Construo esta pesquisa para dar visibilidade ao corpo estranho como produtor de arte, cultura e conhecimentos, quando esse encontra sua casa, o “seu corpo”, na escola. Esta se desenvolve epistemologicamente em Arte-educação descolonial a partir da condição na qual sempre fui colocado, de corpo estranho, por ser imperfeito ao modelo de corpo colonial imposto no ocidente, sempre em relação a um Outro. Continuamente, por isso, vivo sendo posto na categoria de “Ser menos”, na cultura, na vida, no aprendizado, como outros (...) tantos corpos estranhos também vivem: ocupando o fundo da cena para deixar a coreografia em dança bonita ou as apresentações teatrais ou musicais harmônicas. (shrink)

O artigo lança um olhar sobre as deficiências físicas, sensoriais e cognitivas da pessoa humana, substituindo a ideia de Deus como seu causador direto ou indireto pela teoria da aleatoriedade. Define a deficiência como expressão do caráter limitado do ser humano em geral. Propõe uma abordagem pastoral e uma postura ética diante das pessoas com deficiência.

in this article, we experience the exercise of a screen ethnocartography in agency with the film Beasts of the southern wild by the director Benh Zeitlin. We tested a film experimentation that led to a renewed writing ways of life. We bet on cinema and childhood as possibilities for creating cracks and a stutter of language for the creation of new worlds and ways of living. In cinema images less as a representation, and more as art that proposes incompleteness, fissure, (...) a hole in appearances. In childhood as an exercise of differentiation and resistance to dominant narratives in a given context. In childhood as a limiting experience of/in language, tirelessly exposing the human condition in front of the world. Thus, accompanying the main character of the plot, little Hushpuppy — a six-year-old resident of the “Charles Doucet Island”, experienced as “the Bathtub” —, we are shaken by the forms of life there, considered bestial and not recognized by city humans. Hushpuppy, his father and friends resist attempts to destroy their existence by the forms of the state that try to domesticate them, imbued with the logic that primitives must come to civilization, just as children must become adults. (shrink)

1024x768 Normal 0 21 false false false PT-BR X-NONE X-NONE O presente estudo tem como objetivo discutir sobre o diálogo necessário entre comunidade e escola para o projeto da Educação Integral. Parte-se inicialmente da noção da jornada ampliada e a proposta da formação do sujeito, nas suas dimensões afetivas, social, política e cultural. Formação esta que transcende a sala de aula e ocupa o território, os saberes comunitários e as diversas instâncias sociais. E nas entrelinhas reflete-se de fato que ambas, (...) comunidade e escola, estão preparadas para este desafio.  . (shrink)

In his last papers about deontic logic, von Wright sustained that there is no genuine logic of norms. We argue in this paper that this striking statement by the father of deontic logic should not be understood as a death sentence to the subject. Rather, it indicates a profound change in von Wright's understanding about the epistemic and ontological role of logic in the field of norms. Instead of a logical constructivism of deontic systems revealing a necessary structure of prescriptive (...) discourse, which marked his earlier efforts, he adopted the view that such systems should be seem as mere objects of comparison, i.e. as providing practical standards of rationality for normgiving activity. Within such view he proposed an interpretation of standard deontic logic in such a way to free deontic logicians from the philosophical difficulties related to the so-called Jørgensen's dilemma and deontic paradoxes. This effort, as we claim in the present paper, is an application of Wittgenstein's therapeutic method to dissolve philosophical difficulties caused by the use of logical tools to model relations between norms. (shrink)

Parenting is a transforming experience for the life of parents that brings joy and satisfaction as well as challenges, frustration, and demands. The aim of this study was to determine the relationship between “parental stress and satisfaction” and work-home conflict, perceived social support, and global satisfaction with life, and to determine the moderating role of the parent's gender. A sample of 244 participants was studied: 49.6% (121) mothers and 50.4% (123) fathers with children between 2 and 12 years of age. (...) The data was analysed by means of multiple linear regression models and Beta regression for stress and parental satisfaction, respectively, and they were complemented with general and conditional dominance analyses to estimate the relevance of the predictors. Mothers presented higher levels of parental stress and satisfaction than fathers. Being female, having two children, and home-work conflict were predictors of a higher parental stress. Age was also a predictor, as younger parents and also those older than 37 years of age showed more parental stress. Having no partner and being male was associated to lower parental satisfaction. In conclusion, parental stress and satisfaction emerge as clearly differentiated dimensions of parenting experience. The gender gap in parental stress could be linked to the persistence of traditional roles regarding the care of the children, in agreement with the findings in other research. (shrink)

