Beyond protein synthesis and autophagy, emerging evidence has implicated mTORC1 in regulating protein folding and proteasomal degradation as well, highlighting its prominent role in cellular proteome homeostasis or proteostasis. In addition to growth signals, mTORC1 senses and responds to a wide array of stresses, including energetic/metabolic stress, genotoxic stress, oxidative stress, osmotic stress, ER stress, proteotoxic stress, and psychological stress. Whereas growth signals unanimously stimulate mTORC1, stresses exert complex impacts on mTORC1, most of which are repressive. mTORC1 suppression, as a (...) generic adaptive strategy, empowers cell survival under various stressful conditions. In this essay, we provide an overview of the emerging role of mTORC1 in proteostasis, the distinct molecular mechanisms through which mTORC1 reacts to diverse stresses, and the schemes exploited by cancer cells to circumvent stress‐induced mTORC1 suppression. Hence, acting as a stress sensor, mTORC1 intimately couples stresses to cellular proteostasis. (shrink)

Although similar environmental issues are present across the globe, residents of different countries vary in the extent to which they are concerned about and act upon these issues. Drawing on data from the 2010 Environment module of the International Social Survey Programme, this study tests the structural comparability of environmental attitudes across 32 countries and examines how pro-environmental behaviours are linked to relevant attitudes. A confirmatory factor analysis from structural equation modelling helps identify three latent constructs of environmental attitudes: willingness (...) to sacrifice, biospheric orientation and environmental scepticism. Further regression analyses reveal that the linkages between pro-environmental behaviours and the constructs of environmental attitudes converge in some countries but are less consistent in others. The findings help pinpoint signs of global convergence and national disparities, which merit more extensive analyses amid the recent surge in the availability of diverse empirical data from around the world. (shrink)

This article investigates the factors affecting how public relations autonomy, legal dominance, and strategic orientation affect crisis communicative response in corporate contexts. Communication managers, crisis managers, public affairs managers, and/or public relations managers were solicited from Taiwan’s top 500 companies to participate in a survey. The results revealed that, in contrast to public relations autonomy being the strongest and sole predictor of concession strategy, legal dominance could predict defensive and diversionary responses in crisis events. The article concludes with a discussion (...) of practical applications and theoretical implications. (shrink)

Background: Healthcare workers in the front line of diagnosis, treatment, and care of patients with coronavirus disease 2019 are at great risk of both infection and developing mental health symptoms. This study aimed to investigate the following: whether healthcare workers in general hospitals experience higher mental distress than those in psychiatric hospitals; the role played by religion and alexithymic trait in influencing the mental health condition and perceived level of happiness of healthcare workers amidst the stress of the COVID-19 pandemic; (...) and factors that influence the resilience of healthcare workers at 6 weeks' follow-up.Methods: Four-hundred and fifty-eight healthcare workers were recruited from general and psychiatric hospitals, and 419 were followed-up after 6 weeks. All participants filled out the 20-item Toronto Alexithymia Scale, five-item Brief-Symptom Rating Scale, and the Chinese Oxford Happiness Questionnaire.Results: Under the stress of the COVID-19 pandemic, 12.3% of frontline healthcare workers in general hospitals reported having mental distress and perceived lower social adaptation status compared with those working in psychiatric hospitals. Christians/Catholics perceived better psychological well-being, and Buddhists/Taoists were less likely to experience mental distress. The results at 6 weeks of follow-up showed that the perceived lower social adaptation status of general hospital healthcare workers was temporary and improved with time. Christian/Catholic religion and time had independent positive effects on psychological well-being; however, the interaction of Christian/Catholic religion and time had a negative effect.Conclusions: Collectivism and individualism in the cultural context are discussed with regard to alexithymic trait and Buddhist/Taoist and Christian/Catholic religious faiths. Early identification of mental distress and interventions should be implemented to ensure a healthy and robust clinical workforce for the treatment and control of the COVID-19 pandemic. (shrink)

