Neurodegenerative Parkinson's Disease is one of the common incurable diseases among the elderly. Clinical assessments are characterized as standardized means for PD diagnosis. However, relying on medical evaluation of a patient's status can be subjective to physicians' experience, making the assessment process susceptible to human errors. The use of ICT-based tools for capturing the status of patients with PD can provide more objective and quantitative metrics. In this vein, the Personalized Serious Game Suite and intelligent Motor Assessment Tests, produced within (...) the i-PROGNOSIS European project, are explored in the current study. More specifically, data from 27 patients with PD at Stage 1 and Stage 3 produced from their interaction with PGS/iMAT are analyzed. Five feature vector scenarios are set, including features from PGS or iMAT scores or their combination, after also taking into consideration the age of patients with PD. These FVs are fed into three machine learning classifiers, i.e., K-Nearest Neighbor, Support Vector Machines, and Random Forest, to infer the stage of each patient with PD. A Leave-One-Out Cross-Validation method is adopted for testing the classification performance. The experimental results show that a high classification accuracy is achieved from both data sources, justifying the effectiveness of PGS/iMAT to efficiently reflect the motor skill status of patients with PD and further potentiating PGS/iMAT enhancement with a machine learning a part to infer for the stage of patients with PD. Clearly, this integrated approach provides new opportunities for remote monitoring of the stage of patients with PD, contributing to a more efficient organization and set up of personalized interventions. (shrink)

Michael J. Zimmerman explores whether and how our ignorance about ourselves and our circumstances affects what our moral obligations and moral rights are. He rejects objective and subjective views of the nature of moral obligation, and presents a new case for a 'prospective' view.

On its first appearance in 1960, J.O. Urmson's Concise encyclopedia of Western philosophy and philosophers established itself as a classic. Its contributors included many of the leading philosophers of the English-speaking world: Ryle, Hare, Strawson, Ayer, Dummett, Williams and many others. They wrote with an authority and individuality which made the Encyclopedia into a lively and engaging introduction to philosophy as well as a convenient reference work. For this edition, supervised by Jonathan Rée, the original articles have been revised and (...) updated, and eighty articles by thirty one new authors have been added. The additions take account of recent developments in philosophy, of literary, historical and political issues in philosophy, and of developments in continental thought, including in Marxism, psychoanalysis, phenomenology, existentialism, structuralism, post-structuralism and deconstruction. There is a clear, integral cross-referencing system which allows the reader to identify points of overlap between philosophical traditions and their personalities at a glance. (shrink)

Enrique Dussel telah lama dikenal secara luas sebagai seorang filsuf dari Amerika Latin, yang memperkenalkan “filsafat pembebasan”. Buku Ethics of Liberation ini merupakan elaborasi gagasan sentralnya “pembebasan”. Dussel saat ini menjadi profesor filsafat di Universidad Autónoma Metropolitana, Iztapalapa dan di Universidad Nacional Autóma de México di Mexico City. Dalam karya ini ia mencoba mengatasi berbagai sistem etika yang berlatar belakang filsafat kontinental, yang ia sebut sebagai filsafat yang berbasis filsafat Yunani atau disebut juga “hellenosentrisme” atau “eropasentrisme. Filsafat dan sistem etika (...) ini tidak memadai lagi untuk mendorong pembebasan korban peminggiran oleh globalisasi dan kapitalisme neo-liberal. Dussel mengawali bukunya sepanjang 715 halaman ini dengan menyajikan uraian mengenai sistem etika dalam sejarah dunia, yang dipandang sebagai filsafat yang datang dari pinggiran, periferi. Dari sinilah Dussel mengembangkan etika dari perspektif korban yang tereksklusi. Pada Bagian I Dussel membahas “Fondasi Etika” (h. 53-186) yang terdiri dari tiga komponen. Pertama, etika material atau isi dari etika, yaitu reproduksi dan pengembangan kehidupan secara sadar. Dussel memulai uraiannya dengan pandangan antropologisnya, dimana digambarkan tingkat-tingkat kesatuan hidup manusia. Ia mengaitkan padangannya mengenai manusia dengan “neuroscience. Kemudian dibahas beberapa aliran dalam etikla material;, seperti utilitarianisme dan komunitarianisme (A. MacEntyre, Charles Tay;or, M. Walzer), konsep eudaimonis dari Aristoteles, Sittlichkeit dari Hegel, etika matrial dari Max Scheler, gagasan Xavier Zubiri.. Dari uraian yang sifatnya deskriptif itu, Dussel beranjak kepada perumusan universal, yang merupakan komponen kedua. Yang memberi pembenaran atas norma yang telah dirumuskan. Rumusan universal itu dicapai melalui suatu diskursus dari partisipan yang setara, dalam suatu komunitas komunikasi. Itulah syarat tercapainya kesahihan antarsubjektif. Yang dibahas Dussel adalah sistem etika Kant. John Rawls, Karel Otto-Apel dan J. Habermas. Tahap ketiga dibahas komponen kelayakan berhadapan dengan berbagai kendala.............. Buku Ethics of Liberation memuat uraian yang sangat kaya akan berbagai sistem etika, terutama sistem etika yang diajukan oleh berbagai filsuf kontemporer. Sistem itu tidak ditolak, tetapi harus dilengkap dengan sistem etika-kritis, yeng mendorong mereka yang menjadi korban untuk membebaskan diri. Untuk memperdalam analisisnya Dussel banyak mengacu kepada Marx, Sekolah Frankurt, Nietzsche dan Freud. Pandangan Freire mengenai dialog dan “raising consciousness” melengkap apa yang disebut “konsensus” dalam sistem etrika Habermasian. Dialog menjadi penting untuk membangun komunikasi dalam masyarakat yang asimetris. Ini diperkaya dengan pengalaman tumbuhnya kesadaran sebagaimana diuraikan oleh Rigoberto Menchú Sistem etika Emmanuel Levinas memberikan perspektif baru mengenai keharusan “pengakuan” (recognition) dan tanggung jawab terhadap yang lain. Buku Dussel ini akan memperkaya pandangan para dosen etika, yang pada umumnya terpaku pada sistem etika “Eropasentris.” (M. Sastrapratedja, Program Pascasarjana, Sekolah Tinggi Filsafat Driyarkara, Jakarta). (shrink)

