Lysine acetylation has been shown to occur in many protein targets, including core histones, about 40 transcription factors and over 30 other proteins. This modification is reversible in vivo, with its specificity and level being largely controlled by signal‐dependent association of substrates with acetyltransferases and deacetylases. Like other covalent modifications, lysine acetylation exerts its effects through “loss‐of‐function” and “gain‐of‐function” mechanisms. Among the latter, lysine acetylation generates specific docking sites for bromodomain proteins. For example, bromodomains of Gcn5, PCAF, TAF1 and CBP (...) are able to recognize acetyllysine residues in histones, HIV Tat, p53, c‐Myb or MyoD. In addition to the acetyllysine moiety, the flanking sequences also contribute to efficient recognition. The relationship between acetyllysine and bromodomains is reminiscent of the specific recognition of phosphorylated residues by phospho‐specific binding modules such as SH2 domains and 14‐3‐3 proteins. Therefore, lysine acetylation forges a novel signaling partnership with bromodomains to govern the temporal and spatial regulation of protein functions in vivo. BioEssays 26:1076–1087, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Riben Jiuzhou da xue tu shu guan cang you gu xie Huizhou ben "Zhuzi yu lei" yi bai si shi juan. Huizhou ben shang cheng "Chi lu", xia qi li bian, zai yu lu dao yu lei de xing cheng guo cheng zhong chu yu guan jian de di wei, dui xue jie yan jiu zhu xi si xiang de xing cheng guo cheng, Zhu Xi men ren de qing kuang, jin ben "Zhuzi yu lei" de xing cheng guo (...) cheng yi ji zhong gu shi qi gu Han yu bai hua, ti gong le xin de cai liao he xin de shi ye. (shrink)

As an important influencing factor of construction workers' safety performance, safety stressor has received increasing attention. However, no consensus has been reached on the relationship between different types of safety stressors and the subdimensions of safety performance, and the mechanism by which safety stressors influence safety performance remains unclear. This study proposed a multiple mediation model with ego depletion and self-efficacy as mediators between safety stressors and workers' safety performance. Data were collected from 335 construction workers in China. Results demonstrated (...) that: the three types of safety stressors all had negative effects on workers' safety performance ; self-efficacy mediated all the relationships between the three safety stressors and safety performance; ego depletion only mediated part of the relationships between the three safety stressors and safety performance; and only part of the multiple-step mediating effects through ego depletion and self-efficacy were supported. This study made contributions by shedding light on the mechanism by which safety stressors influence workers' safety performance and providing more empirical evidence for the relationship between various safety stressors and the subdimensions of safety performance. Additionally, targeted strategies for improving workers' safety performance were proposed according to the findings. (shrink)

This paper investigates a composite learning prescribed performance control scheme for uncertain strict-feedback system. Firstly, a prescribed performance boundary condition is developed for the tracking error, and the original system is transformed into an equivalent one by using a transformation function. In order to ensure that the tracking error satisfies the PPB, a sufficient condition is given. Then, a control scheme of PPC combined with neural network and backstepping technique is proposed. However, the unknown functions cannot be guaranteed to estimate (...) accurately by this method. To solve this problem, predictive errors are defined by applying online recorded date and instantaneous date. Furthermore, novel composite learning laws are proposed to update NN weights based on a partial persistent excitation condition. Subsequently, the stability of the closed-loop system is guaranteed and all signals are kept bounded by using composite learning PPC method. Finally, simulation results verify the effectiveness of the proposed methods. (shrink)

Objective: Work stress is one of the urgent public health problems, which has aroused wide attention. In addition, work stress also has a negative impact on the development of enterprises. This study has three purposes: to understand the current status of working stress among couriers, to examine the association between work stress, job satisfaction and sleep quality of Chinese couriers, and to verify the mediating role of psychological capital.Methods: A cross-sectional survey was conducted among 3000 couriers in Beijing of China (...) from January to December 2019 using cluster stratified random sampling. Descriptive statistical analysis was used to describe demographic characteristics of respondents. Pearson correlation analysis was used to analyze the correlation among work stress, job satisfaction, sleep quality, and psychological capital. The mediating analysis was calculated role of psychological capital.Results: A total of 2831 participants were included in this study. The average score of work stress was 2.49 ± 0.76. Work stress was negatively correlated with job satisfaction, sleep quality, and psychological capital, respectively. The direct effect of work stress on job satisfaction is –0.223, and the total effect of work stress on job satisfaction is –0.267. The a*b*c’ is positive, indicating the mediating role psychological capital has in explaining the relationship between couriers’ work stress and job satisfaction. Moreover, psychological capital plays a mediating role between work stress and sleep quality among couriers.Conclusion: Couriers face certain work stress and should be paid attention to and psychological capital can effectively alleviate the work stress of couriers, so measures can be taken to improve it, promoting healthy development of employees and organizations. (shrink)

