Recent progress in our understanding of mitotic chromosome dynamics has been accelerated by the identification of two essential protein complexes, cohesin and condensin. Cohesin is required for holding sister chromatids (duplicated chromosomes) together from S phase until the metaphase‐to‐anaphase transition. Condensin is a central player in chromosome condensation, a process that initiates at the onset of mitosis. The main focus of this review is to discuss how the mitotic metaphase chromosome is assembled and shaped by a precise balance between the (...) cohesion and condensation machineries. We argue that, in different eukaryotic organisms, the balance of cohesion and condensation is adjusted in such a way that the size and shape of the resulting chromosomes are best suited for their accurate segregation. BioEssays 23:924–935, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Husserl’s notion of “sense” has often been interpreted through a Fregean lens. I will show that Husserl saw it as an acquaintance with the background or horizon of perceptual objects. He understands reason (Vernunft) as prescribing rules for performance with regard to perceptual objects. Thus Husserl’s view has a wider scope of experience than Kant’s sense of it as a pre-reflective acquaintance with one’s environment. After Ideas I Husserl develops these notions as part of his theory of the intersubjective world. (...) Heidegger takes over the insights of Husserl and brings out the performative turn inherent in phenomenology by critiquing Husserl’s orientation to theoretical perceptual experience. The reference of performative expressions is not determined by the contents but by performance. What is disclosed in the phenomenological notion of sense is the background against which human existence is to be understood. (shrink)

Human B cell stimulatory factor 2 (originally designated BSF2) was initially characterized and isolated as a T cell‐derived factor that caused the terminal maturation of activated B cells to immunoglobulin producing cells. Molecular cloning of the cDNA has revealed that BSF2 is identical with 26 kD protein, interferon β2, plasmacytoma growth factor and hepatocyte stimulating factor and the designation “IL‐6” has been proposed for this molecule. It is now known that BSF2/IL‐6 has a wide variety of biological functions and that (...) abnormal regulation of BSF2/IL‐6 expression may be related to the pathogenesis of certain autoimmune diseases such as rheumatoid arthritis and multiple myeloma. (shrink)

In this paper, I will focus on the phenomenological notion of sense which Husserl calls in Ideen I noematic sense. My reading of Ideen I is based on the interpretation of noema as “object as it is intended”. This notion is developed from “filling sense” in LU. Similar to the Russellian “knowledge by acquaintance”, Husserl means by this notion the direct intuitive acquaintance with an intentional object. However, unlike Russell, Husserl doesn’t restrict this notion to sense data, but extend it (...) to the acquaintance with the perspective way of appearance of an intentional object (Erscheinungsweise, Abschattungen). This is because, unlike Frege, Husserl includes not only intension (Materie), but also illocutionary force (Aktqualität) into his notion of sense (LU, 6. Untersuchung, p. 617). This performative notion of sense requires him to take account of the acquaintance with the background of speech acts as a constitutive part of the broadest notion of sense (Ideen I, p. 233f., 322). If a conjecture e.g. about the back side of a cube: “the back side must be a square”, changes through a perception into a claim about it: “this side is indeed a square”, the change of the illocutionary forces, that is, the “filling sense” of the perception is expressed not by intentional materials (side, square etc.), but by indexicals, modal verbs or tenses, which are understood in a direct acquaintance with the perspective appearance of the cube. Thus, “the changing noematic way of appearance of the whole object as sense” (Husserliana vol. XI, p. 333) is the background or horizon, in implicit acquaintance with which illocutionary forces (Aktqualität in LU, noetischer Charakter in Ideen I) of propositional attitudes towards perceptual objects can be understood. (shrink)

Um encontro com Ferreira Gullar compartilha com os leitores as muitas formas em que uma coisa está em outra. O momento transformador desse encontro marcado entre entrevistador e entrevistado se manifesta aqui em forma de reflexão, diálogo, relato, memória, ensaio fotográfico e, também, poesia.

