OBJECTIVE: How outside factors affect physician decision making remains an open question of vital importance. We sought to investigate the importance of various influences on physician decision making when clinical guidelines differ from patient preference. -/- METHODS: An online survey asking 469 primary care providers (PCPs) across four practice sites whether they would order magnetic resonance imaging for a patient with uncomplicated back pain. Participants were randomized to one of four scenarios: a patient's preference for imaging (control), a patient's preference (...) plus a colleague's opinion against imaging (colleague), a patient's preference plus a professional society's recommendation against imaging (profession), or a patient's preference plus an accountable care organization's quality metric that measures physician use of imaging (ACO). Demographic information and the reasoning behind participants' decisions also were obtained. -/- RESULTS: A total of 168 PCPs completed the survey, yielding a 36% completion rate. A majority chose not to pursue imaging: control 68%, colleague 85%, profession 87%, and ACO 78%. Multivariate logistic regression revealed that participants were more likely not to order advanced imaging only when reminded of a professional society recommendation (P = 0.017). Regression also suggested that practice site exerted an effect on the primary outcome. Evidence-based medicine and clinical judgment were the most cited reasons for the decision. -/- CONCLUSIONS: Our results reinforce the potential to leverage professional societies to advance evidence-based medicine and reduce unnecessary testing. At the same time, practice site appeared to exert influence, suggesting that these recommendations must be part of local institutional culture to be effective. (shrink)

Soluble components of Notch signalling can be applied to manipulate a central pathway essential for the development of metazoans and often deregulated in illnesses such as stroke, cancer or cardiovascular diseases. Commonly, the Notch cascade is inhibited by small compound inhibitors, which either block the proteolysis of Notch receptors by γ‐secretases or interfere with the transcriptional activity of the Notch intracellular domain. Specific antibodies can also be used to inhibit ligand‐induced activation of Notch receptors. Alternatively, naturally occurring endogenous inhibitors of (...) Notch signalling might offer a specific way to block receptor activation. Examples are the soluble variants of the canonical Notch ligand Jagged1 and the non‐canonical Notch ligand Dlk1, both deprived of their transmembrane regions upon ectodomain shedding, or the bona fide secreted molecule EGFL7. We present frequently used methods to decrease Notch signalling, and we discuss how soluble Notch inhibitors may be used to treat diseases. (shrink)

This document represents some preliminary and unpublished content of a chapter in the edited book titled A New Theory of Serendipity: Nature, Emergence and Mechanism, which will soon be published and distributed by De Gruyter Poland (Sciendo Imprint; part of Walter de Gruyter GmbH, Berlin, Germany). A proper referencing should be like: Quan-Hoang Vuong, Tam-Tri Le, Quy Khuc, Minh-Hoang Nguyen. (2022). A new theory of serendipity. In: QH Vuong. (Ed.) A New Theory of Serendipity: Nature, Emergence and Mechanism (pp. 91-108). (...) Berlin, Germany: De Gruyter. (shrink)

Christelijke ethiek, in de traditie ook wel moraaltheologie genoemd, is een van de meest omstreden onderwerpen binnen de theologie, maar ook daarbuiten. Toch is het doel van deze ethiek 'een leven in volheid en vrijheid'. Zonder ethische richtlijnen en persoonlijke verantwoordelijkheid kan een leven niet slagen. Normen en wetten hebben als doel ruimte te scheppen voor het leven en dat te beschermen. Deze vrijheid invullen, daar zijn mensen zelf verantwoordelijk voor. En verantwoordelijk zijn betekent: een antwoord verschuldigd zijn aan iemand. (...) Ethiek voltrekt zich daarom altijd in relatie: tot het eigen geweten, tot het goede dat te verwezenlijken valt, en in relatie tot andere levende wezens en de natuur. Christelijke ethiek plaatst deze verantwoordelijkheid bovendien in relatie tot God. Mensen zijn vrij maar ook beperkt; zij doen elkaar kwaad en hebben behoefte aan vergeving en verzoening. (shrink)

The book examines the psycho-religious mechanism behind the violent extremism of suicide attacks in the post-9/11 world. It employs the mindsponge concept, an original dataset, and original research results obtained from the authors' statistical investigations using the Hamiltonian Markov chain Monte Carlo technique. It provides insights and implications for policymakers and strategists in their efforts to engage in peace talks and reduce violent conflicts worldwide.

This chapter contains sections titled: Philosophical Prohibitions Religious Arguments A Defense of Altered States Cannabis in Particular.