Although religious belief is often claimed to help with physical ailments including pain, it is unclear what psychological and neural mechanisms underlie the influence of religious belief on pain. By analogy to other top-down processes of pain modulation we hypothesized that religious belief helps believers reinterpret the emotional significance of pain, leading to emotional detachment from it. Recent findings on emotion regulation support a role for the right ventrolateral prefrontal cortex, a region also important for driving top-down pain inhibitory circuits. (...) Using functional magnetic resonance imaging in practicing Catholics and avowed atheists and agnostics during painful stimulation, here we show the existence of a context-dependent form of analgesia that was triggered by the presentation of an image with a religious content but not by the presentation of a non-religious image. As confirmed by behavioral data, contemplation of the religious image eneabled the religious group to detach themselves from the experience of pain. Critically, this context-dependent modulation of pain specifically engaged the right VLPFC, whereas group-specific preferential liking of one of the pictures was associated with activation in the ventral midbrain. We suggest that religious belief might provide a framework that allows individuals to engage known pain-regulatory brain processes. (shrink)

L’un des philosophes les plus importants de l’histoire, Friedrich Nietzsche, est presque ignoré par les physiciens. L’auteur qui a déclaré la mort de Dieu au xixe siècle était enthousiasmé par la science, principalement durant la deuxième partie de son œuvre. À l’aide de la notion physique de force, Nietzsche a créé son concept de volonté de puissance. En pensant à la conservation de l’énergie, le philosophe allemand a eu une certaine inspiration pour créer son concept de l’éternel retour. Dans cet (...) article, on souligne certaines influences de la physique sur Nietzsche et on discute de l’actualité de sa position épistémologique—le perspectivisme. À partir du concept de volonté de puissance, je propose que le perspectivisme conduise à l’interprétation où la physique et la science en général sont considérées comme un jeu. (shrink)

In spite of successful tests, the standard cosmological model, the $$\varLambda$$ CDM model, possesses the most problematic concept: the initial singularity, also known as the big bang. In this paper—by adopting the Kantian difference between to think of an object and to cognize an object—it is proposed a degree of scientificity using fuzzy sets. Thus, the notion of initial singularity will not be conceived of as a scientific issue because it does not belong to the fuzzy set of what is (...) known. Indeed, the problematic concept of singularity is some sort of what Kant called the noumenon, but science, on the other hand, is constructed in the phenomenon. By applying the fuzzy degree of scientificity in cosmological models, one concludes that cosmologies with a contraction phase before the current expansion phase are potentially more scientific than the standard model. At the end of this article, it is shown that Kant’s first antinomy of pure reason indicates a limit to our cosmological models. (shrink)

O presente artigo investiga a unidade de valor entre ética e moral, proposta por Ronald Dworkin, assumindo, como ponto de partida, o constitucionalismo pluralista latino-americano. Para tanto, o bem viver, afirmado pelas Constituições boliviana e equatoriana mediante o resgate da sabedoria indígena ancestral – pelo reconhecimento respectivamente do suma qamaña e do sumak kawsay como fundamentos da ordem constitucional – é problematizado a partir da relação que possui com o desafio de consolidação de uma vida boa que expresse o comprometimento (...) com os valores de liberdade, igualdade e comunidade. Referido objeto demandou abordagem interdisciplinar, com destaque para a interação entre o Direito Constitucional e a Filosofia. Os resultados da investigação apontam para a convergência entre a concepção de vida boa aludida por Dworkin e o bem viver que fundamenta as constituições pluralistas latino-americanas. A pesquisa se insere na vertente jurídico-sociológica para o desenvolvimento de investigação de tipo jurídico-investigativo e técnica bibliográfica. Para consideração das fontes, foi adotado o procedimento de análise de conteúdo, com a predominância de raciocínios dedutivos e dialéticos. (shrink)

Resenha da obra: MACIEL, Sonia Maria. Ética e Felicidade - Um Estudo do Filebo de Platão. Porto Alegre> Edipucrs, 2002.

According to Kant, the possibility that pure practical reason may effectively determine the will depends, initially, upon an in-depth investigation of the faculty of desire within the perspective of his transcendental philosophy. In order to demonstrate this, we will present in this paper the critical development of this faculty and with it the bases upon which the concepts of a good will and of a pure practical reason relate themselves to the constitution of morality.

