ObjectiveTo identify the ethical challenges associated with the development and implementation of new tuberculosis drugs and diagnostics.MethodsTwenty-three semi-structured qualitative interviews conducted between December 2015 and September 2016 with programme administrators, healthcare workers, advocates, policymakers, and funders based in the Americas, Europe, and Africa. Interviews were analysed using thematic analysis.ResultsDivergent interests and responsibilities, coupled with power imbalances, are a primary source of ethical challenges; the uncertain risk profiles of new drugs present an additional one. Although this challenge can be partially mitigated (...) through stringent pharmacovigilance, respondents highlighted that high-burden countries tend to lack the resources to facilitate safe implementation. Increased advocacy and community engagement are considered an ethical imperative for future TB development and implementation.ConclusionsThis project helps identify some of the ethical challenges of new TB technologies. It demonstrates that investigating ethical challenges through qualitative research is one way to apprehend the difficulty of implementing new TB technologies. Addressing this difficulty will require that those in positions of power reconsider their interests in relation to disempowered communities.Policy implicationsEfforts to build consensus regarding what values should underpin the global governance of TB research, prevention, and care are essential to facilitate the ethical implementation of new TB technologies. (shrink)

Developing Global Health Programming: A Guidebook for Medical and Professional Schools , edited by Jessica Evert, Paul Drain, and Thomas Hall, is reviewed. In spite of some editorial shortcomings, the book is a terrific aggregation of resources and reflections on the state of global health education that leaves readers with a multitude of useful and diverse tools, as well as directions about where to find additional ones.

This paper argues that international development research should be submitted to the oversight of research ethics committees from the countries where data will be collected. This includes research conducted by individuals who may fall outside the jurisdictions of most ethics guidelines or policies, such as individuals contracted by non-governmental organizations. The argument is grounded in an understanding of social justice that recognizes that not seeking local ethics approval can be an affront to the decolonization movement, and may lead to significant (...) direct harms to participants. Local ethics oversight can help ensure projects appropriately take into consideration local laws, regulations, priorities and context. For example, a local research ethics committee may be in a better position than a foreign one to assess whether any given proposed project carries context-specific risks. In addition, submitting to a local research ethics committee is to acknowledge the legitimacy of local authorities, thereby taking a stance against the history of colonizing disempowerment. Local oversight is a mechanism to increase the accountability of researchers working abroad: if respect for local authority and tailoring to local context are to be upheld, there must be mechanisms to ensure that research that does not meet these requirements does not proceed. Objections based on the limited oversight capacity in some countries and on concerns related to the politicization of the review process are discussed. Finally, the roles and responsibilities of the various stakeholders in the implementation of greater local ethics oversight are laid out. (shrink)

Prominent tuberculosis (TB) actors are invoking solidarity to motivate and justify collective action to address TB, including through intensified development and implementation (D&I) of technologies such as drugs and diagnostics. We characterize the ethical challenges associated with D&I of new TB technologies by drawing on stakeholder perspectives from 23 key informant interviews and we articulate the ethical implications of solidarity for TB technology D&I. The fundamental ethical issue facing TB technological D&I is a failure within and beyond the TB community (...) to stand in solidarity with persons with TB in addressing the complex sociopolitical contexts of technological D&I. The failure in solidarity relates to two further ethical challenges raised by respondents: skewed power dynamics that hinder D&I and uncertainties around weighing risks and benefits associated with new technologies. Respondents identified advocacy and participatory research practices as necessary to address such challenges and to motivate sustained collective action to accelerate toward TB elimination. We present the first empirical examination of bioethical accounts of solidarity in public and global health. Our study suggests that solidarity allows us better to understand and address the ethical challenges that arrest the D&I of new TB technologies. Solidarity lends credence to policies and practices that address the relational nature of illness and health through collective action. (shrink)

