ABSTRACT:While the literature on psychedelic medicine emphasizes the importance of set and setting alongside the quality of subjective drug effects for therapeutic efficacy, few scholars have explored the therapeutic frameworks that are used alongside psychedelics in the lab or in the clinic. Based on a narrative analysis of the treatment manual and post-session experience reports from a pilot study of psilocybin-assisted treatment for tobacco smoking cessation, this article examines how therapeutic frameworks interact with the psychedelic substance in ways that can (...) rapidly reshape participants' identity and sense of self. We identified multiple domains relating to identity shift that appear to serve as smoking cessation mechanisms during psilocybin sessions, each of which had an identifiable presence in the manualized treatment. As psychedelic medicine becomes mainstream, consensual and evidence-based approaches to psychedelic-assisted identity shift that respect patient autonomy and encourage empowerment should become areas of focus in the emergent field of psychedelic bioethics. (shrink)

The COVID-19 crisis has served not just to instil fear in the populace but to highlight the importance of fear as a motivating dynamic in politics. The gradual emergence of political-philosophical approaches calling for concern for ‘positive’ emotions may have made sense under non-pandemic conditions. Now, however, describing fear in the face of a deadly pandemic as ‘irrational’ or born of ‘ignorance’ seems ‘irrational’ and ‘ignorant’. In this article, we draw upon the work of John Gray and behavioural science to (...) present a defence of fear. We show how the pandemic has highlighted deficits in the work of four thinkers highly critical of fear: Martha Nussbaum, Zygmunt Bauman, Hannah Arendt and Sara Ahmed. We argue that, if such approaches are to be of value in anything other than optimal conditions, then they have to acknowledge the fundamental role of fear in helping human beings to pursue fundamental interests. (shrink)

We live in a world that is increasingly shaped by and bathed in science, with most scientific progress occurring in the past century, and much of it in the past few decades. Yet, several authors have puz- zled over the observation that modern societies are also characterized by a high degree of belief in a variety of pseudoscientific claims that have been thoroughly debunked or otherwise discarded by scientists (Anonymous, 2001; Ede, 2000).

The decision of the German regional court in Cologne on 26 June 2012 to prohibit the circumcision of minors is important insofar as it recognises the qualitative similarities between the practice and other prohibited invasive rites, such as female genital cutting. However, recognition of similarity poses serious questions with regard to liberal public policy, specifically with regard to the exceptionalist treatment demanded by certain circumcising groups. In this paper, I seek to advance egalitarian means of dealing with invasive rites which (...) take seriously cultural diversity, minimise harm and place responsibility for the burdens and consequences of beliefs upon those who promote practices. (shrink)

We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. (...) The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer’s disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank. (shrink)

Common sense is not enough -- The "new archaeology" -- Archaeology as a science -- Middle-range theory, ethnoarchaeology, and material culture studies -- Culture and process -- Thoughts and ideologies -- Postprocessual and interpretative archaeologies -- Archaeology, gender, and identity -- Archaeology and cultural evolution -- Archaeology and Darwinian evolution -- Archaeology and history -- Archaeology, politics and culture -- Conclusion : the future of theory.

This article draws upon clinical experience of GPs working in a deprived area of the North East of England to examine the potential contribution of Universal Basic Income to health by mitigating ‘patient-side barriers’ among three cohorts experiencing distinct forms of ‘precariousness’: 1) long-term unemployed welfare recipients with low levels of education (lumpenprecariat); 2) workers on short-term/zero-hours contracts with low levels of education (‘lower’ precariat); 3) workers on short-term/zero-hours contracts with relatively high levels of education (‘upper’ precariat). We argue that (...) any benefits must be accompanied by robust institutions capable of promoting health. (shrink)

One interpretation of the conditional If P then Q is as saying that the probability of Q given P is high. This is an interpretation suggested by Adams (1966) and pursued more recently by Edgington (1995). Of course, this probabilistic conditional is nonmonotonic, that is, if the probability of Q given P is high, and R implies P, it need not follow that the probability of Q given R is high. If we were confident of concluding Q from the fact (...) that we knew P, and we have stronger information R, we can no longer be confident of Q. We show nonetheless that usually we would still be justified in concluding Q from R. In other words, probabilistic conditionals are mostly monotonic. (shrink)

The aim of this article is to review and reconsider what scholars, including historians, archaeologists, and those in other disciplines, are trying to get at when they attempt a “social interpretation” of English late medieval domestic buildings. I focus on the definition and interpretation of “meaning,” and I examine critically a series of concepts routinely deployed in social interpretations in the past, including my own work, such as type, zeitgeist, and intention. I argue that some of these concepts and interpretive (...) moves are problematic and rather than aiding in our understanding, raise further questions in their turn about how buildings were lived in and understood by their medieval inhabitants. I argue for a shift in language and jargon away from “planning” and “meaning” to that of “lived experience”. I explore such a possible shift with reference to different understandings of and debates over the late medieval castle of Bodiam in southeastern England. Such a shift from meaning to lived experience raises fresh challenges for the development and empirical evaluation of interdisciplinary research on medieval buildings, but it also raises fresh possibilities and insights. (shrink)