Currently in Japan, discontinuing an invasive mechanical ventilator (IMV) is illegal; therefore IMV-related decision making is a crucial issue. This study examined IMV decision-making factors and psychological conflict in 50 patients with amyotrophic lateral sclerosis. The Herth Hope Index was used for the assessment of pre- and post-IMV conflict. Interviews identified some decision-making factors: patient’s decision, patient’s and family’s mutual decision, family’s decision, and emergency-induced without patient’s or family’s consent. Participants who experienced no IMV-related regret received sufficient prior IMV education (...) from physicians and nurses, and time for reflection and family consultation. Their hope was similar to their pre-onset levels. Patients who received no prior IMV education accepted treatment as a natural progression. Their hope levels were lower than pre-onset. Those who received only a brief prior IMV explanation rejected the ventilator, experiencing regret if they were given an emergency IMV. Their hope levels were among the lowest. However, some of these patients managed to overcome their regret through being helped by nurses. Sufficient physician explanation and nursing advocacy for autonomous patient decision making are critical for improving hope in this patient group. (shrink)

All surviving jawed vertebrate representatives achieve diversity in immunoglobulin‐based B and T cell receptors for antigen recognition through recombinatorial rearrangement of V(D)J segments. However, the extant jawless vertebrates, lampreys and hagfish, instead generate three types of variable lymphocyte receptors (VLRs) through a template‐mediated combinatorial assembly of different leucine‐rich repeat (LRR) sequences. The clonally diverse VLRB receptors are expressed by B‐like lymphocytes, while the VLRA and VLRC receptors are expressed by lymphocyte lineages that resemble αβ and γδ T lymphocytes, respectively. These (...) findings suggest that three basic types of lymphocytes, one B‐like and two T‐like, are an essential feature of vertebrate adaptive immunity. Around 500 million years ago, a common ancestor of jawed and jawless vertebrates evolved a genetic program for the development of prototypic lymphoid cells as a foundation for an adaptive immune system. This acquisition preceded the convergent evolution of alternative types of clonally diverse receptors for antigens in all vertebrates, as reviewed in this article. (shrink)

Abstract: Die Geisteswissenschaften grenzen sich von den physikalischen Naturwissenschaften durch ihre Bezogenheit auf das menschliche Leben ab. „Covering laws“ können zwar menschliche Handlungen statistisch erklären, aber dabei wird die Subjektivität einzelner Handelnder nicht berücksichtigt. Dagegen kann die Einfühlung oder der Nachvollzug als hermeneutische Methode der Geisteswissenschaften für eine Theorie der Zuschreibung der Ich-Stellungnahme gehalten werden. Bei dieser Zuschreibung handelt es sich aber nicht um die im solipsistischen Bewusstsein abgekapselte Subjektivität, sondern um die lebensweltliche Subjektivität des im eigenen Leib verkörperten Ichs. (...) Die Lebenswelt lässt sich als intersubjektiv geteilter Hintergrund des Sprechaktes verkörperter Ichs interpretieren. In diesem Sinne basiert die Logik der Geisteswissenschaften auf der lebensweltlichen Subjektivität. (shrink)

This essay examines the political implications of Edo (present-day Tokyo) popular culture in early modern Japan by focusing on the interface between distinct forms of literary and visual representation and the configuration of social order (the status hierarchy and the division of labor), as well as moral and ideological discourses that were conducive to the reproduction of the order. Central to the forms of representation in Edo popular culture was the overarching literary and artistic principle, which I call a phrase (...) adapted from M.M. Bakhtin's work on Fyodor Dostoevsky. By creating a dialogical interaction of divergent voices and perspectives, Edo popular culture created pluralized, contentious images of Tokugawa society, images that underlined contradictory realities that had become widely discernible around the turn of the eighteenth century. The most salient of all the contradictions was the growing disjuncture between the ideological premise of social and economic hierarchies and their actual reversals. The dialogic imagination captured and accentuated the fluid and dynamic social interactions that threw the formal arrangements of social order into disarray, as well as the widely perceived tensions originating from these interactions, by supplying images that sharply contrasted with those that the Tokugawa authorities worked hard to foster and defend: of a harmonious, self-contained, and perfectly functioning society. (shrink)

