The human genome is not a uniform structure but, instead, is a mosaic of bands. Some of these bands can be seen by the eye. Stained with Giemsa and viewed under the microscope each human chromosome has a prototypical pattern of light and dark bands (G and R bands respectively). Other bands are not so easily viewed. The human genome is, for example, a mosaic of isochores, blocks of DNA within which the proportion of the bases G and C at (...) silent sites (introns, third positions in codons, intergene spacer) is fairly uniform. Recent work by Matassi and colleagues(1) has revealed what might be a new and unexpected banding pattern. They have found that the genes which are close together on the chromosome have similar rates of evolution. BioEssays 22:105–107, 2000. ©2000 John Wiley & Sons, Inc. (shrink)

A longstanding paradox was first reported by David Miller in 1975 and highlighted by Karl Popper in 1979. Miller showed that the ranking of predictions from two theories, in terms of closeness to observation, appears to be reversed when the problem is transformed into a different mathematical space. He concluded that “… no false theory can … be closer to the truth than is another theory”. This flies in the face of normal scientific practice and is thus paradoxical; it is (...) named here the “Miller-Popper paradox”. This paper proposes a resolution of the paradox, through consideration of the inevitable errors and uncertainties in both observations and predictions. It is proved that, for linear transformations and Gaussian error distributions, the transformation between spaces creates no change in quantitative measures of “closeness-to-observation” when these measures are based in probability theory. The extension of this result to nonlinear transformations and to non-Gaussian error distributions is also discussed. These results demonstrate that concepts used in comparison of predictions with observations—concepts of “closeness”, “consistency”, “agreement”, “falsification”, etc.—all imply some knowledge of the uncertainty characteristics of both predictions and observations. (shrink)

As a parent, you know how much less stressful your life would be if you could count on your children to be more responsible -for their toys, their homework, their household chores, and their choice of friends. You know you want your children to grow up to be responsible adults. In Teaching Your Children Responsibility , bestselling authors Linda and Richard Eyre show you how to make sure your elementary-school-aged children learn this invaluable lesson. The Eyres identify twelve simple (...) kinds of responsibility-from responsibility for things to responsibility for actions, from responsibility for choices to responsibility for younger siblings-that children can relate to. They provide a simple, practical program-with enjoyable exercises, games, and activities-that you can use to teach your children these important concepts. Written by parents for parents, Teaching Your Children Responsibility will help you give your children the tools they need to thrive in today's challenging world-and help them grow up to be happy, fulfilled adults. (shrink)

The author of handbooks that reflected the Victorian emphasis on bettering one's prospects, Charles Eyre Pascoe addressed the topic of female education in this work of 1879, at a time when the Cambridge colleges of Girton and Newnham were in their infancy. 'Chiefly designed for the use of persons of the upper middle class', the guide aims to assist parents in making informed choices about their daughters' education. The coverage extends from kindergarten through to university, before focusing on career (...) options for women in the late nineteenth century, in fields such as teaching, the arts and medicine. Throughout, Pascoe's recommendations are based on consideration of the breadth of the curriculum, the qualifications of the teaching staff and the results achieved in examinations. For higher education, details of entrance examinations are provided, together with information on the subjects and lectures that were open to women at that time. (shrink)

This article describes "Project Breakthrough: A Survey of Corporate Practices for Shattering the Glass Ceiling." Evidence is presented that the "glass ceiling" remains intact in many areas. A list of barriers (social sterotypes) that support the glass ceiling are presented. Some corporate strategies found in the literature are also presented. Sixty-nine companies in the Houston area were surveyed. A summary score based on responses to thirty-four practices listed in the survey were computed. The top twelve organizations were identified as "distinguished," (...) and site visits were conducted. The practices of these companies are listed. (shrink)

For decades a debate has played out in the literature about who bioethicists are, what they do, whether they can be considered professionals qua bioethicists, and, if so, what professional responsibilities they are called to uphold. Health care ethics consultants are bioethicists who work in health care settings. They have been seeking guidance documents that speak to their special relationships/duties toward those they serve. By approving a Code of Ethics and Professional Responsibilities for Health Care Ethics Consultants, the American Society (...) for Bioethics and Humanities (ASBH) has moved the professionalization debate forward in a significant way. This first code of ethics focuses on individuals who provide health care ethics consultation (HCEC) in clinical settings. The evolution of the code's development, implications for the field of HCEC and bioethics, and considerations for future directions are presented here. (shrink)