Avant-propos.--Notes: Y a-t-il eu un "avicennisme latin"? Guillaume d'Auvergne témoin de l'"Avicennisme latin." Avicenne et les décrets de 1210 et 1215. Un témoignage de Guillaume d'Auxerre. Un texte d'Albert le Grand. Le cas de Roger Bacon. La date, les sources et la doctrine du "Liber de causis primis et secundis."--Textes: Le "Liber de causis primis et secundis." La fin du "De anima" de Gundissalinus. Tables.

Site‐specific recombination events are of fundamental importance in many biological systems. In vitro experiments using purified proteins and DNA sub‐strates are yielding insights into strand exchange mechanisms and synapsis of recombination sites. By examining results across a range of systems ‐ prokaryotic and eukaryotic ‐ two distinct classes of site‐specific recombinase enzymes can be defined.

Abstract In the present article, we provide a critical overview of the emerging field of ‘neuroeducation’ also frequently referred to as ‘mind, brain and education’ or ‘educational neuroscience’. We describe the growing energy behind linking education and neuroscience in an effort to improve learning and instruction. We explore reasons behind such drives for interdisciplinary research. Reviewing some of the key advances in neuroscientific studies that have come to bear on neuroeducation, we discuss recent evidence on the brain circuits underlying reading, (...) mathematical abilities as well as the potential to use neuroscience to design training programs of neurocognitive functions, such as working memory, that are expected to have effects on overall brain function. Throughout this review we describe how such research can enrich our understanding of the acquisition of academic skills. Furthermore, we discuss the potential for modern brain imaging methods to serve as diagnostic tools as well as measures of the effects of educational interventions. Throughout this discussion, we draw attention to limitations of the available evidence and propose future avenues for research. We also discuss the challenges that face this growing discipline. Specifically, we draw attention to unrealistic expectations for the immediate impact of neuroscience on education, methodological difficulties, and lack of interdisciplinary training, which results in poor communication between educators and neuroscientists. We point out that there should be bi-directional and reciprocal interactions between both disciplines of neuroscience and education, in which research originating from each of these traditions is considered to be compelling in its own right. While there are many obstacles that lie in the way of a productive field of neuroeducation, we contend that there is much reason to be optimistic and that the groundwork has been laid to advance this field in earnest. Content Type Journal Article Category Original Paper Pages 1-13 DOI 10.1007/s12152-011-9119-3 Authors Daniel Ansari, Numerical Cognition Laboratory, Department of Psychology, The University of Western Ontario, Westminster Hall, London, ON N6A 3K7, Canada Bert De Smedt, Parenting and Special Education Research Group, Katholieke Universiteit Leuven, Leuven, Belgium Roland H. Grabner, Institute for Behavioral Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland Journal Neuroethics Online ISSN 1874-5504 Print ISSN 1874-5490. (shrink)

Dementia is highly prevalent and incurable. The participation of dementia patients in clinical research is indispensable if we want to find an effective treatment for dementia. However, one of the primary challenges in dementia research is the patients’ gradual loss of the capacity to consent. Patients with dementia are characterized by the fact that, at an earlier stage of their life, they were able to give their consent to participation in research. Therefore, the phase when patients are still competent to (...) decide offers a valuable opportunity to authorize research, by using an advance research directive. Yet, the use of ARDs as an authorization for research participation remains controversial. In this paper we discuss the role of autonomous decision-making and the protection of incompetent research subjects. We will show why ARDs are a morally defensible basis for the inclusion of this population in biomedical research and that the use of ARDs is compatible with the protection of incompetent research subjects. (shrink)

Theory suggests that stimulus evaluations automatically evoke approach–avoidance behavior. However, the extent to which approach–avoidance behavior is triggered automatically is not yet clear. Furthermore, the nature of automatically triggered approach–avoidance behavior is controversial. We review research on two views on the type of approach–avoidance behavior that is triggered automatically (arm flexion/extension, distance change). Present evidence supports the distance-change view and corroborates the notion of an automatic pathway from evaluation to distance-change behavior. We discuss underlying mechanisms (direct stimulus–response links, outcome anticipations, (...) goals) as well as implications regarding the flexibility of the evaluation–behavior link. (shrink)

Blood service organizations employ various ways to ensure transfusion blood safety, including the testing of all donations for transfusion-transmissible infections (TTI) and the exclusion of donors who are at increased risk of a recent infection. As some TTIs are more common among men who have sex with men (MSM), many jurisdictions (temporarily) defer the donation of blood by sexually active MSM. This boils down to a categorical exclusion of a large group solely on the basis of their sexual orientation, which (...) is seen as unduly discriminatory and stigmatizing. Blood service organizations in the U.K. and the Netherlands have recently changed their deferral policies for MSM. The problem of the MSM deferral involves a conflict between fundamental rights: the right of MSM to equal treatment and the right to health of the recipients of blood and blood products. We distinguish and discuss three broad alternative options to the current categorical deferral of MSM donations: (1) completely abandoning donor selection on the basis of sexual behavior, (2) individual risk assessment of the sexual activities of each potential donor, and (3) individual risk assessment of the sexual activities of MSM only. The new U.K. policy falls within the second category, and the new Dutch policy is in the third category. We argue that each approach comes with moral costs but that the most reasonable option is different from the policies of both the U.K. and the Netherlands. (shrink)

