Considerable hope surrounds the use of disease‐specific pluripotent stem cells to generate models of human disease allowing exploration of pathological mechanisms and search for new treatments. Disease‐specific human embryonic stem cells were the first to provide a useful source for studying certain disease states. The recent demonstration that human somatic cells, derived from readily accessible tissue such as skin or blood, can be converted to embryonic‐like induced pluripotent stem cells (hiPSCs) has opened new perspectives for modelling and understanding a larger (...) number of human pathologies. In this review, we examine the opportunities and challenges for the use of disease‐specific pluripotent stem cells in disease modelling and drug screening. Progress in these areas will substantially accelerate effective application of disease‐specific human pluripotent stem cells for drug screening. (shrink)

We present the logic K/2 which is a logic with classical implication and only the left part of classical negation.We show that it is possible to define a classical negation into K/2 and that the classical proposition logic K can be translated into this apparently weaker logic.We use concepts from model-theory in order to characterized rigorously this translation and to understand this paradox. Finally we point out that K/2 appears, following Haack's distinction, both as a deviation and an extension of (...) K. (shrink)

This text is an outgrowth of notes prepared by J. Y. Girard for a course at the University of Paris VII. It deals with the mathematical background of the application to computer science of aspects of logic (namely the correspondence between proposition & types). Combined with the conceptual perspectives of Girard's ideas, this sheds light on both the traditional logic material & its prospective applications to computer science. The book covers a very active & exciting research area, & it will (...) be essential reading for all those working in logic & computer science. (shrink)

Many-valued logics are standardly defined by logical matrices. They are truth-functional. In this paper non truth-functional many-valued semantics are presented, in a philosophical and mathematical perspective.

Jean-Yves Béziau Abstract In this paper I relate the story about the new rising of the square of opposition: how I got in touch with it and started to develop new ideas and to organize world congresses on the topic with subsequent publications.

This is a collection of new investigations and discoveries on the theory of opposition (square, hexagon, octagon, polyhedra of opposition) by the best specialists from all over the world. The papers range from historical considerations to new mathematical developments of the theory of opposition including applications to theology, theory of argumentation and metalogic.

of implication and generalization rules have a close relationship, for which there is a key idea for clarifying how they are connected: varying objects. Varying objects trace how generalization rules are used along a demonstration in an axiomatic calculus. Some ways for introducing implication and for generalization are presented here, taking into account some basic properties that calculi can have.

This special issue of Logica Universalis (Springer) deals with the relations between logic and religion, broadly conceived. It contains the following articles: Logic and Religion, by Jean-Yves Beziau and Ricardo Silvestre; Thinking Negation in Early Hinduism and Classical Indian Philosophy, by Purushottama Bilimoria; Karma Theory, Determinism, Fatalism and Freedom of Will, by Ricardo Sousa Silvestre; From Logic in Islam to Islamic Logic, by Musa Akrami; Leibniz’s Ontological Proof of the Existence of God and the Problem of Impossible Objects, (...) by Wolfgang Lenzen; A Logical Analysis of the Anselm’s Unum Argumentum (from Proslogion), by Jean-Pierre Desclés; Monotonic and Non-monotonic Embeddings of Anselm’s Proof, by Jacob Archambault; Computer-Assisted Analysis of the Anderson–Hájek Ontological Controversy, by C. Benzmüller, L. Weber and B. Woltzenlogel Paleo. (shrink)

We present a single sequent calculus common to classical, intuitionistic and linear logics. The main novelty is that classical, intuitionistic and linear logics appear as fragments, i.e. as particular classes of formulas and sequents. For instance, a proof of an intuitionistic formula A may use classical or linear lemmas without any restriction: but after cut-elimination the proof of A is wholly intuitionistic, what is superficially achieved by the subformula property and more deeply by a very careful treatment of structural rules. (...) This approach is radically different from the one that consists in “changing the rule of the game” when we want to change logic, e.g. pass from one style of sequent to another: here, there is only one logic, which—depending on its use—may appear classical, intuitionistic or linear. (shrink)

