The article attempts to define the change ; explores the reasons behind the resistance to change; to analyse the typology, the advantages and disadvantages of comprehensive and partial changes, and the methodologies of its enforcement. Moreover, it shows that the state bureaucracy almost in all societies enjoys a leading role in planning, supervision, coordination and even in the execution of developmental change processes. It tresspasses all existing institutions, groups and individuals in power, organization, legal and financial weapons, freedom of choices (...) and maneuverability.In searching for a convenient methodology of change in the developing societies; the article stresses that since these societies entirely differ in their material and human resources ; politica! stability ; standards ofhealth and education ; and above all in their mentality and emotional reactions, the determination of whichever change - immediate or incremental - to be followed, would certainly be out of question.However, incremental partial change may seem to be more practicable in the majority of these states. (shrink)

Annihilationism provides a fruitful point of contact between philosophers and theologians for further reflection on nonexistence. In this paper I articulate a key commitment of annihilationism; namely, that some persons cease to exist. Such a commitment, I argue, amounts to the claim that some persons exist at time t and then do not exist at t+1, become ‘annihilated objects.’ Claims about annihilated objects induct the annihilationist into a wider realism/anti-realism debate about nonexistent objects. I survey some major viewpoints in this (...) debate. I then draw out some implications for each view for the annihilationist’s commitment to annihilated objects. I show that annihilationism is consistent with some forms of realism and anti-realism and inconsistent with others. (shrink)

DNA replication is both highly conserved and controlled. Problematic DNA replication can lead to genomic instability and therefore carcinogenesis. Numerous mechanisms work together to achieve this tight control and increasing evidence suggests that post‐translational modifications (phosphorylation, ubiquitination, SUMOylation) of DNA replication proteins play a pivotal role in this process. Here we discuss such modifications in the light of a recent article that describes a novel role for the deubiquitinase (DUB) USP7/HAUSP in the control of DNA replication. USP7 achieves this function (...) by an unusual and novel mechanism, namely deubiquitination of SUMOylated proteins at the replication fork, making USP7 also a SUMO DUB (SDUB). This work extends previous observations of increased levels of SUMO and low levels of ubiquitin at the on‐going replication fork. Here, we discuss this novel study, its contribution to the DNA replication and genomic stability field and what questions arise from this work. (shrink)