The DNA‐passage activity of topoisomerase II accidentally produces DNA knots and interlinks within and between chromatin fibers. Fortunately, these unwanted DNA entanglements are actively removed by some mechanism. Here we present an outline on DNA knot formation and discuss recent studies that have investigated how intracellular DNA knots are removed. First, although topoisomerase II is able to minimize DNA entanglements in vitro to below equilibrium values, it is unclear whether such capacity performs equally in vivo in chromatinized DNA. Second, DNA (...) supercoiling could bias topoisomerase II to untangle the DNA. However, experimental evidence indicates that transcriptional supercoiling of intracellular DNA boosts knot formation. Last, cohesin and condensin could tighten DNA entanglements via DNA loop extrusion (LE) and force their dissolution by topoisomerase II. Recent observations indicate that condensin activity promotes the removal of DNA knots during interphase and mitosis. This activity might facilitate the spatial organization and dynamics of chromatin. (shrink)

CONTENIDO: Fenomenología / Daniel Herrera Restrepo / - La hermenéutica y su naturaleza analógica: necesidad de una hermenéutica analógica / Mauricio Beuchot / - La filosofía analítica / Margarita M. Valdés / - Filosofía de la ciencia en el siglo XX / Ana Rosa Pérez Ransanz / - El liberalismo en la segunda mitad del siglo XX / Jesús Antonio Serrano Sánchez / - Filosofía y cultura / Dora Elvira García G. / - Filosofía e interculturalidad en América (...) Latina: intento de introducción no filosófica / Raúl Fornet-Betancourt. (shrink)

Most theories about virtue cultivation fall under the general umbrella of the role model approach, according to which virtue is acquired by emulating role models, and where those role models are usually conceived of as superior in some relevant respect to the learners. I argue that although we need role models to cultivate virtue, we also need good and close relationships with people who are not our superiors. The overemphasis on role models is misguided and misleading, and a good antidote (...) draws on the Aristotelian concept of character friendship. Character friendship constitutes a unique form of experience in which we share a substantial way of seeing with a close other; facilitates a unique form of knowledge, the knowledge of a particular person ; develops other emotions important for virtue cultivation besides admiration, such as love, shame, trust, and hope; and is a praxis in which cooperative interactions and discussions function as a bridge between habituation of virtue at home and the public life. Character friendship provides necessary elements for human cultivation of virtue that the sole experience of having a role model does not. (shrink)

Columbia University Press's multivolume _Prison Notebooks_ is the only complete critical edition of Antonio Gramsci's seminal writings in English. Based on the authoritative Italian edition of Gramsci's work, _Quaderni del Carcere_, this comprehensive translation presents the intellectual as he ought to be read and understood, with critical notes that clarify Gramsci's history, culture, and sources; an index of names; and a contextualization of the thinker's ideas against his earlier writings and letters. This set includes notebooks 1 through 8 with (...) all attendant notes and materials and is an indispensible resource for scholars in the humanities and social sciences. (shrink)

We propose a nonmonotonic Description Logic of typicality able to account for the phenomenon of combining prototypical concepts, an open problem in the fields of AI and cognitive modelling. Our logic extends the logic of typicality ALC + TR, based on the notion of rational closure, by inclusions p :: T(C) v D (“we have probability p that typical Cs are Ds”), coming from the distributed semantics of probabilistic Description Logics. Additionally, it embeds a set of cognitive heuristics for concept (...) combination. We show that the complexity of reasoning in our logic is EXPTIME-complete as in ALC. (shrink)

The paper introduces an extension of the proposal according to which conceptual representations in cognitive agents should be intended as heterogeneous proxytypes. The main contribution of this paper is in that it details how to reconcile, under a heterogeneous representational perspective, different theories of typicality about conceptual representation and reasoning. In particular, it provides a novel theoretical hypothesis - as well as a novel categorization algorithm called DELTA - showing how to integrate the representational and reasoning assumptions of the theory-theory (...) of concepts with the those ascribed to the prototype and exemplars-based theories. (shrink)

Este artículo reconstruye panorámicamente la posición de Agustín de Hipona con respecto a la filosofía en la obra De civitate Dei. Sostiene que la valoración y el reproche que le hace Agustín a los platonici descansan en último término en un concepto de filosofía tomado del mismo platonismo y reinterpretado según textos bíblicos que enfatizan la centralidad de la mediación y el culto para alcanzar la beata vita.

