The current global COVID-19 pandemic has led to a deep and multidimensional crisis across all sectors of society. As countries contemplate their mobility and social-distancing policy restrictions, we have a unique opportunity to re-imagine the deliberative frameworks and value priorities in our food systems. Pre-pandemic food systems at global, national, regional and local scales already needed revision to chart a common vision for sustainable and ethical food futures. Re-orientation is also needed by the relevant sciences, traditionally siloed in their disciplines (...) and without adequate attention paid to how the food system problem is variously framed by diverse stakeholders according to their values. From the transdisciplinary perspective of food ethics, we argue that a post-pandemic scheme focused on bottom-up, regional, cross-sectoral and non-partisan deliberation may provide the re-orientation and benchmarks needed for not only more sustainable, but also more ethical food futures. (shrink)

This article presents results from the national survey conducted in 2018 for the project Research Integrity in Norway. A total of 31,206 questionnaires were sent out to Norwegian researchers by e-mail, and 7291 responses were obtained. In this paper, we analyse the survey data to determine attitudes towards and the prevalence of fabrication, falsification and plagiarism and contrast this with attitudes towards and the prevalence of the more questionable research practices surveyed. Our results show a relatively low percentage of self-reported (...) FFPs, while the number of researchers who report having committed one of the QRPs during the last three years reached a troublesome 40%. The article also presents a ranking of the perceived severity of FFP and QRPs among Norwegian researchers. Overall, there is a widespread normative consensus, where FFP is considered more troublesome than QRPs. (shrink)

The Norwegian National Committee for Research Ethics inScience and Technology (NENT), collaborating with The NorwegianFisherman''s Association and The Research Council of Norway,started in 1999 a project aiming at an ethical assessment of Norwegian fisheries for the year 2020. The project was to preparethe ground for ethical debate in and of the fishery sector inview of pending important decisions on long term strategies. Thispaper has its focus on the method used for achieving these aims,rather than the substantive results concerning the fisheries. (...) Amethod was developed for this purpose, called the ethicalscenario process. This included the construction of scenarios forthe future of Norwegian fisheries, using an ethical matrix for evaluating strategies, and organizing a ``value workshop'''' whereparticipants from different stakeholder groups came together todo ethical evaluations. The positive achievements and theshortcomings of this method are discussed in this paper. The useof an ethical matrix was meant to combine a participatory approachwith insights from theoretical ethics. The project revealedinherent tensions between these two objectives. Possible ways ofdealing with this tension are indicated, but in general a goodgrasp of the socio-political context might be the best guardianagainst the possible pitfalls involved in such an approach. (shrink)

Assuming an essential difference between scientific data and phenomena, this paper argues for the view that we have to understand how empirical findings get transformed into scientific phenomena. The work of scientists is seen as largely consisting in constructing these phenomena which are then utilized in more abstract theories. It is claimed that these matters are of importance for discussions of theory choice and progress in science. A case study is presented as a starting point: paleomagnetism and the use of (...) paleomagnetic data in early discussions of continental drift. Some general features of this study are presented in formalized language. It is suggested that the presentation given is particularly suited for a semantic conception of theories. Even though the construction of scientific phenomena is the main topic of this paper, the view presented here is more adapted to realism than social constructivism. (shrink)

The article raises objections to some fundamental assumptions of ?normative naturalism? as put forth by Larry Laudan. It contests the view that matters of rationality are strictly to be separated from matters of (normative) methodology and progress of knowledge. Thus a modified version of what Laudan calls the ?historicist's meta?methodology thesis? is suggested. In particular, it is argued that methodological rules should not initially be taken as elliptical for hypothetical means?end relations. Assuming that they are taken as such, it is (...) argued that naturalized methodology becomes untestable, since methodological rules (norms) turn out to be either vacuous or not lawlike. It is suggested that methodological norms have a status which has much in common with social norms. Instead of starting with methodological instrumentalities, a view of methodology is sketched in which the traditional idea of rational reconstruction is utilized. Yet the history of science may still serve as a major warrant for normative methodological claims. This becomes possible once we accept John Rawls's justificationary strategy of a ?reflective equilibrium?. Finally, it is claimed that Laudan's misconception of methodology is in part due to an inadequate notion of (scientific) progress. (shrink)

