Secession and the civil war that followed are often regarded as having exclusively structural determinants, expressed in political cleavages. From this point of view, these events are explained, variously, by the rise of abolitionism in the North or sectionalism in the Union or some cultural attribute of the South. This focus gets us part of the way in understanding the events that led to secession, the creation of a Southern Confederacy, and civil war, but this interpretation says too little about (...) precisely how these events and processes played out. Secession occurred in time, sequentially and dynamically, with one state leading and other states following. This article offers a processual specification of the conditions of Southern secession and the creation of a Southern Confederacy. It does so by focusing on mobilization within the vanguard state, South Carolina, and the consequences of this activity for other Southern states. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

I propose that primary conscious awareness arises from synchronized activity in dendrites of neurons in dorsal thalamic nuclei, mediated particularly by inhibitory interactions with thalamic reticular neurons. In support, I offer four evidential pillars: consciousness is restricted to the results of cortical computations; thalamus is the common locus of action of brain injury in vegetative state and of general anesthetics; the anatomy and physiology of the thalamus imply a central role in consciousness; neural synchronization is a neural correlate of consciousness.

ETHICS: A PLURALISTIC APPROACH TO MORAL THEORY, FIFTH EDITION provides a comprehensive yet clear introduction to the main traditions in ethical thought, including virtue ethics, utilitarianism, and deontology. Additionally, the book presents a conceptual framework of ethical pluralism to help students understand the relationship among various theories. Lawrence Hinman, one of today's most respected and accomplished educators in ethics and philosophy education, presents a text that gives students plentiful opportunities to explore ethical theory and their own responses to them, (...) using fascinating features such as the Ethical Inventory sections that appear at the beginning and the end of the text. End-of-chapter discussion questions, and the use of current issues and movies help students retain what they've learned and truly comprehend the subject matter. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version. (shrink)

Wikipedia has challenged traditional notions about the roles of experts in the Internet Age. Section 1 sets up a paradox. Wikipedia is a striking popular success, and yet its success can be attributed to the fact that it is wide open and bottom-up. How can such a successful knowledge project disdain expertise? Section 2 discusses the thesis that if Wikipedia could be shown by an excellent survey of experts to be fantastically reliable, then experts would not need to be granted (...) positions of special authority. But, among other problems, this thesis is self-stultifying. Section 3 explores a couple ways in which egalitarian online communities might challenge the occupational roles or the epistemic leadership roles of experts. There is little support for the notion that the distinctive occupations that require expertise are being undermined. It is also implausible that Wikipedia and its like might take over the epistemic leadership roles of experts. Section 4 argues that a main reason that Wikipedia’s articles are as good as they are is that they are edited by knowledgeable people to whom deference is paid, although voluntarily. But some Wikipedia articles suffer because so many aggressive people drive off people more knowledgeable than they are; so there is no reason to think that Wikipedia’s articles will continually improve. Moreover, Wikipedia’s commitment to anonymity further drives off good contributors. Generally, some decisionmaking role for experts is not just consistent with online knowledge communities being open and bottom-up, it is recommended as well. (shrink)

This book addresses fundamental issues in linguistic theory, including the relation between formal and cognitive approaches, the autonomy of syntax, the content of universal grammar, and the value of generative and functional approaches to grammar. It focuses on the grammar of case relations, signalled by morphological case, prepositions, and word order. Part I offers a critical history of modern grammars of case, focussing on the last four decades and setting this in the context of earlier, including ancient, developments. The subjects (...) considered include the evolution of ideas concerning deep structure and semantic and grammatical relations, and arguments for the maintenance of the traditional central position of case in the grammar. In parts II and III Professor Anderson examines the category of case and central unresolved issues in the grammar of case. The latter include questions relating to the idea of an ontologically-based grammar, particularly the degree to which syntactic categories and relationships are grounded in meaning, and the notion of linguistic creativity. This involves a consideration of the way in which cases may be identified and whether their distribution is determined through semantics. The book sheds new light on the interactions between meaning and grammar and on the structure and development of lexical and grammatical systems. The argument and its far-reaching consequences will be of wide interest to linguists, philosophers and others seeking to understand the workings of language. (shrink)

This book is the first systematic account of the syntax and semantics of names. Drawing on work in onomastics, philosophy, and linguistics John Anderson examines the distribution and subcategorization of names within a framework of syntactic categories, and considers how the morphosyntactic behaviour of names connects to their semantic roles. He argues that names occur in two basic circumstances: one involving vocatives and their use in naming predications, where they are not definite; the other their use as arguments of (...) predicators, where they are definite. This division is discussed in relation to English, French, Greek, and Seri, and a range of other languages. Professor Anderson reveals that the semantic status of names, including prototypicality, is crucial to understanding their morphosyntax and role in derivational relationships. He shows that semantically coherent subsets of names, such as those referring to people and places, are characterized by morphosyntactic properties which may vary from language to language. His original and important investigation will appeal to scholars and advanced students of linguistics and philosophy. (shrink)