Sartre considers the rise of spontaneous not cognitive consciousness or prereflexive cogito as a subject. Without any conditions, without any nature or essence can be determined. The awareness event as an absolute necessity is indeed unjustifiable that refers to the world, is pure intentionality. The abstract ideal of freedom for Sartre is a conscience without any determination. Man is free because it is free of any determination by precognitive structure of consciousness.

La realidad social, política, económica y sanitaria que experimentamos hoy denota que vivimos una crisis planetaria que convulsa al conjunto de las relaciones sociales. Es un imperativo teórico, retomar la fecundidad del concepto de persona y la crítica de Emmanuel Mounier al positivismo y al marxismo del siglo XX. Su crítica se basó en la noción de persona, de profunda raíz en la teología cristiana occidental y hoy considerado Patrimonio Cultural de la Humanidad al permitir fundamentar la validez global de (...) los Derechos Humanos y la posibilidad de la creación de una Ética Universal. En la presente investigación se propone redimensionar el valor de la filosofía personalista de Mounier y su activismo evangélico hacia los pobres, como un nuevo humanismo de una dimensión más que teórica, práctica. A través de una revisión cronológica y bibliográfica de los momentos más relevantes del personalismo, esta investigación se propone en su conclusión, comprender la fecundidad de la reflexión del concepto de persona, como de la vigencia de la crítica de este pensador al positivismo y al marxismo; para contribuir a situar el eje ético y político- social de la actual situación sociosanitaria que atraviesa la humanidad. (shrink)

En el presente artículo expongo brevementelas bases del programa Filosofía paraniños, examino algunas de las objecionesque se le han hecho, y explico por quéconsidero que la comprensión de ésteimplica el abandono de ciertas ideas quepodrían clasificarse como tradicionalesde nt r o de l a ma ne r a de c onc e bi r l aeducación filosófica. Finalmente, valorola importancia del proyecto no sólo por subúsqueda del desarrollo cognitivo de losestudiantes, sino también por su esfuerzoen desarrollar un cierto carácter en (...) ellos.Uno que haga posible la construcción deuna sociedad más justa. In this paper I briefly present the basisof Philosophy for Children program, Iexamine some objections that have beenmade to it, and I explain why I thinkits comprehension implies the rejectionof certain ideas that could be describedas traditional within the conception ofphilosophical education. Finally, I valuethe importance of the project not onlybecause it seeks the cognitive developmentof the students, but also because it aims todevelop a certain character on them. Onethat enables the construction of a morefair society. (shrink)

Como resultado del renacimiento de la ética de la virtud se generaron por lo menos dos grandes reacciones: una que afirma que esta ética es redundante, porque las teorías morales modernas incluyen —o pueden incluir— las virtudes, y otra que afirma que ésta es más amplia y completa, porque aborda la vida moral de mejor manera al poner el énfasis en lo más importante: el carácter moral. En el presente trabajo examino tanto el renacimiento del tema como el debate posterior, (...) y planteo una posible razón para preferir la ética de la virtud. (shrink)

The publication of this book is an event in the making. All over the world scientists, psychologists, and philosophers are waiting to read Antonio Damasio's new theory of the nature of consciousness and the construction of the self. A renowned and revered scientist and clinician, Damasio has spent decades following amnesiacs down hospital corridors, waiting for comatose patients to awaken, and devising ingenious research using PET scans to piece together the great puzzle of consciousness. In his bestselling Descartes' Error, (...) Damasio revealed the critical importance of emotion in the making of reason. Building on this foundation, he now shows how consciousness is created. Consciousness is the feeling of what happens-our mind noticing the body's reaction to the world and responding to that experience. Without our bodies there can be no consciousness, which is at heart a mechanism for survival that engages body, emotion, and mind in the glorious spiral of human life. A hymn to the possibilities of human existence, a magnificent work of ingenious science, a gorgeously written book, The Feeling of What Happens is already being hailed as a classic. (shrink)

