Drosophila melanogaster is often considered to lack genomic 5‐methylcytosine (m5C), an opinion reinforced by two whole genome bisulfite‐sequencing studies that failed to find m5C. New evidence, however, indicates that genomic methylation is indeed present in the fly, albeit in small quantities and in unusual patterns. At embryonic stage 5, m5C occurs in short strand‐specific regions that cover ∼1% of the genome, at tissue levels suggesting a distribution restricted to a subset of nuclei. Its function is not obvious, but methylation in (...) subsets of nuclei would obscure functional associations since transcript levels and epigenetic modifications are assayed in whole embryos. Surprisingly, Mt2, the fly's only candidate DNA methyltransferase, is not necessary for the observed methylation. Full evaluation of the functions of genome methylation in Drosophila must await discovery and experimental inactivation of the DNA methyltransferase, as well as a better understanding of the pattern and developmental regulation of genomic m5C. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Leonhart Fuchs on the Importance of PicturesSachiko KusukawaIf not for the attractive plant with overhanging flute-like flowers that was named after him, Leonhart Fuchs (1501–66) is best known today as one of the pioneers of accurate representations of plants in histories of scientific illustrations.1 The pictures in Fuchs’s Remarkable Commentaries on the History of Plants (1542) have been appreciated usually for their “naturalistic” features (i.e., pictures drawn from observing (...) a plant specimen), as well as for their tendency to discard individual blemishes and portray a universal or ideal “type” of a plant where several varieties of species could be incorporated into one bush, or where various stages of the same plant may be depicted in one figure.2 On the other hand no historian of botany who has examined the text these pictures accompanied has found that such qualities as observation from nature or a sense of “ideal type” contributed to Fuchs’s theoretical understanding of [End Page 403] plants: he lacked any sense of the family genera or Linnean classification, for he had simply adopted an alphabetical ordering.3Fuchs himself considered his pictures remarkable—as he was at pains to point out—and he believed his pictures were absolutely crucial for his commentary on plants. My immediate aim in this paper, therefore, is to offer an interpretation of Fuchs’s Remarkable Commentaries on the History of Plants which does not split the work into artistically positive and botanically negative elements. As I shall argue, the uniqueness and so the controversial nature of Fuchs’s enterprise lies in the kind of argument and procedure he believed to be valid for an academic study of plants. More generally, I hope to use this reassessment of Fuchs’s work to show how pictures could be as controversial as texts and how the uses of texts and pictures together form past acts which require historical explanation. Click for larger view View full resolutionFigure 1.The Artists. Leonhart Fuchs, De historia stirpium, 1542, verso of last folio page. Reproduced by permission of the Syndics of Cambridge University Library.In 1542 Fuchs published his Remarkable Commentaries on the History of Plants Belaboured with Great Expense and Vigilance with More than Five Hundred Live Images of Plants Attached. It begins with a picture of Fuchs, the author, at the age of forty-one and ends with that of the artists (fig. 1). Although the division of labor depicted here seems to have been a standard one for printing illustrated books in this period,4 it is unusual that we know their names. Albrecht Meyer did the drawings from life, Heinrich Füllmaurer transferred the drawings to woodblocks, and Veit Rudolf Speckle cut those woodblocks.5 Fuchs was proud of one of the artists in particular: “the woodcutter [sculptor] Veit Rudolf Speckle, by far the best in Strasbourg, excellently imitated the admirable industry of painters: he has so skilfully expressed the outlines of each picture by carving [sculpendo] that he seems to compete with the painter for glory and victory.”6 A comparison between the painter and the sculptor had been a favorite topic in the Renaissance genre of paragone—Leonardo da Vinci, Galileo, Castiglione, and Michaelangelo composed treatises on it—where the [End Page 404] relative merits of various mimetic arts were discussed.7 Fuchs’s comment on Speckle is more nuanced, however, than a polite competition between the arts over their mimetic skills: Fuchs announces that Speckle is worthy of praise in producing a picture—normally the domain of the painter (pictor)—with the specialized skill of carving of the cutter (sculptor). This is surely an appreciation of the particular skill involved in producing replicable pictures for printed books, just as Erasmus had, a generation earlier, acknowledged in Albrecht Dürer’s prowess at engraving the potential for reproducibility in a print culture.8 Indeed, of the artists involved in printing, it was the woodcutter who could expect to be paid most in this period—nearly fifteen times more than the artist who originally drew the pictures.9 Click for larger view View full resolutionFigure 2.Atriplex. Theodore Dorsten, Botanicon, 1540, fol. 35r. Reproduced... (shrink)

Dienes & Perner's analysis provides a clear theoretical justification for using a demonstration of volitional control as a criterion for conscious awareness. However, in memory tasks, the converse does not hold: A phenomenological awareness of a memory episode can arise involuntarily, even when the task does not require retrieval of the episode. The varying amounts of volitional retrieval required by different memory tasks need to be recognized.

