During immune responses against invading pathogenic bacteria, the cytoskeleton network enables macrophages to implement multiple essential functions. To protect the host from infection, macrophages initially polarize to adopt different phenotypes in response to distinct signals from the microenvironment. The extracellular stimulus regulates the rearrangement of the cytoskeleton, thereby altering the morphology and migratory properties of macrophages. Subsequently, macrophages degrade the extracellular matrix (ECM) and migrate toward the sites of infection to directly contact invading pathogens, during which the involvement of cytoskeleton‐based (...) structures such as podosomes and lamellipodia is indispensable. Ultimately, macrophages execute the function of phagocytosis to engulf and eliminate the invading pathogens. Phagocytosis is a complex process that requires the cooperation of cytoskeleton‐enriched super‐structures, such as filopodia, lamellipodia, and phagocytic cup. This review presents an overview of cytoskeletal regulations in macrophage polarization, ECM degradation, migration, and phagocytosis, highlighting the pivotal role of the cytoskeleton in host defense against infection. (shrink)

Background Relational autonomy is an alternative concept of autonomy in which an individual is recognized as embedded into society and influenced by relational factors. Social context, including social location, political structure, and social forces, significantly influence an agent to develop and exercise autonomy skills. The relational approach has been applied in clinical practice to identify relational factors impacting patient autonomy and decision-making, yet there is a knowledge gap in how these factors influence the demonstration of relational autonomy in the context (...) of medical decisions of adults. Objective The present study targeted the existing knowledge of what and how relational factors impact individuals making medical decisions using the theoretical framework of relational autonomy. Methods A meta-synthesis study was utilized. Four electronic databases, including Embase, OVID Medline, CINAHL, and PubMed, were searched, along with gray literature and reference lists, to identify relevant studies. Results 23 studies reporting 21 qualitative and two mixed-method studies were reviewed. Four themes emerged from the qualitative findings: (1) supportive relationships facilitate an individual’s relational autonomy; (2) obtaining comprehensive information from broader sources helps individuals exercise relational autonomy; (3) undue family pressure impedes the exercising of patient relational autonomy; and (4) healthcare providers’ dominant voice hampers the demonstration of relational autonomy. Conclusions Applying relational autonomy to assist adults in making well-considered decisions is essential. The meta-synthesis suggests establishing a supportive relationship between individuals, healthcare providers, and family. A supportive relationship will allow healthcare providers to make judgments in line with an individual’s values and wishes with the aim of promoting relational autonomy. Advance care planning was proposed as the effective solution to obtain a consensus between individuals and their families while respecting an individual’s values and preferences. Furthermore, it is considered crucial for healthcare providers to appreciate an individual's values and incorporate their preferences into recommendations. (shrink)

ObjectiveRetinal vein occlusion (RVO) is the second most common retinal vascular disorder after diabetic retinopathy, which is the main cause of vision loss. Retinal vein occlusion might lead to macular edema, causing severe vision loss. Previous neuroimaging studies of patients with RVO demonstrated that RVO was accompanied by cerebral changes, and was related to stroke. The purpose of the study is to investigate synchronous neural activity changes in patients with RVO.MethodsA total of 50 patients with RVO and 48 healthy subjects (...) with matched sex, age, and education were enrolled in the study. The ReHo method was applied to investigate synchronous neural activity changes in patients with RVO.ResultsCompared with HC, patients with RVO showed increased ReHo values in the bilateral cerebellum_4_5. On the contrary, patients with RVO had decreased ReHo values in the bilateral middle occipital gyrus, right cerebelum_crus1, and right inferior temporal gyrus.ConclusionOur study demonstrated that patients with RVO were associated with abnormal synchronous neural activities in the cerebellum, middle occipital gyrus, and inferior temporal gyrus. These findings shed new insight into neural mechanisms of vision loss in patients with RVO. (shrink)

ObjectiveThis study used a moderated mediation model to test the mediating effect of anxiety on the relationship between negative perfectionism and sleep quality and the moderating effect of COVID-19 epidemic risk perception during the COVID-19 pandemic in Chinese international students.Materials and methodsA sample of 239 Chinese international students from the south of China, was surveyed with the Negative and Positive Perfectionism Scale, the Pittsburgh Sleep Quality Index, the General Anxiety Disorder Scale, and the COVID-19 Epidemic Risk Perception Inventory. Version 23.0 (...) of SPSS and version 3.4 of PROCESS were used to perform the correlation analyses, mediation analysis, and moderated mediation analysis.Results Negative perfectionism was significantly correlated with anxiety and poor sleep quality. Anxiety was significantly correlated with poor sleep quality. The mediating effect test showed that anxiety had a mediating effect between negative perfectionism and poor sleep quality. Epidemic risk perception moderated the mediating effect of anxiety between negative perfectionism and poor sleep quality.ConclusionNegative perfectionism affected sleep quality indirectly through anxiety. In particular, COVID-19 epidemic risk perception moderated the relationship between anxiety and sleep quality, such that the association was stronger when the COVID-19 epidemic risk perception was high. These results provide a more comprehensive understanding of the negative link between negative perfectionism and poor sleep quality. (shrink)

