15 found
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  1.  8
    Neurophysiological Correlates of Gait in the Human Basal Ganglia and the PPN Region in Parkinson’s Disease.Rene Molina, Chris J. Hass, Kristen Sowalsky, Abigail C. Schmitt, Enrico Opri, Jaime A. Roper, Daniel Martinez-Ramirez, Christopher W. Hess, Kelly D. Foote, Michael S. Okun & Aysegul Gunduz - 2020 - Frontiers in Human Neuroscience 14.
  2.  15
    Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies.Vinata Vedam-Mai, Karl Deisseroth, James Giordano, Gabriel Lazaro-Munoz, Winston Chiong, Nanthia Suthana, Jean-Philippe Langevin, Jay Gill, Wayne Goodman, Nicole R. Provenza, Casey H. Halpern, Rajat S. Shivacharan, Tricia N. Cunningham, Sameer A. Sheth, Nader Pouratian, Katherine W. Scangos, Helen S. Mayberg, Andreas Horn, Kara A. Johnson, Christopher R. Butson, Ro’ee Gilron, Coralie de Hemptinne, Robert Wilt, Maria Yaroshinsky, Simon Little, Philip Starr, Greg Worrell, Prasad Shirvalkar, Edward Chang, Jens Volkmann, Muthuraman Muthuraman, Sergiu Groppa, Andrea A. Kühn, Luming Li, Matthew Johnson, Kevin J. Otto, Robert Raike, Steve Goetz, Chengyuan Wu, Peter Silburn, Binith Cheeran, Yagna J. Pathak, Mahsa Malekmohammadi, Aysegul Gunduz, Joshua K. Wong, Stephanie Cernera, Aparna Wagle Shukla, Adolfo Ramirez-Zamora, Wissam Deeb, Addie Patterson, Kelly D. Foote & Michael S. Okun - 2021 - Frontiers in Human Neuroscience 15.
    We estimate that 208,000 deep brain stimulation devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. The (...)
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  3.  9
    An International Survey of Deep Brain Stimulation Utilization in Asia and Oceania: The DBS Think Tank East.Chencheng Zhang, Adolfo Ramirez-Zamora, Fangang Meng, Zhengyu Lin, Yijie Lai, Dianyou Li, Jinwoo Chang, Takashi Morishita, Tooru Inoue, Shinsuke Fujioka, Genko Oyama, Terry Coyne, Valerie Voon, Paresh K. Doshi, Yiwen Wu, Jun Liu, Bhavana Patel, Leonardo Almeida, Aparna A. Wagle Shukla, Wei Hu, Kelly Foote, Jianguo Zhang, Bomin Sun & Michael S. Okun - 2020 - Frontiers in Human Neuroscience 14.
  4.  8
    The UF Deep Brain Stimulation Cognitive Rating Scale (DBS-CRS): Clinical Decision Making, Validity, and Outcomes.Lauren Kenney, Brittany Rohl, Francesca V. Lopez, Jacob A. Lafo, Charles Jacobson, Michael S. Okun, Kelly D. Foote & Dawn Bowers - 2020 - Frontiers in Human Neuroscience 14.
  5.  4
    Closed-Loop Deep Brain Stimulation to Treat Medication-Refractory Freezing of Gait in Parkinson’s Disease.Rene Molina, Chris J. Hass, Stephanie Cernera, Kristen Sowalsky, Abigail C. Schmitt, Jaimie A. Roper, Daniel Martinez-Ramirez, Enrico Opri, Christopher W. Hess, Robert S. Eisinger, Kelly D. Foote, Aysegul Gunduz & Michael S. Okun - 2021 - Frontiers in Human Neuroscience 15.
    Background: Treating medication-refractory freezing of gait in Parkinson’s disease remains challenging despite several trials reporting improvements in motor symptoms using subthalamic nucleus or globus pallidus internus deep brain stimulation. Pedunculopontine nucleus region DBS has been used for medication-refractory FoG, with mixed findings. FoG, as a paroxysmal phenomenon, provides an ideal framework for the possibility of closed-loop DBS.Methods: In this clinical trial, five subjects with medication-refractory FoG underwent bilateral GPi DBS implantation to address levodopa-responsive PD symptoms with open-loop stimulation. Additionally, PPN (...)