R. Laudan and L. Laudan (1989) have put forth a new model intended to solve the problem of disagreement, the problem of consensus, and the problem of innovation in science. In support of this model they cite the history of the acceptance of continental drift, or plate tectonics. In this discussion, I claim that this episode does not constitute an instance of their model. The historical evidence does not support this model. Indeed, closer examination seems to weaken it. I also (...) sketch an alternative model. (shrink)

This article discusses the widespread belief that secrecy in science is increasing—and that secrecy in science is ethically problematic. To what extent should we worry about this alleged development? In an introduction it is observed that there is very little hard empirical evidence supporting the belief of increasing secrecy in science. Evidence seems mostly to be of the anecdotal kind. The “purist ideology” of science, in which openness of research figures prominently as normative basis, is revealed as one-sided with respect (...) to accepted practice. Issues of commercialization of science and patenting are discussed, and it is claimed that what is ethically problematic is less related to secrecy than to more general ethical issues regarding the social consequences of scientific knowledge. On the basis of a particular case, an area of scientific research is introduced for which it is claimed that secrecy does constitute a serious problem. This area has been characterized, by Funtowicz and Ravetz, as “postnormal science!’ It is claimed that postnormal science and regulatory science necessitate new institutional mechanisms inside science to tackle ethical dilemmas. (shrink)

During the fall of 2001 (October 22–25), The Norwegian Radiation Protection Authority (NRPA) and the Agricultural University of Norway arranged a consensus conference on the protection of the environment against ionising radiation. The motive for the conference was the need to study the ethical and philosophical basis for protection of nature in its own right. The conference was funded by Nordic Nuclear Safety Research (NKS), in cooperation with the International Union of Radioecology (IUR). The National Committee for Research Ethics in (...) Science and Technology (NENT) was hired as facilitators for the consensus process. This paper will give a brief outline of the aims and method of the conference, distinguishing these from other kinds of consensus conferences. The paper ends with some general reflections on the appropriateness of seeking consensus on ethics-related issues among experts. (shrink)

In this paper the claim is made that the new turn to ethics brings about a need to develop a toolbox for practical ethics that makes ethical advice amenable to quality assurance and democratic transparency. This is of great importance when ethical advice is given to policy-making bodies. The mechanism of providing ethical advice through the establishment of an ethics committee is discussed. An analysis of what would follow from conceiving of the work of such a committee as an exercise (...) in discourse ethics (just one among several ethical tools). A number of critical questions and criticisms of ethics committees are presented and discussed. The paper argues that much needs to be done to develop a toolbox for practical ethics of science and technology. If efforts in this direction are neglected, one risks basic doubts about the legitimacy of ethical advice and people will come to see ethics as a mere smokescreen or passing fashion. (shrink)

After Second World War public and political decision makers wished to correct the apparent negative consequences of science and technology. This resulted in a call for ethical responsibility in science and technology and a new generation of environmental regimes aimed at controlling or managing the consequences of human interaction with the environment. The claim of this paper is that the Precautionary Principle can be understood as a combination of these trends. The Precautionary Principle is presented and discussed in detail. In (...) particular it is specified a) when the Principle is to be used, b) what measures follow from the decision to use it, and c) who is to be consulted in democratic decisions of the use of the Principle. (shrink)

In the traditional conception of science one assumes that science produces results which are certain and precise. It is argued that this picture is flawed and needs to be replaced with a view where uncertainty and imprecision are an integral part of the scientific enterprise. Uncertainty is still poorly understood by many practising scientists. However, several developments in science indicate that some epistemological uncertainty, e.g. due to processes of abstraction and idealization, will always follow advances in scientific knowledge. There are (...) also other developments that indicate some principal ontological uncertainties, i.e. uncertainties that are due to how the world is. Complexity is one such example. Remarks on post-normal science are thus included. This paper argues, therefore, that scientific uncertainty is a multi-dimensional concept, and that it is unavoidable because it is often the result as much as the cause of new knowledge. (shrink)

