This article provides a conversation analytic description of a previously unstudied conversational action: ‘articulating the unsaid’ via and-prefaced formulations of other people’s talk. Contributing to the extant research on formulations and on interactional functions of discourse markers, the article shows that and-prefaced formulations accomplish a distinct conversational action that has the following features: these formulations are assertions about the addressee’s domain of knowledge that perform a repair operation in the form of a request for confirmation; they articulate a ‘missing’ element (...) of the addressee’s preceding talk ; what is being formulated is claimably inferable from the prior talk; moreover, such formulations extend the addressee’s course of action on his/her behalf. The article describes compositional and sequential features of and-prefaced formulations and how they shape interactional trajectories of in-progress courses of action. (shrink)

It has become apparent that difficulties to replicate telomeres concern not only the very ends of eukaryotic chromosomes. The challenges already start when the replication fork enters the telomeric repeats. The obstacles encountered consist mainly of noncanonical nucleic acid structures that interfere with replication if not resolved. Replication stress at telomeres promotes the formation of so‐called fragile telomeres displaying an abnormal appearance in metaphase chromosomes though their exact molecular nature remains to be elucidated. A substantial number of factors is required (...) to counteract fragility. In this review we promote the hypothesis that telomere fragility is not caused directly by an initial insult during replication but it results as a secondary consequence of DNA repair of damaged replication forks by the homologous DNA recombination machinery. Incomplete DNA synthesis at repair sites or partial chromatin condensation may become apparent as telomere fragility. Fragility and DNA repair during telomere replication emerges as a common phenomenon which exacerbates in multiple disease conditions. (shrink)

Through an examination of the bacteria that produce the cellulose, an investigation of the growing process and properties, and a discussion of an artistic exploration, one can fully grasp bio cellulose’s potential in becoming a synergist for sustainable fashion. This new creative and radical approach re-imagines the future materials for fashion and other fields requiring textile applications that are grown and renewable. Questions how textile can be created to be sustainable, biodegradable and infinitely reusable and mainly what the paradigms for (...) the new aesthetics are. The aim of this article is to convey the need for new biomaterials inspired by nature. (shrink)

This paper discusses some philosophical aspects related to the recent publication of the experimental results of the 2017 black hole experiment, namely the first image of the supermassive black hole at the center of galaxy M87. In this paper I present a philosophical analysis of the 2017 Event Horizon Telescope (EHT) black hole experiment. I first present Hacking’s philosophy of experimentation. Hacking gives his taxonomy of elements of laboratory science and distinguishes a list of elements. I show that the EHT (...) experiment conforms to major elements from Hacking’s list. I then describe with the help of Galison’s Philosophy of the Shadow how the EHT Collaboration created the famous black hole image. Galison outlines three stages for the reconstruction of the black hole image: Socio-Epistemology, Mechanical Objectivity, after which there is an additional SocioEpistemology stage. I subsequently present my own interpretation of the reconstruction of the black hole image and I discuss model fitting to data. I suggest that the main method used by the EHT Collaboration to assure trust in the results of the EHT experiment is what philosophers call the Argument from Coincidence. I show that using this method for the above purpose is problematic. I present two versions of the Argument from Coincidence: Hacking’s Coincidence and Cartwright’s Reproducibility by which I analyse the EHT experiment. The same estimation of the mass of the black hole is reproduced in four different procedures. The EHT Collaboration concludes: the value we have converged upon is robust. I analyse the mass measurements of the black hole with the help of Cartwright’s notion of robustness. I show that the EHT Collaboration construe Coincidence/Reproducibility as Technological Agnosticism and I contrast this interpretation with van Fraassen’s scientific agnosticism. (shrink)

Musks, the foundation of many perfumes, as well as other ingredients of perfumes, were critical objects of study for establishing theoretical concepts about large ring chemical compounds and polymerization in the 1920s and 1930s. Because fragrance chemistry has been underdeveloped in the historiography, doubtless partly because it has become associated with the feminine, this has been ignored in the historiography. This essay highlights the strategic importance of perfume research, looking in particular at the work of Leopold Ružičkač, 1939 Nobel laureate (...) in chemistry who had close ties to the fragrance industry, and Wallace Carothers at DuPont, whose well-known work on polymerization was intimately concerned with large ring compounds, including musk, and which indeed led to DuPont producing a synthetic musk in the 1930s. (shrink)

