The origin of eukaryotes is one of the major challenges of evolutionary cell biology. Other than the endosymbiotic origin of mitochondria and chloroplasts, the steps leading to eukaryotic endomembranes and endoskeleton are poorly understood. Ras‐family small GTPases are key regulators of cytoskeleton dynamics, vesicular trafficking and nuclear function. They are specific for eukaryotes and their expansion probably traces the evolution of core eukaryote features. The phylogeny of small GTPases suggests that the first endomembranes to evolve during eukaryote evolution had secretory, (...) and not phagocytic, function. Based on the reconstruction of putative roles for ancestral small GTPases, a hypothetical scenario on the origins of the first endomembranes, the nucleus, and phagocytosis is presented. BioEssays 25:1129–1138, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

The Sublime Reader, edited by Robert Clewis, provides a broad selection of 38 authors who attempt to describe, analyse, and explain that elusive object, feeling or experience consisting of “both el...

Los recientes acontecimientos económicos y su trascendental repercusión a nivel mundial, tienen entre alguna de sus más notables consecuencias la caída generalizada en los niveles de consumo. Paralelamente otro de los fenómenos cuasi-globales, el consumo masivo de objetos, se caracteriza cada vez más por la frugalidad de dichos objetos de consumo y la necesidad de sustituirlos por otros que aporten alguna novedad; lo que implica que el consumidor no pueda descansar en sus ansias consumistas. A partir de la unión de (...) estos dos aspectos, crisis económica y consumo posmoderno, se plantea un análisis social de algunos de los aspectos que caracterizan a la sociedad de consumo española en el momento presente y su repercusión en la distribución del gasto. (shrink)

The cilium/flagellum is a sensory-motile organelle ancestrally present in eukaryotic cells. For assembly cilia universally rely on intraflagellar transport (IFT), a specialised bidirectional transport process mediated by the ancestral and conserved IFT complex. Based on the homology of IFT complex proteins to components of coat protein I (COPI) and clathrin-coated vesicles, we propose that the non- vesicular, membrane-bound IFT evolved as a specialised form of coated vesicle transport from a protocoatomer complex. IFT thus shares common ancestry with all protocoatomer derivatives, (...) including all vesicle coats and the nuclear pore complex (NPC). This has major implications for the evolutionary origin of the cilium. First, it reinforces the tenet that duplication and divergence of pre-existing structures, rather than symbiosis, were the major themes during cilium evolution. Second, it suggests that the initial step in the autogenous origin of the cilium was the establishment of a membrane patch with transmembrane proteins transported by the ancestral vesicle-coating IFT complex. We propose a scenario for how the initial membrane patch gradually protruded to enhance exposure to the environment, then started to move, and finally compartmentalised to render receptor signalling and ciliary beating more efficient. BioEssays 28: 191–198, 2006. © 2006 Wiley periodicals, Inc. (shrink)

Con un'impostazione che coniuga la fedeltà testuale e l'approfondimento critico, il percorso di questo libro mira a ricondurre l'edificazione kierkegaardina - spesso considerata mera esortazione spirituale - allo spessore autenticamente filosofico d'una via soggettiva alla verità. Un modello antioggettivistico di filosofare senza perdere di vista né l'esercizio del dubbio né la dimensione della fede. Attraverso l' interpretazione kierkegaardiane di C. Fabro si è giunti all'esposizione e ai lineamenti descrittivi fondamentali della nozione del singolo. Il singolo viene presentato dallo stesso Kierkegaard (...) come la mia categoria. Sta di fatto che si può intendere l'intera produzione kierkegaardiana come un pensare soggettivamente il singolo. Pensiero etico carico di conseguenze pratiche, giacchè il danese non pretendeva fondare una scuola filosofica ma soltanto rendere attenti, svegliare le coscienze. (shrink)