The hexagon of opposition is an improvement of the square of opposition due to Robert Blanché. After a short presentation of the square and its various interpretations, we discuss two important problems related with the square: the problem of the I-corner and the problem of the O-corner. The meaning of the notion described by the I-corner does not correspond to the name used for it. In the case of the O-corner, the problem is not a wrong-name problem but a no-name (...) problem and it is not clear what is the intuitive notion corresponding to it. We explain then that the triangle of contrariety proposed by different people such as Vasiliev and Jespersen solves these problems, but that we don’t need to reject the square. It can be reconstructed from this triangle of contrariety, by considering a dual triangle of subcontrariety. This is the main idea of Blanché’s hexagon. We then give different examples of hexagons to show how this framework can be useful to conceptual analysis in many different fields such as economy, music, semiotics, identity theory, philosophy, metalogic and the metatheory of the hexagon itself. We finish by discussing the abstract structure of the hexagon and by showing how we can swing from sense to non-sense thinking with the hexagon. (shrink)

Jean-Jacques Rousseau est l'auteur de l'entrée "économie politique" dans l'Encyclopédie en 1755. A ce titre, il aurait pu être l'un des fondateurs de cette discipline. Pourtant, la définition qu'il en donne est à l'encontre de la pensée libérale des physiocrates, puis des classiques, et constitue une véritable "anti-économique". En hypertrophiant le rôle de l'Etat et en niant l'intérêt personnel, Rousseau est au contraire l'un des pères du socialsme. En niant la liberté humaine, il nie aussi l'existence de choix éthiques.

This paper introduces the special issue on Logic and Religion of the journal Logica Universalis (Springer). The issue contains the following articles: Logic and Religion, by Jean-Yves Beziau and Ricardo Silvestre; Thinking Negation in Early Hinduism and Classical Indian Philosophy, by Purushottama Bilimoria; Karma Theory, Determinism, Fatalism and Freedom of Will, by Ricardo Sousa Silvestre; From Logic in Islam to Islamic Logic, by Musa Akrami; Leibniz’s Ontological Proof of the Existence of God and the Problem of Impossible Objects, (...) by Wolfgang Lenzen; A Logical Analysis of the Anselm’s Unum Argumentum (from Proslogion), by Jean-Pierre Desclés; Monotonic and Non-monotonic Embeddings of Anselm’s Proof, by Jacob Archambault; Computer-Assisted Analysis of the Anderson–Hájek Ontological Controversy, by C. Benzmüller, L. Weber and B. Woltzenlogel Paleo. (shrink)

The theory of the square of opposition has been studied for over 2,000 years and has seen a resurgence in new theories and research since the second half of the twentieth century. This volume collects papers presented at the Sixth World Congress on the Square of Opposition, held in Crete in 2018, developing an interdisciplinary exploration of the theory. Chapter authors explore subjects such as Aristotle’s ontological square, logical oppositions in Avicenna’s hypothetical logic, and the power of the square of (...) opposition to solve theological problems regarding predestination and theodicy. Other topics covered include: Hegel’s opposition to diagrams De Morgan’s unpublished octagon of opposition turnstile figures of opposition institutional model-theoretic treatment of oppositions Lacan’s four formulas of sexuation the theory of oppositional poly-simplexes The Exoteric Square of Opposition will appeal to pure logicians, historians of logic, semioticians, philosophers, theologians, mathematicians, and psychoanalysts. (shrink)

Dans un texte désormais célèbre, Ferdinand de Saussure insiste sur l’arbitraire du signe dont il vante les qualités. Toutefois il s’avère que le symbole, signe non arbitraire, dans la mesure où il existe un rapport entre ce qui représente et ce qui est représenté, joue un rôle fondamental dans la plupart des activités humaines, qu’elles soient scientifiques, artistiques ou religieuses. C’est cette dimension symbolique, sa portée, son fonctionnement et sa signification dans des domaines aussi variés que la chimie, la théologie, (...) les mathématiques, le code de la route et bien d’autres qui est l’objet du livre La Pointure du symbole. -/- Jean-Yves Béziau, franco-suisse, est docteur en logique mathématique et docteur en philosophie. Il a poursuivi des recherches en France, au Brésil, en Suisse, aux États-Unis (UCLA et Stanford), en Pologne et développé la logique universelle. Éditeur-en-chef de la revue Logica Universalis et de la collection Studies in Universal Logic (Springer), il est actuellement professeur à l’Université Fédérale de Rio de Janeiro et membre de l’Académie brésilienne de Philosophie. SOMMAIRE -/- PRÉFACE L’arbitraire du signe face à la puissance du symbole Jean-Yves BÉZIAU La logique et la théorie de la notation (sémiotique) de Peirce (Traduit de l’anglais par Jean-Marie Chevalier) Irving H. ANELLIS Langage symbolique de Genèse 2-3 Lytta BASSET -/- Mécanique quantique : quelle réalité derrière les symboles ? Hans BECK -/- Quels langages et images pour représenter le corps humain ? Sarah CARVALLO Des jeux symboliques aux rituels collectifs. Quelques apports de la psychologie du développement à l’étude du symbolisme Fabrice CLÉMENT Les panneaux de signalisation (Traduit de l’anglais par Fabien Shang) Robert DEWAR Remarques sur l’émergence des activités symboliques Jean LASSÈGUE Les illustrations du "Songe de Poliphile" (1499). Notule sur les hiéroglyphes de Francesca Colonna Pierre-Alain MARIAUX Signes de vie Jeremy NARBY Visualising relations in society and economics. Otto Neuraths Isotype-method against the background of his economic thought Elisabeth NEMETH Algèbre et logique symboliques : arbitraire du signe et langage formel Marie-José DURAND – Amirouche MOKTEFI Les symboles mathématiques, signes du Ciel Jean-Claude PONT La mathématique : un langage mathématique ? Alain M. ROBERT. (shrink)