The Ethical Matrix was developed to help decision-makers explore the ethical issues raised by agri-food biotechnologies. Over the decade since its inception the Ethical Matrix has been used by a number of organizations and the philosophical basis of the framework has been discussed and analyzed extensively. The role of tools such as the Ethical Matrix in public policy decision-making has received increasing attention. In order to further develop the methodological aspects of the Ethical Matrix method, work was carried out to (...) study the potential role of the Ethical Matrix as a decision support framework. When considering which frameworks to apply when analyzing the ethical dimensions of the application of agri-food biotechnologies, it is important to clarify the substantive nature of any prospective framework. In order to further investigate this issue, reflections on the neologism “ethical soundness” of an ethical framework are presented here. This concept is introduced in order to provide more structured evaluations of a range of ethical tools, including ethical frameworks such as the Ethical Matrix. As well as examining the philosophical dimensions of the method, theoretical analysis and literature studies were combined with stakeholder engagement exercises and consultations in order to review the Ethical Matrix from a user perspective. This work resulted in the development of an Ethical Matrix Manual, which is intended to act as a guide for potential user groups. (shrink)

Die philosophische Diskussion des Begriffes wissenschaftlicher Fortschritt hat sich als schwieriger erwiesen, als es die Philosophen der ersten Hälfte unseres Jahrhunderts sich noch vorgestellt haben. Spätestens seit den Arbeiten Thomas Kuhns ist hierzu eine lebhafte Diskussion entbrannt. Die vorliegende Studie schlägt ein grundsätzliches Neudenken zu diesem Thema vor. Neuere Beiträge, wie der Falsifikationismus, Strukturalismus, Naturalismus und Realismus werden kritisch diskutiert. Es wird dann versucht, der realen Wissenschaftsgeschichte angepasst einen neuen Ausgangspunkt für wissenschaftstheoretisches Denken zu erarbeiten. Eine ausführliche Untersuchung der Geschichte (...) der Kontinentalverschiebung und Plattentektonik bildet den Ausgangspunkt für eine neue Konzeption wissenschaftlicher Erfahrung und Theoriebildung. Der Autor argumentiert für die Position des kritischen Realismus, behauptet die Unabhängigkeit empirischen Fortschritts in der Wissenschaft und ersetzt die Dichotomie Theorie-Erfahrung durch die Trichotomie Theorie-Phänomen-Erfahrung. (shrink)

We argue for a foundational epistemic claim and a hypothesis about the production and uses of mathematical epidemiological models, exploring the consequences for our political and socio-economic lives. First, in order to make the best use of scientific models, we need to understand why models are not truly representational of our world, but are already pitched towards various uses. Second, we need to understand the implicit power relations in numbers and models in public policy, and, thus, the implications for good (...) governance if numbers and models are used as the exclusive drivers of decision making. (shrink)

The paper starts with the assumption that the Precautionary Principle (PP) is one of the most important elements of the concept of sustainability. It is noted that PP has entered international treaties and national law. PP is widely referred to as a central principle of environmental policy. However, the precise content of PP remains largely unclear. In particular it seems unclear how PP relates to science. In section 2 of the paper a general overview of some historical and systematic features (...) of PP are presented. In section 3 a specific case is discussed in greater detail. It is claimed that the escape of farmed salmon from fish cages in the Sea, and its eventual invasion of the breeding places of the wild salmon up the rivers, must be regarded a proper case for applying PP. Yet there is no single PP-strategy. Instead, four different strategies are presented, and all of them can be regarded precautionary strategies in the light of PP. The choice between these strategies is based upon personal values. In section 4 of the paper a general analysis is given which relates these different value perspectives to basic differences in risk aversion, which in turn are related to differing conceptions of nature and/or society. In the concluding section 5 some general consequences of the foregoing analysis are outlined. (shrink)

This document presents the Bonn PRINTEGER Consensus Statement: Working with Research Integrity—Guidance for research performing organisations. The aim of the statement is to complement existing instruments by focusing specifically on institutional responsibilities for strengthening integrity. It takes into account the daily challenges and organisational contexts of most researchers. The statement intends to make research integrity challenges recognisable from the work-floor perspective, providing concrete advice on organisational measures to strengthen integrity. The statement, which was concluded February 7th 2018, provides guidance on (...) the following key issues: § 1. Providing information about research integrity§ 2. Providing education, training and mentoring§ 3. Strengthening a research integrity culture§ 4. Facilitating open dialogue§ 5. Wise incentive management§ 6. Implementing quality assurance procedures§ 7. Improving the work environment and work satisfaction§ 8. Increasing transparency of misconduct cases§ 9. Opening up research§ 10. Implementing safe and effective whistle-blowing channels§ 11. Protecting the alleged perpetrators§ 12. Establishing a research integrity committee and appointing an ombudsperson§ 13. Making explicit the applicable standards for research integrity. (shrink)

