Meiotic defects cause abnormal chromosome segregation leading to aneuploidy in mammalian oocytes. Chromosome segregation is particularly error‐prone in human oocytes, but the mechanisms behind such errors remain unclear. To explain the frequent chromosome segregation errors, recent investigations have identified multiple meiotic defects and explained how these defects occur in female meiosis. In particular, we review the causes of cohesin exhaustion, leaky spindle assembly checkpoint (SAC), inherently unstable meiotic spindle, fragmented kinetochores or centromeres, abnormal aurora kinases (AURK), and clinical genetic variants (...) in human oocytes. We mainly focus on meiotic defects in human oocytes, but also refer to the potential defects of female meiosis in mouse models. (shrink)

Ben shu wei wo she chong dian tu shu hua xia wen ku ru xue shu xi zhong di yi ben. Gai shu yi jian ming de wen zi gou le le Gu Yanwu, Wang Fuzhi, Huang Zongxi san wei Ming mo da ru sheng huo de shi dai bei jing, hong ru de sheng ping jing li, ta men de xue shu zao yi (zhu yao zhi ta men zai ru xue fang mian de cheng jiu), cheng yu jiao (...) you yi ji san wei zai li shi shang de di wei he gong xian, ta men ren sheng de kan ke du lai ling ren bu sheng xi. (shrink)

陈清(1937~ ),福建福州人,北京语言学院汉语学院语言文化专业部文化教研室主任.

At that time [around 1916-17—Ed.], Cai Jiemin [Cai Yuanpei—Ed.] took office as president of Beijing University, and directed his efforts at breaking away from the school's stale and decayed atmosphere. The Xin qingnian zazhi operated by Chen Duxiu had ideological revolution as its main objective, and gradually drew the attention of the general public. And there was also the article entitled "Guoren zhi gongdu", published by Huang Yuanyong in Dongfang zazhi, which very bitterly castigated the roots of the maladies in (...) China's ideological and academic circles. I was very much emboldened by the many unexpected views I encountered—views similar to my own haughty views that I had always kept well hidden. Although I had ventured to offer a few criticisms in the past, I was daunted by the oppressive force of traditional ideology, and I thought that the words of the ancients were perhaps not as simple as they appeared to me, or that there indeed were fallacies or errors in my observations. For instance, when I was taking exams at the Cun gu xuetang, and received a comment by the examinations official that "It is wrong to reproach Zheng [Xuan]"; I was constantly taking note of Zheng Xuan's fallacies, but I always felt a sort of respect for him … or [thought that] there were aspects about him that deserved respect but that these aspects had somehow escaped my attention. By this time, however, everyone was advocating ideological innovation. I myself began to acquire a perception of the need to get rid of old ways of thinking. I realized that it was precisely because scholars of the Qing dynasty had been bound by the old ideology of believing the ancients and venerating tradition that they had never dared to smash the idol that was Zheng Xuan, although their learning was a thousand time superior to his, and the encumbrances created by that idol had hindered their work of seeking the truth. And so I began to voice criticisms with greater courage and boldness. (shrink)

The netherworld marriage or the wedding for dead persons is a folk religious ritual in ancientChina. It is based on ancient Chinese folk belief of afterlife in the netherworld. Through a textual research and investigation based on relevant historical records and other ancient documents, as well as some archeological discoveries, this paper tries to give a brief account of the origin and development of netherworld marriage and its cultural and ideological background in ancient China. It finds that netherworld marriage might (...) originate from human sacrifice in early ancient times, and its name varies in different periods. It has gone through its prevailing in the Tang Dynasty, declining in the Song and Yuan Dynasties, and reviving again in the Ming and Qing Dynasties. During the long history, this custom was generally criticized and condemned by orthodoxy Confucian intellectuals, yet it was practiced and sometimes even prevailed among both noble class and common people, due to its deep root in the folk belief. The paper also intends to clarify some misconceptions and misunderstandings concerning the study of this unique cultural phenomenon. (shrink)

Jiang Yong (1681-1762) -- Hui Dong (1697-1758) -- Lu Wenchao (1717-1796) -- Wang Mingsheng (1722-1797) -- Ji Yun (1724-1805) -- Zhao Yi (1727-1814) -- Qian Daxin (1728-1804) -- Jiao Xun (1732-1820) -- Duan Yucai (1735-1815) -- Wang Niansun (1744-1832) -- Wang Yinzhi (1766-1834) -- Wang Zhong (1745-1794) -- Hao Yixing (1757-1825) -- Jiang Fan (1761-1831) -- Yan Kejun (1762-1843) -- Huang Pilie (1763-1825) -- Ruan Yuan (1764-1849) -- Gu Qianli (1766-1835) -- Wang Jun (1784-1854) -- Zhu Junsheng (1788-1858).