Due to the COVID-19 pandemic, preschool teachers must quickly adjust to online education. During COVID-19, teachers have been forced to embrace technology. This study investigates the lived experiences and challenges of preschool teachers. Employing the Interpretative Phenomenological Analysis, the findings of this study were: It was found that managing parent expectations and dealing with challenging parent behavior were among the sources of stress for preschool teachers. This fear of being judged or criticized by parents could influence their teaching practices and (...) interactions with students, leading to feelings of anxiety or insecurity. Further, preschool teachers faced challenges in implementing blended learning, including technological issues, a lack of support and resources, and difficulties creating engaging online content. However, as teachers gained more experience and knowledge about effectively using online tools and technologies for instruction, these challenges became more manageable. Also limited or unreliable internet connectivity was also a significant challenge faced by teachers and students in the transition to online learning. The digital divide and various technical, bandwidth, and security concerns exacerbated it. Internet connection was a major frustration for her during online classes as it affected her ability to communicate and teach her students effectively. Moreover, preschool teachers have had to adapt to the challenges of blended learning by implementing various strategies and making preparations to guide and support their students effectively. These strategies have included using games and other engaging activities to keep students motivated and engaged, developing online lesson plans, and using online teaching platforms and tools. However, the transition to blended learning has also been a source of stress for preschool teachers. They have had to manage additional workloads and responsibilities and deal with challenges such as supporting students with varying technology access and skills. (shrink)

L’un des philosophes les plus importants de l’histoire, Friedrich Nietzsche, est presque ignoré par les physiciens. L’auteur qui a déclaré la mort de Dieu au xixe siècle était enthousiasmé par la science, principalement durant la deuxième partie de son œuvre. À l’aide de la notion physique de force, Nietzsche a créé son concept de volonté de puissance. En pensant à la conservation de l’énergie, le philosophe allemand a eu une certaine inspiration pour créer son concept de l’éternel retour. Dans cet (...) article, on souligne certaines influences de la physique sur Nietzsche et on discute de l’actualité de sa position épistémologique—le perspectivisme. À partir du concept de volonté de puissance, je propose que le perspectivisme conduise à l’interprétation où la physique et la science en général sont considérées comme un jeu. (shrink)

Resumo: Esta é uma leitura onto-topológica de Nietzsche inspirada na microesferologia de Peter Sloterdijk. Trabalha com a diferença entre "mergulhar no mundo" e "recuar". Essa diferença permite acessar de modo concreto a posição do avaliador de medidas e genealogista. Palavras-chave: Nietzsche; onto-topologia; estranhamento; Sloterdijk; self negativo.

It is shown that a notion of natural place is possible within modern physics. For Aristotle, the elements—the primary components of the world—follow to their natural places in the absence of forces. On the other hand, in general relativity, the so-called Carter–Penrose diagrams offer a notion of end for objects along the geodesics. Then, the notion of natural place in Aristotelian physics has an analog in the notion of conformal infinities in general relativity.

Judgments about the validity of at least some elementary inferential patterns(say modus ponens) are a priori if anything is. Yet a number of empirical conditions mustin each case be satisfied in order for a particular inference to instantiate this or that inferentialpattern. We may on occasion be entitled to presuppose that such conditions aresatisfied (and the entitlement may even be a priori), yet only experience could tell us thatsuch was indeed the case. Current discussion about a perceived incompatibility betweencontent externalism (...) and first-person authority exemplifies how damaging the neglect ofsuch empirical presuppositions of correct reasoning can be. An externalistic view of mentalcontent is ostensibly incompatible with the assumption that a rational subject should beable to avoid inconsistency no matter what the state of her empirical knowledge may be.That fact, however, needs not be taken (as it often is) as a reductio of externalism: alternatively,we may reject that assumption, adding to the agenda of a philosophical investigationof rationality an examination of the vicissitudes of logical luck. I offer an illustrationand defense of that alternative. (shrink)

O objetivo central do trabalho é analisar a posição evolucionista proposta por Michael Ruse a respeito da ética no âmbito de primeira e de segunda ordem. Para cumprir com este objetivo, inicialmente distinguiremos a posição evolucionista de Ruse, de fundamentação darwiniana, com a posição evolucionista clássica, de fundamentação spenceriana. Mostraremos como Ruse inicialmente reformula a ética evolucionista spenceriana, tornando o âmbito da ética substantiva descritivo, e não mais prescritivo, a partir da compreensão correta do conceito de altruísmo. No âmbito da (...) metaética, mostraremos como Ruse desenvolve uma posição evolucionista sem recair nos problemas clássicos da lei de Hume e da falácia naturalista. Por fim, mostraremos que a metaética darwiniana de Ruse pode ser considerada como um tipo de teoria do erro. Concluiremos que a proposta de ética e metaética darwiniana de Ruse trazem grandes avanços para a discussão, fortalecendo a importância da biologia na investigação tradicionalmente filosófica. (shrink)

