciousness and Cognition 11 (3):461-474.score: 39.0
  10. Hector Escriva, Franck Delaunay & Vincent Laudet (2000). Ligand Binding and Nuclear Receptor Evolution. Bioessays 22 (8):717-727.score: 36.0
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  11. Kimford J. Meador, P. G. Ray, J. R. Echauz, D. W. Loring & G. J. Vachtsevanos (2002). Gamma Coherence and Conscious Perception. Neurology 59 (6):847-854.score: 30.0
  12. Douglas Tudhope & Ceri Binding (2008). Faceted Thesauri. Axiomathes 18 (2):211-222.score: 30.0
    The basic elements of faceted thesauri are described, together with a review of their origins and some prominent examples. Their use in browsing and searching applications is discussed. Faceted thesauri are distinguished from faceted classification schemes, while acknowledging the close similarities. The paper concludes by comparing faceted thesauri and related knowledge organization systems to ontologies and discussing appropriate areas of use.
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  13. Linda L. Binding & Dianne M. Tapp (2008). Human Understanding in Dialogue: Gadamer's Recovery of the Genuine. Nursing Philosophy 9 (2):121-130.score: 30.0
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  14. Pengmin Qin, Niall W. Duncan, Christine Wiebking, Paul Gravel, Oliver Lyttelton, Dave J. Hayes, Jeroen Verhaeghe, Alexey Kostikov, Ralf Schirrmacher & Andrew J. Reader (2012). GABAA Receptors in Visual and Auditory Cortex and Neural Activity Changes During Basic Visual Stimulation. Frontiers in Human Neuroscience 6.score: 24.0
    Recent imaging studies have demonstrated that levels of resting GABA in the visual cortex predict the degree of stimulus-induced activity in the same region. These studies have used the presentation of discrete visual stimulus; the change from closed eyes to open also represents a simple visual stimulus, however, and has been shown to induce changes in local brain activity and in functional connectivity between regions. We thus aimed to investigate the role of the GABA system, specifically GABAA receptors, in the (...)
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  15. Georg Northoff Pengmin Qin, Niall W. Duncan, Christine Wiebking, Paul Gravel, Oliver Lyttelton, Dave J. Hayes, Jeroen Verhaeghe, Alexey Kostikov, Ralf Schirrmacher, Andrew J. Reader (2012). GABAA Receptors in Visual and Auditory Cortex and Neural Activity Changes During Basic Visual Stimulation. Frontiers in Human Neuroscience 6.score: 24.0
    Recent imaging studies have demonstrated that levels of resting GABA in the visual cortex predict the degree of stimulus-induced activity in the same region. These studies have used the presentation of discrete visual stimulus; the change from closed eyes to open also represents a simple visual stimulus, however, and has been shown to induce changes in local brain activity and in functional connectivity between regions. We thus aimed to investigate the role of the GABA system, specifically GABAA receptors, in the (...)
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  16. Stuart K. Archer, Charles Claudianos & Hugh D. Campbell (2005). Evolution of the Gelsolin Family of Actin-Binding Proteins as Novel Transcriptional Coactivators. Bioessays 27 (4):388-396.score: 21.0
    The gelsolin gene family encodes a number of higher eukaryotic actin-binding proteins that are thought to function in the cytoplasm by severing, capping, nucleating or bundling actin filaments. Recent evidence, however, suggests that several members of the gelsolin family may have adopted unexpected nuclear functions including a role in regulating transcription. In particular, flightless I, supervillin and gelsolin itself have roles as coactivators for nuclear receptors, despite the fact that their divergence appears to predate the evolutionary appearance of nuclear (...)
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  17. Christopher J. G. Meacham (2010). Binding and its Consequences. Philosophical Studies 149 (1):49-71.score: 18.0
    In “Bayesianism, Infinite Decisions, and Binding”, Arntzenius et al. (Mind 113:251–283, 2004 ) present cases in which agents who cannot bind themselves are driven by standard decision theory to choose sequences of actions with disastrous consequences. They defend standard decision theory by arguing that if a decision rule leads agents to disaster only when they cannot bind themselves, this should not be taken to be a mark against the decision rule. I show that this claim has surprising implications for (...)
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  18. Eric LaRock (2007). Disambiguation, Binding, and the Unity of Visual Consciousness. Theory and Psychology 17 (6):747-77.score: 18.0
    Recent findings in neuroscience strongly suggest that an object’s features (e.g., its color, texture, shape, etc.) are represented in separate areas of the visual cortex. Although represented in separate neuronal areas, somehow the feature representations are brought together as a single, unified object of visual consciousness. This raises a question of binding: how do neural activities in separate areas of the visual cortex function to produce a feature-unified object of visual consciousness? Several prominent neuroscientists have adopted neural synchrony and (...)