This document presents the Bonn PRINTEGER Consensus Statement: Working with Research Integrity—Guidance for research performing organisations. The aim of the statement is to complement existing instruments by focusing specifically on institutional responsibilities for strengthening integrity. It takes into account the daily challenges and organisational contexts of most researchers. The statement intends to make research integrity challenges recognisable from the work-floor perspective, providing concrete advice on organisational measures to strengthen integrity. The statement, which was concluded February 7th 2018, provides guidance on (...) the following key issues: § 1.Providing information about research integrity § 2.Providing education, training and mentoring § 3.Strengthening a research integrity culture § 4.Facilitating open dialogue § 5.Wise incentive management § 6.Implementing quality assurance procedures § 7.Improving the work environment and work satisfaction § 8.Increasing transparency of misconduct cases § 9.Opening up research § 10.Implementing safe and effective whistle-blowing channels § 11.Protecting the alleged perpetrators § 12.Establishing a research integrity committee and appointing an ombudsperson § 13.Making explicit the applicable standards for research integrity. (shrink)

A number of EU institutions and government committees across Europe have expressed interest in developing methods and decision-support tools to facilitate consideration of the ethical dimensions of biotechnology assessment. As part of the work conducted in the EC supported project on ethical tools (Ethical Bio-TA Tools), a number of ethical frameworks with the potential to support the work of public policy decision-makers has been characterized and evaluated. One of these potential tools is the Delphi method. The Delphi method was originally (...) developed to assess variables that are intangible and/or shrouded in uncertainty by drawing on the knowledge and abilities of a diverse group of experts through a form of anonymous and iterative consultation. The method has hitherto been used by a diversity of practitioners to explore issues such as technology assessment, environmental planning, and public health measures. From the original (classical) Delphi, a family of Delphi-related processes has emerged. As a result of the evaluation of the various Delphi processes, it is proposed that the classical method can be further developed and applied as a form of ethical framework to assist policy-makers. Through a series of exercises and trials, an Ethical Delphi has been developed as a potential approach for characterizing ethical issues raised by the use of novel biotechnologies. Advantages and disadvantages of the method are discussed. Further work is needed to develop the procedural aspects of the Ethical Delphi method and to test its use in different cultural contexts. However, utilizing an ethical framework of this type combines the advantages of a methodical approach to capture ethical aspects with the democratic virtues of transparency and openness to criticism. Ethical frameworks such as the Ethical Delphi should contribute to better understanding of and decision-making on issues that involve decisive ethical dimensions. (shrink)

Philons Biographie Abrahams ist eine Werbeschrift fur das Judentum. Sie entstand vermutlich als literarisches Begleitprojekt zu Philons politischer Mission in Rom: In Alexandria waren Ausschreitungen gegen die judische Bevolkerung erfolgt, die Philon bei Kaiser Caligula zur Sprache bringen sollte. Der vorliegende Band fuhrt in diesen zeitgeschichtlichen Kontext ein und bietet den mit Anmerkungen versehenen Text der Schrift samt einer Neuubersetzung. Erlauternde Essays aus unterschiedlichen Fachperspektiven wurdigen Philon als Biograph und als Philosoph, ergrunden sein Tugendverstandnis und sein Frauenbild und beleuchten (...) sein Schriftverstandnis aus der Perspektive des antiken Orakelwesens. Abgerundet wird der Band durch einen Ausblick auf die Rezeption Abrahams im Islam, bei der sich bemerkenswerte Parallelen zu Philons allegorischen Auslegungen wiederfinden lassen. (shrink)

Der dritte Band behandelt die ausseren Umstande, unter denen die platonischen Philosophen im 2. und 3. Jh. n. Chr. lebten, insbesondere ihre Forderung durch Stadte und Kaiser, offentliche Ehrungen, das Urteil Aussenstehender uber sie, den Ruckgang der Philosophie im 3. Jh. n. Chr.; daruber hinaus wird die Beschaftigung mit den Schriften Platons dargestellt: Kommentare zu den Dialogen Platons, Gesamtdarstellungen der Lehre Platons, Monographien zu wichtigen Streitfragen, Platonlexika.

