Androgens (testosterone), acting via the androgen receptor (AR) a nuclear transcription factor, regulate male sexual development and body composition. In addition, AR expression plays an important role in the proliferation of human prostate cancer and confers a better prognosis in breast cancer. AR mRNA stability is central to the regulation of AR expression in prostate and breast cancer cells, and recent studies have demonstrated binding by members of the ELAV/Hu and poly(C) RNA‐binding protein families to a highly conserved UC‐rich element (...) in the 3′‐untranslated region of AR mRNA, with functional impact on AR protein expression. Remarkably, a CAG trinucleotide repeat in exon 1 of the AR, the length of which has been linked to prostate cancer survival, is also a target for multiple RNA‐binding proteins from a variety of human and murine tissues. In this review, we will detail the current knowledge of the mechanisms involved in regulating AR mRNA stability, the nature, potential role and structural biology of several novel AR mRNA–protein interactions, and the implications for novel therapeutics in human prostate cancer. BioEssays 26:672–682, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Much of what we know about cognitive mapping comes from observing how biological agents behave in their physical environments, and several of these ideas were implemented on robots, imitating such a process. In this paper a novel approach to cognitive mapping is presented whereby robots are treated as a species of their own and their cognitive mapping is being investigated. Such robots are referred to as Albots. The design of the first Albot, Albot0, is presented. Albot0 computes an imprecise map (...) and employs a novel method to find its way home. Both the map and the return-home algorithm exhibited characteristics commonly found in biological agents. What we have learned from Albot0’s cognitive mapping are discussed. One major lesson is that the spatiality in a cognitive map affords us rich and useful information and this argues against recent suggestions that the notion of a cognitive map is not a useful one. (shrink)

The symbol grounding problem is concerned with the question of how the knowledge used in AI programs, expressed as tokens in one form or another or simply symbols, could be grounded to the outside world. By grounding the symbols, it is meant that the system will know the actual objects, events, or states of affairs in the world to which each symbol refers and thus be worldly-wise. Solving this problem, it was hoped, would enable the program to understand its own (...) action and hence be truly intelligent ). The problem becomes more acute after a challenge posed by Searle in his now famous Chinese Room Gedanken experiment. Searle argued that no AI programs can be said to understand or have other cognitive states, if all they do is formal symbol manipulation. (shrink)

Universities are expected to be places where knowledge is shared freely among academicians. However, the reality shows that knowledge sharing is barely present within universities these days. As Malaysia shifts towards building a knowledge-based society, academic institutions, particularly the public universities, now face ever-growing faculty demands for sharing quality resources and expertise. As a result, knowledge sharing in academia has become a rising concern. The purpose of this study, then, is to uncover the factors that propel knowledge sharing among academicians (...) in higher learning institutions of Malaysia. Using the Theory of Reasoned Action as the basis for this study’s research framework, data was gathered from 447 academicians in 10 public universities scattered throughout the country. Findings from the Partial Least Squares analysis revealed that extrinsic motivation, reciprocal relationships, sense of self-worth and subjective norm are vital determinants of an academician’s attitude towards knowledge sharing. In turn, this attitude that is formed will largely determine whether the academician engages in knowledge sharing behaviors or not. Besides having a positive effect on attitude, sense of self-worth also exhibited a positive impact on the subjective norm to share knowledge. Consequently, this subjective norm will have an impact upon knowledge sharing behavior. In addition, perceived behavioral control and organizational climate were discovered to have a direct influence on knowledge sharing behaviors. Implications, limitations as well as suggestions for future research are accordingly discussed in this paper. (shrink)

The species concept is one of the oldest and most fundamental in biology. And yet it is almost universally conceded that no satisfactory definition of what constitutes a species has ever been proposed. The present article is devoted to an attempt to review the status of the problem from a methodological point of view. Since the species is one of the many taxonomic categories, the question of the nature of these categories in general needs to be entered into.

This is an EXACT reproduction of a book published before 1923. This IS NOT an OCR'd book with strange characters, introduced typographical errors, and jumbled words. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our (...) continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. (shrink)

Au plan européen, la réflexion sur le rôle de la religion dans la société dite sécularisée ou libérale reste embryonnaire. Toutefois, les trois principes classiques de l’éthique sociale chrétienne se reflètent dans les objectifs de l’Union européenne. L’article rappelle d’abord l’histoire souvent conflictuelle des rapports Église-État en Europe. Il évoque également le débat entre Jürgen Habermas et le Cardinal Joseph Ratzinger, consacré à la pertinence d’une approche de la religion et des principes d’une éthique sociale chrétienne au sein de l’État (...) libéral et sécularisé. Il esquisse enfin quelques conséquences pour un renouveau de la théologie morale. (shrink)