Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that (...) has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility. (shrink)

Judith Jarvis Thomson, The Realm Of Rights Harvard University Press, 1990, viii, 383pp.

In his early work, the philosopher Stanley Cavell offers a sustained engagement with the threat of epistemological scepticism, shaped by the intuition that although (as the late Wittgenstein shows) ordinary language use is the practice within which alone meaning is possible (and which can thus not be further analysed or rationalised), it is also a basic human inclination to wish to escape the limitations of the ‘ordinary’. This, for Cavell, is the root of scepticism. Scepticism, on this view, thus appears (...) not primarily as an epistemological but as an (injurious) moral stance, which cannot be refuted but must be continually confronted and overcome. Vis-à-vis scepticism, ‘acknowledgement’ is the practice-based recognition of the world and other people in their continuing elusiveness, which ineluctably involves risk, but just so is the only way of knowing that is appropriate to and honours the (finite) human condition. One problematic aspect of this (very fertile) approach is that Cavell’s secular viewpoint makes it difficult for him to say both why the desire for a ‘beyond’ arises in the first place, and why its expression as denial is morally wrong (rather than merely misguided). His approach thus invites a theological ‘supplementation’ which grounds the human condition in an original and real relation to God that is meant to draw the believer, through Christ, into the divine life itself. Such a reinterpretation both elucidates the concepts of scepticism and acknowledgement, and makes these concepts available for a theological outlook that is able to accommodate Cavell’s profound insights into ‘the human’. (shrink)

The impetus to revisit the issues involved in readings of Genesis 2-3 came from Deborah Rooke’s article in Feminist Theology published in 2007, and in particular follows a presentation at an ‘Afternoon of Theology’ at a girls’ secondary school, where the author provided a response to the challenge set by the history of interpretation and the subsequent cultural assumptions of the meaning of the Garden of Eden narrative. The discussion proceeds partly through narrative retelling, partly through a critical commentary and (...) partly through an Eve/snake dialogue. (shrink)

Production and comprehension have long been viewed as inseparable components of language. The study of vision, by contrast, has centered almost exclusively on comprehension. Here we investigate drawing—the most basic form of visual production. How do we convey concepts in visual form, and how does refining this skill, in turn, affect recognition? We developed an online platform for collecting large amounts of drawing and recognition data, and applied a deep convolutional neural network model of visual cortex trained only on natural (...) images to explore the hypothesis that drawing recruits the same abstract feature representations that support natural visual object recognition. Consistent with this hypothesis, higher layers of this model captured the abstract features of both drawings and natural images most important for recognition, and people learning to produce more recognizable drawings of objects exhibited enhanced recognition of those objects. These findings could explain why drawing is so effective for communicating visual concepts, they suggest novel approaches for evaluating and refining conceptual knowledge, and they highlight the potential of deep networks for understanding human learning. (shrink)

Choisir un livre, c'est en exclure beaucoup d'autres, contribuer à circonscrire le cercle lumineux de l'attention, participer à une aventure dont l'enjeu est la survie; vivre dans les lettres, ce n'est pas s'installer dans un patrimoine mais l'inventer, faire du soleil et de la place, inséparablement. Rééditer ce livre dans une édition de poche, ce n'est pas seulement faire en sorte qu'il soit de nouveau disponible; c'est en prolonger le rayonnement mais aussi le déplacer, l'inscrire autrement dans l'aventure de la (...) survie. Dans sa première vie, La Mémoire des œuvres s'est imposé à quelques-uns comme un bréviaire. Écrit pour tous et pour chacun, il demande et appelle l'amitié d'un plus large public, c'est un livre ami de la mémoire, qui aide à penser et qui aide à vivre, à habiter plus librement le séjour des livres. (shrink)

Proposer une oeuvre nouvelle, developper une idee neuve ou une vision personnelle differente, c'est dire autre chose. Mais c'est aussi dire quelque chose qui n'est pas radicalement inoui et sans connexion. Impacts, emprunts, initiatives, traditions ou ruptures: ces relations d'influence traversent la vie des idees et des oeuvres, leurs rapports entre elles, leurs caracteres de famille, et ce qui les rend chacune distincte. Invention et memoire vont ensemble. Leur liaison et leur ecart organisent ce qu'il y a d'autonome et d'unique (...) dans un point de vue novateur, et ce qu'il y a de commun et de partage. (shrink)

In this article I argue that evolutionary psychological strategies for making inferences about present-day human psychology are methodologically unsound. Evolutionary psychology is committed to the view that the mind has an architecture that has been conserved since the Pleistocene, and that our psychology can be fruitfully understood in terms of the original, fitness-enhancing functions of these conserved psychological mechanisms. But for evolutionary psychological explanations to succeed, practitioners must be able to show that contemporary cognitive mechanisms correspond to those that were (...) selected for in the environment of evolutionary adaptedness, that these present-day cognitive mechanisms are descended from the corresponding ancestral mechanisms, and that they have retained the functions of the ancestral mechanisms from which they are descended. I refer to the problem of demonstrating that these conditions obtain as “the matching problem,” argue that evolutionary psychology does not have the resources to address it, and conclude that evolutionary psychology, as it is currently understood, is therefore impossible. (shrink)

This paper addresses the question of what organisms are and therefore what kinds of biological entities qualify as organisms. For some time now, the concept of organismality has been eclipsed by the notion of individuality. Biological individuals are those systems that are units of selection. I develop a conception of organismality that does not rely on evolutionary considerations, but instead draws on development and ecology. On this account, organismality and individuality can come apart. Organisms, in my view, are as Godfrey- (...) class='Hi'>Smith puts it “essentially persisters.” I argue that persistence is underpinned by differentiation, integration, development, and the constitutive embeddedness of organisms in their worlds. I examine two marginal cases, the Portuguese Man O’ War and the honey bee colony, and show that both count as organisms in light of my analysis. Next, I examine the case of holobionts, hosts plus their microsymbionts, and argue that they can be counted as organisms even though they may not be biological individuals. Finally, I consider the question of whether other, less tightly integrated biological systems might also be treated as organisms. (shrink)

Toute oeuvre veut tenir l'attention, la diriger et produire de l'effet. Mais l'attention et l'effet ne sont pas les memes selon que l'oeuvre en dit plus ou en dit moins c'est-a-dire selon sa densite. Le developpe ou le concis, l'emphatique ou l'elude, le riche ou l'austere ne produisent pas les memes intensites. En explorant les variations de la densite litteraire, on retrouve directement des enjeux essentiels. Que vise l'ideal du complet face a l'ideal du pur? Comment la litterature se rapporte-t-elle (...) au langage ordinaire? Quel peut etre le minimum artistique qui subsiste au bord du silence? Comment comprendre l'echec de la lecture, l'interet perdu et l'ennui? (shrink)

Although Paton depends for his materials on virtually all of Kant's writings on moral philosophy, he makes the Grundlegung zur Metaphysik der Sitten central to his analysis. This is a wise choice and one that is defensible since Paton has set for himself the task of elucidating the categorical imperative and it is in the Grundlegung that Kant sought to grasp the supreme principle of morality and its appearance to us as a categorical imperative. Despite the fact that, as the (...) author points out on many occasions, the Grundlegung neither stresses morality from the standpoint of action, nor does it deal in detail with many significant problems, it must nevertheless always be looked upon as central to Kant's ethics just because it does deal with the supreme principle as a categorical imperative. The seemingly more authoritative Critique of Practical Reason is more definitely concerned with the larger subject of reason in its practical employment and does not deal as directly with Paton's special concern as the Grundlegung does. (shrink)