The author- following his own research on the subject- argues that Wittgenstein ignores argumentation theory and in general, the problems of rhetoric and argumentation. From this point of view, he frames Stephen Toulmin’s reading of Wittgenstein, arguing that the British philosopher- who was a student of the Austrian- advocates precisely the same thesis. He explains that this happens in a very peculiar (rhetorical) context on Toulmin’s part; a context in which, in essence, Wittgenstein’s philosophy is being rehabilitated.

O objetivo deste artigo consiste em propor uma leitura acerca da necessária relação entre corpo e alma na elaboração do desejo, tal como exposto em obras como o Filebo e o Banquete de Platão. Na medida em que esses textos versam, dentre seus assuntos principais e de modo mais específico, sobre temas como o prazer e o amor respectivamente, ambos discutem o componente do desejo na gênese tanto da sensação prazerosa, quanto na afecção amorosa. Assim, o que se pretende demonstrar (...) aqui é em que medida o corpo e a alma, de modo indissociável, participam da ação de desejar. Palavras-chave: Platão; Desejo: Corpo; Alma. (shrink)

This article aims to make public part of the research on the concept of ‘light’ in the theological and, above all, liturgical tradition of the Greek Orthodox Church, based on its representation of the concept of ‘hypostasis’. Taking as a point of departure the interpretation of the expression ‘light of light’ [φῶς ἐκ φωτός (phôs ek phōtos)] of the text of the Niceno-Constantinopolitan Symbol, the article presents a proposal for the interpretation of the concept of ‘representation’ for this specific case, (...) based on the idea of apomímesis, and applies this concept to a reading of the place of ‘light’ in the Holy Scripture, in the Patrology and in the Greek Eastern Liturgies. (shrink)

In the last papers published by Alchourrón, he attacked non-monotonic logics, which he considered philosophically unsound for the representation of defeasible reasoning. Instead of a non-monotonic consequence relation, he proposed a formal representation of defeasibility based on an AGM-like revision of implicit assumptions connected to the premises. Given that this is a procedure to generate non-monotonic logics, it is not clear, from a mathematical standpoint, why he was so suspicious of such logics. In the present paper we try to answer (...) this question based on Alchourrón' s convictions about epistemology, particularly the epistemology of law. We also propose another revision operator on theories called refinement, which provides a faithful representation of the sort of epistemic change considered by Alchourrón as intrinsic to defeasibility. En sus últimos escritos publicados, Alchourrón desarrolló un ataque contra las lógicas no-monotónicas, que consideraba filosóficamente inadecuadas a la representación del razonamiento derrotable. En vez de una relación de consecuencia no-monotónica, él propuso una representación formal de la derrotabilidad basada en un modelo de revisión de las asunciones implícitas ligadas a las premisas. Dado que éste es un procedimiento para generar lógicas no-monotónicas, no está claro -en el nivel matemático- por qué él era tan desconfiado de tales lógicas. En el presente texto intentamos contestar a esta pregunta basados en las convicciones de Alchourrón sobre epistemología, particularmente la epistemología jurídica. También proponemos otro operador de revisión aplicado a las teorías, llamado refinamiento, que proporciona una representación fiel de la especie de cambio epistémico considerado por Alchourrón como intrínseco a la derrotabilidad. (shrink)

Perceptual experience and visual imagination both offer a first-person perspective on visible objects. But these perspectives are strikingly different. For it is distinctive of ordinary perceptual intentionality that objects seem to be present to the perceiver. I term this phenomenal property of experience ‘presence’. This paper introduces a positive definition of presence. Dokic and Martin (2017) argue that presence is not a genuine property of perceptual experience, appealing to empirical research on derealisation disorders, Parkinson’s disease, virtual reality and hallucination. I (...) demonstrate that their arguments fall short of establishing that presence is not perceptual. (shrink)