Given that work teams have been widely used in a variety of organizations to complete critical tasks and that the use of social media in work teams has been growing, investigating whether and how team social media usage affects team creativity is imperative. However, little research has empirically explored how TSMU affects team creativity. This study divides TSMU into two categories, namely, work-related TSMU and relationship-related TSMU. Basing on communication visibility theory and social exchange theory, this study constructs a moderating (...) mediation model to understand how TSMU affects team creativity. In this model, team knowledge sharing is used as mediating role and team-member exchange is used as moderating role. Two-wave research data collected from 641 employees in 102 work teams in Chinese organizations are used for regression analysis. Results show that Work-related TSMU and relationship-related TSMU are positively affect team creativity. Team knowledge sharing plays a partly mediating effect on the relationship between work-related TSMU and team creativity and that between relationship-related TSMU and team creativity. TMX not only positively moderates the indirect effect of work-related TSMU and relationship-related TSMU on team creativity through team knowledge sharing. Theoretical and practical implications are also discussed. (shrink)

Evidence supports predictive roles of non-social smartphone use for smartphone addiction, but the relationship of social smartphone use and smartphone addiction is unclear. This study explored whether social smartphone use has a double-edged impact on smartphone addiction. Using data from a sample of 909 Chinese undergraduates, we tested a parallel mediation model that considered online social support and realistic social support as mediators. As predicted, social smartphone use weakened smartphone addiction through realistic social support and contributed to smartphone addiction through (...) online social support. Moreover, we tested the moderating role of agreeableness in the mediation path of online social support. Agreeableness only moderated the indirect effects. Specifically, the predictive effects of online social support on smartphone addiction was greater for lower rather than higher agreeableness. The results suggest that social needs play an important role in the formation of smartphone addiction. Several limitations and implications are also discussed herein. (shrink)

This study applies identity and social identity theories to develop and test a framework in which retail brand personality influences consumer outcomes [i.e., positive word-of-mouth about and patronage intention toward the retailer] through public and/or private self-congruity, strengthened by shopping conspicuousness situation, and retail brand identification. This is the first study to include social shopping situations to study brand personality and self-congruity. A questionnaire with a 2 × 2 between-subjects design was conducted on a sample of US consumers. Structural equation (...) modeling was used to test the hypotheses. The findings suggest a framework in which Genuine, the most influential dimension of retail brand personality, predicted outcome behaviors both directly and indirectly through self-congruities and RBI. The high shopping conspicuousness situation strengthened the relationship between public self-congruity and the overall RBI. The concept of RBI provides an additional theoretical perspective for guiding future research on shopper–brand relationships. In addition, this framework provides practical implications for retail environment design and customer-brand relationship management. (shrink)

Previous research has indicated that parenting factors affect the risk of maladaptive psychological outcomes, and that positive parenting is a prospective risk factor for maladaptive psychological outcomes. However, the mechanisms underlying the relationships between positive parenting, mindfulness, and maladaptive psychological outcomes remain unknown, as do the processes that mediate the effect of positive parenting on maladaptive psychological outcomes in adolescents. The objective of the present study was to investigate the longitudinal relationship between positive parenting, mindfulness, and maladaptive psychological outcomes in (...) middle school students, as well as the mediating effect of mindfulness in the relationships between positive parenting and depression, aggression, and suicidal ideation. In this study, 386 middle school children were tested three times over a period of 6 months. Positive parenting was assessed at Time 1, mindfulness at Time 2, and depression, aggression, and suicidal ideation at Time 3. Using structural equation modeling, positive parenting was revealed to be longitudinally associated with mindfulness and negatively associated with maladaptive psychological outcomes. More crucially, mindfulness mediated the relationship between positive parenting and maladaptive psychological outcomes. This research provides important insights into how to effectively decrease adolescent maladaptive psychological outcomes and highlights the importance of teaching mindfulness to youths. (shrink)

It is commonly agreed that logic studies the form of arguments and that the concept of a consequence relation is based on the idea of truth-preservation in all models. Based on some observations about arguments involving conditionals, Brogaard and Salerno argue that the consequence relation should be defined in terms of truth-preservation within one fixed context. I will argue that Ichikawa’s contextualism for counterfactuals can be treated as an elucidation of what they have in mind. Instead of standing for or (...) against Stalnaker’s or Lewis’s semantics of counterfactuals, I will argue that the key to explaining the phenomena in question is the concept of a consequence relation. To support the point above, logical contextualism or relativism will be introduced and defended. I thus suggest that the concept of a consequence relation is sensitive to the context in which a certain argument is asserted. (shrink)