These lectures on logic, more specifically proof theory, are basically intended for postgraduate students and researchers in logic. The question at stake is the nature of mathematical knowledge and the difference between a question and an answer, i.e., the implicit and the explicit. The problem is delicate mathematically and philosophically as well: the relation between a question and its answer is a sort of equality where one side is ``more equal than the other'': one thus discovers essentialist blind spots. Starting (...) with Godel's paradox --so to speak, the incompleteness of answers with respect to questions--the book proceeds with paradigms inherited from Gentzen's cut-elimination. Various settings are studied: sequent calculus, natural deduction, lambda calculi, category-theoretic composition, up to geometry of interaction, all devoted to explicitation, which eventually amounts to inverting an operator in a von Neumann algebra. Mathematical language is usually described as referring to a preexisting reality. Logical operations can be given an alternative procedural meaning: typically, the operators involved in GoI are invertible, not because they are constructed according to the book, but because logical rules are those ensuring invertibility. Similarly, the durability of truth should not be taken for granted: one should distinguish between imperfect and perfect modes. The procedural explanation of the infinite thus identifies it with the unfinished, i.e., the perennial. But is perenniality perennial? This questioning yields a possible logical explanation for algorithmic complexity. This highly original course on logic by one of the world's leading proof theorists challenges mathematicians, computer scientists, physicists, and philosophers to rethink their views and concepts on the nature of mathematical knowledge in an exceptionally profound way. (shrink)

Jean-Yves Strasser The Olympia of Alexandria and the Pancratiast M. Aur. Asklepiades p.421-468 The Alexandrian Olympia are known thanks to inscriptions and especially papyri. The latter mention the olympionikoi, who may have been victors not in the great competition at Pisa, but in the Olympia of the Egyptian city. These competitions, created under Marcus Aurelius, became eiselastikoi under Gallien; they were first celebrated in 268. Like the majority of the great competitions in Egypt, they took place in the (...) winter of even years divisible by four. That was the case already in the 2nd century AD: the first Olympia were organised in 180. In 200, at the time of the sixth celebration, the periodonikes M. Aur. Asklepiades won the Olympia pancration in the presence of Septimius Severus and Caracalla. An inscription at Coptus (I. Portes 88) mentions a hellanodikes of Alexandria: he could have been serving at the time of the seventeenth Olympiad in 244; in 246-247 he had a statue of Sarapis Polieus erected under the prefect of Egypt Valerius Firmus. (shrink)

The paper extends a result in Dutta and Ray's (1989) theory of constrained egalitarianism initiated by relying on the concept of proportionate rather than absolute equality. We apply this framework to redistributive systems in which what the individuals get depends on what they receive or pay qua members of generally overlapping groups. We solve the constrained equalization problem for this class of models. The paper ends up comparing our solution with the alternative solution based on the Shapley value, which has (...) been recommended in some distributive applications. (shrink)

Go back to An-fang, the Peace Square at An-Fang, the Beginning Place at An-Fang, where all things start (… ) An-Fang was near a city, the only living city with a pre-atomic name (… ) The headquarters of the People Programmer was at An-Fang, and there the mistake happened: A ruby trembled. Two tourmaline nets failed to rectify the laser beam. A diamond noted the error. Both the error and the correction went into the general computer. Cordwainer SmithThe Dead Lady (...) of Clown Town, 1964. (shrink)