In this paper I inquire into Bogen and Woodward’s data/phenomena distinction, which in a similar way to Cartwright’s construal of the model of superconductivity —although in a different domain—argues for a ‘bottom-up’ construction of phenomena from data without the involvement of theory. I criticise Bogen and Woodward’s account by analysing their melting point of lead example in depth, which is usually cited in the literature to illustrate the data/phenomenon distinction. Yet, the main focus of this paper lies on Matthias (...) Kaiser’s case study of the plate tectonic revolution, the most extensive case study that has been put forth to support the bottom-up construction of phenomena. On the basis of new historical evidence, which has been overlooked not only by Kaiser but also by the entire historical literature on the plate tectonic revolution, I demonstrate that phenomena are not constructed from the bottom-up but rather, admittedly counter-intuitively, from the top-down.Keywords: Data; Phenomena; Bottom-up; Theory-ladenness; Plate tectonic revolution. (shrink)

Contents: PART 1. MODELS IN SCIENTIFIC PROCESSES. Joseph AGASSI: Why there is no theory of models. Ma??l??gorzata CZARNOCKA: Models and symbolic nature of knowledge. Adam GROBLER: The representational and the non-representational in models of scientific theories. Stephan HARTMANN: Models as a tool for the theory construction; some strategies of preliminary physics. William HERFEL: Nonlinear dynamical models as concrete construction. Elzbieta KA??L??USZY??N??SKA: Styles of thinking. Stathis PSILLOS: The cognitive interplay between theories and models: the case of 19th century optics. PART 2. (...) TOOLS OF SCIENCE. Nancy D. CARTWRIGHT, Towfic SHOMAR, Maricio SUAREZ: The tool-box of science. Javier ECHEVERRIA: The four contexts of scientific activity. Katline HAVAS: Continuity and change; kinds of negation in scientific progress. Matthias KAISER: The independence of scientific phenomena. W??l??adys??l??aw KRAJEWSKI: Scientific meta-philosophy. Ilkka NIINILUOTO: The emergence if scientific specialities: six models. Leszek NOWAK: Antirealism, realism and idealization. Rinat M. NUGAYEV: Classic, modern and postmodern scientific unification. Veikko RANTALA: Translation and scientific change. Gerhard SCHURZ: Theories and their applications - a case of nonmonotonic reasoning. Witold STRAWI??N??SKI: The unity of science today. Vardan TOROSIAN: Are the ethic and logic of science compatible. PART 3. UNSHARP APPROACHES IN SCIENCE. Ernest W. ADAMS: Problems and prospects in a theory of inexact first-order theories. Wolfgang BALZER and Gerhard ZOUBEK: On the comparison of approximative empirical claims. Gianpierro CATTANEO, Maria Luisa DALLA CHIARA, Roberto GIUNTINI: The unsharp approaches to quantum theory. Theo A.F. KUIPERS: Falsification versus efficient truth approximation. Bernhard LAUTH: Limiting decidability and probability. Jaros??l??aw PYKACZ: Many-valued logics in foundations of quantum mechanics. Roman R. ZAPATRIN: Logico-algebraic approach to spacetime quantization. (shrink)

Making good decisions in extremely complex and difficult processes and situations has always been both a key task as well as a challenge in the clinic and has led to a large amount of clinical, legal and ethical routines, protocols and reflections in order to guarantee fair, participatory and up-to-date pathways for clinical decision-making. Nevertheless, the complexity of processes and physical phenomena, time as well as economic constraints and not least further endeavours as well as achievements in medicine and healthcare (...) continuously raise the need to evaluate and to improve clinical decision-making. This article scrutinises if and how clinical decision-making processes are challenged by the rise of so-called artificial intelligence-driven decision support systems (AI-DSS). In a first step, this article analyses how the rise of AI-DSS will affect and transform the modes of interaction between different agents in the clinic. In a second step, we point out how these changing modes of interaction also imply shifts in the conditions of trustworthiness, epistemic challenges regarding transparency, the underlying normative concepts of agency and its embedding into concrete contexts of deployment and, finally, the consequences for (possible) ascriptions of responsibility. Third, we draw first conclusions for further steps regarding a ‘meaningful human control’ of clinical AI-DSS. (shrink)

