BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

Biography of Nguyễn Sinh Sắc (1862-1929), the father of President Ho Chi Minh.

Монография представляет собой исследование философских взглядов одного из представителей второй половины XIX века, мыслителя, публициста, литературного критика, переводчика, издателя, Н. Н. Страхова.

Монография представляет собой исследование философских взглядов одного из представителей второй половины XIX века, мыслителя, публициста, литературного критика, переводчика, издателя, Н. Н. Страхова.

Works of Tran Duc Thao, a Vietnamese philosopher.

Theravada Buddhist teachings and philosophies, and the cause and effect of human deeds.

1. P'it'agorasŭ Hakp'a ŭi ŭmangnon kwa ujuron -- 2. Arisŭt'ok'ŭsenusŭ ŭi kyŏnghŏm kwahakchŏk ŭmak iron -- 3. P'ŭllat'on-P'it'agorasŭjŏk chŏnt'ong -- 4. Kŭndae roŭi ihaeng -- 5. K'ep'ŭllŏ ŭi ŭmakchŏk ujuron -- 6. Sirhŏm kwahak kwa ŭmak ŭi hamnihwa -- 7. Nyut'ŏn ŭi ŭmakchŏk yubi -- Maejŭmmal : Nyut'ŏn ihu.

The Stanford Encyclopedia of Philosophy is an open access, dynamic reference work designed to organize professional philosophers so that they can write, edit, and maintain a reference work in philosophy that is responsive to new research. From its inception, the SEP was designed so that each entry is maintained and kept up to date by an expert or group of experts in the field. All entries and substantive updates are refereed by the members of a distinguished Editorial Board before they (...) are made public. (shrink)

Издание содержит: Музыка моя; XIX век. Россия. первые опыты философствования о музыке; XIX век. Россия. Четыре имени в метафизике музыки; XX век. Мордовия. Бахтинские и яушевские страницы и др.

"Mediante otras acciones, otras ideas y otras maneras de vivir, disidencia es la posibilidad humana de no ser parte ni formar parte del sistema de valores, representaciones y relaciones al que se estaba destinado o que aparece ineluctable. Desvío de lo preasignado, de lo que debía pensarse o creerse, del curso biográfico, filosófico o político que debía seguirse, disidir es romper con lo impuesto y con las imposturas para una exploración sin garantías de lo que aún no sabemos. Toda religión, (...) grupo político o escuela filosófica -toda sociedad, en fin- aloja, latente o en acto, el movimiento de la disidencia, de la no aceptación y la fractura en el centro de lo que busca mantenerse ortodoxo. La de Spinoza fue una vida filosófica disidente, aunque no una "filosofía de la deserción". Desertor es quien abandona, el que se aparta, el que abjura de su lugar -sus dos remisiones fundamentales son la guerra y la escuela- y de sus funciones o tareas. Desierto es lo abandonado, el territorio que es desertado por completo. La de Spinoza no es una filosofía de la deserción sino de la disidencia porque su ruptura no abandona el lugar ni escamotea el trabajo sobre él; si rompe, es para iniciar, explorar y generar de otro modo. Se tratará de una ruptura que no es autónoma de la pregunta que interroga sobre cómo vivir-juntos." --Contratapa. (shrink)