COVID-19 has revealed that science needs to learn how to better deal with the irreducible uncertainty that comes with global systemic risks as well as with the social responsibility of science towards the public good. Further developing the epistemological principles of new theories and experimental practices, alternative investigative pathways and communication, and diverse voices can be an important contribution of history and philosophy of science and of science studies to ongoing transformations of the scientific enterprise.

The biological sciences have become increasingly reliant on so-called ‘model organisms’. I argue that in this domain, the concept of a descriptive model is essential for understanding scientific practice. Using a case study, I show how such a model was formulated in a preexplanatory context for subsequent use as a prototype from which explanations ultimately may be generated both within the immediate domain of the original model and in additional, related domains. To develop this concept of a descriptive model, I (...) focus on use of the nematode worm Caenorhabditis elegans and the wiring diagrams that were developed as models of its neural structure. In addition, implications of the concept of a descriptive model, particularly its relevance for the data-phenomena distinction as well as its relation to long-standing debates on realism, are briefly examined. (shrink)

In this paper we argue that an operational organism concept can help to overcome the structural deficiency of mathematical models in biology. In our opinion, the structural deficiency of mathematical models lies mainly in our inability to identify functionally relevant biological characters in biological systems, and not so much in a lack of adequate mathematical representations of biological processes. We argue that the problem of character identification in biological systems is linked to the question of a properly formulated organism concept. (...) Lastly, we demonstrate how a decomposition of an organism into independent characters in the context of a specific biological process--such as adaptation by means of natural selection--depends on the dynamical properties and invariance conditions of the equations that describe this process. (shrink)

Biology lacks a central organism concept that unambiguously marks the distinction between organism and non-organism because the most important questions about organisms do not depend on this concept. I argue that the two main ways to discover useful biological generalizations about multicellular organization—the study of homology within multicellular lineages and of convergent evolution across lineages in which multicellularity has been independently established—do not require what would have to be a stipulative sharpening of an organism concept.

In this paper we argue that an operational organism concept can help to overcome the structural deficiency of mathematical models in biology. In our opinion, the structural deficiency of mathematical models lies mainly in our inability to identify functionally relevant biological characters in biological systems, and not so much in a lack of adequate mathematical representations of biological processes. We argue that the problem of character identification in biological systems is linked to the question of a properly formulated organism concept. (...) Lastly, we demonstrate how a decomposition of an organism into independent characters in the context of a specific biological process—such as adaptation by means of natural selection—depends on the dynamical properties and invariance conditions of the equations that describe this process. (shrink)

Caenorhabditis elegans is a tiny worm that has become the focus of a large number of worldwide research projects examining its genetics, development, neuroscience, and behavior. Recently several groups of investigators have begun to tie together the behavior of the organism and the underlying genes, neural circuits, and molecular processes implemented in those circuits. Behavior is quintessentially organismal—it is the organism as a whole that moves and mates—but the explanations are devised at the molecular and neurocircuit levels, and tested in (...) populations using protocols that span many levels of aggregation. Following a brief review of the main relevant features of C. elegans, I describe some of these circuits, and then discuss two contrasting approaches in behavioral genetics and neural network analysis of the worm. Finally, I outline the rudiments of a “field and focus” explanation model using the two contrasting approaches. (shrink)

Das "Kleine Worterbuch der marxistisch-Ieninistischen Philoso­ phie", das 1966 in erster Auflage, 1974 in zweiter und 1975 in dritter Auflage erschienen ist, wird nun in einer vierten, iiberarbei­ teten und erweiterten Auflage herausgegeben. Die Tatsache, dal3 die hohe Auflage der zweiten und dritten Ausgabe vergriffen ist und die Nachfrage unvermindert anhalt, zeigt, da/3 dieses Nach­ schlagewerk sich inzwischen einen festen Platz im geistigen Leben erobert hat. Das wachsende Interesse breiter Kreise an der marxi­ stisch-Ieninistischen Philosophie ist als ein Ausdruck des (...) geistigen Reifeprozesses un serer Gesellschaft objektiv bedingt: Die weitere Gestaltung der entwickelten sozialistischen Gesellschaft in der DDR entsprechend dem Programm der SED und den Beschliissen des IX. Parteitages der SED, die sich vertiefende Zusammenarbeit der sozialistischen Gemeinschaft und auch der sich verscharfende ideo­ logische Kampf zwischen Sozialismus und Imperialismus erfordern einen hoheren Grad an theoretischen Kenntnissen, ideologischer Klarheit und politischer Bewul3theit. Immer mehr Menschen machen sich aus diesen Griinden in den verschiedensten Studienformen mit dem Marxismus-Leninismus und seinen philosophischen Grund­ lagen vertraut, um sich die Weltanschauung des Sozialismus anzu­ eignen, ihre Personlichkeit geistig zu bereichern und die vor ihnen stehenden Aufgaben mit grol3erer Sachkenntnis zu meistern. Mit der vorliegenden vierten, iiberarbeiteten und erweiterten Auf­ lage des,. Kleinen Worterbuchs der marxistisch-Ieninistischen Philo­ sophie" versuchen Autoren und Verlag, diesem wichtigen geseIl­ schaftlichen Bediirfnis noch besser zu entsprechen. (shrink)

1. Aufklärung, Gesellschaft, Kritik -- 2. Aufklärung, Geschichte, Revolution.

Kant's philosophy, the peak, the culminating point of the European bourgeois Enlightenment, also represents the starting point of German classic bourgeois philosophy, leading through Fichte and Schelling to Hegel and Feuerbach. With the last-named, as we know, classic German philosophy, one of the theoretical sources of Marxism, "terminates.".

This paper argues in defense of theanti-reductionist consensus in the philosophy ofbiology. More specifically, it takes issues with AlexRosenberg's recent challenge of this position. Weargue that the results of modern developmentalgenetics rather than eliminating the need forfunctional kinds in explanations of developmentactually reinforce their importance.