Was heißt die existenziale Analytik? Um diese Grundfrage der Fundamentalontologie zu beantworten, geht der Autor von der Problematik des Ich-Sagens aus. Während der Marburger Vorlesungen entstand der Begriff Dasein durch Heideggers Umdeutung der aristotelischen Seele anhand des leiblich-lebensweltlichen Subjektivitätsbegriffs Husserls. Dabei entwickelte Heidegger mittels des Diltheyschen Begriffs Bedeutsamkeit das Noema als Zeug hermeneutisch weiter. Um das Sein eines Ich durch Handlungsprädikate auszulegen, ist es notwendig, mit der Bedeutsamkeit der Welt vorbegrifflich vertraut zu sein. Das Verstehen als Weltvertrautheit ist das Existenzial, (...) d. h. die Bedingung der Möglichkeit für das Ich-Sagen. So schlägt der Autor vor, die Schemata: Das Umwillen seiner , das Wovor und das Um-zu als Schematismus der Handlung zu deuten. Darüber hinaus wird untersucht, warum die geschichtliche Rationalität trotz seiner Aufnahme der praktischen Philosophie Aristoteles’ und Kants von Heidegger vernachlässigt wurde. (shrink)

BackgroundEmotional regulation is important for adolescents’ adaptive development. Preventive interventions for anxiety and depression are necessary for reducing the development of disorders later in life, and emotional regulation is a potentially relevant factor.ObjectiveWe investigated the effects of a mindfulness-based psychological education and prevention program [the Mindfulness and Awareness Program ] on the mental health of junior high school students in Japan.MethodsOur MAP primarily focused on mindfulness meditation to improve emotional regulation, thereby reducing depression and anxiety. The MAP comprised eight sessions (...) administered by a school counselor in a school setting. All participants were 12–13-year-old adolescents from nine classes in two Japanese schools. The program was provided to the intervention group, wherein students were educated on emotional expression, emotional cognition, and emotional regulation. The control group received regular school counseling services.ResultsCompared with the control group, the intervention group showed significant improvement in emotional regulation and a decrease in depression and generalized anxiety. The effect was greater at the follow-up assessment than at the immediate post-intervention assessment, and greater in female students.ConclusionOur mental health prevention program exhibited efficacy in reducing depression and anxiety and enhancing emotional regulation in early adolescence. Further, it appeared to be more effective for female adolescents. (shrink)

Previous studies have suggested that musical training in childhood is beneficial for sociability. However, it remains unclear how age of onset of group music lessons is associated with the late sociability of children from a long-term perspective. This study investigated associations between group music lessons conducted at a music school and children’s levels of sociability by focusing on the age of onset of the lessons. We conducted a survey of 276 children aged 4–5 years (M = 58.5 months) and 6–7 (...) years (M = 82.7 months) who commenced music lessons at ages 1, 2, 4, and 6 years. We found that (1) the empathy scores of children aged 6–7 years who began lessons when 1-year-old were greater than those who began lessons when 4-years-old, (2) the communication scores of children aged 4–5 years who began lessons when 1-year-old were greater than those who began lessons when older than 1 year, and (3) the empathy and extraversion scores were high in those aged 6–7 years who began lessons in that age range. The results suggest that early onset of music lessons could positively influence children’s sociability; in contrast, after about age 7 years, children who already had high sociability may be more inclined to select group music lessons. By focusing on the impact of regular group music lessons from a very young age on later levels of sociability, these results further elucidate the effects of musical lessons. In sum, participation in group music lessons 2–4 times per month can be effective social training for very young children and foster their later sociability. (shrink)