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  19. Jonathan Cohen & Samuel C. Rickless (2007). Binding Arguments and Hidden Variables. Analysis 67 (1):65–71.score: 18.0
    o (2000), 243). In particular, the idea is that binding interactions between the relevant expressions and natural lan- guage quantifiers are best explained by the hypothesis that those expressions harbor hidden but bindable variables. Recently, however, Herman Cappelen and Ernie Lepore have rejected such binding arguments for the presence of hid- den variables on the grounds that they overgeneralize — that, if sound, such arguments would establish the presence of hidden variables in all sorts of ex- pressions where (...)
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  20. Peter Pagin & Dag Westerståhl (1993). Predicate Logic with Flexibly Binding Operators and Natural Language Semantics. Journal of Logic, Language and Information 2 (2):89-128.score: 18.0
    A new formalism for predicate logic is introduced, with a non-standard method of binding variables, which allows a compositional formalization of certain anaphoric constructions, including donkey sentences and cross-sentential anaphora. A proof system in natural deduction format is provided, and the formalism is compared with other accounts of this type of anaphora, in particular Dynamic Predicate Logic.
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  21. Casey O'Callaghan (forthcoming). Intermodal Binding Awareness. In David Bennett & Christopher Hill (eds.), Sensory Integration and the Unity of Consciousness. MIT.score: 18.0
    It is tempting to hold that perceptual experience amounts to a co-conscious collection of visual, auditory, tactual, gustatory, and olfactory episodes. If so, each aspect of perceptual experience on each occasion is associated with a specific modality. This paper, however, concerns a core variety of multimodal perceptual experience. It argues that there is perceptually apparent intermodal feature binding. I present the case for this claim, explain its consequences for theorizing about perceptual experience, and defend it against objections. I maintain (...)
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  22. Alfredo Pereira & Gene Johnson (2003). Toward an Explanation of the Genesis of Ketamine-Induced Perceptual Distortions and Hallucinatory States. Brain and Mind 4 (3):307-326.score: 18.0
    The NMDA receptor (NMDAR) channel has been proposed to function as a coincidence-detection mechanism for afferent and reentrant signals, supporting conscious perception, learning, and memory formation. In this paper we discuss the genesis of distorted perceptual states induced by subanesthetic doses of ketamine, a well-known NMDA antagonist. NMDAR blockage has been suggested to perturb perceptual processing in sensory cortex, and also to decrease GABAergic inhibition in limbic areas (leading to an increase in dopamine excitability). We propose that perceptual distortions and (...)
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  23. Alfredo Pereira Jr (2003). Toward an Explanation of the Genesis of Ketamine-Induced Perceptual Distortions and Hallucinatory States. Brain and Mind 4 (3):307-326.score: 18.0
    The NMDA receptor (NMDAR) channel has been proposed to function as a coincidence-detection mechanism for afferent and reentrant signals, supporting conscious perception, learning, and memory formation. In this paper we discuss the genesis of distorted perceptual states induced by subanesthetic doses of ketamine, a well-known NMDA antagonist. NMDAR blockage has been suggested to perturb perceptual processing in sensory cortex, and also to decrease GABAergic inhibition in limbic areas (leading to an increase in dopamine excitability). We propose that perceptual distortions and (...)
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  24. Hajime Fukui & Kumiko Toyoshima (2013). Influence of Music on Steroid Hormones and the Relationship Between Receptor Polymorphism and Music Ability: A Pilot Study. Frontiers in Psychology 4:910.score: 18.0
    Studies have shown that music confers plasticity to the brain. In a preliminary pilot study, we examined the effect of music listening on steroid hormones and the relationship between steroid hormone receptor polymorphisms and musical ability. Twenty-one subjects (10 males and 11 females) were recruited and divided into musically talented and control groups. The subjects selected (1) music they preferred (chill-inducing music) and (2) music they did not like. Before and after the experiments, saliva was collected to measure the levels (...)