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  6.  6
    Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury.Joshua K. Wong, Günther Deuschl, Robin Wolke, Hagai Bergman, Muthuraman Muthuraman, Sergiu Groppa, Sameer A. Sheth, Helen M. Bronte-Stewart, Kevin B. Wilkins, Matthew N. Petrucci, Emilia Lambert, Yasmine Kehnemouyi, Philip A. Starr, Simon Little, Juan Anso, Ro’ee Gilron, Lawrence Poree, Giridhar P. Kalamangalam, Gregory A. Worrell, Kai J. Miller, Nicholas D. Schiff, Christopher R. Butson, Jaimie M. Henderson, Jack W. Judy, Adolfo Ramirez-Zamora, Kelly D. Foote, Peter A. Silburn, Luming Li, Genko Oyama, Hikaru Kamo, Satoko Sekimoto, Nobutaka Hattori, James J. Giordano, Diane DiEuliis, John R. Shook, Darin D. Doughtery, Alik S. Widge, Helen S. Mayberg, Jungho Cha, Kisueng Choi, Stephen Heisig, Mosadolu Obatusin, Enrico Opri, Scott B. Kaufman, Prasad Shirvalkar, Christopher J. Rozell, Sankaraleengam Alagapan, Robert S. Raike, Hemant Bokil, David Green & Michael S. Okun - 2022 - Frontiers in Human Neuroscience 16.
    DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers can freely discuss current and emerging deep brain stimulation technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank IX speakers was that DBS expanded in (...)
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  7. Safety of Deep Brain Stimulation in Pregnancy: A Comprehensive Review.Caroline King, T. Maxwell Parker, Kay Roussos-Ross, Adolfo Ramirez-Zamora, John C. Smulian, Michael S. Okun & Joshua K. Wong - 2022 - Frontiers in Human Neuroscience 16.
    IntroductionDeep brain stimulation is increasingly used to treat the symptoms of various neurologic and psychiatric conditions. People can undergo the procedure during reproductive years but the safety of DBS in pregnancy remains relatively unknown given the paucity of published cases. We thus conducted a review of the literature to determine the state of current knowledge about DBS in pregnancy and to determine how eligibility criteria are approached in clinical trials with respect to pregnancy and the potential for pregnancy.MethodsA literature review (...)
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  8.  8
    STN Versus GPi Ddeep Brain Stimulation for Action and Rest Tremor in Parkinson’s Disease.Joshua K. Wong, Vyas T. Viswanathan, Kamilia S. Nozile-Firth, Robert S. Eisinger, Emma L. Leone, Anuj M. Desai, Kelly D. Foote, Adolfo Ramirez-Zamora, Michael S. Okun & Aparna Wagle Shukla - 2020 - Frontiers in Human Neuroscience 14.
  9.  1
    Temporally Optimized Patterned Stimulation (TOPS®) as a Therapy to Personalize Deep Brain Stimulation Treatment of Parkinson’s Disease.Michael S. Okun, Patrick T. Hickey, Andre G. Machado, Alexis M. Kuncel & Warren M. Grill - 2022 - Frontiers in Human Neuroscience 16.
    Deep brain stimulation is a well-established therapy for the motor symptoms of Parkinson’s disease, but there remains an opportunity to improve symptom relief. The temporal pattern of stimulation is a new parameter to consider in DBS therapy, and we compared the effectiveness of Temporally Optimized Patterned Stimulation to standard DBS at reducing the motor symptoms of PD. Twenty-six subjects with DBS for PD received three different patterns of stimulation while on medication and using stimulation parameters optimized for standard DBS. Side (...)
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  10.  6
    Square Biphasic Pulse Deep Brain Stimulation for Parkinson’s Disease: The BiP-PD Study.Sol De Jesus, Michael S. Okun, Kelly D. Foote, Daniel Martinez-Ramirez, Jaimie A. Roper, Chris J. Hass, Leili Shahgholi, Umer Akbar, Aparna Wagle Shukla, Robert S. Raike & Leonardo Almeida - 2019 - Frontiers in Human Neuroscience 13.