In their discussion of the interpretation of the literary work of fiction, Peter Lamarque and Stein Haugom Olsen explain that: “Literary appreciation is the appreciation of how a work interprets and develops the general themes which the reader identifies through the application of thematic concepts. […] The thematic concepts are, by themselves, vacuous. They cannot be separated from the way they are ‘anatomized’ in literature and other cultural discourses” (Lamarque and Olsen: 399). The subtle unravelling of the work’s thematic concepts (...) relies on the context of its reception, with its idiosyncratic sensitivities and cultural sensibilities of that time and place. However, cultural sensitivity also has a dark side as it may occasionally ignite a sort of allergic reaction to a work, identifying it as a threat that must be eliminated. My paper examines the case of literary censorship in Israel. Three partially banned works of fiction reflect three aspects of the Israeli right-wing anxiety concerning the Israeli-Palestinian confl ict: The futility of sacrificing Israeli soldiers’ lives, the acknowledgement of the Palestinian perspective, and, fi nally, the possibility of deflecting the animosity between the two nations to a point of allowing for mutual love. (shrink)

Susanne Langer sees the ‘the public importance of art’ as one of ‘the ultimate questions in a philosophy of art’. Indeed, Langer is often referred to as an authority on the justification of art education and is cited as providing good reasons for incorporating the arts in the curriculum. It is therefore surprising to note, as Elliot Eisner does, that Langer’s theory has had little influence on actual art education. For while many theoreticians in the social sciences and education have (...) found Langer’s contribution to the understanding of the arts highly significant, Eisner laments that ‘alas, the lesson Susanne Langer was trying to teach … in her remarkable book, never took hold in … American public schools’. It seems that policy-makers outside of art education circles remain sceptical regarding the need for art education. The substantiation of art education requires firm ground against scepticism. It is therefore important to understand the ways in which Langer’s project fails to fulfil its promise. In examining Langer’s aesthetic theory, I will show that despite its philosophical acuity, Langer’s argument fails to persuade the art education sceptic who believes that art occupies a minor role in education and should therefore remain marginal in the school curriculum. (shrink)

This paper describes an experimental course in the preparation of art teachers. The goal of the course was to engage final-year art students in thinking about the fundamental questions in aesthetic education and in considering various views of their roles as teachers of art. The classes presented a dialogue between two teachers: a philosopher of art and an artist. We discussed the social justification of art, the place of art in education and more generally the portrayal of visual culture in (...) philosophical thought. The bibliography for the course comprised a list of basic texts in aesthetic education, from Friedrich Schiller to Nelson Goodman. In class we linked the range of philosophical views examined to the artistic exploration of themes (mainly in contemporary and local art). The course also incorporated guest speakers who presented their own projects relating to different meeting points of art and education, including social-activist artists, curators, philosophers of education and school architects. The article presents the rationale for the course, its method and a sample of its content. (shrink)

From the perspective of art education, the worst-case philosophical scenario is the hedonist-subjectivist account of art. If we measure art by the pleasure we gain from it, it may seem senseless to attempt teaching the reception of art. David Hume's ‘Of the Standard of Taste’ provides an argument for the art-education enthusiast, explaining that—even on a subjectivist account—art education crystallises our own preferences. While I refer to a historical debate and provide a close reading of an 18th-century essay, my goal (...) is to offer a philosophical solution to an ongoing dilemma; I use Hume's essay to ground the justification of art education. (shrink)

La encarnación del Verbo de Dios, que culmina en el misterio pascual de la muerte y resurección de Jesucristo, es el hecho fundamental y la novedad radial del Cristianismo. En la encarnación del Verbo, el Dios infinito y creador se autocomunica amorosamente a lo otro creado, para redención y divinización del hombre, para recapitulación del cosmos.

We examined how the cultural dimension of universalism–particularism influences managers’ attitudes toward relational favoritism. Paradoxically, we found in a survey study that Brazilian and Chinese managers perceived more negative consequences of relational favoritism than did American managers—even though the Brazilians and the Chinese perceived stronger particularistic cultural norms in their countries than Americans did in the United States. We attribute this pattern of results to “cultural reflexivity”—the ability of people from transforming economies to be culturally self-critical during a period of (...) dramatic societal change. This pattern of results also emerged in a scenario study in which we asked these same Brazilian, Chinese, and American participants to assess managerial succession decisions made by a General Manager. We varied the scenarios so that the promoted manager was either a colleague with no pre-existing relation with the GM or a colleague who was a relative, a close friend, from the same town, or from the same school. Consistent with the results of the survey study, we found that perceived cultural norms of particularism were negatively related to perceptions of fairness. In other words, Brazilians and Chinese, even while living in more particularistic cultures, were more harsh in judging relational favoritism. We conclude with a discussion on the implications of these paradoxical relationships. (shrink)