Ben shu shi cai yuan pei xian sheng guan yu gong min dao de xiu yang fang mian de dai biao zuo, Zhu yao shou lu ta zui wei zhong yao de dao de si xiang dai biao zuo pinzhong xue xiu shen jiao ke shu hehua gong xue xiao jiang yi, Bing shou lu cai yuan pei qi ta you guan dao de xiu yang de ling san wen zhang, Chong fen ti xian le cai (...) yuan pei xian sheng dui yu xian dai zhong guo ren ying ju you de dao de su yang de zong ti gou xiang. (shrink)

BackgroundIn the early days of COVID-19 outbreak, the normally orderly health system was severely challenged by large numbers of feverish patients and shortage of healthcare workers. The outbreak played a harmful role in the mental health of these healthcare workers.ObjectiveWe aim to assess the prevalence of moderate or severe anxiety and depression symptoms of healthcare workers in different regions during COVID-19 disaster and identify the potential risk factors.MethodsWe did a cross-sectional study on ADS of healthcare workers in epicenter-Hubei province and (...) regions in lower epidemic-other provinces by questionnaire online. The data of ADS, the demographic characteristics, occupational exposure, physical condition, family situation, and coping styles were collected and analyzed.ResultsA total of 24.68% of the respondents had experienced moderate or severe ADS. Moderate or severe ADSs were in a higher prevalence in Hubei than other provinces. Suspicious symptoms on their own and in family members were independent risk factors of moderate or severe ADS of all health workers. Working on the frontline was the independent risk factor for participants in Hubei province, whereas quarantine was the independent risk factor for those in other provinces. Moreover, among all participants, those with negative coping style were more than four times more likely to have moderate or severe ADS than those with positive coping style.ConclusionModerate or severe ADSs were in a higher prevalence in healthcare workers of Hubei province during COVID-19 outbreak. The coping style may have major impact on ADS in such situation. (shrink)

IntroductionTranscranial direct current stimulation is a noninvasive brain stimulation technique that applied to modulate brain activity and enhance motor recovery. However, the neurobiological substrates underlying the effects of tDCS on brain function remain poorly understood. This study aimed to investigate the central mechanisms of tDCS on improving the athletic performance of male rowing athletes.MethodsTwelve right-handed male professional rowing athletes received tDCS over the left primary motor cortex while undergoing regular training. The resting-state functional magnetic resonance imaging data were acquired before (...) and after tDCS. Measures of amplitude of low-frequency fluctuation and regional homogeneity were calculated and compared between baseline and follow-up, as well as topological measures including global and local efficiency of functional brain networks constructed by graph theoretical analysis.ResultsMale rowing athletes showed increased isokinetic muscle strength of the left knee and left shoulder after tDCS. Increased ALFF values were found in the right precentral gyrus of male rowing athletes after tDCS when compared with those before tDCS. In addition, male rowing athletes showed increased ReHo values in the left paracentral lobule following tDCS. Moreover, increased nodal global efficiency was identified in the left inferior frontal gyrus of male rowing athletes after tDCS.ConclusionThe findings suggested that simultaneous tDCS-induced excitation over the primary motor cortex might potentially improve the overall athletic performance in male rowing athletes through the right precentral gyrus and left paracentral lobule, as well as left inferior frontal gyrus. (shrink)

Ben shu yi dong zhong shu zi ran guan wei shi jiao,Chan shu le dong zhong shu de"tian ren gan ying"lun,"wu lei lei bi"he"xun ming de li"de fang fa lun,Yi tian wei yuan ben de yu zhou lun,"bian er you chang"de bian zheng tian dao guan,Yi ji dong zhong shu you guan yuan qi,Yin yang,Wu xing de zi ran ke xue si xiang,Zai zong ti shang ken ding le dong zhong shu zai jie shi he ren shi (...) zi ran gui lü shang de jin bu xing,Ken ding le dong zhong shu dui zhong guo gu dai zi ran ke xue de gong xian,Bing pi ping le yi wang dui dong zhong shu bu gong zheng di ping pan.Ben shu tong shi ye zhi chu le dong zhong shu de mou xie si xiang dui hou shi de fu mian ying xiang. (shrink)

Publications by Chinese researchers in scientific journals have dramatically increased over the past decade; however, academic misconduct also becomes more prevalent in the country. The aim of this prospective study was to understand the perceptions of Chinese biomedical researchers towards academic misconduct and the trend from 2010 to 2015. A questionnaire comprising 10 questions was designed and then validated by ten biomedical researchers in China. In the years 2010 and 2015, respectively, the questionnaire was sent as a survey to biomedical (...) researchers at teaching hospitals, universities, and medical institutes in mainland China. Data were analyzed by the Chi squared test, one-way analysis of variance with the Tukey post hoc test, or Spearman’s rank correlation method, where appropriate. The overall response rates in 2010 and 2015 were 4.5% and 5.5%, respectively. Data from 15 participants in 2010 were invalid, and analysis was thus performed for 1263 participants. Among the participants, 54.7% thought that academic misconduct was serious-to-extremely serious, and 71.2% believed that the Chinese authorities paid no or little attention to the academic misconduct. Moreover, 70.2 and 65.2% of participants considered that the punishment for academic misconduct at the authority and institution levels, respectively, was not appropriate or severe enough. Inappropriate authorship and plagiarism were the most common forms of academic misconduct. The most important factor underlying academic misconduct was the academic assessment system, as judged by 50.7% of the participants. Participants estimated that 40.1% of published scientific articles were associated with some form of academic misconduct. Their perceptions towards academic misconduct had not significantly changed over the 5 years. Reform of the academic assessment system should be the fundamental approach to tackling this problem in China. (shrink)