Resumen: Las dinastías Ming y Qing marcaron un periodo de grandes cambios en el pensamiento político y cultural chino. Durante este periodo, la relación monarca-súbdito fue un tema central en el estudio del confucianismo y un componente central de la cultura tradicional china, que durante mucho tiempo ha sido objeto de interés entre estudiosos de diversos campos. Este artículo examina el desarrollo de las antiguas relaciones monarca-súbdito chinas desde la perspectiva de los factores históricos y el desarrollo del confucianismo. (...) Además, se analiza y discute la relación monarca-súbdito en el confucianismo Ming y Qing a partir de las teorías de influyentes pensadores como Gu Yanwu, Huang Zongxi y Wang Fuzhi. Este análisis ofrece valiosas perspectivas sobre la innovación integral del confucianismo en el nuevo contexto histórico. (shrink)

I have read some outrageous books and as a result have lost my innocence. In English, to lose one's innocence also means to become sly and devious, and that is what has happened to me. My innocence was lost in the University of Pittsburgh library. It was there that I borrowed a book called The Pleasurable Experiences of a Foreign Devil in China, which was about the travels of an American in China. On the surface, this American seemed to be (...) passionate about Chinese culture—as soon as he disembarked in Shanghai, toward the end of the Qing dynasty, and saw what Chinese people were like, he became crazy about them. I could have been very pleased that other people like us, but not in this case, because this fellow was a "sadist" and a "bisexual" [Wang uses the English words here and below, and I have put them in quotes.— Trans.] or, in Chinese, a bisexual sadist. There is no way that being liked by this sort of person could please you, unless you happened to be a masochist. (shrink)

[v. 1] Xian Qin juan -- [v. 2] Qin Han juan -- [v. 3] Wei Jin Nan Bei Chao juan -- [v. 4] Sui Tang Wu Dai juan -- [v. 5] Song Liao Xi Xia Jin Yuan juan -- [v. 6] Ming Qing juan.

BackgroundResponsive neurostimulation has been utilized as a treatment for intractable epilepsy. The RNS System delivers stimulation in response to detected abnormal activity, via leads covering the seizure foci, in response to detections of predefined epileptiform activity with the goal of decreasing seizure frequency and severity. While thalamic leads are often implanted in combination with cortical strip leads, implantation and stimulation with bilateral thalamic leads alone is less common, and the ability to detect electrographic seizures using RNS System thalamic leads is (...) uncertain.ObjectiveThe present study retrospectively evaluated fourteen patients with RNS System depth leads implanted in the thalamus, with or without concomitant implantation of cortical strip leads, to determine the ability to detect electrographic seizures in the thalamus. Detailed patient presentations and lead trajectories were reviewed alongside electroencephalographic analyses.ResultsAnterior nucleus thalamic leads, whether bilateral or unilateral and combined with a cortical strip lead, successfully detected and terminated epileptiform activity, as demonstrated by Cases 2 and 3. Similarly, bilateral centromedian thalamic leads or a combination of one centromedian thalamic alongside a cortical strip lead also demonstrated the ability to detect electrographic seizures as seen in Cases 6 and 9. Bilateral pulvinar leads likewise produced reliable seizure detection in Patient 14. Detections of electrographic seizures in thalamic nuclei did not appear to be affected by whether the patient was pediatric or adult at the time of RNS System implantation. Sole thalamic leads paralleled the combination of thalamic and cortical strip leads in terms of preventing the propagation of electrographic seizures.ConclusionThalamic nuclei present a promising target for detection and stimulation via the RNS System for seizures with multifocal or generalized onsets. These areas provide a modifiable, reversible therapeutic option for patients who are not candidates for surgical resection or ablation. (shrink)

Philosophy, Islamic; Shiites; early works to 1800.

Vorwort - Einleitung Erster Teil. Hegels philosophische Kritik. Kapitel 1. Der Skeptizismus als Vorstufe und Moment der Hegelschen Dialektik. 1 Der systemtheoretische Gesichtspunkt der Hegelschen Skeptizismus-Rezeption - 2 Die Grundprinzipien des Schulzeschen Skeptizismus - 3 Hegels Kritik an Schulzes Kritik der theoretischen Philosophie - 4 Hegels Stellungnahme zum antiken Skeptizismus - Kapitel 2. Platonische und Hegelsche Dialektik. 5 Der Platonische Parmenides in Hegels Sicht - 6 Die Differenz der Platonischen und der Hegelschen Dialektik - Kapitel 3. Die Stellung des Spinozismus (...) in Hegels Dialektik - 7 Allgemeine Charakteristik der Hegelschen Widerlegung der Philosophie Spinozas - 8 Die Kategorie der Substanz in der Jenenser Logik - 9 Die Spinozistische Philosophie des Absoluten als Organon der Kritik an der Reflexionsphilosophie - 10 Die berwindung des Spinozismus in der Wissenschaft der Logik - Kapitel 4. Kants transzendentale Apperzeption und Hege. (shrink)