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  25. Jean-Rémy Martin (2013). Experiences of Activity and Causality in Schizophrenia: When Predictive Deficits Lead to a Retrospective Over-Binding. Consciousness and Cognition 22 (4):1361-1374.score: 18.0
    In this paper I discuss an intriguing and relatively little studied symptomatic expression of schizophrenia known as experiences of activity in which patients form the delusion that they can control some external events by the sole means of their mind. I argue that experiences of activity result from patients being prone to aberrantly infer causal relations between unrelated events in a retrospective way owing to widespread predictive deficits. Moreover, I suggest that such deficits may, in addition, lead to an aberrant (...)
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  26. Rana Kruse Ronald Hübner (2011). Effects of Stimulus Type and Level Repetition on Content-Level Binding in Global/Local Processing. Frontiers in Psychology 2.score: 18.0
    The processing and representation of hierarchical objects not only involves the identification of information at the different levels, but also the binding of the identified content to its respective level. Whereas identification is well understood, little is known about content-level binding. In a recent study, however, it has been shown that attentional priming of certain spatial frequencies is advantageous for this binding. Therefore, the present study investigated effects of related factors on the binding process, namely stimulus (...)
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  27. James P. Morris Allison Jack, Jessica J. Connelly (2012). DNA Methylation of the Oxytocin Receptor Gene Predicts Neural Response to Ambiguous Social Stimuli. Frontiers in Human Neuroscience 6.score: 18.0
    Oxytocin and its receptor (OXTR) play an important role in a variety of social perceptual and affiliative processes. Individual variability in social information processing likely has a strong heritable component, and as such, many investigations have established an association between common genetic variants of OXTR and variability in the social phenotype. However, to date, these investigations have primarily focused only on changes in the sequence of DNA without considering the role of epigenetic factors. DNA methylation is an epigenetic mechanism by (...)
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  28. Alodie Rey-Mermet Beat Meier (2012). Beyond Feature Binding: Interference From Episodic Context Binding Creates the Bivalency Effect in Task-Switching. Frontiers in Psychology 3.score: 18.0
    When switching between different tasks and bivalent stimuli occur only occasionally on one of them, performance is slowed on subsequent univalent trials even if they have no overlapping features with the bivalent stimulus. This phenomenon has been labeled the “bivalency effect”. Recent evidence has revealed that this effect is robust, general, and enduring. Moreover, it challenges current theories of task switching and cognitive control. Here, we review these theories and propose a new, episodic context binding account. According to this (...)
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  29. André W. Keizer Bernhard Hommel (2012). Binding Success and Failure: Evidence for the Spontaneous Integration of Perceptual Features and Object Evaluations. Frontiers in Psychology 3.score: 18.0
    Humans represent perceptual events in a distributed, feature-specific fashion, which called for some sort of feature integration. It has been suggested that processing an event leads to the creation of a temporary binding of the corresponding feature codes—an object file. Here we show that object files do not only comprise of perceptual feature codes but also include codes that reflect evaluations of the perceptual event.
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  30. Randall O'Reilly Dean Wyatte, Seth Herd, Brian Mingus (2012). The Role of Competitive Inhibition and Top-Down Feedback in Binding During Object Recognition. Frontiers in Psychology 3.score: 18.0
    How does the brain bind together visual features that are processed concurrently by different neurons into a unified percept suitable for processes such as object recognition? Here, we describe how simple, commonly accepted principles of neural processing can interact over time to solve the brain's binding problem. We focus on mechanisms of neural inhibition and top-down feedback. Specifically, we describe how inhibition creates competition among neural populations that code different features, effectively suppressing irrelevant information, and thus minimizing illusory conjunctions. (...)
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  31. Hector Escriva, Franck Delaunay & Vincent Laudet (2000). Ligand Binding and Nuclear Hormone Receptors Evolution. Bioessays 22:717-727.score: 18.0
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  32. Robert H. Lipsky Frank Krueger, Raja Parasuraman, Vijeth Iyengar, Matthew Thornburg, Jaap Weel, Mingkuan Lin, Ellen Clarke, Kevin McCabe (2012). Oxytocin Receptor Genetic Variation Promotes Human Trust Behavior. Frontiers in Human Neuroscience 6.score: 18.0
    Given that human trust behavior is heritable and intranasal administration of oxytocin enhances trust, the oxytocin receptor (OXTR) gene is an excellent candidate to investigate genetic contributions to individual variations in trust behavior. Although a single-nucleotide polymorphism involving an adenine (A)/ guanine (G) transition (rs53576) has been associated with socio-emotional phenotypes, its link to trust behavior is unclear. We combined genotyping of healthy male students with the administration of a trust game experiment. Our results show that a naturally occurring genetic (...)