This volume offers an important re-evaluation of early modern philosophy. It takes issue with the received notion of a 'revolution' in philosophical thought in the 17th-century, making the case for treating the 16th and 17th centuries together. Taking up Charles Schmitt's formulation of the many 'Aristotelianisms' of the period, the papers bring out the variety and richness of the approaches to Aristotle, rather than treating his as a homogeneous system of thought. Based on much new research, they provide case studies (...) of how philosophers used, developed, and reacted to the framework of Aristotelian logic, categories and distinctions, and demonstrate that Aristotelianism possessed both the flexibility and the dynamism to exert a continuing impact - even among such noted 'anti-Aristotelians' as Descartes and Hobbes. This constant engagement can indeed be termed 'conversations with Aristotle'. (shrink)

This book provides a systematic exposition of mathematical economics, presenting and surveying existing theories and showing ways in which they can be extended. One of its strongest features is that it emphasises the unifying structure of economic theory in such a way as to provide the reader with the technical tools and methodological approaches necessary for undertaking original research. The author offers explanations and discussion at an accessible and intuitive level providing illustrative examples. He begins the work at an elementary (...) level and progessively takes the reader to the frontier of current research. This second edition brings the reader fully up to date with recent research in the field. (shrink)

Recent studies have fruitfully examined the intersection between early modern science and visual culture by elucidating the functions of images in shaping and disseminating scientific knowledge. Given its rich archival sources, it is possible to extend this line of research in the case of the Royal Society to an examination of attitudes towards images as artifacts—manufactured objects worth commissioning, collecting, and studying. Drawing on existing scholarship and material from the Royal Society Archives, I discuss Fellows’ interests in prints, drawings, varnishes, (...) colorants, images made out of unusual materials, and methods of identifying the painter from a painting. Knowledge of production processes of images was important to members of the Royal Society, not only as connoisseurs and collectors, but also as those interested in a Baconian mastery of material processes, including a “history of trades.” Their antiquarian interests led to discussion of painters’ styles, and they gradually developed a visual memorial to an institution through portraits and other visual records. (shrink)

This book contains short analyses of Ogyū Sorai’s most important works, as well as a biography and a number of essays. The essays explore various aspects of his teachings, of the origins of his thought, and of the reception of his ideas in Japan, China, and Korea before and after "modernization" struck in the second half of the nineteenth century. Ogyū Sorai has come to be considered the pivotal thinker in the intellectual history of Early Modern Japan. More research has (...) been done on Sorai than on any other Confucian thinker of this period. This book disentangles the modern reception from the way in which Sorai's ideas were understood and evaluated in Japan and China in the century following his death. The joint conclusion of the research of a number of the foremost specialists in Japan, Taiwan, and the West is that Sorai was and remains an original, innovative, and important thinker, but that his position within East-Asian thought should be redefined in terms of the East-Asian tradition to which he belonged, and not in the paradigms of European History of Philosophy or Intellectual History. The book represents up-to-date scholarship and allows both the young scholar to acquaint himself with Sorai, and the intellectual historian to compare Sorai with other thinkers of other times and of other philosophical traditions. (shrink)

啓蒙思想の系譜を繙き、理性の力を問い直す。古代ギリシアから、ホッブズ、カント、フランクフルト学派を経て最新の議論まで。啓蒙を巡る問題意識の変遷を追う論考集。.

Este artigo pretende fazer uma breve apresentação do platonismo não-realista de Abelardo através da solução dada na Logica Ingredientibus à célebre “querela dos universais”.

ABSTRACT In volume two of his work Democracy in America, Alexis de Tocqueville argued that religion could guarantee individual liberties against the tyranny of the majority. However, in volume one of this work, Tocqueville presented a conventional ‘civil religion’ as a phenomenon that was identical to or subsumed by American social mores or opinions. Thus, the following questions are raised: How can such a religion represent a brake on potential tyranny? How can genuine religion be distinguished from common opinion? Consequently, (...) understanding Tocqueville’s approach to religion remains a major problem. This article demonstrates that in the second volume of Democracy in America, Tocqueville suggested a different type of civil religion, one that has a transcendent authority that distinguishes it from public opinion but that, nevertheless, facilitates intellectual liberty. It also shows how Tocqueville resolved the dilemmas of authority and liberty in the civil religion, by focusing on, with his observations of American Christianity, his reading of Blaise Pascal’s works regarding religious authority and human reason, in which Pascal exhorted human beings to willingly recognise the limits of reason. (shrink)

第5回東京大学南原繁記念出版賞受賞作。徳川日本の思想家らが構想した、美しく「人に接」わるための制度とその実践を鋭利に分析。思想史、文学史、文化史研究の新たな地平。.