Space tourism is an emerging field where few people have direct experience. However, considering the potential in the near future, it is beneficial to better understand how related information influences people’s attitudes about this new form of tourism. Employing information-processing-based Bayesian Mindsponge Framework (BMF) analytics on a dataset of 361 respondents consuming content related to space tourism on Chinese social media, we found that induced happiness and impression are positively associated with willingness to try space tourism. Information authenticity positively moderates (...) these two associations. Our findings emphasize three aspects of information during the processes of reception and filtering: meaning, intensity, and trust. Since promotional materials for space tourism rely heavily on mental simulations rather than objective feedback, creative uses of digital technology are advantageous. However, precautions must be taken to prevent exploitation, such as false advertising, exaggeration, and emotional manipulation. (shrink)

Reproduit quatre conférences faites en 1946 et 1947 sous ce titre au Collège de philosophie, et interroge la notion de temps comme limitation même de l'être fini ou comme relation de l'être fini à Dieu (Electre).

Depuis quelques années, un mouvement d'idées venu des Etats-Unis, qualifié de "Révolution transhumaniste", a pris un essor considérable. Demain, on vivra 200 ou 300 ans... et bien sûr en parfaite santé : l'immortalité n'est pas loin! Ces prophéties s'appuient sur les avancées réelles de l'intelligence artificielle et de la recherche en biologie, en particulier dans le domaine du vieillissement, passant ainsi allègrement de l'homme préservé et/ou augmenté à un véritable homme dieu. Mais dès que l'on s'intéresse au cerveau, les données, (...) particulièrement complexes, ne vont pas dans leur sens. Il existe une contradiction criante entre la jeunesse éternelle promise et la réalité actuelle, marquée en particulier par les échecs thérapeutiques répétés dans les maladies neurodégénératives. Forts de leur expérience et de leur autorité dans le domaine des neurosciences et du vieillissement, Danièle Tritsch et Jean Mariani dénoncent l'imposture du transhumanisme et ses excès ou délires, données scientifiques à l'appui. De façon accessible et vivante, avec de nombreux exemples de la vie quotidienne, ils démontrent que les efforts lents et soutenus de la recherche biologique et médicale - auxquels contribuera l'intelligence artificielle - restent la seule voie pour comprendre le fonctionnement du cerveau, le maintenir en bonne santé (cerveau préservé), le doter de capacités nouvelles (cerveau augmenté) et, dans un délai non prévisible, guérir ou stabiliser les maladies neurodégénératives (cerveau réparé). L'homme dieu, quant à lui, ne s'appuie sur rien de tangible. (shrink)

A classic source for understanding the connections between information theory and physics, this text was written by one of the giants of 20th-century physics and is appropriate for upper-level undergraduates and graduate students. Topics include the principles of coding, coding problems and solutions, the analysis of signals, a summary of thermodynamics, thermal agitation and Brownian motion, and thermal noise in an electric circuit. A discussion of the negentropy principle of information introduces the author's renowned examination of Maxwell's demon. Concluding chapters (...) explore the associations between information theory, the uncertainty principle, and physical limits of observation, in addition to problems related to computing, organizing information, and inevitable errors. 1962 ed. 81 figures. 14 tables. (shrink)

Cheating is widely considered a condemnable behavior in society and a big problem in the educational system. In this study, we employ the information-processing-based Bayesian Mindsponge Framework to explore deeper the subjective cost-benefit evaluation involving the perceived value of cheating. Conducting Bayesian analysis on 493 university students from Germany, Vietnam, China, Taiwan, and Japan, we found that students who have more positive attitudes toward cheating are more likely to cheat. However, a higher capability of cognitive reflection acts as a moderator (...) that negates the above effect. Re-evaluation of prior thoughts allows for more accurate assessments of the associated risks and possible costs, which help reduce the probability of carrying out cheating behavior. As rapid technological advancement may introduce new and efficient cheating methods, a better understanding of the psychology of cheating in students can help schools prepare better countermeasures. (shrink)

"La solidarité que je ressentais avec les opprimés, avec ceux qui souffraient, a fait que je me suis spontanément`: tourné vers l'anarchisme - cette théorie qui traite des rapports de domination".