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  33. Franco Giorgi, Luis Emilio Bruni & Roberto Maggio (2010). Receptor Oligomerization as a Process Modulating Cellular Semiotics. Biosemiotics 3 (2):157-176.score: 18.0
    The majority of G protein-coupled receptors (GPCRs) self-assemble in the form dimeric/oligomeric complexes along the plasma membrane. Due to the molecular interactions they participate, GPCRs can potentially provide the framework for discriminating a wide variety of intercellular signals, as based on some kind of combinatorial receptor codes. GPCRs can in fact transduce signals from the external milieu by modifying the activity of such intracellular proteins as adenylyl cyclases, phospholipases and ion channels via interactions with specific G-proteins. However, in spite of (...)
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  34. Motoyuki Hattori & Eric Gouaux (2012). Molecular Mechanism of ATP Binding and Ion Channel Activation in P2X Receptors. In Jeffrey Kastner (ed.), Nature. Mit Press. 485--7397.score: 18.0
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  35. Allison Jack, Jessica J. Connelly & James P. Morris (2012). DNA Methylation of the Oxytocin Receptor Gene Predicts Neural Response to Ambiguous Social Stimuli. Frontiers in Human Neuroscience 6.score: 18.0
    Oxytocin and its receptor (OXTR) play an important role in a variety of social perceptual and affiliative processes. Individual variability in social information processing likely has a strong heritable component, and as such, many investigations have established an association between common genetic variants of OXTR and variability in the social phenotype. However, to date, these investigations have primarily focused only on changes in the sequence of DNA without considering the role of epigenetic factors. DNA methylation is an epigenetic mechanism by (...)
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  36. Snehlata Jaswal (2013). The Process of Feature Binding. Frontiers in Psychology 4.score: 18.0
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  37. Martin Jean-Rémy (2013). Experiences of Activity and Causality in Schizophrenia: When Predictive Deficits Lead to a Retrospective Over-Binding. Consciousness and Cognition 22 (4):1361-1374.score: 18.0
    In this paper I discuss an intriguing and relatively little studied symptomatic expression of schizophrenia known as experiences of activity in which patients form the delusion that they can control some external events by the sole means of their mind. I argue that experiences of activity result from patients being prone to aberrantly infer causal relations between unrelated events in a retrospective way owing to widespread predictive deficits. Moreover, I suggest that such deficits may, in addition, lead to an aberrant (...)
     
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  38. Glyn W. Humphreys Kevin Dent, Harriet A. Allen, Jason J. Braithwaite (2012). Parallel Distractor Rejection as a Binding Mechanism in Search. Frontiers in Psychology 3.score: 18.0
    The relatively common experimental visual search task of finding a red X amongst red O’s and green X’s (conjunction search) presents the visual system with a binding problem. Illusory conjunctions of features across objects must be avoided and only features present in the same object bound together. Correct binding into unique objects by the visual system may be promoted, and illusory conjunctions minimised, by inhibiting the locations of distractors possessing non-target features (e.g. Treisman & Sato, 1990). Such parallel (...)
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  39. Frank Krueger, Raja Parasuraman, Vijeth Iyengar, Matthew Thornburg, Jaap Weel, Mingkuan Lin, Ellen Clarke, Kevin McCabe & Robert H. Lipsky (2012). Oxytocin Receptor Genetic Variation Promotes Human Trust Behavior. Frontiers in Human Neuroscience 6.score: 18.0
    Given that human trust behavior is heritable and intranasal administration of oxytocin enhances trust, the oxytocin receptor (OXTR) gene is an excellent candidate to investigate genetic contributions to individual variations in trust behavior. Although a single-nucleotide polymorphism involving an adenine (A)/ guanine (G) transition (rs53576) has been associated with socio-emotional phenotypes, its link to trust behavior is unclear. We combined genotyping of healthy male students with the administration of a trust game experiment. Our results show that a naturally occurring genetic (...)
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  40. Korbinian Moeller, Elise Klein & Hans-Christoph Nuerk (2013). Influences of Cognitive Control on Numerical Cognition—Adaptation by Binding for Implicit Learning. Topics in Cognitive Science 5 (2):335-353.score: 18.0
    Recently, an associative learning account of cognitive control has been suggested (Verguts & Notebaert, 2009). In this so-called adaptation by binding theory, Hebbian learning of stimulus–stimulus and stimulus–response associations is assumed to drive the adaptation of human behavior. In this study, we evaluated the validity of the adaptation-by-binding account for the case of implicit learning of regularities within a stimulus set (i.e., the frequency of specific unit digit combinations in a two-digit number magnitude comparison task) and their association (...)
