SUPPORT, a study involving approximately 1,300 premature infants who were randomly assigned to treatment protocols that differed in whether they offered higher or lower levels of oxygen saturation, was purportedly an example of comparative effectiveness research performed in the intensive care unit. However, SUPPORT became highly controversial. One source of controversy involved the proper determination of “reasonably foreseeable risks.” Commentators debated whether randomization to contrasting restrictive strategies that are within existing standard‐of‐care treatments imposed additional “reasonably foreseeable risks” greater than what (...) study participants would have received outside of the research. A second controversial issue had to do with disclosures in informed consent documents. This article explores these issues.We argue that randomization to contrasting restrictive interventions lying at the outer ends of “standard‐of‐care” practices differs in important ways from unrestricted “standard‐of‐care” practices available outside of a proposed study; that research involving such randomization might pose additional “reasonably foreseeable risks” from what occurs in “standard‐of‐care” practices; and that for trials whose study designs are similar to the SUPPORT study, respect for persons requires the disclosure of information about the nature of the experimental procedures and their risks. (shrink)

A commentary on “SUPPORT: Risks, Harms, and Equipoise,” by Robert M. Nelson; “The Controversy over SUPPORT Continues and the Hyperbole Increases,” by Alan R. Fleischman; and “SUPPORT and the Ethics of Study Implementation,” by John D. Lantos and Chris Feudtner, all in the January‐February 2015 issue.

French end-of-life law aims at protecting patients from unreasonable treatments, but has been used to force caregivers to prolong treatments deemed unreasonable. We describe six cases (five intensi...

A commentary on “Were There ‘Additional Foreseeable Risks’ in the SUPPORT Study?,” by Henry J. Silverman and Didier Dreyfuss; “SUPPORT: Risks, Harms, and Equipoise,” by Robert M. Nelson; “The Controversy over SUPPORT Continues and the Hyperbole Increases,” by Alan R. Fleischman; and “SUPPORT and Comparative Effectiveness Trials: What's at Stake?,” by Lois Shepherd, all in the January‐February 2015 issue.

A response to “What Counts as Equipoise?” by Henry J. Silverman and Didier Dreyfuss.

When he died in 1984, Michel Foucault was widely regarded as one of the most powerful minds of this century. Hailed by historians and lionized in America, he continues to provoke lively debate. This meticulously documented narrative debunks the many myths and rumors surrounding the brilliant philosopher to consider that all Foucault's books are "fragments of an autobiography".

This chapter contains sections titled: Introduction West African Conceptions of Person East and Southern African Conceptions of Person Concluding Remarks.

Ce livre offre un parcours en compagnie d'ecrivains, philosophes et poetes, parmi les plus marquants de la deuxieme moitie du XXe siecle. Son point de depart est une question qui porte sur l'essence meme de la litterature: que signifie aimer avec passion une oeuvre et l'homme qui est derriere?... Comment vit-on avec? Et qu'y trouve-t-on pour vivre avec soi meme, apprendre a vivre ainsi? Il s'agit donc d'un livre ecrit a la premiere personne par un auteur qui aura eu la (...) chance de croiser le chemin de quelques grandes figures de la pensee francaise contemporaine: Edmond Jabes, Jacques Derrida et Andre du Bouchet, Maurice Blanchot de facon plus lointaine. On y trouvera pourtant une volonte clairement pedagogique. Didier Cahen reprend et etudie les enonces multiples de ces createurs de la postmodernite sur l'articulation de la pensee et de la litterature ou sur l'espace commun de la philosophie et de la poesie. Dans la foulee, il aborde des questions plus ouvertes, qui touchent a l'intuition de l'autre, au non-savoir qu'explore la face cachee de la litterature. Comme le demontrent les oeuvres singulieres de Roger Laporte et de Marcel Cohen, ecrire c'est mettre sa vie en jeu, se fier a ce qui vient, suivre l'ordre de l'Autre... en se jouant de l'etre. Indiscipline au coeur des disciplines, cet exercice de la litterature traverse ainsi les genres, engage son ecriture au-dela des lignes du livre, delivre le message qui se lit a livre ouvert. (shrink)