The conduct of research in settings affected by disasters such as hurricanes, floods and earthquakes is challenging, particularly when infrastructures and resources were already limited pre-disaster. However, since post-disaster research is essential to the improvement of the humanitarian response, it is important that adequate research ethics oversight be available. We aim to answer the following questions: 1) what do research ethics committee members who have reviewed research protocols to be conducted following disasters in low- and middle-income countries perceive as the (...) key ethical concerns associated with disaster research?, and 2) in what ways do REC members understand these concerns to be distinct from those arising in research conducted in non-crisis situations? This qualitative study was developed using interpretative description methodology; 15 interviews were conducted with REC members. Four key ethical issues were identified as presenting distinctive considerations for disaster research to be implemented in LMICs, and were described by participants as familiar research ethics issues that were amplified in these contexts. First, REC members viewed disaster research as having strong social value due to its potential for improving disaster response, but also as requiring a higher level of justification compared to other research settings. Second, they identified vulnerability as an overarching concern for disaster research ethics, and a feature that required careful and critical appraisal when assessing protocols. They noted that research participants’ vulnerabilities frequently change in the aftermath of a disaster and often in unpredictable ways. Third, they identified concerns related to promoting and maintaining safety, confidentiality and data security in insecure or austere environments. Lastly, though REC members endorsed the need and usefulness of community engagement, they noted that there are significant challenges in a disaster setting over and above those typically encountered in global health research to achieve meaningful community engagement. Disaster research presents distinctive ethical considerations that require attention to ensure that participants are protected. As RECs review disaster research protocols, they should address these concerns and consider how justification, vulnerability, security and confidentially, and community engagement are shaped by the realities of conducting research in a disaster. (shrink)

Disaster research has grown in scope and frequency. Research in the wake of disasters and during humanitarian crises – particularly in resource-poor settings – is likely to raise profound and unique ethical challenges for local communities, crisis responders, researchers, and research ethics committees. Given the ethical challenges, many have questioned how best to provide research ethics review and oversight. We contribute to the conversation concerning how best to ensure appropriate ethical oversight in disaster research and argue that ethical disaster research (...) requires of researchers and RECs a particular sort of ongoing, critical engagement which may not be warranted in less exceptional research. We present two cases that typify the concerns disaster researchers and RECs may confront, and elaborate upon what this ongoing engagement might look like – how it might be conceptualized and utilized – using the concept of real-time responsiveness. The central aim of RTR, understood here as both an ethical ideal and practice, is to lessen the potential for research conducted in the wake of disasters to create, perpetuate, or exacerbate vulnerabilities and contribute to injustices suffered by disaster-affected populations. Well cultivated and deployed, we believe that RTR may enhance the moral capacities of researchers and REC members, and RECs as institutions where moral agency is nurtured and sustained. (shrink)

The American Journal of Bioethics, Volume 11, Issue 10, Page 24-26, October 2011.

Imagine that you are part of the editorial board of a young bioethics journal committed to publishing open access (OA) and to ensuring accessibility to high quality and innovative scholarship. To support junior and interna- tional scholars who might not otherwise find places for their work in the leading Western bioethics journals, you do not charge author fees. Imagine also that you have no financial resources to pay for a professional website, auto- mated submissions manager, or even a part-time coordina- (...) tor: Your government has cut all grants for journals, you cannot go to industry for private funding because of the evident risk of apparent conflicts of interest, and your strapped-for-cash institution cannot afford to offer you any support. If one of the major publishers were to approach you to sign a deal, the temptation would be strong to accept. However, this would likely mean putting aside your ideals: It would be impossible to stay a “Green OA” publication (i.e., free of author publication charges) or supportive of junior and international scholars (because of pressures to “increase credibility” through artificially high rejection rates, for example). (shrink)