Serious incident investigations—often conducted by means of Root Cause Analysis methodologies—are increasingly seen as platforms to learn from multiple perspectives and experiences: professionals, patients and their families alike. Underlying this principle of inclusiveness is the idea that healthcare staff and service users hold unique and valuable knowledge that can inform learning, as well as the notion that learning is a social process that involves people actively reflecting on shared knowledge. Despite initiatives to facilitate inclusiveness, research shows that embracing and learning (...) from diverse perspectives is difficult. Using the concept of ‘epistemic injustice’, pointing at practices of someone’s knowledge being unjustly disqualified or devalued, we analyze the way incident investigations are organized and executed with the aim to understand why it is difficult to embrace and learn from the multiple perspectives voiced in incident investigations. We draw from 73 semi-structured interviews with healthcare leaders, managers, healthcare professionals, incident investigators and inspectors, document analyses and ethnographic observations. Our analysis identified several structures in the incident investigation process, that can promote or hinder an actor’s epistemic contribution in the process of incident investigations. Rather than repeat calls to ‘involve more’ and ‘listen better’, we encourage policy makers to be mindful of and address the structures that can cause epistemic injustice. This can improve the outcome of incident investigations and can help to do justice to the lived experiences of the involved actors in the aftermath of a serious incident. (shrink)

This article’s aim is to understand if and how the efforts to accumulate and organize clinical data transformed the regulation of pharmaceutical care. The authors analyze how the employment of databases by collectives of physicians and researchers shape both clinical and policy practice—and thereby reshape the relation between clinical work and policy. Since the late 1990s, Dutch government has supported the development of clinical databases for specific expensive medicines to gain oversight about actual medicine use. To be able to produce (...) evidence for appropriate medicine use, the collectives set regulations in clinical practice. These internal regulations provide a framework for establishing “appropriate medicine use”, steering reimbursement decisions. However, internal regulation and policy rules differ in how quickly they can change. While the employment of databases in clinical practices results in a constant adjustment of the protocols, policy makers require the databases to provide for static moments of “proven appropriate medicine use” in order to account for and define a fixed and closed formulary. Subsequently, the employment of the databases did not deliver on the promise of oversight and control due to different clinical and policy requirements. Nevertheless, the databases did stimulate appropriate medicine use and reimbursement in clinical practice. (shrink)

Une approche philosophique de la prière à des fins politiques est possible dans le cas où les deux substantifs sont mis en relais inconditionnel. Le premier élément responsable de cette filature des liens c’est la présence de l’autre. Prier et faire de la politique sont deux activités humaines trop humaines qui exigent l’ouverture à l’autre, pour l’autre comme pour l’édification de sa propre identité individuelle et collective. Comme les rites et les cultes, la liturgie, notamment la prière collective, a un (...) effet thérapeutique, et pédagogique, disons didactique et sociopolitique. Elle calme les esprits, la volonté, apaise l’angoisse et solidifie les liens sociaux. L'Eglise, par exemple, est née du rassemblement du peuple de Dieu en prière et c'est dans son sein que toute célébration liturgique trouve perpétuellement son accomplissement aussi bien que sa régénération dans l’invocation du nom du Christ-Vérité, Rédempteur, Fondateur, Roi et Prêtre. La présente étude sur « Vérité et Royauté » focalise l’attention sur l’essence même du politique qui se nourrit du religieux tout en lui fournissant gloire, pouvoir et moyens d’existence. (shrink)

Au nom d'un "rationalisme économique morbide" une nouvelle colonisation des esprits envahit la planète. Avec ses agences d'évaluation et ses hommes de main, cette "religion du marché" interdit de penser le monde, notre monde, autrement que comme un stock de marchandises ou de produits financiers. Pour réaliser cette nouvelle manière de civiliser les moeurs il fallait faire chuter la valeur de l'expérience et celle du récit - de la parole - qui la transmet. En faisant baisser le cours de la (...) parole au profit de l'information, de sa part la plus technique et mesurable, nous perdons le monde commun, nous perdons notre monde. Et plus encore en Occident, nous nous habituons à lâcher la démocratie pour l'ombre d'une technocratie qui organise insidieusement nos servitudes volontaires. Cet ouvrage invite au retour du politique pour retrouver les conditions sociales et culturelles permettant de penser, de juger et de décider. Cela exige que soit d'abord interrogé le statut du savoir dans la culture, son rapport à l'expérience et aux pratiques sociales. Mais comment retrouver aujourd'hui la dignité de penser dans une culture qui ignore la légitimité du savoir du conte, du rêve, du jeu et de leurs récits? La France qui se lève tôt a-t-elle encore le temps de raconter sa vie, son histoire et ses rêves? (shrink)

Analyse: Contient un chapitre sur Francis Giauque et une évocation de Henri-Frédéric Amiel.

"Il n'y a pas de philosophie de Wittgenstein. Il y a l'histoire d'un homme qui lutta pied à pied contre la folie et le suicide avec pour seules armes la logique et l'éthique. Cet homme, on l'a dépeint tantôt comme un monstre, tantôt comme un saint, tantôt comme un génie, tantôt comme un détraqué sexuel. A Vienne où il a passé sa jeunesse, comme à Cambridge où il a enseigné, il est vite devenu une légende. Les rumeurs les plus extravagantes (...) ont circulé sur son compte : on prétendit même que sa grande oeuvre n'était pas le "Tractacus logico-philosophicus" mais le suicide de son ancien camarade de classe Adolf Hitler et de sa compagne, Eva Braun, dans leur bunker berlinois. Ce qui demeure certain, c'est qu'aucun philosophe n'aura mené avec un tel acharnement son enquête sur "le monde tel qu'il l'a trouvé", ni sur les fins ultimes de l'existence. Dans ce bref essai, R. J. tente "à la manière de Stefan Zweig parlant de Montaigne, de Nietzsche, de Freud, " de cerner la personnalité de Wittgenstein et de faire quelques pas en sa compagnie.". (shrink)