ABSTRACT:U.S. Organizational Sentencing Guidelines provide firms with incentives to develop formal ethics programs to promote ethical organizational cultures and thereby decrease corporate offenses. Yet critics argue such programs are cosmetic. Here we studied bank employees before and after the introduction of formal ethics training—an important component of formal ethics programs—to examine the effects of training on ethical organizational culture. Two years after a single training session, we find sustained, positive effects on indicators of an ethical organizational culture (observed unethical behavior, (...) intentions to behave ethically, perceptions of organizational efficacy in managing ethics, and the firm’s normative structure). While espoused organizational values also rose in importance post-training, the boost dissipated after the second year which suggests perceptions of values are not driving sustained behavioral improvements. This finding conflicts with past theory which asserts that enduring behavioral improvements arise from the inculcation of organizational values. Implications for future research are discussed. (shrink)

ABSTRACT:U.S. Organizational Sentencing Guidelines provide firms with incentives to develop formal ethics programs to promote ethical organizational cultures and thereby decrease corporate offenses. Yet critics argue such programs are cosmetic. Here we studied bank employees before and after the introduction of formal ethics training—an important component of formal ethics programs—to examine the effects of training on ethical organizational culture. Two years after a single training session, we find sustained, positive effects on indicators of an ethical organizational culture (observed unethical behavior, (...) intentions to behave ethically, perceptions of organizational efficacy in managing ethics, and the firm’s normative structure). While espoused organizational values also rose in importance post-training, the boost dissipated after the second year which suggests perceptions of values are not driving sustained behavioral improvements. This finding conflicts with past theory which asserts that enduring behavioral improvements arise from the inculcation of organizational values. Implications for future research are discussed. (shrink)

William Pietz’s series of articles in the journal Res during the mid-1980s, republished now and with additional chapters as The Problem of the Fetish, traced the concept of the ‘fetish’ to the enco...

El artículo se enfoca en el dilema al que se enfrentan los gobiernos democráticos para hacer frente a la amenaza del terrorismo. Desde el marco de la filosofía política, el autor busca aportar un enfoque que contribuya a la discusión del tema. Como contexto, toma en cuenta las medidas implementadas después del 11 de septiembre de 2001, por parte de los gobiernos de Estados Unidos de América y de países de Europa para combatir al terrorismo. La mayoría de los gobiernos (...) coincide en que, para garantizar la seguridad de sus ciudadanos frente al peligro del terrorismo, es necesario un recorte de libertades en favor de buscar el fortalecimiento del gobierno. (shrink)

In her recent book, Only Imagine, Kathleen Stock promotes extreme intentionalism with respect to fictional content. She writes, ‘the fictional content of a particular text is equivalent to exactly what the author of the text intended the reader to imagine’. There are at least three separate points here: the author’s intentions determine the fictional content; the fictional content is identical with the content of what the reader imagines; reading fiction necessarily entails imagining. The first two points are normative; they are (...) concerned with truth in fiction. The third point takes for granted that fiction necessarily involves imagining on the part of the reader; the main debates here focus on the kind of imagining that is involved in reading fiction. In the following discussion, I leave aside the normative issues marked by the first two points and concentrate on the third point—namely, the relation between fiction and imagining. (shrink)

_Aesthetic Order_ challenges contemporary theories of aesthetics, offering the idea of beauty as quantitative yet different from the traditional discursive order. It will be of importance to all interested in aesthetic theory.

SummaryThis paper deals with the less researched issue of regional federation projects in East-Central Europe from the period 1848 to 1918. Based on exhaustive research, primarily using original sources—works of the intellectuals who designed these projects—the paper examines the reasons why these federation projects were written, their historical-political context, and why these plans had to fail at their time. Similarities and differences of ideas in these projects are also presented. The intention is not to give a simple presentation of a (...) series of historical facts, but to present some early ideas focused on regional integration, which, in turn, could also provide inspiration in the present. (shrink)