本书主要介绍新兴学科精神文明学初创的时代背景、直接起因、历程和成果,阐述新兴学科在理论上触及的本体层次,内部结构,创建活动等内容。.

探索山水美与人类社会中各种物质文明和精神文明的关系,山水美学内外双方各种错综复杂的关系和规律等。.

本书分为理论探索、个案解读、研究生审美文化论坛三部分。收录的文章有:《文艺美学新形态——审美文化研究及其人文品位》、《略谈当代审美文化的“审美”内涵》、《论审美活动的学术定位——从“社会个体生成论”看 美学的研究对象》、《论审美抽象》等。.

潘知常(1956~ ),湖南醴陵人,南京大学企业形象研究中心主任、教授,中国文艺理论学会理事,中华美学学会青年学术委员会副主任.

本书从词源学的视角研究了现代性、后现代、现代性科学和后现代科学等概念的本真语义和众多大师的注解,并参照这种历史性思想提出了独特的诠释;透过科学巨匠们的思想过程,挖掘其中的形上基础、方法准则和价值指向.

本书从美学的历史与学科定位、美学的研究对象与研究方法、审美现象与美的本质、美的形态、美学理论形态、中国美学研究的现状与希望六个方面进行美学的反思性研究。.

本书对犯罪学中的诸多美学问题做全面分析,为预防犯罪和改造罪犯提供新思路和运作的实践。.

本书选择并论述的美育范畴,较全面的反映了美育现代性。包括现代美育、审美个性、时间与空间、功利超越与文化超越等内容。.

本書通過選取「自然」、「靜」、「靈」、「適」、「化」等主體審美心境范疇為研究的切入點，結合中國審美心境歷史發展的脈絡，厘清范疇內涵，同時兼與其他相關范疇比較，揭示各范疇間的內在邏輯聯系，從而探討其中蘊 含着的我們民族獨特的審美思維方式、心靈境界和修養方法等。主體審美心境范疇的研究，不僅在中國美學和文論范疇研究上有重要意義（因為除個別主體論范疇已有人作過研究外，整體性的理論觀照還相當薄弱），而且對西方 當代藝術及理論的發展，以及現代人性心靈的建構，也具有相當的參考價值。.

本书通过一些困扰当代美学的难题的指引，以揭示宗白华美学思想的内在矛盾，从而深层次地思考“中国美学”的困境。.

本书采用人类学视野，直面本土现实，依循新人文学科的建设路径，在中西当代学术思想的碰撞和融会中，对于马克思主义文艺理论的中国范式、民族艺术与文明冲突、美学意识形态、中国当代悲剧问题、人文精神建设、全球化 与文化多样性、地方性审美经验与认同危机、民族审美经验等重要理论问题做了深沉的思考。.

本書通過對當代中國美學思想形態轉變過程的歷時性掃描，指出當代中國美學一方面在努力克服先前美學思想弊端，另一方面又不可避免地對美產生新的誤解，把美要麼等同於認識，要麼看作實踐活動，甚至認為美是人的全部生 命的最高表現形式，出現了遮蔽美、懸置美和放大美的“非美化”現象。康得以先驗批判的方式檢視了人類的認識原則、倫理原則和情感原則，揭示出美與認識、美與道德之間的複雜關係，為美劃邊定界，成為後來西方美學的規 範與方向。.

本书为一部当代作家系统论述玄学及在玄学理论影响下形成的中国传统文艺思想和美学思想的理论专著。.

本书对西方的审美范式演变作了一个比较深入具体和系统的研究,包括从古典范式到浪漫范式,以及从浪漫范式到现代范式的演变。.

本书以中国文艺审美的民族心理特征与哲学思维向度为基点, 对中国古典文艺美学的"表现"范型进行"扫描", 在"表现"层面对中国古典文艺美学进行新的探索, 彰显了中国古典文艺美学与西方古典文艺美学不同的美学趣味, 并进而探索了中国文艺理论古为今用个有效途径.