Que la musique soit faite pour etre ecoutee semble une evidence, et pourtant... C'est pour guider les melomanes et les aider a passer d'une audition passive a une ecoute active que Jean-Yves Bras partage ici son experience d'ecouteur. Apres avoir defini ce qu'est la musique, il s'interroge ensuite sur la nature de l'ecoute: que faut-il entendre par ecouter? Sur quoi porter notre attention? Comment ecouter? Les conditions materielles dans lesquelles nous consommons la musique, notre comportement au concert ou (...) a l'ecoute d'un disque, ont egalement une incidence importante sur la qualite de notre ecoute. Puis il analyse ces liens si mysterieux et si essentiels tisses entre compositeurs, interpretes et nous-memes, auditeurs. Enfin, il trace a grands traits l'histoire de nos oreilles de l'Antiquite a nos jours, pour conclure sur les differentes categories d'auditeurs actuels. Parallelement, l'auteur a cree un site Internet, www.artdecouter.fr, qui apporte un complement d'information agremente d'exemples sonores. Ce chemin d'initiation se parcourt sous forme de dialogue: une jeune personne souhaitant s'instruire, Mademoiselle Croche, nous permet par ses questions d'entendre s'ouvrir pour nous le langage de la musique. Jean-Yves Bras a ete directeur de la Documentation musicale de Radio France et a participe a de nombreuses emissions. Responsable artistique du Festival Chopin a Paris, il est l'auteur des Courants musicaux du XXe siecle et d'un ouvrage sur le chef d'orchestre Carlo Maria Giulini. (shrink)

In some situations, a decision is best represented by an incompletely analyzed act: conditionally on a given event A, the consequences of the decision on sub-events are perfectly known and uncertainty becomes probabilizable, whereas the plausibility of this event itself remains vague and the decision outcome on the complementary event ${\bar{A}}$ is imprecisely known. In this framework, we study an axiomatic decision model and prove a representation theorem. Resulting decision criteria aggregate partial evaluations consisting of (i) the conditional expected utility (...) associated with the analyzed part of the decision, and (ii) the best and worst consequences of its non-analyzed part. The representation theorem is consistent with a wide variety of decision criteria, which allows for expressing various degrees of knowledge on ( ${A, \bar{A}}$ ) and various types of attitude toward ambiguity and uncertainty. This diversity is taken into account by specific models already existing in the literature. We exploit this fact and propose some particular forms of our model incorporating these models as sub-models and moreover expressing various types of beliefs concerning the relative plausibility of the analyzed and the non-analyzed events ranging from probabilities to complete ignorance that include capacities. (shrink)

The present book discusses all aspects of paraconsistent logic, including the latest findings, and its various systems. It includes papers by leading international researchers, which address the subject in many different ways: development of abstract paraconsistent systems and new theorems about them; studies of the connections between these systems and other non-classical logics, such as non-monotonic, many-valued, relevant, paracomplete and fuzzy logics; philosophical interpretations of these constructions; and applications to other sciences, in particular quantum physics and mathematics. Reasoning with contradictions (...) is the challenge of paraconsistent logic. The book will be of interest to graduate students and researchers working in mathematical logic, computer science, philosophical logic, linguistics and physics. (shrink)

Using methods of abstract logic and the theory of valuation, we prove that there is no paraconsistent negation obeying the law of double negation and such that $\neg(a\wedge\neg a)$ is a theorem which can be algebraized by a technique similar to the Tarski-Lindenbaum technique.

Jean-Yves Leloup nous propose ici deux lectures magistrales de deux géants de la culture occidentale : Nietzsche, l'athée et Maître Eckhart, le théologien-mystique. Il tente de remettre "à l'endroit" un texte de Nietzsche, Ecce Homo, souvent cité pour justifier tous les athéismes. Leloup montre que le Dieu en lequel Nietzsche voyait une "antithèse de la vie" n'a rien à voir avec le Dieu des Evangiles qui est au contraire une puissance de vie et de libération, une claire lumière (...) par laquelle le monde est vu. L'auteur, avec Maître Eckhart, nous entraîne ensuite au-delà des contraires, au-delà même de Dieu et de tous les Absolus que nous imaginons, vers notre essentielle et silencieuse liberté... Ce livre délicieux et audacieux nous montre, comme le disait Pascal, que "l'athéisme est une marque de force d'esprit, mais jusqu'à un certain degré seulement". (shrink)