It is commonly agreed that logic studies the form of arguments and that the concept of a consequence relation is based on the idea of truth-preservation in all models. Based on some observations about arguments involving conditionals, Brogaard and Salerno argue that the consequence relation should be defined in terms of truth-preservation within one fixed context. I will argue that Ichikawa’s contextualism for counterfactuals can be treated as an elucidation of what they have in mind. Instead of standing for or (...) against Stalnaker’s or Lewis’s semantics of counterfactuals, I will argue that the key to explaining the phenomena in question is the concept of a consequence relation. To support the point above, logical contextualism or relativism will be introduced and defended. I thus suggest that the concept of a consequence relation is sensitive to the context in which a certain argument is asserted. (shrink)

Sleep quality, personality, and cognitive load potentially increase second language writing anxiety and subsequently affect SLW achievement. This study investigates the predictions of sleep quality, personality, and cognitive load toward SLW anxiety and achievement in a computer-based test. Participants included 172 voluntary undergraduates majoring in English as foreign language. SLW anxiety in a computer-based test, sleep disturbance, personality and cognitive load was assessed with the SLW Anxiety Inventory, Pittsburg Sleep Quality Index, Type-D Personality, and cognitive load questionnaires. A structural equation (...) modeling approach was applied to examine the interdependence among the observed variables. An adequate-fit SLW anxiety model was built. The structural model showed that sleep disturbance, social inhibition personality, and computer-induced cognitive load were significant predictors of SLW anxiety in a computer-based test. Subsequently, SLW anxiety in a computer-based test and computer-induced cognitive load were significant negative predictors of computer-based SLW achievement. (shrink)

In light of the dramatic growth of Chinese learners worldwide and a need for cross-linguistic research on Chinese literacy development, this study drew upon theories of visual complexity effect (Su & Samuels, 2010) and dual-coding processing (Sadoski & Paivio, 2013) and investigated a) the effects of character properties (i.e., visual complexity and radical presence) on character acquisition and b) the relationship between individual learner differences in radical awareness and character acquisition. Participants included adolescent English-speaking beginning learners of Chinese in the (...) U.S. Following Kuo et al. (2014), a novel character acquisition task was used to investigate the process of acquiring the meaning of new characters. Results showed that a) characters with radicals and with less visual complexity were easier to acquire than characters without radicals and with greater visual complexity; and b) individual differences in radical awareness were associated with the acquisition of all types of characters, but the association was more pronounced with the acquisition of characters with radicals. Theoretical and practical implications of the findings were discussed. (shrink)

Resumen: En la era del cientificismo, no es sorprendente revivir la visión realista de Lukács de la literatura. Aunque algunos estudiosos han criticado su visión holística, a juzgar por la preocupación por la realidad de la vida humana y la crítica de la realidad social, su visión realista de la literatura es exactamente lo que los tiempos necesitan. En el contexto del postmodernismo, cuando se critica su visión universal e ideológica del pueblo, se ignora la utilidad de esta visión universal (...) para lograr los efectos realistas de la crítica literaria basada en la visión universal irracional. Su "realismo" no es lo mismo que la "imitación" del realismo clásico, ni la "reproducción" del realismo crítico. La creación artística, incluida la literatura, no es solo una simple adhesión a la realidad social, sino un reflejo de la realidad social histórica general a través de prototipos. (shrink)

我們已有的知識，雖然作為學科各有領域，但並不是孤立地存在，而是互為聯繫、互為影響。這些知識的積累，會逐漸地擴大認知領域，由此及彼、由近到遠，由小到大，由現象而至規律，由規律而至本質，直至去認識終極事物 ——宇宙——世界的本質。.