Se trata de mostrar y analizar algunas de las lecturas que se han hecho de la obra de Mohandas Gandhi en América Latina en las últimas décadas, a través de un escrito que se balancea entre una investigación empírica y el estudio de un caso que permite presentar dos problemas teóricos. Para esto se abordan autores y autoras de diversos países de la región, que permiten aludir a dos problemas teóricos que se formulan en este trabajo: la circulación de las (...) ideas entre regiones Sur-Sur, la reelaboración de las ideas en la región receptora. Estos problemas son claves en el desarrollo de los estudios eidéticos como disciplina. Se realiza una introducción respecto a la recepción de las ideas de Gandhi en la región hacia 1930, estudiando las articulaciones del pensamiento de éste con otros autores y tendencias de pensamiento y señalando algunas recepciones y cruzamientos posteriores. Luego el trabajo se focaliza en estudiosos de Argentina, Brasil, Chile, México, Nicaragua, Puerto Rico y Venezuela, tratando de presentar varios casos diferentes y que cubran numerosos países de la región, apuntando a un muestreo válido, aunque sin suficiente afirmación metodológica. The intention of this work is to show and analyze some of the readings that have been done about Mohandas Gandhi’s work in Latin America in the last decades, by means of a writing that swings between an empirical research and the study of a case that allows to present two theoretical problems. For this there are approached authors and authoresses of diverse countries of the region, who allow to allude to two theoretical problems that are formulated in this work: the flow of the ideas between South-South regions, the reformulation of the ideas in the receiving region. These issues are key to the development of the eidéticos studies as a discipline. An introduction is made regarding the reception of the ideas of Gandhi in the region by 1930, studying the joints of his thought and of those of other authors and trends of thought, pointing out some receptions and later crosses. Then the work focuses in experts of Argentina, Brazil, Chile, Mexico, Nicaragua, Puerto Rico and Venezuela, trying to present several different cases covering numerous countries of the region, pointing at a valid sampling, though without sufficient methodological affirmation. (shrink)

En este artículo examino el problema de si la concepción socrática de la eudaimonia entraña el egoísmo. Esto es, si, según Sócrates, un hombre que actúa teniendo como criterio final su felicidad es un egoísta. Este punto de vista parece entrar en contradicción con lo que pensamos comúnmente acerca de lo que debe decir una teoría moral. Clasifico los intentos que se han hecho por resolver el problema en dos grupos: los formalistas y los sustantivistas, con base en sus objetivos (...) generales. Argumento que la segunda clase de enfoque es más efectiva, puesto que trata de interpretar la teoría de Sócrates como un todo y la hace más coherente. Asume que Sócrates ofrece una teoría de la motivación humana para actuar en la que el agente busca su felicidad, pero otorgando también una función central a la amistad, el amor y la justicia. (shrink)

Que se ha llamado “ética del cuidado”de si tal ética podría remplazar la éticason razonables. Al final del artículofundamental para la construcción de unabuena teoría ética.

El artículo muestra la forma en que laepistemología de las virtudes puederesolver algunos de los problemasepistemológicos clásicos, y la manera enque puede lograrse una concepciónintegrada de las variantes confiabilistay responsabilista de la epistemología delas virtudesThis paper shows the way in which Virtue Epistemology can solve some ofthe classical epistemological problems,and the way in which an integrated approach of the Reliabilist and Responsibilist variants of Virtue Epistemology can be achieved.