In this work I attempt to articulate a principle or set of principles that can guide violent revolution, or emancipatory violence, and yet still prevent the end-stage backlash that generally follows; e.g., the Terror's culmination in which the originators are the targets of the Terror.

Discussion of J. Kevin O’Regan’s “Why Red Doesn’t Sound Like a Bell: Understanding the Feel of Consciousness” Content Type Journal Article Pages 1-20 DOI 10.1007/s13164-012-0090-7 Authors J. Kevin O’Regan, Laboratoire Psychologie de la Perception, CNRS - Université Paris Descartes, Centre Biomédical des Saints Pères, 45 rue des Sts Pères, 75270 Paris cedex 06, France Ned Block, Departments of Philosophy, Psychology and Center for Neural Science, New York University, 5 Washington Place, New York, NY 10003, USA Journal Review of Philosophy and (...) Psychology Online ISSN 1878-5166 Print ISSN 1878-5158. (shrink)

This essay is written on the following premises and argues for them. “Enlightenment” is a word or signifier, and not a single or unifiable phenomenon which it consistently signifies. There is no single or unifiable phenomenon describable as “the Enlightenment,” but it is the definite article rather than the noun which is to be avoided. In studying the intellectual history of the late seventeenth century and the eighteenth, we encounter a variety of statements made, and assumptions proposed, to which the (...) term “Enlightenment” may usefully be applied, but the meanings of the term shift as we apply it. The things are connected, but not continuous; they cannot be reduced to a single narrative; and we find ourselves using the word “Enlightenment” in a family of ways and talking about a family of phenomena, resembling and related to one another in a variety of ways that permit of various generalizations about them. We are not, however, committed to a single root meaning of the word “Enlightenment,” and we do not need to reduce the phenomena of which we treat to a single process or entity to be termed “the” Enlightenment. It is a reification that we wish to avoid, but the structure of our language is such that this is difficult, and we will find ourselves talking of “the French” or “the Scottish,” “the Newtonian” or the “the Arminian” Enlightenments, and hoping that by employing qualifying adjectives we may constantly remind ourselves that the keyword “Enlightenment” is ours to use and should not master us. (shrink)

Much has been published about the ethical issues encountered by clinicians in genetics/genomics, but those experienced by clinical laboratory scientists are less well described. Clinical laboratory scientists now frequently face navigating ethical problems in their work, but how they should be best supported to do this is underexplored. This lack of attention is also reflected in the ethics tools available to clinical laboratory scientists such as guidance and deliberative ethics forums, developed primarily to manage issues arising within the clinic.We explore (...) what ethical issues are being experienced by clinical scientists, how they think such issues could be best analysed and managed, and whether their practice might be enhanced by more situated approaches to ethics deliberation and practice such as ethical preparedness. From thematic analysis of cases presented by clinical scientists at a specially convened meeting of the UK Genethics Forum, we derived three main ethical themes: (1) the redistribution of labour and responsibilities resulting from the practice of genomic medicine; (2) the interpretation and certainty of results and (3) the proposal that better standardisation and consistency of ethical approaches (for example, more guidelines and policy) could resolve some of the challenges arising.We argue that although standardisation is important for promoting shared understandings of good (including ethical) practice, supplementary approaches to enhance and sustain ethical preparedness will be important to help clinical scientists and others in the recently expanded genetic/genomic medicine environment foster quality ethical thinking. (shrink)

This book is available either individually, or as part of the specially-priced Arguments of the Philosphers Collection.

Jian Zhou,* Weiqiang Ju,* Xiaopeng Yuan, Xiaofeng Zhu, Dongping Wang, Xiaoshun HeOrgan Transplant Center, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China *These authors contributed equally to this work: Hyperosmolar nonketotic hyperglycemic coma is a serious, rare complication induced by methylprednisolone pulse therapy for acute rejection after orthotopic liver transplantation. Herein, we report an unusual case of a 58-year-old woman who experienced acute rejection at 30 months after OLT, only one case in which HNKHC resulted in MP (...) pulse therapy for acute rejection in all 913 recipients in our center. The general morbidity of HNKHC was 1.09‰ in this study. HNKHC is characterized by rapid onset, rapid progression, and a lack of specific clinical manifestations. High-dose MP management was a clear risk factor. The principle of treatment included rapid rehydration, low-dose insulin infusion, and correcting disorders of electrolytes and acidosis. In conclusion, clinicians considering MP pulse therapy after OLT should be alert to the occurrence of HNKHC. Keywords: liver transplantation, complications, hyperosmolar nonketotic hyperglycemic coma, methylprednisolone pulse therapy, principle of treatment. (shrink)