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  41. Rosanna K. Olsen, Sandra N. Moses, Lily Riggs & Jennifer D. Ryan (2012). The Hippocampus Supports Multiple Cognitive Processes Through Relational Binding and Comparison. Frontiers in Human Neuroscience 6.score: 18.0
    It has been well established that the hippocampus plays a pivotal role in explicit long-term recognition memory. However, findings from amnesia, lesion and recording studies with non-human animals, eye-movement recording studies, and functional neuroimaging have recently converged upon a similar message: the functional reach of the hippocampus extends far beyond explicit recognition memory. Damage to the hippocampus affects performance on a number of cognitive tasks including recognition memory after short and long delays and visual discrimination. Additionally, with the advent of (...)
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  42. Thomas J. Schmidt (1986). Binding Receptors. Bioscience 36 (7):494-494.score: 18.0
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  43. Rosemarie Velik (2012). From Simple Receptors to Complex Multimodal Percepts: A First Global Picture on the Mechanisms Involved in Perceptual Binding. Frontiers in Psychology 3.score: 18.0
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  44. Dean Wyatte, Seth Herd, Brian Mingus & Randall O'Reilly (2012). The Role of Competitive Inhibition and Top-Down Feedback in Binding During Object Recognition. Frontiers in Psychology 3.score: 18.0
    How does the brain bind together visual features that are processed concurrently by different neurons into a unified percept suitable for processes such as object recognition? Here, we describe how simple, commonly accepted principles of neural processing can interact over time to solve the brain's binding problem. We focus on mechanisms of neural inhibition and top-down feedback. Specifically, we describe how inhibition creates competition among neural populations that code different features, effectively suppressing irrelevant information, and thus minimizing illusory conjunctions. (...)
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  45. Paul Thagard & Terrence C. Stewart (2011). The AHA! Experience: Creativity Through Emergent Binding in Neural Networks. Cognitive Science 35 (1):1-33.score: 16.0
    Many kinds of creativity result from combination of mental representations. This paper provides a computational account of how creative thinking can arise from combining neural patterns into ones that are potentially novel and useful. We defend the hypothesis that such combinations arise from mechanisms that bind together neural activity by a process of convolution, a mathematical operation that interweaves structures. We describe computer simulations that show the feasibility of using convolution to produce emergent patterns of neural activity that can support (...)
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  46. L. Shastri & V. Ajjanagadde (1993). From Simple Associations to Systematic Reasoning: A Connectionist Representation of Rules, Variables, and Dynamic Binding Using Temporal Synchrony. Behavioral and Brain Sciences 16 (3):417-51.score: 16.0
    Human agents draw a variety of inferences effortlessly, spontaneously, and with remarkable efficiency – as though these inferences were a reflexive response of their cognitive apparatus. Furthermore, these inferences are drawn with reference to a large body of background knowledge. This remarkable human ability seems paradoxical given the complexity of reasoning reported by researchers in artificial intelligence. It also poses a challenge for cognitive science and computational neuroscience: How can a system of simple and slow neuronlike elements represent a large (...)
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  47. Anna Szabolcsi (2003). Binding On the Fly: Cross-Sentential Anaphora in Variable— Free Semantics. In R. Oehrle & J. Kruijff (eds.), Resource Sensitivity, Binding, and Anaphora. Kluwer. 215--227.score: 15.0
    Combinatory logic (Curry and Feys 1958) is a “variable-free” alternative to the lambda calculus. The two have the same expressive power but build their expressions differently. “Variable-free” semantics is, more precisely, “free of variable binding”: it has no operation like abstraction that turns a free variable into a bound one; it uses combinators—operations on functions—instead. For the general linguistic motivation of this approach, see the works of Steedman, Szabolcsi, and Jacobson, among others. The standard view in linguistics is that (...)
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  48. Casey O'Callaghan (2013). Audible Independence and Binding. In Richard Brown (ed.), Consciousness Inside and Out: Phenomenology, Neuroscience, and the Nature of Experience. Springer Studies in Brain and Mind.score: 15.0
  49. Syed Hasan Arif (2009). A Ca2+‐Binding Protein with Numerous Roles and Uses: Parvalbumin in Molecular Biology and Physiology. Bioessays 31 (4):410-421.score: 15.0
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  50. Zvi Penner (1988). The Grammar of the Nominal Sentence: A Government-Binding Approach. Universitaet Bern, Institut für Sprachwissenschaft.score: 15.0
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