Introducción: las tecnologías de la información y las comunicaciones se utilizan cada vez más en las universidades como medios de enseñanza. Se ha optado por el uso de los objetos de aprendizaje para lograr la reutilización, accesibilidad, durabilidad e interoperabilidad en sus recursos educativos. Objetivo: enunciar algunos de los valores humanos que se que se manifiestan en el proceso de autoformación con los objetos de aprendizaje. Método: se utilizó la observación como método científico durante el proceso enseñanza-aprendizaje con los objetos (...) de aprendizaje para la autoformación de los estudiantes. Resultados: se enunciaron algunos valores intelectuales, éticos, estéticos, físicos, morales y sociales, que se revelan en el proceso de autoformación con los objetos de aprendizaje. Conclusiones: Los valores humanos que manifiestan los estudiantes durante el proceso de autoformación con los objetos de aprendizaje sirven para establecer juicios de valor consistentes, derivados de modos de pensar y sentir que les permitan enfrentar sus decisiones vitales. Introduction: Information technology and communications are increasingly used in universities as teaching means in the teaching-learning process. The use of learning objects has been opted to achieve reusability, accessibility, durability and interoperability in its educational resources. Objective: To enunciate some human values occurring in the process of self-education with learning objects. Method: The observation as a scientific method for the teaching-learning process with learning objects for independent self-training of students was used. Results: There have been enunciated some intellectual, ethical, aesthetic, physical, moral and social values that are revealed in the process of self-training with learning objects. Conclusions: The human values that students showed during self-training with learning objects serve to establish consistent value judgments derived from modes of thinking and feeling that enable them to cope with their vital decisions. (shrink)

El cuerpo se presenta en una doble perspectiva como mediación en la configuración de la realidad y como elemento de alienación para el sujeto. Esta condición estudiada ya en autores como Marcel, Sartre y Merleau Ponty es retomada aquí como posibilidad para entender mejor las relaciones del hombre con el mundo y las diferentes vivencias que el ser humano experimenta en el proceso de su existencia. Para la Antropología filosófica entender la mediación cuerpo humano — mundo se convierte en punto (...) de partida y eje de estudios interdisciplinares que generan y facilitan un conocimiento integral del hombre como es el caso del estudio fenomenológico de la enfermedad y el dolor. (shrink)

The present paper reveals (non-relativistic) quantum mechanics as an emergent property of otherwise classical ergodic systems embedded in a stochastic vacuum or zero-point radiation field (zpf). This result provides a theoretical basis for understanding recent numerical experiments in which a statistical analysis of an atomic electron interacting with the zpf furnishes the quantum distribution for the ground state of the H atom. The action of the zpf on matter is essential within the present approach, but it is the ergodic demand (...) what ultimately leads to the matrix formulation of quantum mechanics. The paper thus represents a step forward in the quest for an elucidation of the fundamentals of quantum mechanics. (shrink)

Antonio Negri, one of the world's leading scholars on Baruch Spinoza (1632-1677) and his contemporary legacy, offers a straightforward explanation of the philosopher's elaborate arguments and a persuasive case for his ongoing relevance. Responding to a resurgent interest in Spinoza's thought and its potential application to contemporary global issues, Negri demonstrates the thinker's special value to politics, philosophy, and related disciplines. Negri's work is both a return to and an advancement of his initial affirmation of Spinozian thought in _The (...) Savage Anomaly_. He further defends his understanding of the philosopher as a proto-postmodernist, or a thinker who is just now, with the advent of the postmodern, becoming contemporary. Negri also connects Spinoza's theories to recent trends in political philosophy, particularly the reengagement with Carl Schmitt's "political theology," and the history of philosophy, including the argument that Spinoza belongs to a "radical enlightenment." By positioning Spinoza as a contemporary revolutionary intellectual, Negri addresses and effectively defeats twentieth-century critiques of the thinker waged by Jacques Derrida, Alain Badiou, and Giorgio Agamben. (shrink)

This article addresses an open problem in the area of cognitive systems and architectures: namely the problem of handling (in terms of processing and reasoning capabilities) complex knowledge structures that can be at least plausibly comparable, both in terms of size and of typology of the encoded information, to the knowledge that humans process daily for executing everyday activities. Handling a huge amount of knowledge, and selectively retrieve it according to the needs emerging in different situational scenarios, is an important (...) aspect of human intelligence. For this task, in fact, humans adopt a wide range of heuristics (Gigerenzer & Todd) due to their “bounded rationality” (Simon, 1957). In this perspective, one of the requirements that should be considered for the design, the realization and the evaluation of intelligent cognitively-inspired systems should be rep- resented by their ability of heuristically identify and retrieve, from the general knowledge stored in their artificial Long Term Memory (LTM), that one which is synthetically and contextually relevant. This requirement, however, is often neglected. Currently, artificial cognitive systems and architectures are not able, de facto, to deal with complex knowledge structures that can be even slightly comparable to the knowledge heuris- tically managed by humans. In this paper I will argue that this is not only a technological problem but also an epistemological one and I will briefly sketch a proposal for a possible solution. (shrink)