Summary We offer a novel historical-philosophical framework for discussing experimental practice which we call ‘Generating Experimental Knowledge’. It combines three different perspectives: experimental systems, concept formation, and the pivotal role of error. We then present an historical account of the invention of the Scanning Tunnelling Microscope (STM), or Raster-Tunnelmikroskop, and interpret it within the proposed framework. We show that at the outset of the STM project, Binnig and Rohrer—the inventors of the machine—filed two patent disclosures; the first is dated 22 (...) December 1978 (Switzerland), and the second, two years later, 12 September 1980 (US). By studying closely these patent disclosures, the attempts to realize them, and the subsequent development of the machine, we present, within the framework of generating experimental knowledge, a new account of the invention of the STM. While the realization of the STM was still a long way off, the patent disclosures served as blueprints, marking the changes that had to be introduced on the way from the initial idea to its realization. (shrink)

The paper is based on the original study of Galina Kolomiets named «The conception of music value as a substance and as the way of value interaction between the person and the world» which is presented in the monograph “The music value: philosophical aspect”. The phenomenon of music is considered as the indissoluble unity of its two hypostases – the essence of music (musical substance) and musical skill, which belongs to the person and the world. The basicidea of the (...) author is to show, how the extra-historical essence of music (world harmony, universal rhythm) is connected with the man and the world and what are “the cohesion mechanisms” of musical substance as a form of art. According to the study such mechanisms are: the music value and value in the music, inverted, from one side, to the highest sense, from another - to the senses of human life. (shrink)

The paper is based on the original study of Galina Kolomiets named «The conception of music value as a substance and as the way of value interaction between the person and the world» which is presented in the monograph “The music value: philosophical aspect”. The phenomenon of music is considered as the indissoluble unity of its two hypostases – the essence of music (musical substance) and musical skill, which belongs to the person and the world. The basicidea of the (...) author is to show, how the extra-historical essence of music (world harmony, universal rhythm) is connected with the man and the world and what are “the cohesion mechanisms” of musical substance as a form of art. According to the study such mechanisms are: the music value and value in the music, inverted, from one side, to the highest sense, from another - to the senses of human life. (shrink)

This article provides an empirical demonstration of the saliency of epistemics to two core conversational organizations, turn-taking and repair. To that end, I examine cases in which a participant of a multiparty conversation intervenes into a repair sequence to respond to a repair initiation addressed to the trouble-source speaker, that is, in violation of the turn-taking rules, without having an epistemically grounded entitlement to do so. I show that such interventions enact a range of corrective actions vis-a-vis the repair initiation, (...) such as contesting and correcting assumptions or understandings conveyed by the repair initiation. In providing these corrections ‘out of turn’, the intervening speakers demonstrate their own attentive recipiency or cultural expertise and, at the same time, expose the repair initiator’s interactional faux pas. The analysis demonstrates the procedural consequentiality of epistemic considerations for the interlocutors – and, thus, the necessity to incorporate them into an empirically grounded analysis of their actions. (shrink)

The article presents philosophical views on music in the context of the transformations of the worldview from Antiquity to the Modern Time. In this research author also mentions the contemporary issues, and uses her own philosophical concept of the music, which can be described as following: the value of music as a substance and the way of the valuable interaction of a person with the world affirm the essence of musical being, in which the invariable principle of Harmony, the principle (...) of Chaos-Form movement, is preserved. Music expresses the fluid essence of the world and changes of being in space and time. Philosophy of music as a field of philosophical knowledge considers music from ontological-epistemological and phenomenological-axiological prospectives, as something more than just a form of art. It explores the deep, ultimate foundations of the existence of music as such and the philosophical and aesthetic foundations of musical art. Since ancient times music has been a representation of the world in the human conscience and served as the harmonic equivalent of cosmological philosophy, mathematics, astronomy, and astrophysics. The scientific view on music was enriched in the Modern Time by the expanded view on the cosmo-sound space reflected in musical art, which at the same time transforms the mathematical ideas of geometricity, squareness etc. The tendency to create integral world music in the musical practice of the XX-XXI centuries explains the attempt of mankind to present music by modern methods of composing musical art as an expression of fear towards the secret Harmony of universal existence, and, on the other hand - as a form of search for salvation and mental balance, intuitively reflecting what is happening in natural science, which more and more points to the abyss of unknowable universe, and the unstable place of man in the world. (shrink)

L’article étudie comment les idées de la France des Lumières et de la France révolutionnaire ont contribué au changement de la langue sociopolitique russe, comment elles ont interféré avec le processus littéraire du romantisme en Russie et ont finalement contribué au changement du paradigme intellectuel en Russie dans la deuxième moitié du XIXe siècle. L’histoire des concepts de citoyen, de société, d’opposition politique est retracée de la deuxième moitié du XVIIIe siècle – à travers des documents officiels (Instructions, par Catherine (...) II), des textes littéraires (A. Radichtchev) – jusqu’au premier tiers du XIXe siècle – à travers les écrits politiques des décembristes. En conclusion, il est soutenu que l’échec du républicanisme des décembristes inspiré par la France des Lumières a orienté, dans la deuxième moitié du XIXe siècle, la pensée russe vers la problématique de la diversité humaine et de la nationalisation de l’Empire. Les principes universels du siècle des Lumières sont remplacés par l’intérêt porté à la diversité humaine de l’Empire russe, ce qui nécessitera, à son tour, l’élaboration d’un langage spécifique et de ses concepts. Cependant, ce tournant serait une conséquence du processus de réception des idées et des concepts de la France des Lumières et aurait été accéléré par la Révolution française. (shrink)