Ben shu dui Luling Wang xue de yan jiu, zhu yao cong yi xia liang fang mian zhan kai: shou xian, zhong dian jie shao le ti chu Luling Wang xue de li lun yi ju he Luling Wang xue fa zhan de ge ge jie duan de jie ding, te dian ji qi zhu yao de dai biao ren wu. Qi ci, ju ti lun shu le Luling Wang xue fa zhan de ge ge jie duan de zui zhu (...) yao dai biao ren wu de zhi xue li lu, xin xue si xiang, jing xue te dian. Tong guo dui Luling Wang xue zong ti shang de yan jiu, gai kuo he zheng li yi ji dui ge ge fa zhan jie duan zhu yao de dai biao ren wu Wang xue si xiang de bu tong shi jiao de tan tao chan fa, cong zong ti shang rang shi ren jiao wei xi tong de liao jie Luling Wang xue de gai mao ji qi cao chuang, fa zhan, ding sheng ji shi wei de li shi guo cheng he zhong yao dai biao ren wu de Wang xue si xiang. Tong shi, zai qian mian yan jiu de ji chu shang, dui Luling Wang xue zai Jiang you Wang xue nai zhi Yangming hou xue fa zhan guo cheng zhong de zhong yao di wei yi ji dui zhong wan Ming ru xue si xiang fa zhan de ying xiang zuo le zong jie. (shrink)

Le problème de l’identité personnelle est une préoccupation essentielle des philosophes modernes depuis que la conscience est mise en scène philosophiquement. Cependant parmi eux il n’y en a pas beaucoup qui considèrent la mémoire comme le fondement de l’identité humaine, bien qu’aujourd’hui, et grâce aux neurosciences, on sache pourtant qu’elle joue un rôle capital. D’une manière générale, les empiristes s’y intéressent davantage que les rationnalistes. Ceux‐ci ayant comme idéal normatif les systèmes mathématiques ne pensent pas qu’elle puisse contribuer à élargir (...) nos connaissances du monde. C’est ce qui explique que le système des idées claires et distinctes chez Descartes, s’établit directement par la conscience présente. De son côté, l’empiriste sceptique Hume, bien qu’il ait souligné l’importance de la mémoire dans notre personnalité, n’a pas pu mettre en pleine lumière sa nature et son fonctionnement. L’esprit considéré comme l’ensemble des perceptions et des idées est loin de constituer l’identité de l’homme normal. On voit dans les théoriesbergsoniennes de la durée et de la mémoire une toute autre perspective qui fonde l’identité personnelle sur l’équilibre mental de la conscience présente et de l’inconscient, c’est‐à‐dire du moi superficiel et du moi profond. (shrink)

This article describes the mystery of a long lost codex of Archimedes that resurfaced briefly at the turn of the last century by Johan Ludwig Heiberg. Long enough for the Danish historian of mathematics Heiberg to identify, photograph and eventually transcribe “The Method” and several other works by Archimedes of considerable mathematical interest. In 1879 Heiberg completed his dissertation, Quaestiones Archimedeae, devoted to Archimedes’ life, works, and transmission of his texts.Este artículo describe el misterio de un códice de Arquímedes perdido (...) hace mucho tiempo que reapareció brevemente a principios del siglo pasado de la mano de Johan Ludwig Heiberg. Tiempo suficiente para que el historiador danés de las matemáticas Heiberg pudiese identificar, fotografiar y, finalmente, transcribir “El Método” y varias otras obras de Arquímedes de interés matemático considerable. En 1879 Heiberg completó su tesis doctoral, Quaestiones Archimedeae, dedicado a la vida de Arquímedes, las obras, y la transmisión de sus textos. (shrink)

È noto come il capolavoro di Marcel Proust, À la recherche du temps perdu, sia stato fin dal suo apparire oggetto privilegiato dell’interesse dei filosofi: non sarebbe pertanto fruttuoso, in questa breve recensione, limitarci a porre l’attenzione su tale osservazione. Forse meno noto, e in ogni caso meritevole d’essere posto in evidenza e degno di attenta considerazione, è il fatto che anche negli ultimi anni, i primi del secolo appena nato, si sia assistito, in Italia come in ambito internaz...

