Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

Although undergraduate students are exposed to ethical issues through class assignments, discussions, and readings, they typically do not have first hand experience with business dilemmas. Student opinions on ethical standards and behavior in American business have received scant attention in the literature. The purpose of the study is to provide additional information to both educators and organizations about the ethical perceptions of students. Furthermore, the study contrasts student responses to business and community leaders' responses obtained in a prior study conducted (...) by Touche Ross (1988). The findings from this study are based on an opinion survey about ethics in American business, completed by 476 liberal arts and business students attending a private, religiously affiliated college in New York State. The data indicate numerous differences in perceptions between students and business and community leaders. Differences were also found when students were classified by school (Arts & Science versus Business) and by gender. Overall, students appear to place a strong value on education. Students are the source of new entrants to the business world and the foundation for ethical structures being built by organizations. The findings from this study should assist both educators and employers in the development of necessary programs to maximize the ethical potential of their constituents. (shrink)

It is an experimental fact that \ -decays produce in a cloud chamber at most one track and that this track points in a random direction. This seems to contradict the description of decay in Quantum Mechanics: according to Gamow a spherical wave is produced and moves radially according to Schrödinger’s equation. It is as if the interaction with the supersaturated vapor turned the wave into a particle. The aim of this note is to place this effect in the context (...) of Schrödinger’s Quantum Mechanics. We shall see that the properties of the initial wave function suggest the introduction of a semiclassical formalism in which the \ -wave can be described as a collection of semiclassical wavelets; each of them interacts with an atom and forms an entangled state. The interaction can be regarded as a semiclassical inelastic scattering event. The measurement selects the wave function of one of the ions, with a probability given by Born’s rule. This ion interacts with the atoms nearby leading to the formation of a droplet. One can reasonably assume that also the wavelet entangled with the selected ion has probability one to remain as part of the description of the system. The measurement process is therefore represented by a unitary operator. The wavelet remains sharply localized on a classical path \ It is still a probability wave: it determines the probability that another atom be ionized. This probability is essentially zero unless the atom lies on \ . This gives the visible track. (shrink)

Il presente articolo ha come proprio oggetto specifico di indagine la questione dell’allattamento del bambino. L’autore si propone, più specificatamente, di sottolineare i vantaggi dell’allattamento naturale. Questi non si limitano a dei vantaggi per la salute del bambino, ma hanno anche una ricaduta psicologica sul rapporto madre-bambino.