Endowing artificial systems with explanatory capacities about the reasons guiding their decisions, represents a crucial challenge and research objective in the current fields of Artificial Intelligence (AI) and Computational Cognitive Science [Langley et al., 2017]. Current mainstream AI systems, in fact, despite the enormous progresses reached in specific tasks, mostly fail to provide a transparent account of the reasons determining their behavior (both in cases of a successful or unsuccessful output). This is due to the fact that the classical problem (...) of opacity in artificial neural networks (ANNs) explodes with the adoption of current Deep Learning techniques [LeCun, Bengio, Hinton, 2015]. In this paper we argue that the explanatory deficit of such techniques represents an important problem, that limits their adoption in the cognitive modelling and computational cognitive science arena. In particular we will show how the current attempts of providing explanations of the deep nets behaviour (see e.g. [Ritter et al. 2017] are not satisfactory. As a possibile way out to this problem, we present two different research strategies. The first strategy aims at dealing with the opacity problem by providing a more abstract interpretation of neural mechanisms and representations. This approach is adopted, for example, by the biologically inspired SPAUN architecture [Eliasmith et al., 2012] and by other proposals suggesting, for example, the interpretation of neural networks in terms of the Conceptual Spaces framework [Gärdenfors 2000, Lieto, Chella and Frixione, 2017]. All such proposals presuppose that the neural level of representation can be considered somehow irrelevant for attacking the problem of explanation [Lieto, Lebiere and Oltramari, 2017]. In our opinion, pursuing this research direction can still preserve the use of deep learning techniques in artificial cognitive models provided that novel and additional results in terms of “transparency” are obtained. The second strategy is somehow at odds with respect to the previous one and tries to address the explanatory issue by avoiding to directly solve the “opacity” problem. In this case, the idea is that one of resorting to pre-compiled plausible explanatory models of the word used in combination with deep-nets (see e.g. [Augello et al. 2017]). We argue that this research agenda, even if does not directly fits the explanatory needs of Computational Cognitive Science, can still be useful to provide results in the area of applied AI aiming at shedding light on the models of interaction between low level and high level tasks (e.g. between perceptual categorization and explanantion) in artificial systems. (shrink)

Spin is a fundamental and distinctive property of the electron, having far-reaching implications. Yet its purely formal treatment often blurs the physical content and meaning of the spin operator and associated observables. In this work we propose to advance in disclosing the meaning behind the formalism, by first recalling some basic facts about the one-particle spin operator. Consistently informed by and in line with the quantum formalism, we then proceed to analyse in detail the spin projection operator correlation function \=\left\langle (...) \left \left \right\rangle \) for the bipartite singlet state, and show it to be amenable to an unequivocal probabilistic reading. In particular, the calculation of \\) entails a partitioning of the probability space, which is dependent on the directions \.\) The derivation of the CHSH- or other Bell-type inequalities, on the other hand, does not consider such partitioning. This observation puts into question the applicability of Bell-type inequalities to the bipartite singlet spin state. (shrink)

Scientists are rapidly mapping the chemical and physical pathways that constitute biological systems, making the complexity of processes such as inheritance, development, evolution, and even the origin of life increasingly tractable. Through genetics and neuroscience, biological understanding is now being extended deeply into the human sciences and has begun to transform our understanding of behavior, mind, culture, and values. The idea of a science-driven unity of knowledge has reemerged in several forms in both reductionist and nonreductionist frameworks. This volume examines (...) some of the extraordinary empirical discoveries that have caused a revival of this idea and presents theories from thinkers in a variety of disciplines, including E. O. Wilson, Eric Kandel, and Elaine Scarry. (shrink)