In recent years, multivariate pattern analysis has been hugely beneficial for cognitive neuroscience by making new experiment designs possible and by increasing the inferential power of functional magnetic resonance imaging, electroencephalography, and other neuroimaging methodologies. In a similar time frame, “deep learning” has produced a parallel revolution in the field of machine learning and has been employed across a wide variety of applications. Traditional MVPA also uses a form of machine learning, but most commonly with much simpler techniques based on (...) linear calculations; a number of studies have applied deep learning techniques to neuroimaging data, but we believe that those have barely scratched the surface of the potential deep learning holds for the field. In this paper, we provide a brief introduction to deep learning for those new to the technique, explore the logistical pros and cons of using deep learning to analyze neuroimaging data – which we term “deep MVPA,” or dMVPA – and introduce a new software toolbox intended to facilitate dMVPA for neuroscientists everywhere. (shrink)

From which evaluative base should we develop public policies designed to promote wellbeing among different cultural groups in different circumstances? This article attempts to advance an objective, universal theory of cultural evaluation grounded in a eudaemonistic account of human wellbeing. The approach evaluates cultures on the success with which they enable societies to promote the wellbeing of individuals through provision of needs and capabilities within their given, determinate circumstances. This provides the basis for a normative functionalism capable of identifying and (...) explaining cultural deficits. (shrink)

This article provides an account of the ethical issues that arise when digital technologies and online spaces are structured by Big Data algorithms. We show that although the uses of Big Data may be new, traditional theological and ethical categories are still applicable, including “the sins of the fathers” from hamartiology and the scholastic concept of haecceity. Using these resources, we map the overall ecosystem in which digital technologies are developed and used, identifying the relationships between the individuals and organizations (...) involved. We show how these relationships are often characterized by various kinds of harm. We then argue for a reorientation of the tech ecosystem toward co‐liberation—and ultimately, joy. (shrink)

At a time of COVID-19 pandemic, universal basic income (UBI) has been presented as a potential public health ‘upstream intervention’. Research indicates a possible impact on health by reducing poverty, fostering health-promoting behaviour and ameliorating biopsychosocial pathways to health. This novel case for UBI as a public health measure is starting to receive attention from a range of political positions and organisations. However, discussion of the ethical underpinnings of UBI as a public health policy is sparse. This is depriving policymakers (...) of clear perspectives about the reasons for, restrictions to and potential for the policy’s design and implementation. In this article, we note prospective pathways to impact on health in order to assess fit with Rawlsian, capabilities and perfectionist approaches to public health policy. We suggest that Raz’ pluralist perfectionist approach may fit most comfortably with the prospective pathways to impact, which has implications for allocation of resources. (shrink)

With everything from answers to frequent new-teacher questions and warnings of common new teacher pitfalls to specific strategies and veteran tricks useful for clawing back precious hours of the day, Matthew Johnson gives clear tips and clear reasons for them in a straightforward, jargonless voice and a mixture of practicality and philosophy.

I highly recommend Philosophy of Psychedelics by Chris Letheby to both the public and academics who want to dig deeper into the modern therapeutic science of psychedelics. In this piece, I will draw attention to key topics covered in the book that I judge as particularly compelling and likely to influence psychedelic therapy and our understanding of it going forward. Clearly, the importance of philosophy in the modern psychedelic therapy renaissance will increase, and Letheby’s Philosophy of Psychedelics will hold a (...) place as a foundational work helping to shape this future. (shrink)

Clinical responses to dopamine replacement therapy for individuals with Parkinson’s disease are often difficult to predict. We characterized changes in MDS-UPDRS motor factor scores resulting from a short-duration L-Dopa response, and investigated how the inter-subject clinical differences could be predicted from motor cortical magnetoencephalography. MDS-UPDRS motor factor scores and resting-state MEG recordings were collected during SDR from twenty individuals with a PD diagnosis. We used a novel subject-specific strategy based on linear support vector machines to quantify motor cortical oscillatory frequency (...) profiles that best predicted medication state. Motor cortical profiles differed substantially across individuals and showed consistency across multiple data folds. There was a linear relationship between classification accuracy and SDR of lower limb bradykinesia, although this relationship did not persist after multiple comparison correction, suggesting that combinations of spectral power features alone are insufficient to predict clinical state. Factor score analysis of therapeutic response and novel subject-specific machine learning approaches based on subject-specific neuroimaging provide tools to predict outcomes of therapies for PD. (shrink)

Subthalamic nucleus deep brain stimulation is an established therapy for Parkinson’s disease motor symptoms. The ideal site for implantation within STN, however, remains controversial. While many argue that placement of a DBS lead within the sensorimotor territory of the STN yields better motor outcomes, others report similar effects with leads placed in the associative or motor territory of the STN, while still others assert that placing a DBS lead “anywhere within a 6-mm-diameter cylinder centered at the presumed middle of the (...) STN produces similar clinical efficacy.” These discrepancies likely result from methodological differences including targeting preferences, imaging acquisition and the use of brain atlases that do not account for patient-specific anatomic variability. We present a first-in-kind within-patient demonstration of severe mood side effects and minimal motor improvement in a Parkinson’s disease patient following placement of a DBS lead in the limbic/associative territory of the STN who experienced marked improvement in motor benefit and resolution of mood side effects following repositioning the lead within the STN sensorimotor territory. 7 Tesla magnetic resonance imaging data were used to generate a patient-specific anatomical model of the STN with parcellation into distinct functional territories and computational modeling to assess the relative degree of activation of motor, associative and limbic territories. (shrink)