A memoir and a meditation on individual and class identity, and the forces that keep us locked in political closets. On thinking the matter through, it doesn't seem exaggerated to assert that my coming out of the sexual closet, my desire to assume and assert my homosexuality, coincided within my personal trajectory with my shutting myself up inside what I might call a class closet. —from Returning to Reims After his father dies, Didier Eribon returns to his hometown of (...) Reims and rediscovers the working-class world he had left behind thirty years earlier. For years, Eribon had thought of his father largely in terms of the latter's intolerable homophobia. Yet his father's death provokes new reflection on Eribon's part about how multiple processes of domination intersect in a given life and in a given culture. Eribon sets out to investigate his past, the history of his family, and the trajectory of his own life. His story weaves together a set of remarkable reflections on the class system in France, on the role of the educational system in class identity, on the way both class and sexual identities are formed, and on the recent history of French politics, including the shifting voting patterns of the working classes—reflected by Eribon's own family, which changed its allegiance from the Communist Party to the National Front. Returning to Reims is a remarkable book of sociological inquiry and critical theory, of interest to anyone concerned with the direction of leftist politics in the contemporary world, and to anyone who has ever experienced how sexual identity can clash with other parts of one's identity. A huge success in France since its initial publication in 2009, Returning to Reims received enthusiastic reviews in Le Monde, Libération, L'Express, Les Inrockuptibles, and elsewhere. (shrink)

Contemporary political theory (CPT) has approached questions of plurality and diversity by drawing rather implicitly on anthropological accounts of difference. This was the case with the ‘cultural turn’, which significantly shaped theories of multiculturalism. Similarly, the current ‘ontological turn’ is gaining influence and leaving a marked impact on CPT. I examine the recent turn and assess both the possibilities it offers and the challenges it poses for decentering CPT and opening radical, decolonial avenues for thinking difference otherwise. I take Paul (...) Nadasdy's critique of the ontological turn as an invitation to reflect on the methodological precepts that inform how the field frames the scope and limits of comparison. In pursuit of this, I examine the Zapatistas’ notion of a ‘world of many worlds’, which provides a way of approaching difference that captures the generative aspects of the ontological turn while avoiding the pitfalls of relativism and political inertia. I argue that the Zapatistas’ insights offer ethical guidance towards social and ecological thriving. Ultimately, my goal is to move CPT towards a more capacious form of making sense of what is out there in the world, and thus make room for better ways of inhabiting the Earth. (shrink)

Entre Nietzsche et le Saint-Suaire, qu'y a t-il de commun? Une ville : Turin. C'est là que le philosophe a passé les mois qui ont précédé son effondrement dans la démence, en mai 1888, tout près de la chapelle qui conserve le Suaire. Faut-il n'y voir qu'une coïncidence? Né de l'étonnement devant l'ignorance qui entoure ce dernier moment de la vie lucide de Nietzsche, ce livre nous fait découvrir le combat spirituel que le philosophe mène avec le Christ. Il commence (...) par une enquête historique à nouveaux frais et révèle des épisodes méconnus - voire encore inconnus - de la vie de Nietzsche à Turin. La figure de l'homme y apparaît sous un jour bien différent de la légende attachée à son nom. Puis Didier Rance présente le face à face entre celui qui s'était autoproclamé Antichrist et Jésus Christ. Les attaques de Nietzsche à l'endroit du christianisme et de son fondateur sont connues ; on les dit décisives. A travers la voix des papes contemporains qui ont tous médité devant le Suaire, il est possible de pressentir la réponse que le Crucifié apporte à la critique nietzschéenne. Une réponse fondée sur la miséricorde qui éclaire en profondeur le sens du nihilisme dont Nietzsche a voulu être le prophète, et dans lequel se trouve plongé notre monde. (shrink)

The commentary raises political questions about the ways in which data has been constituted as an object vested with certain powers, influence, and rationalities. We place the emergence and transformation of professional practices such as ‘data science’, ‘data journalism’, ‘data brokerage’, ‘data mining’, ‘data storage’, and ‘data analysis’ as part of the reconfiguration of a series of fields of power and knowledge in the public and private accumulation of data. Data politics asks questions about the ways in which data has (...) become such an object of power and explores how to critically intervene in its deployment as an object of knowledge. It is concerned with the conditions of possibility of data that involve things, language, and people that together create new worlds. We define ‘data politics’ as both the articulation of political questions about these worlds and the ways in which they provoke subjects to govern themselves and others by making rights claims. We contend that without understanding these conditions of possibility – of worlds, subjects and rights – it would be difficult to intervene in or shape data politics if by that it is meant the transformation of data subjects into data citizens. (shrink)