Defined narrowly, epistemology is the study of knowledge and justified belief. As the study of knowledge, epistemology is concerned with the following questions: What are the necessary and sufficient conditions of knowledge? What are its sources? What is its structure, and what are its limits? As the study of justified belief, epistemology aims to answer questions such as: How we are to understand the concept of justification? What makes justified beliefs justified? Is justification internal or external to one's own mind? (...) Understood more broadly, epistemology is about issues having to do with the creation and dissemination of knowledge in particular areas of inquiry. This article will provide a systematic overview of the problems that the questions above raise and focus in some depth on issues relating to the structure and the limits of knowledge and justification. (shrink)

Epistemic deontology is the view that the concept of epistemic justification is deontological: a justified belief is, by definition, an epistemically permissible belief. I defend this view against the argument from doxastic involuntarism, according to which our doxastic attitudes are not under our voluntary control, and thus are not proper objects for deontological evaluation. I argue that, in order to assess this argument, we must distinguish between a compatibilist and a libertarian construal of the concept of voluntary control. If we (...) endorse a compatibilist construal, it turns out that we enjoy voluntary control over our doxastic attitudes after all. If, on the other hand, we endorse a libertarian construal, the result is that, for our doxastic attitudes to be suitable objects of deontological evaluation, they need not be under our voluntary control. (shrink)

This book explores the future of critique in view of our planetary condition. How are we to intervene in contemporary constellations of finance capitalism, climate change and neoliberalism?

Der Zeuge spielt eine zentrale Rolle in den Szenarien der Wahrheitsfindung und in Kontexten der Verhandlung und Verwaltung von Erkenntnis und Wissen. Gleichzeitig gilt, dass ein mittels Zeugenschaft generiertes Wissen immer einen umstrittenen Status hatte - und hat. Das Zeugnis bedarf stets einer Akkreditierung durch den oder die Empfänger, um Geltung erlangen zu können. In diesem Band werden verschiedene Typen und Formen des testimonialen Wissens diskutiert, kulturhistorische und systematische Perspektiven zusammengeführt und in ihren Verflechtungen zwischen epistemischem Wert und ethischer, politischer, (...) sozialer, künstlerischer und religiöser Bedeutung beleuchtet. Im Fokus stehen dabei vor allem die Praktiken und Handlungsszenarien der Bezeugung, da sich in ihren Konstellationen und Dynamiken die Frage der Glaubwürdigkeit des Zeugnisses und die Optionen zur Etablierung eines Zeugenwissens entscheiden.--Backcover. (shrink)

When I take a sip from the coffee in my cup, I can taste that it is sweet. When I hold the cup with my hands, I can feel that it is hot. Why does the experience of feeling that the cup is hot give me justification for believing that the cup is hot?And why does the experience of tasting that the coffee is sweet give me justification for believing that the coffee is sweet?In general terms: Why is it that (...) a sense experience that P is a source of justification—a reason—for believing that P? Call this the Question. I will discuss various answers to the Question, and defend the one I myself favor. (shrink)

European Journal of Philosophy, EarlyView.

We used Chinese prenominal relative clauses to test the predictions of two competing accounts of sentence comprehension difficulty: the experience-based account of Levy () and the Dependency Locality Theory. Given that in Chinese RCs, a classifier and/or a passive marker BEI can be added to the sentence-initial position, we manipulated the presence/absence of classifiers and the presence/absence of BEI, such that BEI sentences were passivized subject-extracted RCs, and no-BEI sentences were standard object-extracted RCs. We conducted two self-paced reading experiments, using (...) the same critical stimuli but somewhat different filler items. Reading time patterns from both experiments showed facilitative effects of BEI within and beyond RC regions, and delayed facilitative effects of classifiers, suggesting that cues that occur before a clear signal of an upcoming RC can help Chinese comprehenders to anticipate RC structures. The data patterns are not predicted by the DLT, but they are consistent with the predictions of experience-based theories. (shrink)

Rational drug design is a method for developing new pharmaceuticals that typically involves the elucidation of fundamental physiological mechanisms. It thus combines the quest for a scientific understanding of natural phenomena with the design of useful technology and hence integrates epistemic and practical aims of research and development. Case studies of the rational design of the cardiovascular drugs propranolol, captopril and losartan provide insights into characteristics and conditions of this integration. Rational drug design became possible in the 1950s when theoretical (...) knowledge of drug-target interaction and experimental drug testing could interlock in cycles of mutual advancement. The integration does not, however, diminish the importance of basic research for pharmaceutical development. Rather, it can be shown that still in the 1990s, linear processes of innovation and the close combination of practical and epistemic work were interdependent. (shrink)