T. H. Marshall, a British sociologist, gave a series of lectures in 1949 under the title “Citizenship and Social Class.” To many American intellectuals, his analysis still offers a persuasive account of the origins of the welfare state in the West. But Marshall spoke in the early postwar era, when the case for expanded social benefits seemed unassailable. Today's politics are more conservative. In every Western country the welfare state is under review. Yet Marshall's conception can still help define the (...) issues in social policy and the way forward. (shrink)

An award-winning theoretical physicist and best-selling author of A Universe from Nothing traces the dramatic discovery of the counterintuitive world of reality, explaining how readers can shift their perspectives to gain greater understandings of our individual roles in the universe.

Shepard proposes that the human mind relies on screw displacement because of its adaptive simplicity and uniqueness. I discuss this hypothesis by assessing screw displacement with respect to (1) other plausible spatial transformations, (2) a variety of criteria for adaptive efficiency and utility, and (3) a variety of psychological conditions in which observed responses discriminate amongst alternative spatial procedures. [Shepard].

Search engines play an increasingly pivotal role in the distribution and eventual construction of knowledge, yet they are largely unnoticed, their procedures are opaque, and they are almost completely devoid of independent oversight. In this paper the author examines three areas in which we encounter difficult and persistent ethical issues in search engine technology: The problem of algorithm and the lack of transparency of the search process, the problem of privacy with regards of the possibility to monitor search histories, and (...) the problem of local censorship. The given findings lead to the conclusion that the development of structures of accountability for search engines is an important task for the near future. (shrink)

Rarely has a philosopher demanded such a purity of moral motives. Even when he discusses those “many spirits of so sympathetic a temper that, without any further motive of vanity or self-interest, they find an inner pleasure in spreading happiness around them and can take delight in the contentment of others as their own work,” Kant maintains that, “in such a case an action of this kind, however right and however amiable it may be, still has no genuinely moral worth.” (...) Because the action is done from inclination rather than duty, it cannot qualify as a morally good action in Kant’s eyes. Indeed, this seems to suggest that from a moral point of view the person who is naturally unsympathetic to others almost has an advantage, at least in terms of the opportunity for moral action, over those who are naturally inclined to altruistic acts. Kant hardly seems to shrink from such a conclusion. His own words best convey his position here. (shrink)

Corpus linguistics is becoming a respected method of statutory and constitutional interpretation in the United States over the past decade, yet it has also generated a backlash from a group of scholars that engage in empirical work. This essay attempts to demonstrate both the contributions and the risks of using linguistic corpora as a primary tool in legal interpretation. Its legitimacy stems from the fact that courts routinely state that statutory terms, when not defined as a matter of law, are (...) to be given their ordinary meaning. Judges have responded to this challenge, with the assistance of the linguistics community, by using corpora to determine which meanings are ordinary. However, legal analysts have not determined exactly what makes one meaning ordinary and another not ordinary. This gap has led to a level of disagreement in the field. Moreover, while linguists who engage in corpus linguistic analysis typically emphasize the importance of context, the legal application is peculiarly context-free, in keeping with legal philosophies that eschew reliance on reference to a law’s purpose and the intent of the legislature that enacted it. This move adds a political dimension to corpus analysis as a means of legal interpretation. Yet, the article concludes that by relying on a blend of general and specialized corpora, the legal system can substantially reduce the problem of contextualization, as some linguists and practitioners have already recognized. (shrink)

Cloning and reproductive technologies -- Abortion -- Euthanasia -- Punishment and the death penalty -- War, terrorism, and counterterrorism -- Race and ethnicity -- Gender -- Sexual orientation -- World hunger and poverty -- Living together with animals -- Environmental ethics -- Cyberethics.

During development, large numbers of cells die by a process known as programmed cell death. This loss of cells plays a number of important roles, including the sculpting of the body form and the removal of vestigial tissues. Data obtained from a variety of organisms has suggested that a cell's ‘decision’ to die is a differentiative event, requiring the activation of specific sets of genes. Several putative ‘cell death’ genes have recently been cloned, and one has been identified as the (...) product of the polyubiquitin gene. Accumulation of ubiquitin has been observed not only during programmed cell death, but also in several neurodegenerative disorders, including Alzheimer's Disease. (shrink)