Ben shu jie shao le liang shu ming xian sheng shi shang ge shi ji de zhong guo wen hua ming ren zhi yi, Shi 20 shi (...) ji xin ru jia de kai chuang zhe, Shi si xiang jia, Zhe xue jia, Jiao yu jia, You shi po you ying xiang de she hui huo dong jia. You qi ta de du te de si xiang he xue shi, Ta de te li du xing de kan ke ren sheng jing li, Yi bei zi jian chi jiang zhen hua, Shi bu tong xun chang de, Ye shi ruo gan tong shi dai de zhi ming ren shi suo bu ke qi ji de. (shrink)
Scientific workflow is a valuable tool for various complicated large-scale data processing applications. In recent years, the increasingly growing number of scientific processes available necessitates the (...) class='Hi'>development of recommendation techniques to provide automatic support for modelling scientific workflows. In this paper, with the help of heterogeneous information network and tags of scientific workflows, we organize scientific workflows as a HIN and propose a novel scientific workflow similarity computation method based on metapath. In addition, the density peak clustering algorithm is introduced into the recommendation process and a scientific workflow recommendation approach named HDSWR is proposed. The effectiveness and efficiency of our approach are evaluated by extensive experiments with real-world scientific workflows. (shrink)
Previous studies on the Structural Alignment Model suggest that people compare the alignable attributes and nonalignable attributes during the decision-making process and preference formation process. Alignable (...) class='Hi'>attributes are easier to process and more effective in clue extracting. Thus, it is believed that people rely more on alignable than nonalignable attributes when comparing alternatives. This article supposes that consumers’ product experience and personal characteristics also play a significant role in regulating consumers’ reliance on attribute alignability. The authors conducted three experiments to examine the moderating role of consumers’ product familiarity and self-construal in the impact of attribute alignability on consumer product purchase. The results show the following: When making a purchase decision, consumers with a high level of product familiarity will rely more on nonalignable attributes, while those with a low level of product familiarity will rely more on alignable attributes. The difference in consumer dependency on attribute alignability is driven by their perceived diagnosticity of attributes. The dependency of consumers with different levels of familiarity on attribute alignability will be further influenced by consumers’ self-construal. Individuals with interdependent self-construal rely more on alignable attributes when unfamiliar with the product, while relying more on nonalignable attributes when familiar with the product. Individuals with independent self-construal, however, rely more on nonalignable attributes regardless of the degree of product familiarity. The conclusions of this paper can be used as references for enterprises to establish product positioning and communication strategies. (shrink)
Wei Jin xuan xue jia de xuan lun, ru jin zhi zai zhi ben wen ju jian. Dan bing bu jing mo, na xie xuan lun zong (...) shi dui du zhe zhan xian qi zi ji. Wei Jin zhi shi, xuan xiao rao rang, xuan si zhe huo sa tuo fang da, huo yi yu shen yin, ru he zai xian shi jian yi wei, shun ni shi Wei Jin xuan yin zhong zui shen ke de di yun. Zuo zhe Lu Guizhen pan wang tou guo xiang Wei Jin xuan lun zhe de kou wen, zhi chu yi ge fang xiang,er zai ci yi fang xiang de guan zhu xia, neng gou cheng xian yi ge yu xuan lun rong he de xin shi yu, bing jie ci dui yu mou xie zhong yao de ke ti jin xing sheng si, shi quan shi de jie guo ju you yi ding cheng du de yi yi. Ben shu zhong ji lu de liu pian lun wen, ji shi zhe xie nian zuo zhe bu duan xiang Wei Jin zhe ren ti wen zhi hou suo huo zhi de da an.--. (shrink)
Faithful DNA replication and accurate chromosome segregation are the key machineries of genetic transmission. Disruption of these processes represents a hallmark of cancer and often results from (...) loss of tumor suppressors. PTEN is an important tumor suppressor that is frequently mutated or deleted in human cancer. Loss of PTEN has been associated with aneuploidy and poor prognosis in cancer patients. In mice, Pten deletion or mutation drives genomic instability and tumor development. PTEN deficiency induces DNA replication stress, confers stress tolerance, and disrupts mitotic spindle architecture, leading to accumulation of structural and numerical chromosome instability. Therefore, PTEN guards the genome by controlling multiple processes of chromosome inheritance. Here, we summarize current understanding of the PTEN function in promoting high-fidelity transmission of genetic information. We also discuss the PTEN pathways of genome maintenance and highlight potential targets for cancer treatment. PTEN is a guardian of the genome. However, the role of PTEN in guarding the genome has not been revealed until recently. PTEN controls multiple fundamental processes of genomic transmission. By physically interacting with key molecules in DNA replication, DNA repair/decatenation, and chromosome segregation during the cell cycle, PTEN maintains genomicintegrity and fitness. (shrink)