Les Cyniques grecs ne nous ont pas l gu de savants trait s. Leur philosophie, plut t pragmatique, s'exprimait par l'observance d'une vie asc tique franchement marginale. Le lecteur d couvrira dans ces fragments qui leur sont attribu s, dans ces t moignages de contemporains, pr sent s ici dans leur version fran aise, l'univers et l'id al des Cyniques. Le texte de cette nouvelle dition a t enti rement revu par l'auteur. Les recherches effectu es depuis la premi re (...) publication (1975) ont permis de compl ter plusieurs sections et d'y inclure des fragments nouveaux et des traductions r centes. Une bibliographie enti rement r vis e et deux nouveaux index viennent compl ter l'ouvrage. (shrink)

De christelijke ethiek is een ethiek in wording. Dit tweede deel van het 'Handboek Moraaltheologie' legt aan de hand van de trefwoorden wetten, waarheid en waardigheid uit hoe de morele denkpatronen zich in de tijd hebben ontwikkeld. (Kerk)historische en dogmatische veranderingen hadden een belangrijke invloed op de moraaltheologie. Niet alleen de inhouden, maar ook methoden veranderden door de eeuwen heen: bij de eerste christenen leidde een oorspronkelijke overtuiging tot een overtuigende ethiek. In de Middeleeuwen droeg een systematisering van de theologische (...) waarheid bij aan een systematisering van morele normen en wetten. In de moderne en postmoderne tijd wordt naarmate het waarheidsbegrip in de wijsgerige ethiek verdwijnt, de morele leer aan de orde gesteld. Dit boek brengt fenomenologie, antropologie en theologie met elkaar in gesprek: eidetische fenomenologie en een existentiële antropologie dragen bij aan een mogelijke vertaalslag van geopenbaarde inhouden. (shrink)

In the trust-health relationship, how trusting other people in society may promote good health is a topic often examined. However, the other direction of influence – how health may affect trust – has not been well explored. In order to investigate this possible effect, we employed Bayesian Mindsponge Framework (BMF) analytics to go deeper into the information processing mechanisms underlying the expressions of trust. Conducting Bayesian analysis on a dataset of 1237 residents from Cali, Colombia, we found that general health (...) status is positively associated with generalized trust, but recent experiences of illnesses/injuries have a negative moderating effect. Personalized trust is largely unchanged across different general health conditions, but the trust level becomes higher with recent experiences of illnesses/injuries. Psychophysiological mechanisms of increasing information filtering intensity toward unfamiliar sources during a vulnerable state of health is a plausible explanation of found patterns in generalized trust. Because established personal relationships are reinforced information channels, personalized trust is not affected as much. Rather, the results suggest that people may rely even more on loved ones when they are in bad health conditions. This exploratory study shows that the trust-health relationship can be examined from a different angle that may provide new insights. (shrink)

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Emmanuel Levinas (1905-1995) is at the center of the renewed debate over the question of the ethical. In the context of the phenomenological tradition, Levinas defines ethics as an originary response to the face of the other. Between 1982 and 1992, Levinas gave numerous interviews, closing a distinguished sixty-year career. Of the twenty interviews collected in this volume, seventeen appear in English for the first time. In the interviews Levinas sets forth the central features of his ethical philosophy. He underlies (...) his dedication to the phenomenological search for the concrete and the nonformal signification of alterity. He also elaborates on issues that do not receive extensive treatment in his formal philosophical works, including the question of pre-philosophical experiences, the ethical signification of money, justice, and the State. The informality of the interviews prompt Levinas to address matters about which he is reticent in his published works. (shrink)

By applying the MIC theory to their analyses of English, German, French, Polish, Russian, Greek, Latin, and Japanese, the authors provide comprehensive explanations of the most puzzling aspects of the pragmatic use of basic universal linguistic categories.

'The Levinas Reader' collects, often for the first time in English, essays by Levinas encompassing every aspect of his thought: the early phenomenological studies written under the guidance and inspiration of Husserl and Heidegger; the fully developed ethical critique of such totalizing philosophies; the pioneering texts on the moral dimension to aesthetics; the rich and subtle readings of the Talmud which are an exemplary model of an ethical, transcendental philosophy at work; the admirable meditations on current political issues.

Analyse dans la perspective phénoménologique de l'essence comme expression de "l'être" différent de l'"étant". Substitution, dans la subjectivité, de soi à autrui.

Reality and its shadow -- Freedom and command -- The ego and the totality -- Philosophy and the idea of infinity -- Phenomenon and enigma -- Meaning and sense -- Language and proximity -- Humanism and an-archy -- No identity -- God and philosophy -- Transcendence and evil.