O objetivo deste artigo é articular a influência da análise hegeliana da modernidade na crítica à filosofia da subjetividade moderna em Charles Taylor. Embora essa influência seja conhecida, ela não é trabalhada nos diversos estudos sobre Taylor. Este realiza uma hermenêutica da filosofia hegeliana, tornando-se responsável por uma das principais recepções do pensamento hegeliano na comunidade filosófica de língua inglesa. A influência de Hegel na obra de Taylor permanece como uma dimensão pressuposta, mas pouco explorada. Reconstruir tal influência hegeliana na (...) crítica à filosofia da subjetividade moderna em Taylor é o objetivo deste artigo. Em seus estudos sobre Hegel, como defende Rainer Forst, Taylor interpretou a crítica hegeliana ao conceito moderno de liberdade tal qual uma crítica ao conceito de sujeito vazio, não situado no contexto formador das identidades. A essa visão estreita de subjetividade, Taylor contrapôs, inspirado em Hegel, uma versão alternativa de identidade linguística, histórica, cultural e comunicativamente situada, os seja, uma identidade que é parte abrangente de uma comunidade que nos forma enquanto sujeitos. Primeiramente, explicitaremos a emergência do eu no contexto da modernidade; em seguida, enfatizaremos a crítica hegeliana à noção de sujeito moderno autoconsciente; por fim, articularemos como a crítica hegeliana influenciou diretamente Taylor em sua crítica à subjetividade moderna. (shrink)

O artigo pretende apresentar de modo geral a situação do homem contemporâneo, cuja noção se esvazia diante das provocações do animalismo, de um lado, e do pós-humanismo, de outro. Quem é realmente o homem? Um animal como os outros ou uma potencial máquina a ser desenvolvida através do enhancement de suas capacidades? Está-se diante de dois fenômenos preocupantes: uma absolutização do dado biológico no caso do animalismo, fazendo do ser humano somente um momento específico dentro do gênero animal; ou senão (...) o abandono do biológico, transformado pela tecnologia que produz o “além-homem”, em condições diversas de existência, no caso do pós-humanismo. De qualquer modo, nessas novas antropologias (naturalista e tecnicista) perde-se aquilo que torna o homem propriamente humano, ou seja, o que a tradição chama de espírito ou alma (nous, psyché). Sem descer a detalhes, deseja- se indicar as principais teses, bem como os autores de referência, que caracterizam ambas as posições mencionadas. A atenção também se dirige à tentativa de re-dizer o humano como pessoa, partindo dos elementos presentes nas posições em estudo, mas indo além de seus reducionismos. (shrink)

Os signos e as classes dos signos estão entre os tópicos mais importantes do sistema filosófico de Charles S. Peirce. As 10, 28, e 66 classes de signos são classificações desenvolvidas especialmente a partir de 1903 e representam um grande refinamento da divisão fundamental de signos – ícone, índice, símbolo. Nossa abordagem aqui define uma estratégia de visualização das classificações dos signos, com especial atenção para as 10 e 66 classes de signos. O livro está dividido em duas partes: (i) (...) bases teóricas, (ii) diagramas para as classes de signos. Na Parte I (bases teóricas), são apresentadas introdutoriamente as noções fundamentais das categorias fenomenológicas, classes de signos, as tricotomias e diagramas, assim como implicações gerais de nossa abordagem, metodologia e aplicações. Na Parte II (diagramas para as classes de signos), são apresentados e discutidos os modelos das classes, propostos por Peirce e seus comentadores, incluindo uma introdução detalhadamente documental de nossos modelos, 10cubes e 3N3, diagramas dinâmicos para as classes de signos. (shrink)

O artigo discute as inovações propostas nas políticas públicas formativas implantadas no Brasil, especialmente, em contexto norte do estado de Mato Grosso e analisa as ações formativas para professores atuantes na área de Língua Portuguesa. Defendemos a tese de que, embora os empreendimentos propositivos de formação tenham alcance significativo na atualidade, insta refletir sobre novos modos para atuar junto às demandas educativas. Atentos ao mundo contemporâneo e conscientes de que a solidez se transforma em liquidez, reconhecemos, que o futuro professor (...) e aqueles em atuação devem irromper as barreiras hegemônicas educacionais, construir sua identidade com protagonismo e criticidade e intervir nas práticas situadas de linguagem. Nesse sentido, o respaldo metodológico fixa nos estudos qualitativo-interpretativistas e para tal recortamos do documento que direciona a Política Educacional do Estado de Mato Grosso, a Portaria Normativa n. 17, de 28 de dezembro de 2009, a qual dispõe sobre o Programa de Formação Nacional em Rede e a Portaria 46, de 11 de abril de 2016 e regulamenta o Programa Institucional de Bolsa de Iniciação à Docência e propomos algumas questões: a) De que forma as políticas formativas interferem/contribuem para o desenvolvimento profissional docente? Pautados na Linguística Aplicada Crítica construímos algumas asseverações, dentre elas, que as ações implementadas – e que se quer permanentes – demandam maior integração e investimento público. (shrink)

