Scientific workflow is a valuable tool for various complicated large-scale data processing applications. In recent years, the increasingly growing number of scientific processes available necessitates the (...) class='Hi'>development of recommendation techniques to provide automatic support for modelling scientific workflows. In this paper, with the help of heterogeneous information network and tags of scientific workflows, we organize scientific workflows as a HIN and propose a novel scientific workflow similarity computation method based on metapath. In addition, the density peak clustering algorithm is introduced into the recommendation process and a scientific workflow recommendation approach named HDSWR is proposed. The effectiveness and efficiency of our approach are evaluated by extensive experiments with real-world scientific workflows. (shrink)
Previous studies on the Structural Alignment Model suggest that people compare the alignable attributes and nonalignable attributes during the decision-making process and preference formation process. Alignable (...) class='Hi'>attributes are easier to process and more effective in clue extracting. Thus, it is believed that people rely more on alignable than nonalignable attributes when comparing alternatives. This article supposes that consumers’ product experience and personal characteristics also play a significant role in regulating consumers’ reliance on attribute alignability. The authors conducted three experiments to examine the moderating role of consumers’ product familiarity and self-construal in the impact of attribute alignability on consumer product purchase. The results show the following: When making a purchase decision, consumers with a high level of product familiarity will rely more on nonalignable attributes, while those with a low level of product familiarity will rely more on alignable attributes. The difference in consumer dependency on attribute alignability is driven by their perceived diagnosticity of attributes. The dependency of consumers with different levels of familiarity on attribute alignability will be further influenced by consumers’ self-construal. Individuals with interdependent self-construal rely more on alignable attributes when unfamiliar with the product, while relying more on nonalignable attributes when familiar with the product. Individuals with independent self-construal, however, rely more on nonalignable attributes regardless of the degree of product familiarity. The conclusions of this paper can be used as references for enterprises to establish product positioning and communication strategies. (shrink)
Faithful DNA replication and accurate chromosome segregation are the key machineries of genetic transmission. Disruption of these processes represents a hallmark of cancer and often results from (...) loss of tumor suppressors. PTEN is an important tumor suppressor that is frequently mutated or deleted in human cancer. Loss of PTEN has been associated with aneuploidy and poor prognosis in cancer patients. In mice, Pten deletion or mutation drives genomic instability and tumor development. PTEN deficiency induces DNA replication stress, confers stress tolerance, and disrupts mitotic spindle architecture, leading to accumulation of structural and numerical chromosome instability. Therefore, PTEN guards the genome by controlling multiple processes of chromosome inheritance. Here, we summarize current understanding of the PTEN function in promoting high-fidelity transmission of genetic information. We also discuss the PTEN pathways of genome maintenance and highlight potential targets for cancer treatment. PTEN is a guardian of the genome. However, the role of PTEN in guarding the genome has not been revealed until recently. PTEN controls multiple fundamental processes of genomic transmission. By physically interacting with key molecules in DNA replication, DNA repair/decatenation, and chromosome segregation during the cell cycle, PTEN maintains genomicintegrity and fitness. (shrink)
Given the absence of a theoretical formula to analyze the influence of parameters on the contact stress of cylindrical gear with arc tooth, an explicit mathematical model (...) of cylindrical gear with arc tooth between the design parameters and the contact stress is established based on Kriging surrogate model. The parameters of the variation function of Kriging model are optimized by using the whale optimization algorithm, and the explicit mathematical model accuracy between the design parameters and the contact stress of the gear is in turn optimized by the improved Kriging surrogate model. The influence of design parameters on the contact stress of cylindrical gear with arc tooth is analyzed based on the established mathematical model. The proposed algorithm was realized via the programming platform MATLAB; the simulation results indicate that the precision evaluation indexes, root mean square error, and the relative maximum absolute error ) of the proposed Kriging model are improved, in addition to the error range which is narrowed from to. As the tooth width, modulus, pressure angle, and tooth line radius increased, the contact stress of the cylindrical gear with arc tooth gear declined, which was negatively correlated with the design parameter. The amplitude of contact stress of the cylindrical gear with arc tooth was the largest due to the change of tooth radius, followed by the change of modulus, while the influence of tooth width was less. Finally, the influence of modulus-tooth line radius interaction and pressure angle-tooth line radius interaction on contact stress of cylindrical gear with arc tooth was significant. (shrink)
The growing prevalence of health care ethics consultation (HCEC) services in the U.S. has been accompanied by an increase in calls for accountability and quality assurance, (...) class='Hi'>and for the debates surrounding why and how HCEC is evaluated. The objective of this study was to evaluate the effectiveness of HCEC as indicated by several novel outcome measurements in East Asian medical encounters. (shrink)