教科書には絶対に載らない真実の数々―かの米国総司令官の初仕事は、日本に慰安婦を供出させることだった!「週刊新潮」連載の超辛口名物コラム。傑作選、第八弾。.

Eukaryotic genome DNA is wrapped around core histones and forms a nucleosome structure. Together with associated proteins and RNAs, these nucleosomes are organized three‐dimensionally in the cell as chromatin. Emerging evidence demonstrates that chromatin consists of rather irregular and variable nucleosome arrangements without the regular fiber structure and that its dynamic behavior plays a critical role in regulating various genome functions. Single‐nucleosome imaging is a promising method to investigate chromatin behavior in living cells. It reveals local chromatin motion, which reflects (...) chromatin organization not observed in chemically fixed cells. The motion data is like a gold mine. Data analyses from many aspects bring us more and more information that contributes to better understanding of genome functions. In this review article, we describe imaging of single‐nucleosomes and their tracked behavior through oblique illumination microscopy. We also discuss applications of this technique, especially in elucidating nucleolar organization in living cells. (shrink)

This paper introduces an agent system for supporting user's dairy work on the Internet like a secretary. In this system, an agent is assigned to a user, and receives requests from the user or other agents. Since there are various kinds of requests, it is difficult to prepare a complete set of request-handling rules in advance. In order to handle various requests, the agent uses Case Based Reasoning (CBR), which is an approach to solve a problem by referring old cases. (...) Requests and cases are described as XML documents, that are easily understandable for both the user and agent, because the agent needs to interact with them. Describing documents in XML enables an agent to match a request and a case more exactly. This agent consists of a request receipt module, planning module, executing module, and case storage module. The request receipt module receive a request from the user or other agents. The request is described as a XML document by interacting with the user. The planning module searches an old case similar to the request, and generates a sequence of basic operations as a plan by referring the case. The executing module executes the plan. If the agent fails to execute a basic operation or requires user's instruction, then it carries out the plan by interacting with the user. The case storage module stores the new case with user's evaluation score into the case base. The experimental results shows that increase in the number of cases raises a proposal rate and accuracy rate. However, too many cases may cause decline in the accuracy rate by inconsistency of user's evaluation. (shrink)

Images in the service of scientific knowledge (broadly construed) in early modern Europe have received much scholarly attention in recent years. Given that this was a period where there was a large...

This is an important volume of seventeen essays that historicizes observation as a practice, concept and ideal. It belongs to the historiographical tradition of scrutinizing central aspects of the scientific enterprise such as experiments and objectivity that once appeared too self-evident to be probed. The challenge of historicizing such a significant idea is that it has to be a collective enterprise.The volume starts with three essays that provide a chronological survey of the period from 500 to 1800. Katherine Park, covering (...) the period from 500 to 1500, explains how observation for Cicero and Pliny had nothing to do with experiment or systematic investigation, but rather was a collective and largely anonymous process, associated with originary phrases of natural knowledge of a distant past and intelligible even by the illiterate. It was the basis for conjectural knowledge that lacked causal explanation. Observation of celestial events occurred from time to time, but in the context o .. (shrink)

In this paper, I discuss a drawing that substituted for an engraving in a copy of Philosophical Transactions once owned by Thomas Kirke (1650–1706, FRS 1693). I suggest that prints allowed Kirke to train his eye as well as his hand. His case is useful for raising further questions about visual representations in early modern science.

This paper examines the inter-relationship between image, text and object in the Codex Kentmanus, which is one of the earliest records of the plants in the botanical garden at Padua, studied by Johannes Kentmann . The manuscript shows that “observation” for Kentmann involved a gradual process of assimilating knowledge from other physicians, apothecaries, and books in order to make the plants which were originally encountered at a specific time and place into a more generalised object of study for learned physicians.

This paper examines the inter-relationship between image, text and object in the Codex Kentmanus, which is one of the earliest records of the plants in the botanical garden at Padua, studied by Johannes Kentmann . The manuscript shows that “observation” for Kentmann involved a gradual process of assimilating knowledge from other physicians, apothecaries, and books in order to make the plants which were originally encountered at a specific time and place into a more generalised object of study for learned physicians.

The four papers in this volume arise out of a research project, “Making Visible: The visual and graphic practices of the early Royal Society,” funded by the Arts and Humanities Research Council of the United Kingdom.1 The project sought to understand how visual resources and practices contributed to, and shaped the development and dissemination of scientific knowledge in the first fifty years of the Royal Society. The Royal Society, as an early institution dedicated to promoting natural knowledge, has received substantial (...) scholarly attention from historians of science, aided by a rich administrative archive that has been preserved virtually unbroken since its foundation.2 Because modern cataloguing of manuscripts... (shrink)