L'oeuvre de Merleau-Ponty est tout entiere commandee par le souci de mettre rigoureusement en oeuvre le mot d'ordre husserlien de retour aux choses memes, ce qui exige, conformement au geste amorce par Husserl dans la Krisis, de reconnaitre l'oeuvre de l'idealisation -c'est-a-dire de l'objectivation- la meme ou elle se fait oublier, afin de la neutraliser. A l'instar de Bergson, pour qui la tache de la philosophie etait d'aller chercher l'experience au-dessus du tournant ou, s'inflechissant dans le sens de l'utilite, elle (...) devient proprement l'experience humaine, pour Merleau-Ponty, la tache de la pensee est de se situer a ce tournant ou l'experience s'accomplit et se voile a la fois dans des productions ou elle se fait proprement humaine, de definir un sens de l'Etre anterieur a la bifurcation du preobjectif et de l'oeuvre idealisante. Le but des recherches est de tenter de clarifier la nature exacte du tournant de l'experience ainsi que le projet phenomenologique merleau-pontien. (shrink)

Cette introduction explique la perception, reconnue par Husserl sous le titre de "donation par esquisses". Il s'agit d'opérer une réduction radicale qui va de la critique du néant au monde comme a priori de tout apparaître. A ce monde correspond un sujet dont le sens d'être fait problème puisqu'il est à la fois un moment du monde et en rapport avec la totalité comme telle.

This chapter discusses the phenomenology of life. The a priori of correlation characterises the being as what presents itself in its appearances only by being absent from them, as offering itself up to an exploration, in the face of which it continuously steps back or withdraws. Transcendental life must contain something living in order to be able to characterise itself as life. Desire never meets its object except in the mode of the object's own absence, and this is why nothing (...) stops it. The link between desire and the world is the truth of the relation between consciousness and object. The phenomenological dynamic that sees in desire the essence of the subject leads to a dynamic which has a truly ontological scope. In truth, ‘Life’ is the name given to the sense of Being: nothing that claims to be can stand outside life's embrace. (shrink)

Les textes du recueil Quand le geste fait sens sont pour partie issus d’un colloque, pour partie rédigés directement pour cette publication. Outre une Préface de Renaud Barbaras et une Introduction de Lucia Angelino, le volume comporte neuf études. Il est dépourvu d’index. Ces études sont réunies sous la bannière de l’expression « le geste f...

Les textes du recueil Quand le geste fait sens sont pour partie issus d’un colloque, pour partie rédigés directement pour cette publication. Outre une Préface de Renaud Barbaras et une Introduction de Lucia Angelino, le volume comporte neuf études (une consacrée à la danse, quatre à la musique, une au jeu, une à l’art conceptuel, deux à la vie et à la philosophie envisagées comme des performances). Il est dépourvu d’index. Ces études sont réunies sous la bannière de l’expression (...) « le geste f... (shrink)

This paper investigates how and when pairs of terms such as “local–global” and “im Kleinen–im Grossen” began to be used by mathematicians as explicit reflexive categories. A first phase of automatic search led to the delineation of the relevant corpus, and to the identification of the period from 1898 to 1918 as that of emergence. The emergence appears to have been, from the very start, both transdisciplinary (function theory, calculus of variations, differential geometry) and international, although the AMS-Göttingen connection played (...) a specific part. First used as an expository and didactic tool (e.g. by Osgood), it soon played a crucial part in the creation of new mathematical concepts (e.g. in Hahn’s work), in the shaping of research agendas (e.g. Blaschke’s global differential geometry), and in Weyl’s axiomatic foundation of the manifold concept. We finally turn to France, where in the 1910s, in the wake of Poincaré’s work, Hadamard began to promote a research agenda in terms of “passage du local au general.”. (shrink)

resumo Neste artigo exploramos algumas indicações, presentes nos textos de Patočka, que apontam para uma concepção da linguagem que não a põe mais como camada derivada com relação a um solo perceptivo originário. Dissociando intuitividade e originariedade, Patoˇcka estabelece uma co-originariedade entre linguagem e percepção, co-originariedade da qual procuramos ao mesmo tempo esclarecer o sentido e determinar os limites. palavras-chave linguagem – percepção – fenomenologia – intuição – fala.