Background Ethical decision making in intensive care is a demanding task. The need to proceed to ethical decision is considered to be a stress factor that may lead to burnout. The aim of this study is to explore the ethical problems that may increase burnout levels among physicians and nurses working in Portuguese intensive care units . A quantitative, multicentre, correlational study was conducted among 300 professionals.Results The most crucial ethical decisions made by professionals working in ICU were related to (...) communication, withholding or withdrawing treatments and terminal sedation. A positive relation was found between ethical decision making and burnout in nurses, namely, between burnout and the need to withdraw treatments , to withhold treatments and to proceed to terminal sedation . This did not apply to physicians. Emotional exhaustion was the burnout subdimension most affected by the ethical decision. The nurses' lack of involvement in ethical decision making was identified as a risk factor. Nevertheless, in comparison with nurses , it was the physicians who more keenly felt the need to proceed to ethical decisions in ICU.Conclusions Ethical problems were reported at different levels by physicians and nurses. The type of ethical decisions made by nurses working in Portuguese ICUs had an impact on burnout levels. This did not apply to physicians. This study highlights the need for education in the field of ethics in ICUs and the need to foster inter-disciplinary discussion so as to encourage ethical team deliberation in order to prevent burnout. (shrink)

Viruses have generally been thought of as infectious agents. New data on mimivirus, however, suggests a reinterpretation of this thought. Earth’s biosphere seems to contain many more viruses than previously thought and they are relevant in the maintenance of ecosystems and biodiversity. Viruses are not considered to be alive because they are not free-living entities and do not have cellular units. Current hypotheses indicate that some viruses may have been the result of genomic reduction of cellular life forms. However, new (...) studies relating to the origins of biological systems suggest that viruses could also have originated during the transition from First to the Last Universal Common Ancestor. Within this setting, life has been established as chemical informational system and could be interpreted as a macrocode of multiple layers. The first entity to acquire these features was the First Universal Common Ancestor that evolved to an intermediate ancestral that could be named T-LUCA and be equated to Woese’s concept of progenotes. T-LUCA may have remained as undifferentiated subsystems with viruses-like structures. The net result is that both cellular life forms and viruses shared protein synthesis apparatuses. In short, virus is a strategy of life reached by two paths: T-LUCAs like entities and the reduction of cellular life forms. (shrink)

Viruses have generally been thought of as infectious agents. New data on mimivirus, however, suggests a reinterpretation of this thought. Earth’s biosphere seems to contain many more viruses than previously thought and they are relevant in the maintenance of ecosystems and biodiversity. Viruses are not considered to be alive because they are not free-living entities and do not have cellular units. Current hypotheses indicate that some viruses may have been the result of genomic reduction of cellular life forms. However, new (...) studies relating to the origins of biological systems suggest that viruses could also have originated during the transition from First to the Last Universal Common Ancestor. Within this setting, life has been established as chemical informational system and could be interpreted as a macrocode of multiple layers. The first entity to acquire these features was the First Universal Common Ancestor that evolved to an intermediate ancestral that could be named T-LUCA and be equated to Woese’s concept of progenotes. T-LUCA may have remained as undifferentiated subsystems with viruses-like structures. The net result is that both cellular life forms and viruses shared protein synthesis apparatuses. In short, virus is a strategy of life reached by two paths: T-LUCAs like entities and the reduction of cellular life forms. (shrink)

Recently it has become clear that integrins and other adhesive receptors play an important role in the control of cell growth and differentiation. In various cell types, anchorage to the extracellular matrix via integrins strongly influences the ability of the cell to respond to soluble mitogens or to differentiation factors. Thus adhesive receptors must generate signals that influence cell behavior. Some of the pathways of adhesion receptor signaling are now beginning to be worked out, but there is still much to (...) learn. In particular, the mechanistic basis for the cooperation between anchorage signals and signals from soluble growth and differentiation factors remains ill‐defined. This review will examine some of the current information linking adhesion receptors to control of mitogenesis and differentiation. (shrink)