Didier Zúñiga | : Le présent article examine la façon dont Charles Taylor a entrepris de poser le problème politique de la sécularisation. Plus spécifiquement, nous voudrions montrer que, si son effort pour articuler une théorie de l’aménagement de la diversité morale et religieuse a certes contribué à critiquer les régimes rigides de la laïcité, Taylor accorde une prééminence incontestable à la liberté de conscience. Or, notre analyse entend démontrer que, selon cette vue, il n’y a pas de place (...) pour l’autonomie religieuse. Notre hypothèse est qu’en présentant les conflits moraux et religieux comme des enjeux de justice, Taylor néglige l’important clivage existant entre, d’une part, les questions de reconnaissance reliées à la différence culturelle et, d’autre part, les revendications d’autorité exprimées par des groupes — et pas simplement des membres individuels — au sein de la sphère publique. | : This paper aims to challenge the assumption that Charles Taylor’s conception of political secularism is pluralist. The article argues that, although Taylor’s work provides the basis for an important critique of the most rigid forms of secularism, his theory places a strong focus on individual conscience. Yet Taylor’s almost exclusive concern for individual conscience excludes the pluralist claim to religious institutional autonomy. In addition, this article argues that Taylor presents moral and religious conflicts as questions of justice, which can be resolved with a correct interpretation of freedom of conscience. Against Taylor’s conception of “laïcité,” the article attempts to show that these problems are best grasped as conflicts between the authority of different groups—not just individuals—and that of the state. (shrink)

Philosopher, c'est bien faire comprendre ce que l'on pense, mais ce que l'on pense n'est ni sensible, ni audible, ni lisible, mais intelligible, c'est-à-dire saisissable par la seule intelligence. La philosophie, comme éducation du sensible, est donc aussi dissolution des réalités apparentes et congédiement de l'opinion. La réalité n'est donc pas le sensible et l'idée commune de réel est plutôt une représentation. La représentation, en effet, est sans élaboration théorique ; entièrement passive, elle ne saurait être une idée ; mais (...) elle n'est pas non plus une idée du réel, puisqu'elle ne parle, en fait, que du sensible. (shrink)

Manifesto for the recognition of the principle of linguistic and cultural diversity in language research Preamble Over the years, and for several decades now, higher education institutions have been gradually and increasingly urging teacher-researchers to increase their international visibility. It is normal for these teacher-researchers to participate in international debates in their disciplines. This is done during conferences and in the course of article writing, not for advertising purpo...

Didier Méhu | : Le sermon 163 d’Augustin d’Hippone aurait été prononcé à l’occasion de la dédicace de la basilica Honoriana de Carthage, le 23 septembre 417. Ancré dans le commentaire du verset 5,16 de l’épître aux Galates, Spiritu ambulate et concupiscentias carnis ne perfeceritis, il propose une comparaison entre le processus du salut humain et l’édification de l’église. Les deux aboutissent à la « dédicace », celle du temple de pierres que l’on célèbre alors et celle des élus (...) réunis auprès de Dieu. Nous cherchons à discerner les implications historiques de la dialectique aedificatio-dedicatio qui traverse le sermon, en regard de l’évolution du discours sur le lieu de culte chrétien et de la mise en place d’une structure sociale polarisée par les églises au tournant des ive et ve siècles. | : Augustine of Hippo’s Homily 163 is supposed to have been delivered on the occasion of the dedication of the basilica Honoriana in Carthage, September 23, 417. Rooted in the commentary of Galatians 5:16, Spiritu ambulate et concupiscentias carnis ne perfeceritis, it proposes a comparison between the process of human salvation and the building of a church. Both achieve in the “dedication”, that of the temple of stones, that is then celebrated, and that of the elected gathered with God. We seek to discern the historical implications of the dialectic aedificatio-dedicatio that appears throughout the sermon, in relation to the evolution of the discourse on the Christian place of worship and the establishment of a social structure polarized by the churches, at the turn of the 4th and the 5th centuries. (shrink)

