Cilia are microtubule‐based hair‐like structures that project from the surfaces of eukaryotic cells. Cilium formation relies on intraflagellar transport (IFT) to move ciliary proteins such as tubulin from the site of synthesis in the cell body to the site of function in the cilium. A large protein complex (the IFT complex) is believed to mediate interactions between cargoes and the molecular motors that walk along axonemal microtubules between the ciliary base and tip. A recent study using purified IFT complexes has (...) identified a tubulin‐binding module in the two core IFT proteins IFT74 and IFT81 that likely serves to bind and transport tubulin within cilia. Here, we calculate the amount of tubulin required to support the observed cilium assembly kinetics and explore the possibility of multiple tubulin binding sites within the IFT complex. (shrink)

Systematische Annäherung an das Problem einer philosophischen Letztbegründung ethischer Normen -- Konzeption und Funktion der Kommunikationsgemeinschaft in der Normbegründungsstrategie Karl-Otto Apels.

The first commented edition of K.W.F. Solger's Vorlesungen über Ästhetik (1819), edited by Giovanna Pinna.

In 1946 Ferdinand Gonseth founded, together with Paul Bernays, Karl Dürr, and Sir Karl Popper, the International Society for Logic and Philosophy of Science. In the next year the first number of Dialectica, a philosophical review devoted mainly to epistemological subjects, was issued. Gonseth's bibliography presents more than 190 items — roughly 25 books, several prefaces, and, for the rest, papers published in numerous reviews. A good deal of his publications concern mathematics — he was appointed professor (...) of mathematics first in Berne and then in Zurich at the well‐known Swiss Federal Institute of Technology — but he has never completely separated his mathematical activities from his philosophical work. (shrink)

I. THE TASK OF DOGMATICS As a theological discipline dogmatics is the scientific self- examination of the Christian Church with respect to the content of ...

Preface--I. The definition of pragmatism and humanism--II. From Plato to Protagoras.--III. The relations of logic and psychology.--IV. Truth and Mr. Bradley.--V. The ambiguity of truth.--VI. The nature of truth.--VII. The making of truth.--VIII. Absolute truth and absolute reality.--XI. Empiricism and the absolute.--X. Is absolute idealism solipsistic? XI. Absolutism and the dissociation of personality.--XII. Absolutism and religion.--XIII. The papyri of Philonous, I-II.--XIV. I. Protogoras the humanist.--XV. II A dialogue concerning gods and priests.--XVI. Faith, reason, and religion.--XVII. The progress of psychical research.--XVIII. (...) Freedom.--XIX. The making of reality.--XX. Dreams and idealism.-- Index. (shrink)

Realist evaluation has gained prominence in the field of evaluation in recent years. Its theory-driven approach to explaining how and why programmes work or not makes it attractive to many novices, early career researchers, and organizations implementing various programmes globally and relevant to policymakers and programme implementers. While realist evaluation seeks to be pragmatic, adopting principles and methods that can be used to help focus an evaluation, its deep ontological and epistemological foundations make its application in real-life situations challenging. In (...) this paper, we seek to unpack the key tenets scaffolding the practical application of realist evaluation. Although Pawson and Tilley foreground realist evaluation in applied scientific realism, we argue that an amalgam of scientific and critical realist principles underpins realist evaluation. We unpack these principles and illustrate how they fit into each other to provide a cogent theoretical foundation for realist evaluation. (shrink)

In this article I offer an opinionated overview of the central elements of Kant’s philosophical methodology during the critical period. I begin with a brief characterization of how Kant conceives of the aims of human inquiry – focusing on the idea that inquiry ideally aims at not just cognition (Erkenntnis), but also the more demanding cognitive achievements that Kant labels insight (Einsehen) and comprehension (Begreifen). Then I explore the implications of this picture for philosophy — emphasizing Kant’s distinction between critical (...) and doctrinal phases of philosophical inquiry, with the first of these playing both a negative and a positive role with respect to the second. Then, I will argue that this positive role is possible, according to Kant, only insofar as philosophy follows what I call a “capacities-first” methodology – that is, one that treats basic cognitive capacities (such as reason) and their self-conscious activities as fundamental (in both a cognitive sense and in an explanatory sense) for the sort of philosophy human beings are capable of. It is this methodology, I will argue, that allows Kant to introduce the first principles that philosophy in its doctrinal phase requires in a manner that is neither arbitrary nor (at least obviously) incompatible with Kant’s own critical restrictions on cognition. I conclude by discussing some of the implications of this methodological picture – including the methodological significance of self-consciousness and regressive or “transcendental” arguments, Kant’s distinction between analytic and synthetic methods in philosophy, and Kant’s conception of reason as autonomous. (shrink)