Ben shu fen wei yi ban ke xue zhe xue,Zi ran ke xue zhe xue yu shu xue zhe xue,She hui ke xue zhe xue,Ren zhi yu xin li xue zhe xue,Ke xue ji shu yu she hui wu ge bu fen,Ju ti nei rong bao kuo:gui fan xing wen ti de yu yi zhuan xiang yu yu yong jin lu,Gui ze zun xun yu yi yi de gui fan xing,Dang dai wu li xue zhe xue de yan jiu xian (...) zhuang ji qu shi,Guai ren jia she yu fu xian xiang lun deng. (shrink)

Xue xi he yan jiu Zhongguo zhe xue, yi ban lai shuo, Feng xian sheng shi ke chao er bu ke yue de. Yi si shi, hou ren wan quan ke neng er qie ye ying dang sheng guo Feng xian sheng, dan shi que bu neng rao guo Feng xian sheng. Rao guo Feng xian sheng, bu dan bi ran yao duo fei li qi, er qie rong yi zou wan lu er nan yu shen ru tang ao. Feng (...) Youlan zuo wei wo guo jin dai zhe xue de yi dai ju bo, zai mou zhong yi yi shang, ying xiang liao zheng ge jin dai Zhongguo zhe xue de ge ju. Er dui yu Feng Youlan zhe xue ji qi xue shu sheng ya de yan jiu, ye sui zhe dang dai guo xue yan jiu de xing qi, shou dao yue lai yue duo de guan zhu. Minguo shi qi de Zhongguo xue shu jie, ying gai shuo shi hui ju le yi da pi kua shi dai de xue shu jing ying, te bie shi zai chuan tong xue shu ling yu, kan cheng yi chang si xiang de sheng yan.ben shu zuo zhe zai hao ru yan hai de Minguo wen xian zhong, jing xin zheng li chu dang shi xue jie dui Feng Youlan zhe xue de hui ying he dui hua, qi zhong bao kuo zhu ru Chen Yinke, Jin Yuelin, Hu Shi, Zhang Dainian, Cai Shangsi deng yi da pi xue jie tai dou de wen zhang, zi liao xing fei chang qiang, bu jin fan ying le zhu wei xue zhe ge ren de du dao jian jie, geng cong yi ge ce mian fan ying le Minguo shi qi Feng Youlan zhe xue yan jiu de sheng kuang, dui dang xia yan jiu Feng Youlan zhe xue si xiang ju you zhong yao de can kao jia zhi. (shrink)

Straipsnyje aptariami gimnazijas baigiančių jaunuolių tolesnio gyvenimo pasirinkimų ir studijų regioninėse aukštosiose mokyklose motyvacijos sociologinio tyrimo rezulta­tai. Gilinamasi, su kuo artimiausias gyvenimo perspektyvas sieja Pietvakarių Lietuvos regiono III–IV gimnazijos klasių mokiniai: kiek jas sieja su studijų, darbo, kitų veik­lų pasirinkimu, kokie motyvai lemia studijų vietos ir studijų programos pasirinkimą, ypač regioninėse aukštosiose mokyklose. Tyrimo rezultatai atskleidė, kad studijų vietos pasirinkimui įtakos turi studijų proceso kokybė, mokymosi sąlygos (kokybės aspek­tas), gyvenimo sąlygos ir pragyvenimo išlaidos, studijų kaina (finansinis aspektas), atsiliepimai apie instituciją (...) (įvaizdžio aspektas). Rinktis studijų programą labiausiai motyvuoja galimybė studijuoti norimą specialybę, geras švietimo įstaigos įvaizdis, ge­ros mokymosi sąlygos, pažangumo lygmuo. Studijų Pietvakarių Lietuvos regioninėse aukštosiose mokyklose motyvai siejami su galimybe rinktis norimą studijų programą, artumu, geromis mokymosi sąlygomis. (shrink)

Ben shu gong liu pian, Nei rong bao kuo:zhong guo ren de pin de, Wo men xu yao shen me yang de she hui he zheng fu, Min zhu yu zi you, Shi ye yu ren sheng, Wo men xu yao shen me yang de wen xue, Wo men xu yao shen me yang de jiao yu deng.

