Nuclear pre‐mRNAs must be precisely processed to give rise to mature cytoplasmic mRNAs. This maturation process, known as splicing, involves excision of intron sequences and ligation of the exon sequences. One of the major problems in understanding this process is how splice sites, the sequences which form the boundaries between introns and exons, can be accurately selected. A number of studies have defined conserved sequences within introns which were later shown to interact with small nuclear ribonucleoproteins (snRNPs). However, due to (...) the simplicity of these conserved sequences it has become clear that other elements must be involved and a number of studies have indicated the importance of secondary structures within pre‐mRNAs. Using various examples, we shall show that such structures can help to specify splice sites by modifying physical distances within introns or by being involved in the definition of exons and, lastly, that they can be part of the regulation of alternative splicing. (shrink)

This article suggests a new reading for Oribasius’ Libri ad Eunapium 3.13.4. Based on evidence from both Greek and Syriac sources, it argues that the variant contained in Oribasius’ Synopsis ad Eustathium should be adopted as the correct reading of the original.

Critical thinking instructors are faced with an overwhelming number of textbooks to choose from for their courses. Many of these texts do not reflect an awareness of current scholarship in critical thinking and informal logic. I argue that instructors should only adopt textbooks that reflect a sound theoretical understanding of the topic by acknowledging the central role of critical thinking dispositions, offering a more nuanced approach to the teaching of fallacies and of inference, stressing dialectic and argument revision, focusing on (...) the analysis and evaluation of real arguments, and broadening the scope of critical thinking beyond argument analysis and evaluation. To support instructors in this regard, I critique one popular textbook now in its sixth edition that does not satisfy many of these criteria, Munson and Black (2012), and applaud one new textbook that I find does succeed on many of these fronts, Bailin and Battersby (2010). (shrink)

d. 1. Van 1900 tot 1950 -- d. 2. Van 1950 tot 1998.

Pliny the Younger Epistularum Libri Decem.

Liber principiorum theologiae.--Liber principiorum philosophiae.--Liber principiorum juris.--Liber principiorum medicinae.

In posteriora Aristotelis. In Physica. In libros De anima.--Pseudo-Themistius (Sophonias). In De memoria et reminiscentia. In De somno et vigilia. In De insomniis. In De divinatione per somnium.

The critical edition of Robert Kilwardby’s Notule libri Priorum by Thom and Scott is a great scholarly achievement. The edition of the thirteenth-century Dominican’s commentary to Aristotle’s Prior...