Merleau-Ponty disparaît brusquement en 1961, laissant inachevée une œuvre essentielle qui devait fixer la signification ultime de toutes ses recherches antérieures et qui nourrira de nombreux courants de la philosophie contemporaine. Le propos du présent ouvrage est à la fois d'en tenter une lecture, c'est-à-dire une reconstitution aussi précise que possible s'appuyant de manière privilégiée sur les notes de travail posthumes, et de prendre la mesure de cette " intra-ontologie " que Merleau-Ponty considérait comme l'accomplissement nécessaire de la phénoménologie husserlienne. (...) L'ambition de cette ontologie est d'assumer, c'est-à-dire de dépasser la " diplopie " de l'ontologie occidentale depuis Descartes, la tension entre la reconnaissance d'un ordre brut de l'existence, irréductible aux thématisations de la science, et la nécessité de fonder la connaissance et l'objectivité. Une telle entreprise ne peut aboutir qu'au prix d'un changement de terrain radical. Celui-ci passe d'abord par la dénonciation du " positivisme " ontologique à l'œuvre dans la revendication réaliste du fait, dans la position intellectualiste de l'eidos, comme dans la tentative de dépasser dialectiquement leur opposition. Il s'accomplit sous la forme d'un mouvement régressif qui, de l'expression, fait retour vers le logos originaire en lequel elle s'enracine, mettant ainsi à jour un univers de l'essence sauvage, sol phénoménologique ultime que les notions de Chair et de Dimension visent à thématiser. Celles-ci permettent de penser une unité et une signifiance du monde qui ne compromettent pas sa profondeur originaire, une expression qui n'est pas ordonnée à la positivité d'un eidos ou d'un telos, une phénoménalisation qui excède de toutes parts les phénomènes qu'elle déploie. L'ambition de cet ouvrage est ainsi de tenter de restituer à l'ontologie de Merleau-Ponty la place qui lui revient: par-delà Husserl et Heidegger. (shrink)

Pt. 1. La séparation -- Les deux sens de la finitude -- La scission -- L'archi-événement -- La métaphysique -- Le langage -- Biologie privative -- L'exode -- L'exil -- Le langage -- Pt. 2. Le sentiment -- Le poétique -- Le sentiment -- Ipséité et ouverture -- Michel Henry -- Merleau-Ponty -- Heidegger -- Henri Maldiney.

Historical work on the emergence of sheaf theory has mainly concentrated on the topological origins of sheaf cohomology in the period from 1945 to 1950 and on subsequent developments. However, a shift of emphasis both in time-scale and disciplinary context can help gain new insight into the emergence of the sheaf concept. This paper concentrates on Henri Cartan’s work in the theory of analytic functions of several complex variables and the strikingly different roles it played at two stages of the (...) emergence of sheaf theory: the definition of a new structure and formulation of a new research programme in 1940–1944; the unexpected integration into sheaf cohomology in 1951–1952. In order to bring this two-stage structural transition into perspective, we will concentrate more specifically on a family of problems, the so-called Cousin problems, from Poincaré (1883) to Cartan. This medium-term narrative provides insight into two more general issues in the history of contemporary mathematics. First, we will focus on the use of problems in theory-making. Second, the history of the design of structures in geometrically flavoured contexts—such as for the sheaf and fibre-bundle structures—which will help provide a more comprehensive view of the structuralist moment, a moment whose algebraic component has so far been the main focus for historical work. (shrink)