Tout au long de son oeuvre, depuis Réflexions sur la question gay, en 1999, jusqu'à Principes d'une pensée critique, en 2016, mais déjà dans l'ouvrage biographique qu'il a consacré à Michel Foucault en 1989, Didier Eribon s'est attaché à élaborer une théorie historique, sociale et politique de la subjectivité : il s'agit de comprendre comment les individus et les groupes sont produits comme des sujets assujettis par de multiples formes de domination, ce qu'il appelle les " verdicts sociaux ", (...) et comment ils peuvent résister aux pouvoirs et travailler à la transformation sociale. Une telle démarche ne saurait se développer en se tenant simplement à l'écart de la doctrine psychanalytique. Elle doit entrer en conflit avec celle-ci, et mettre en question non seulement ses velléités normatives et ses tentations autoritaires, qui sont inscrites dans sa logique même, mais aussi son architecture notionnelle et sa conception du psychisme et de l'inconscient. C'est à cet effort pour " échapper à la psychanalyse " que sont consacrés les essais rassemblés dans ce volume. Didier Eribon est philosophe et sociologue. Il est l'auteur de nombreux ouvrages parmi lesquels Réflexions sur la question gay (Fayard, 1999, et Champs-Flammarion, 2012), Une morale du minoritaire (Fayard, 2001, et Champs-Flammarion, 2015), Retour à Reims (Fayard, 2009, et Champs-Flammarion, 2010), La Société comme verdict (Fayard, 2013, et Champs-Flammarion, 2014), Principes d'une pensée critique (Fayard, 2016, et Pluriel, 2019). (shrink)

Il y a quelques années, la mère de Didier Eribon est entrée en maison de retraite. Après plusieurs mois au cours desquels elle a peu à peu perdu son autonomie physique et cognitive, Didier Eribon et ses frères ont dû se résoudre à l'installer, malgré ses réticences, dans un établissement médicalisé. Mais le choc de l'entrée en maison de retraite fut trop brutal et, quelques semaines seulement après son arrivée, elle y est décédée. Après la mort de sa (...) mère, Didier Eribon reprend le travail d'exploration personnelle et théorique qu'il avait entrepris dans Retour à Reims après la mort de son père. Il analyse le déclin de sa mère, ce qui l'amène à réfléchir sur la vieillesse et la maladie, sur nos rapports aux personnes âgées et à la mort, mais aussi sur l'expérience du vieillissement. Il s'interroge également sur les conditions de l'accueil des personnes dépendantes. Il montre que si l'expérience du vieillissement nous est très difficile à penser, c'est parce qu'il s'agit d'une expérience-limite dans la philosophie occidentale, dont l'ensemble des concepts semblent se fonder sur une exclusion de la vieillesse. Eribon reparcourt également la vie de sa mère, et notamment les périodes où elle était femme de ménage, ouvrière puis retraitée, la saisissant dans toute sa complexité, de sa participation aux grèves à son racisme obsessionnel. Il conclut sa démarche en faisant de la vieillesse le point d'appui d'une réflexion sur la politique : comment pourraient se mobiliser des personnes qui n'ont plus de mobilité ni de capacité à prendre la parole et donc à dire "nous"? Les personnes âgées peuvent-elles parler si personne ne parle pour elles, pour faire entendre leur voix?"--Page 4 of cover. (shrink)

The paper first introduces a cube of opposition that associates the traditional square of opposition with the dual square obtained by Piaget’s reciprocation. It is then pointed out that Blanché’s extension of the square-of-opposition structure into an conceptual hexagonal structure always relies on an abstract tripartition. Considering quadripartitions leads to organize the 16 binary connectives into a regular tetrahedron. Lastly, the cube of opposition, once interpreted in modal terms, is shown to account for a recent generalization of formal concept analysis, (...) where noticeable hexagons are also laid bare. This generalization of formal concept analysis is motivated by a parallel with bipolar possibility theory. The latter, albeit graded, is indeed based on four graded set functions that can be organized in a similar structure. (shrink)

In political philosophy one often encounters claims on behalf of pluralism, yet there is anything but a consensus over the meaning of this fundamental concept. It is true that there is no single pluralist tradition; rather, there are different pluralist traditions within different domains of practical reason. No one would object, however, to the notion that Isaiah Berlin’s “value pluralism” is a genuine form of meta-ethical pluralism. Charles Taylor is another philosopher who is often called a pluralist, but I shall (...) argue that this is a mistake. One of the central goals of his philosophy is that of reconciling competing aims and ends and this is incompatible with pluralism. (shrink)

Although it is usually assumed that in Michel Foucault’s work biopolitics is a politics which has life for its object, a closer analysis of the courses he gave at the Collège de France on this topic, as well as of the other seminars and papers of this period, shows that he took a quite different direction, restricting it to the regulation of population. The aim of this article is to return to the origins of the concept and to confront the (...) issue of life as such. This implies four shifts with respect to Foucault’s theory: Politics is not only about the rules of the game of governing, but also about its stakes. More than the power over life, contemporary societies are characterized by the legitimacy they attach to life. Rather than a normalizing process, the intervention in lives is a production of inequalities. The politics of life, then, is not only a question of governmentality and technologies, but also of meaning and values. The discussion is grounded on a series of empirical investigations conducted in France and South Africa on how life and lives are treated in our world. (shrink)