The controversial status of goluboi as a basic color term is discussed. Fuzzy logic alone cannot reliably attribute basic status to goluboi. Recent linguistic studies support a single basic blue category. Psychophysical data on color-space distances and color naming are currently ambiguous in this regard. Correspondence:p1 Institut für Arbeitsphysiologie an der Universität Dortmund, 44139 Dortmund, Germany [email protected] www.ifado.de/projekt-06/.

Primary headaches are highly prevalent and represent a major cause of disability in young adults. Neurofeedback is increasingly used in the treatment of chronic pain; however, there are few studies investigating its efficacy in patients with headaches. We report the results of a cross-over sham-controlled study on the efficacy of neurofeedback in the prophylactic treatment of tension-type headache. Participants received ten sessions of infra-low frequency electroencephalographic neurofeedback and ten sessions of sham-neurofeedback, with the order of treatments being randomized. The study (...) also included a basic psychotherapeutic intervention — a psychoeducational session performed before the main study phases and emotional support provided throughout the study period. The headache probability was modeled as a function of the neurofeedback and sham-neurofeedback sessions performed to date. As a result, we revealed a strong beneficial effect of neurofeedback and no influence of the sham sessions. The study supports the prophylactic use of infra-low frequency neurofeedback in patients with TTH. From a methodological point of view, we advocate for the explicit inclusion of psychotherapeutic components in neurofeedback study protocols. (shrink)

This book pieces together the jigsaw puzzle of Einstein's journey to discovering the special theory of relativity. Between 1902 and 1905, Einstein sat in the Patent Office and may have made calculations on old pieces of paper that were once patent drafts. One can imagine Einstein trying to hide from his boss, writing notes on small sheets of paper, and, according to reports, seeing to it that the small sheets of paper on which he was writing would vanish into his (...) desk-drawer as soon as he heard footsteps approaching his door. He probably discarded many pieces of papers and calculations and flung them in the waste paper basket in the Patent Office. The end result was that Einstein published nothing regarding the special theory of relativity prior to 1905. For many years before 1905, he had been intensely concerned with the topic; in fact, he was busily working on the problem for seven or eight years prior to 1905. Unfortunately, there are no surviving notebooks and manuscripts, no notes and papers or other primary sources from this critical period to provide any information about the crucial steps that led Einstein to his great discovery. In May 1905, Henri Poincare sent three letters to Hendrik Lorentz at the same time that Einstein wrote his famous May 1905 letter to Conrad Habicht, promising him four works, of which the fourth one, Relativity, was a rough draft at that point. In the May 1905 letters to Lorentz, Poincare presented the basic equations of his 1905 "Dynamics of the Electron", meaning that, at this point, Poincare and Einstein both had drafts of papers relating to the principle of relativity. The book discusses Einstein's and Poincare's creativity and the process by which their ideas developed. The book also explores the misunderstandings and paradoxes apparent in the theory of relativity, and unravels the subtleties and creativity of Einstein. (shrink)

Tolstoy became acquainted with the works of Henry George as he was writing his treatise “What Then Should We Do?” George’s economic ideas fascinated him so much that he stepped away from the treati...

This article examines the role of medical interpreters in structuring interaction between physicians and their patients. Through a detailed analysis of interpreters' involvement in the history-taking part of medical consultations, it is demonstrated that their participation in this activity is organized by their understanding of its goals rather than by the task of translation alone. Specifically, the different ways in which interpreters participate in history taking display their orientation to obtaining from the patient and conveying to the doctor medically relevant (...) information about the patient's symptoms - and doing so as effectively as possible. Medical interpreters are found to share the physicians' normative orientation to obtaining objectively formulated information about relevant biomedical aspects of patients' conditions. Thus, far from being passive participants in the interaction, interpreters will often pursue issues they believe to be diagnostically relevant, just as they may choose to reject patients' information offerings if they contain subjective accounts of their socio-psychological concerns. (shrink)