M. Ally: Why Jaspers gives us Hope: Deconstruc ting the Myth of Cultural Impermeability B. Andrzejewski: Über Kant und Schelling hinaus. Zur Frage der existenziellen Theorie der Kommunikation bei Jaspers A. Cesana: Weltphilosophie und philosophischer Glaube J. M. Cho: Cross-Cultural Adaptations in Karl Jaspers J. Fukaya: The Japanese Moral Framework and Jaspers Philosophy K. Fukui: Karl Jaspers Philosophie aus Sicht der Kyoto-Schule J.-C. Gens: Jaspers Begegnung mit und sein Verhältnis zu China S. Hanyu: The Cross-Cultural Thought in Jaspers Philosophy. In (...) comparison with Kantian Thought in Toward Perpetual Peace K. Hara: Konflikte und Kommunikation der Religionen. Zur Möglichkeit des philosophischen Glaubens A. Hirano: Arendt und Jaspers: Der innere Zusammenhang und die Unterschiede zwischen den Gedanken beider S. C. Kim: Der philosophische Glaube angesichts des religiösen Pluralismus L. Lambrecht: Philosophie gegen den Nationalsozialismus: Hannah Arendt und Karl Jaspers E. Lee: Heidegger and Jaspers on the Public Sphere: Jaspers Theory of Communication as an Antidote to Heideggers Dark Public World W. Lee: Philosophischer Glaube und universale Kommunikation bei Karl Jaspers T. Nakajima: Die Idee der Universität inmitten der Popularisierung" T. Nakayama: Jaspers Philosophie und Buddhismus. Das Denken der Leerheit" C. Olay: Öffentlichkeit bei Jaspers und Hannah Arendt S.-K. Paek: Kants Schrift Zum ewigen Frieden im Spiegel dreier Interpretationen: Volker Gerhardt, Jürgen Habermas, Karl Jaspers E. Park: The Possibility of Social Existenz. A Reinterpretation of the Concept of Existenz in Karl Jaspers F. Peach: Jaspers, Existential Communication and Globalisation C. Piecuch: Welteinheit: Rationale Entscheidung oder kosmische Notwendigkeit? I. Ren: Zwei Wege der philosophischen Logik: Jaspers und Heidegger N. Reyhani: Die Anthropologie-Debatte und der Vorwurf des Positivismus gegen Karl Jaspers I. Sarin: Jaspers on Bridging the Intercultural Gap H.-J. Seideneck: Der Zusammenprall von Kulturkreisen im Weltdorf unter dem Blickwinkel des erhebenden Scheiterns bei Karl Jaspers H. Stelzer: Das Aufbrechen fixierter Weltbilder in der interkulturellen Kommunikation E. Struchholz: Karl Jaspers und Jacob Burckhardt: Existenz und Existenzbild A. Takahashi: Zur Wechselbeziehung zwischen der Kommunikation in der Geschichte und derjenigen in unserer Zeit bei Jaspers M. Wirtz: Die Regionen des Geistes. Zur interkulturellen Relevanz einer Weltphilosophiegeschichtsschreibung nach Karl Jaspers M. Wischke: Kommunikative Übergänge und Grenzsituationen. Über Schuld und Gedächtnis bei Jaspers. (shrink)

In “Why Forgiving the Unrepentant is not Demeaning or Insulting: A Reply to Nicholas Wolterstorff,” David E. Wright argues against Wolterstorff’s view in Justice in Love that it is wrong or impossible to forgive the unrepentant wrongdoer. In response to Wolterstorff’s claim that it is impossible to forgive the unrepentant, Wright presents the case of Timothy and Hubert, which seems to show that one can forgive the unrepentant and take the wrong seriously. In response to Wolterstorff’s claim that it is (...) not morally permissible to forgive the unrepentant, Wright employs Trudy Govier and Colin Hirano’s invitational model of forgiveness, in which the act of forgiveness serves as the impetus or “invitation” for reconciliation. To illustrate this, Wright presents the case of Timothy and Jake, which seems to show that forgiving the unrepentant can be respectful of both the victim and the wrongdoer. (shrink)