The processing of emotional nonlinguistic information in speech is defined as emotional prosody. This auditory nonlinguistic information is essential in the decoding of social interactions and in our capacity to adapt and react adequately by taking into account contextual information. An integrated model is proposed at the functional and brain levels, encompassing 5 main systems that involve cortical and subcortical neural networks relevant for the processing of emotional prosody in its major dimensions, including perception and sound organization; related action tendencies; (...) and associated values that integrate complex social contexts and ambiguous situations. (shrink)

A critical view of the alleged significance of Belnap four-valued logic for reasoning under inconsistent and incomplete information is provided. The difficulty lies in the confusion between truth-values and information states, when reasoning about Boolean propositions. So our critique is along the lines of previous debates on the relevance of many-valued logics and especially of the extension of the Boolean truth-tables to more than two values as a tool for reasoning about uncertainty. The critique also questions the significance of partial (...) logic. (shrink)

Avant même d'être condamné pour "contestation de crime contre l'humanité" au tournant du siècle, Roger Garaudy était déjà marginalisé dans les champs intellectuel et politique français. Après avoir incarné la résistance au néostalinisme dans le Parti communiste, le philosophe qui fut longtemps l'interlocuteur privilégié de Jean-Paul Sartre au sein du PCF en fut spectaculairement exclu en 1970 pour s'être opposé aux Soviétiques qui venaient d'écraser le Printemps de Prague. Celui que l'historiographie du communisme retient plus volontiers comme le "stalinien modèle", (...) qu'il fut en effet dans l'après-guerre, était pourtant devenu, malgré sa proximité avec Thorez, un critique de plus en plus affirmé du stalinisme après les révélations du XXe Congrès du Parti communiste de l'Union soviétique (PCUS) en 1956 et un acteur majeur de l'aggiornamento du PCF. Son combat pour rénover le communisme français et son goût précoce pour l'écologie et le dialogue des civilisations en firent quelque temps une figure respectée du progressisme français, mais celui qui répétait que le Socialisme était condamné s'il refusait de s'ouvrir à la "transcendance" vit son étoile pâlir après 1970 au point qu'il devint un intellectuel illégitime, celui que l'on condamne sans l'avoir lu. Ce livre explique ce parcours singulier et les raisons de cette "descente aux enfers" de l'ancien philosophe du Bureau politique, avant sa condamnation ultime."--Page 4 of cover. (shrink)

"Classée au sein de la morale et considérée à la fin du Moyen Âge comme une simple pratique, un art de gouverner, la politique ne pouvait prétendre proprement au titre de science, réservé aux savoirs purement théoriques. À la charnière entre les XIIIe et XIVe siècles, certains penseurs vont néanmoins chercher à donner un nouveau sens à la science civile en utilisant, à l'instar de Dante, des raisonnements démonstratifs dans leurs traités. Ce n'est pourtant qu'avec le Defénsor pacis de Marsile (...) de Padoue (1324) que cette discipline à la fois théorique et pratique parvient à s'extraire du domaine de l'art. En produisant un véritable discours de la méthode inspiré par la médecine, le Padouan rend ainsi possible la naissance de la science politique."--Page 4 of cover. (shrink)

Nietzsche a été continuellement malade. Or, si la maladie n'est pas l'inspiratrice de l'œuvre de Nietzsche, elle est source continuelle de réflexions et enrichit les perspectives de Nietzsche sur la santé. Les oppositions affirmatif -réactif, grégaire - solitaire, noble-vulgaire se ramènent à cette opposition santé-maladie (c'est le vécu de la maladie qui a appris à Nietzsche à se faire un point de vue sur sa santé et vice-versa). La maladie est même devenue source du renversement des valeurs et d'affirmation de (...) sa grande santé. C'est pourquoi ces expériences de la maladie qui ponctuent toute la vie de Nietzsche ont une telle importance dans la genèse et l'approfondissement de sa pensée. (shrink)