The non-academic education as the development of socio-cultural experience that takes place outside the pedagogically organized process is considered in the article. The freedom of human cognitive activity, the expansion of the range of his hobbies, the enrichment of the spiritual world is ensured through a network of institutions of non-academic education. Non-academic education institutions transfer the knowledge and skills necessary in the field of work, which does not belong directly to the scientific content of professional activity. The term “non-academic (...) education” is not yet widespread, it is used mainly by practitioners in the field of solving general problems of education, based on human educational needs. However, the reality it reflects is well known to all, it is learning in the process of daily life. In essence and content, it is the same process of acquiring knowledge and skills, deepening worldview and enriching personal potential, which is in academic education. The difference is that it takes place outside the walls of institutions that are part of the education system. Non-academic education takes place in social institutions that perform other functions in the social division of labor: in the family, in the field of work, in various formal and informal groups and associations. A clear training goal is not necessary. Non-academic education is spontaneous, without time limits, not certified, unlike academic. Non-academic education may have some kind of documentary evidence, albeit of a non-state type. A teacher in academic education is necessarily an employee of an educational institution, and in non-academic education it is an employee, a coach, and a teacher. Training in non-academic education can be carried out on the educational portal through social services, distance learning courses of various organizations, mass open courses. (shrink)

This book focuses on Albert Einstein and his interactions with, and responses to, various scientists, both famous and lesser-known. It takes as its starting point that the discussions between Einstein and other scientists all represented a contribution to the edifice of general relativity and relativistic cosmology. These scientists with whom Einstein implicitly or explicitly interacted form a complicated web of collaboration, which this study explores, focusing on their implicit and explicit responses to Einstein s work. This analysis uncovers latent undercurrents, (...) indiscernible to other approaches to tracking the intellectual pathway of Einstein to his general theory of relativity. The interconnections and interactions presented here reveal the central figures who influenced Einstein during this intellectual period. Despite current approaches to history presupposing that the efforts of scientists such as Max Abraham and Gunnar Nordström, which differed from Einstein s own views, be relegated to the background, this book shows that they all had an impact on the development of Einstein s theories, stressing the limits of approaches focusing solely on Einstein. As such, General Relativity Conflict and Rivalries proves that the general theory of relativity was not developed as a single, coherent construction by an isolated, brooding individual, but, rather, that it came to fruition through Einstein's conflicts and interactions with other scientists, and was consolidated by his creative processes during these exchanges. (shrink)

This article extends prior conversation analytic research on the preference organization of sequence-initiating actions. Across two languages, this article examines one such action: explicitly soliciting an account for human conduct. Prior work demonstrates that this action conveys a challenging stance towards the warrantability of the accountable event/conduct. When addressees are somehow responsible for the accountable event/conduct, explicit solicitations of accounts are frequently critical of, and thus embody disaffiliation with, addressees. This article demonstrates that, when explicit solicitations of accounts embody disaffiliation, (...) they are systematically ‘withheld’ and, thus, can be characterized as ‘dispreferred’ actions. This article also examines: a) deviant cases, where account solicitations are not withheld, which is a practice for embodying aggravated disaffiliation; and b) negative cases, where account solicitations actually embody affiliation, and as such are typically treated as preferred actions and not withheld. (shrink)

Roberto Frega argues for the advancement of workplace democracy theorisation by synergising the conceptual pathways of various disciplines. He places a particular emphasis on the practice of employee involvement, which, according to him, constitutes one of the three pillars of workplace democracy, the other two being voice and representation. The present commentary broadens the interdisciplinary horizons of this debate by reflecting on the central role of accountability in workplace democracy and the workings of the three pillars identified by Frega. The (...) commentary explores the potential of accountability and the insights drawn from critical accounting research to translate democratic ideals into meaningful and sustainable organisational practices and so strengthen workplace democracy. (shrink)

The study examines a problematic hypothesis of possible approaches to identifying the quantum physical foundations of the functioning of consciousness. The authors proceed from the fact that in modern conditions, not a single science, nor all sciences taken together, gives a final answer to the question of the “mechanism” of the origin of thought. However, this does not mean at all that research in this direction needs to be stopped. The authors express confidence that modern and subsequent research into the (...) “quantum concept of consciousness” will lead to the identification of previously unknown patterns, opening the way to the formation of new principles and approaches. As an example, the corresponding Penrose - Hameroff concept is considered. Quantum mechanics complements the tools of neurobiology and other branches of neuroscience, which together form an interdisciplinary field of knowledge that is dynamically growing and developing. The authors are not apologists for the omnipotence of quantum physics. Quantum correlates of consciousness actually mean that it is not today’s quantum mechanics itself that explains the emergence of mental states, but the fact that in the birth of these states it is essential that in the very process of the formation of neurodynamic impulses in the neurons of the cerebral cortex that generate mental states, there are processes of quantum nature. It should also be recognized that the quantum-molecular level (nanolevel) of processes in the neurons of the brain really exists and it is this that is the source of proto-consciousness. Science strives to move forward, new research programs are emerging within the framework of quantum biology, quantum psychology, quantum information science, which in turn can shed light on the hypothesis of the “quantum concept of consciousness.”. (shrink)