In the field of psychology, filial piety is usually defined in terms of traditional Chinese culture-specific family traditions. The problem with this approach is that it tends to emphasize identification of behavioral rules or norms, which limits its potential for application in other cultural contexts. Due to the global trend of population aging, governments are searching for solutions to the accompanying financial burden so greater attention is being focused on the issue of elder care and its relevance to filial practices. (...) We contend that the psychological investigation of filial piety in Chinese societies has progressed to the point that it can now provide a solid structure for research targeting intergenerational relations in other cultures. We describe an indigenous psychology approach that integrated Chinese historical, philosophical, and social trends to construct a model of filial piety in terms of the dual reciprocal and authoritarian filial aspects underlying parent-child relations: the dual filial piety model (DFPM). We use this model to re-conceptualize filial piety from its usual definition as a set of Chinese culture-specific norms to a contextualized personality construct represented by a pair of culturally-sensitive psychological schemas of parent-child interaction. We then describe how the DFPM can provide a framework for research on filial relations on individual, structural, societal, and cross-cultural levels. We conclude with a discussion of how the model may be able to integrate and extend Western research on intergenerational relations and contribute to the issue of elder care beyond Chinese societies. (shrink)

"Philosopher, c'est chercher, c'est impliquer qu'il y a des choses à voir et à dire. Or, aujourd'hui, on ne cherche guère. On revient à l'une ou l'autre des traditions, on la «défend». Nos convictions se fondent moins sur des valeurs ou des vérités aperçues que sur les vices ou les erreurs de celles dont nous ne voulons pas. Notre pensée est en retraite ou en repli. Dans ce monde où la dénégation et les passions moroses tiennent lieu de certitudes, on (...) ne cherche surtout pas à voir, et c'est la philosophie, parce qu'elle demande à voir, qui passe pour impiété."Maurice Merleau-Ponty. "Les philosophes n'ont de leçons à donner à personne. La philosophie s'arrête, en effet, où commence la certitude de savoir. La leçon inaugurale de Maurice Merleau-Ponty pour son entrée au collège de France, publiée en tête de ce recueil, est donc en son principe paradoxale. Occuper une chaire pour un professeur de philosophie, ce n'est pas transmettre à ses auditeurs des vérités acquises mais plutôt leur apprendre à poser les bonnes questions.Cet éloge de la philosophie, à l'instar des autres essais publiés sous ce titre, est ainsi frappé du sceau de l'ironie socratique. Vivant témoignage d'un homme qui a su marquer son temps sans jamais se prendre pour un maître à penser, ce texte est rédigé dans un style limpide, accessible à un large public. L'auteur nous y fait simplement saisir, souvent de manière imagée, en quoi consiste l'exercice philosophique.Ce qui fait la philosophie, c'est le mouvement qui reconduit sans cesse du savoir à l'ignorance, de l'ignorance au savoir, et une sorte de repos dans ce mouvement."Paul Klein. (shrink)

In this dialogue with Yuk Hui, Pieter Lemmens explains the discipline called philosophy of technology and gives a concise overview of the most important contemporary approaches within this field. He also offers a critical evaluation of what are probably the two most salient characteristics of contemporary philosophy of technology, the so-called “empirical turn” and the “ethical turn,” which are deeply related and partly reflect the discipline’s on-going alignment with the global neoliberal agenda of exclusively profit-driven technological innovation. He also critically (...) reflects on recent developments in the molecular and informational life sciences such as genomics, metabolomics, bioinformatics and synthetic biology. (shrink)

Ce livre raconte la pensée de Michel Serres à travers des entretiens vivants où le penseur revient sur son itinéraire, depuis la traversée de la guerre au bord de la Garonne jusqu'à aujourd'hui. Passeur des savoirs, capable de faire comprendre l'histoire des idées au travers de récits savoureux, Michel Serres reste insuffisamment connu. Sait-on que ce philosophe pour qui "penser, c'est anticiper", a vu venir avant tout le monde toutes les grandes révolutions de notre temps : la fin de l'agriculture, (...) l'avènement des communications, la crise de l'écologie, la révolution numérique, l'éloignement de la mort. Pour saisir ces événements, il a forgé des concepts nouveaux - l'Hominescence, le Contrat Naturel - mais également imaginé des personnages grâce auxquels ces expériences neuves de notre humanité s'incarnent : Hermès, Le Tiers-Instruit, Petite Poucette. Pantopie (du grec "pantopos", "tous les lieux") est l'espace où tous ces personnages prennent sens. Martin Legros, philosophe, et Sven Ortoli, historien des sciences, ont su amener Michel Serres à organiser la présentation de son œuvre autour des grands personnages qui l'habitent et à la replacer dans le paysage intellectuel et philosophique contemporain. (shrink)