Scientific workflow is a valuable tool for various complicated large-scale data processing applications. In recent years, the increasingly growing number of scientific processes available necessitates the development of recommendation techniques to provide automatic support for modelling scientific workflows. In this paper, with the help of heterogeneous information network and tags of scientific workflows, we organize scientific workflows as a HIN and propose a novel scientific workflow similarity computation method based on metapath. In addition, the density peak clustering algorithm is introduced (...) into the recommendation process and a scientific workflow recommendation approach named HDSWR is proposed. The effectiveness and efficiency of our approach are evaluated by extensive experiments with real-world scientific workflows. (shrink)

Faithful DNA replication and accurate chromosome segregation are the key machineries of genetic transmission. Disruption of these processes represents a hallmark of cancer and often results from loss of tumor suppressors. PTEN is an important tumor suppressor that is frequently mutated or deleted in human cancer. Loss of PTEN has been associated with aneuploidy and poor prognosis in cancer patients. In mice, Pten deletion or mutation drives genomic instability and tumor development. PTEN deficiency induces DNA replication stress, confers stress tolerance, (...) and disrupts mitotic spindle architecture, leading to accumulation of structural and numerical chromosome instability. Therefore, PTEN guards the genome by controlling multiple processes of chromosome inheritance. Here, we summarize current understanding of the PTEN function in promoting high-fidelity transmission of genetic information. We also discuss the PTEN pathways of genome maintenance and highlight potential targets for cancer treatment. PTEN is a guardian of the genome. However, the role of PTEN in guarding the genome has not been revealed until recently. PTEN controls multiple fundamental processes of genomic transmission. By physically interacting with key molecules in DNA replication, DNA repair/decatenation, and chromosome segregation during the cell cycle, PTEN maintains genomicintegrity and fitness. (shrink)