  11.  5
    Global Variability in Deep Brain Stimulation Practices for Parkinson’s Disease.Abhimanyu Mahajan, Ankur Butala, Michael S. Okun, Zoltan Mari & Kelly A. Mills - 2021 - Frontiers in Human Neuroscience 15.
    IntroductionDeep brain stimulation has become a standard treatment option for select patients with Parkinson’s disease. The selection process and surgical procedures employed have, to date, not been standardized.MethodsA comprehensive 58-question web-based survey was developed with a focus on DBS referral practices and peri-operative management. The survey was distributed to the Parkinson’s Foundation Centers of Excellence, members of the International Parkinson’s Disease and Movement Disorders Society, and the Parkinson Study Group between December 2015 and May 2016.ResultsThere were 207 individual respondents drawn (...)
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  12.  4
    Secondary Worsening Following DYT1 Dystonia Deep Brain Stimulation: A Multi-Country Cohort.Takashi Tsuboi, Laura Cif, Philippe Coubes, Jill L. Ostrem, Danilo A. Romero, Yasushi Miyagi, Andres M. Lozano, Philippe De Vloo, Ihtsham Haq, Fangang Meng, Nutan Sharma, Laurie J. Ozelius, Aparna Wagle Shukla, James H. Cauraugh, Kelly D. Foote & Michael S. Okun - 2020 - Frontiers in Human Neuroscience 14.
  13.  3
    Safety and Tolerability of Burst-Cycling Deep Brain Stimulation for Freezing of Gait in Parkinson’s Disease.Joshua K. Wong, Wei Hu, Ryan Barmore, Janine Lopes, Kathryn Moore, Joseph Legacy, Parisa Tahafchi, Zachary Jackson, Jack W. Judy, Robert S. Raike, Anson Wang, Takashi Tsuboi, Michael S. Okun & Leonardo Almeida - 2021 - Frontiers in Human Neuroscience 15.
    Background: Freezing of gait is a common symptom in Parkinson’s disease and can be difficult to treat with dopaminergic medications or with deep brain stimulation. Novel stimulation paradigms have been proposed to address suboptimal responses to conventional DBS programming methods. Burst-cycling deep brain stimulation delivers current in various frequencies of bursts, while maintaining an intra-burst frequency identical to conventional DBS.Objective: To evaluate the safety and tolerability of BCDBS in PD patients with FOG.Methods: Ten PD subjects with STN or GPi DBS (...)
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  14.  1
    Cognitive Outcomes for Essential Tremor Patients Selected for Thalamic Deep Brain Stimulation Surgery Through Interdisciplinary Evaluations.Jacob D. Jones, Tatiana Orozco, Dawn Bowers, Wei Hu, Zakia Jabarkheel, Shannon Chiu, Adolfo Ramirez-Zamora, Kelly Foote, Michael S. Okun & Aparna Wagle Shukla - 2020 - Frontiers in Human Neuroscience 14.
    Objective: Deep brain stimulation targeted to the ventral intermediate nucleus of the thalamus is effective for motor symptoms in essential tremor, but there is limited data on cognitive outcomes. We examined cognitive outcomes in a large cohort of ET DBS patients.Methods: In a retrospective analysis, we used repeated-measures ANOVA testing to examine whether the age of tremor onset, age at DBS surgery, hemisphere side implanted with lead, unilateral vs. bilateral implantations, and presence of surgical complications influenced the cognitive outcomes. Neuropsychological (...)
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  15.  1
    Case Report: Globus Pallidus Internus (GPi) Deep Brain Stimulation Induced Keyboard Typing Dysfunction.Joshua K. Wong, Melissa J. Armstrong, Leonardo Almeida, Aparna Wagle Shukla, Addie Patterson, Michael S. Okun & Irene A. Malaty - 2020 - Frontiers in Human Neuroscience 14.
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