This paper first investigates logical characterizations of different structures of opposition that extend the square of opposition in a way or in another. Blanché’s hexagon of opposition is based on three disjoint sets. There are at least two meaningful cubes of opposition, proposed respectively by two of the authors and by Moretti, and pioneered by philosophers such as J. N. Keynes, W. E. Johnson, for the former, and H. Reichenbach for the latter. These cubes exhibit four and six squares of (...) opposition respectively. We clarify the differences between these two cubes, and discuss their gradual extensions, as well as the one of the hexagon when vertices are no longer two-valued. The second part of the paper is dedicated to the use of these structures of opposition for discussing the comparison of two items. Comparing two items usually involves a set of relevant attributes whose values are compared, and may be expressed in terms of different modalities such as identity, similarity, difference, opposition, analogy. Recently, J.-Y. Béziau has proposed an “analogical hexagon” that organizes the relations linking these modalities. Elementary comparisons may be a matter of degree, attributes may not have the same importance. The paper studies in which ways the structure of the hexagon may be preserved in such gradual extensions. As another illustration of the graded hexagon, we start with the hexagon of equality and inequality due to R. Blanché and extend it with fuzzy equality and fuzzy inequality. Besides, the cube induced by a tetra-partition can account for the comparison of two items in terms of preference, reversed preference, indifference and non-comparability even if these notions are a matter of degree. The other cube, which organizes the relations between the different weighted qualitative aggregation modes, is more relevant for the attribute-based comparison of items in terms of similarity. (shrink)

The starting point of this work is the gap between two distinct traditions in information engineering: knowledge representation and data - driven modelling. The first tradition emphasizes logic as a tool for representing beliefs held by an agent. The second tradition claims that the main source of knowledge is made of observed data, and generally does not use logic as a modelling tool. However, the emergence of fuzzy logic has blurred the boundaries between these two traditions by putting forward fuzzy (...) rules as a Janus-faced tool that may represent knowledge, as well as approximate non-linear functions representing data. This paper lays bare logical foundations of data - driven reasoning whereby a set of formulas is understood as a set of observed facts rather than a set of beliefs. Several representation frameworks are considered from this point of view: classical logic, possibility theory, belief functions, epistemic logic, fuzzy rule-based systems. Mamdani's fuzzy rules are recovered as belonging to the data - driven view. In possibility theory a third set-function, different from possibility and necessity plays a key role in the data - driven view, and corresponds to a particular modality in epistemic logic. A bi-modal logic system is presented which handles both beliefs and observations, and for which a completeness theorem is given. Lastly, our results may shed new light in deontic logic and allow for a distinction between explicit and implicit permission that standard deontic modal logics do not often emphasize. (shrink)

From the resurrection of body to eternal recurrence -- The shadow of God -- The guiding thread -- The logic of the body -- The system of identical cases -- From eternal recurrence to the resurrection of body.

The biogenesis of RNAs and proteins is a threat to the cell. Indeed, the act of transcription and nascent RNAs challenge DNA stability. Both RNAs and nascent proteins can also initiate the formation of toxic aggregates because of their physicochemical properties. In reviewing the literature, I show that co-transcriptional and co-translational biophysical constraints can trigger DNA instability that in turn increases the likelihood that sequences that alleviate the constraints emerge over evolutionary time. These directed genetic variations rely on the biogenesis (...) of small RNAs that are transcribed directly from challenged DNA regions or processed from the transcripts that directly or indirectly generate constraints or aggregates. These small RNAs can then target the genomic regions from which they initially originate and increase the local mutation rate of the targeted loci. This mechanism is based on molecular pathways involved in anti-parasite genome defence systems, and implies that gene expression-related biophysical constraints represent a driving force of genome evolution. Are randomly generated mutations the only source of genetic variation during evolution? This paper describes the molecular mechanisms by which co-transcriptional and co-translational biophysical constraints trigger genetic variations in targeted-genomic sequences in an RNA-depending manner. This directed-mutational process that drives genome evolution is related to antiparasite genome defence systems. (shrink)

We have entered a new era of nature. What remains of the frontiers of modern thought that divided the living from the inert, subjectivity from objectivity, the apparent from the real, value from fact, and the human from the nonhuman? Can the great oppositions that presided over the modern invention of nature still claim any cogency? In _Nature as Event_, Didier Debaise shows how new narratives and cosmologies are necessary to rearticulate that which until now had been separated. Following (...) William James and Alfred North Whitehead, Debaise presents a pluralistic approach to nature. What would happen if we attributed subjectivity and potential to all beings, human and nonhuman? Why should we not consider aesthetics and affect as the fabric that binds all existence? And what if the senses of importance and value were no longer understood to be exclusively limited to the human? (shrink)

A phenomenological approach to questions of the body, ego, temporality and intersubjective relations with the 'other' by a leading French thinker and Husserl scholar.