L'objet de ce livre est de montrer que l'intentionnalite, condition de l'apparition de l'etant, ne peut etre caracterisee de maniere conforme a son essence que si elle est comprise comme vie. En effet, une philosophie rigoureuse de l'intentionnalite est soumise a une double contrainte. D'un cote, comme l'a souligne Merleau-Ponty, le sujet de la perception ne peut etre defini comme une sphere d'etre absolue surplombant le monde: il est du monde, et cette intramondaneite doit etre comprise comme incarnation. Cependant, en (...) mettant en avant un concept univoque de la chair, par dela la difference des etants du monde et du corps propre, Merleau-Ponty d'interdit d'acceder au sens d'etre veritable de celui-ci. Or, comme l'a montre Heidegger pour sa part, le monde ne saurait etre eclaire dans sa constituion par un retour a un etant du meme mode d'etre: le Dasein humain differe de tous les autres etants en ce qu'il existe et c'est donc bien au plan existential que l'intentionnalite doit etre ressaisie. C'est a Patocka qu'il revient d'avoir su concilier la difference radicale du sujet intentionnel et son intramondaneite en proposant une caracterisation existentiale du corps comme mouvement vivant. Les etudes reunies ici visent toutes a explorer la voie, ouverte par Patocka, d'une phenomenologie de la vie. (shrink)

The culmination of three decades of studying and treating survivors of adult onset trauma, _Wounded by Reality_ is the first systematic attempt to differentiate adult onset trauma from childhood trauma, with which it is frequently confused. When catastrophic events overtake adult lives, they often scar the psyche in ways that psychodynamically oriented clinicians struggle to understand. For Ghislaine Boulanger, the enormous challenge of working with these patients is unsurprising. Survivors of major catastrophe, whether a natural disaster, a life-threatening assault, (...) a serious accident, or an act of terrorism, experience a near-fatal disruption of fundamental aspects of self experience. The sense of agency, of affectivity, of bodily integrity, the capacity for self-reflection, the sense of time, and the ability to relate to others - all are called into question. (shrink)

This paper delves into the work of Clive L. Spash, a British radical ecological economist well-known in his field who currently holds a professorship at the Vienna University of Economics and Business. We start with an examination of the principles of his “social ecological economics.” We then critically evaluate his attack on economic growth and his perspective on the standard economic models of climate change. Lastly, we explore his approach to science as a theoretical pursuit and his policy recommendations. The (...) first version of this paper was given as a keynote lecture at the 7th Austrian Economics Meeting Europe, May 12-13, 2023, Université Catholique de l’Ouest, Angers, France, and a second version at the Summer University in Political Economy, July 20-22, 2023, Aix-Marseille University, France. I wish to thank the organizers of these conferences, and also the anonymous referees whose remarks have been taken into account to improve the paper. (shrink)

The Being of the Phenomenon opens European post-structuralism to further study and is certain to inspire new thinking about the origins of Merleau-Ponty’s phenomenology.

tome 1. Mémoires ; Traité de la cause et des phénomènes de l'électricité ; Lettre à M. Nollet sur l'électricité ; avec l'Histoire d'Alexandre le Grand.

Appearing in English for the first time, Schelling’s 1842 lectures develop the idea that many philosophical concepts are born of religious-mythological notions.

Peu à peu, tandis que Virgile achève la description ethnographique de la ruche, un glissement s’opère dans son propos : il célèbre d’abord la chasteté des abeilles, et le renouvellement de l’espèce par une miraculeuse génération spontanée ; il explique ensuite leur admirable organisation sociale par un lien privilégié avec la divinité, puisque les abeilles posséderaient une « parcelle d’intelligence divine » ; après ce bref aperçu d’une mystique panthéiste, i...

D. Boulanger. Colloque Lamarck Paris, Vrin, 1980 EVOLUTION DU GROUPE DES NUMMULITES C'est en 1801 que Lamarck dans son Système des animaux sans vertèbres proposa le genre Nummulites qu'il considéra comme le 89e des ...

In this article, I seek to make sense of the oft-invoked idea of 'public emergency' and of some of its (supposedly) radical moral implications. I challenge controversial claims by Tom Sorell, Michael Walzer, and Giorgio Agamben, and argue for a more discriminating understanding of the category and its moral force.