In the present study, we tested the effectiveness of color coding on the programming learning of students who were learning from video lectures. Effectiveness was measured using multimodal physiological measures, combining eye tracking and electroencephalography. Using a between-subjects design, 42 university students were randomly assigned to two video lecture conditions. The participants’ eye tracking and EEG signals were recorded while watching the assigned video, and their learning performance was subsequently assessed. The results showed that the color-coded design was more beneficial (...) than the grayscale design, as indicated by smaller pupil diameter, shorter fixation duration, higher EEG theta and alpha band power, lower EEG cognitive load, and better learning performance. The present findings have practical implications for designing slide-based programming learning video lectures; slides should highlight the format of the program code using color coding. (shrink)

Ben shu fen li shi yu wen hua nei han,Shan zong li shi yu wen hua,Dao jiao li shi yu wen hua,Tian ren he yi de si xiang nei han deng duo ge lan mu lai jie shao ru jia si xiang.

Chengbing WangShanxi University, Taiyuan, ChinaMichael A. PetersBeijing Normal University, Beijing, ChinaContemporary Chinese Marxism is not only an important theory in the humanities and social sc...

Ben shu shou ci dui ming mo qing chu zui fu sheng ming de hui zu san da han wen yi zhu jia--Wang Daiyu, Ma Zhu, Liu Zhi de zheng zhi lun li si xiang, jing ji lun li si xiang, hun yin jia ting lun li si xiang, ren xing shan e guan, dao de xiu yang guan jin xing le quan fang wei, duo jiao du de shu li, gou chen he kao cha.

In this paper, a seven-parameter BRDF model with double-peak characteristic, which could fit double-peak data, was adopted to fit the BRDF of Mars simulation soil. At the same time, the three-dimensional figure of the original data of the sample and the three-dimensional curve of the fitted curve were given. The results proved that the model worked well for this type of data. In addition, the experimental data of four kinds of earth sand samples with different roughness were also fitted and (...) analyzed. It was found that the model still had a good fitting effect on such data. At last, the Mars simulation soil and the four kinds of earth sand samples with different roughness were compared horizontally and vertically. Moreover, the double-peak characteristics and other properties of the Mars simulation soil and the earth sand were analyzed under the same and different roughness. (shrink)

Particle Swarm Optimization is an excellent population-based optimization algorithm. Meanwhile, because of its inspiration source and the velocity update feature, it is also widely used in the collaborative searching tasks for swarm robotics. One of the PSO-based models for robotic swarm searching tasks is Robotic PSO. It adds additional items for obstacle avoidance into standard PSO and has been applied to many single-target search tasks. However, due to PSO’s global optimization characteristics, it is easy to converge to a specific position (...) in the search space and lose the ability to explore further. When faced with the problem of multitarget searching, it may become inefficient or even invalid. This paper proposes an Exploration Enhanced Robotic PSO method for multitarget searching problems for robotic swarms. The proposed method modifies the third item in the RPSO as an additional attraction term. This item not only enables the robot to avoid collisions but also guides the swarm to search unexplored regions as much as possible. This operation increases the swarm’s task-specific diversity, making the system cover a broader search area and avoid falling into local optimums. Besides, the aggregation degree and evolution speed factors are also included in determining the inertia weight of the proposed method, which adjusts the swarm’s internal diversity dynamically. The comparison results show that this method can balance the relationship between exploration and exploitation well, which has the potential to be applied to multitarget searching scenarios. (shrink)

Objective: We aimed to evaluate the activity of the human glymphatic system in type 2 diabetes mellitus using diffusion tensor image analysis along with the perivascular space.Methods: Diffusion tensor images were acquired to calculate the diffusivities in the direction of the x-axis, y-axis, and z-axis of the plane of the lateral ventricle body in 20 patients with type 2 diabetes and 10 people in a control group. We evaluated the diffusivity along with the perivascular spaces, as well as the projection (...) fibers and association fibers, separately. The analysis along the perivascular space was defined as the mean /mean, where the Dxpro and Dxasc were the Dx values in the projection and association fiber areas, respectively.Results: There were significant differences in diffusivity along the projection fibers and the association fibers among the groups. The significant differences among the groups along the perivascular spaces, shown as the ALPS-index and medical history of T2DM, indicating lower water diffusivity along the perivascular space concerning type 2 diabetes severity, was also observed.Conclusion: Lower diffusivity along the perivascular space on DTI-APLS can reflect impairment of the glymphatic system in T2DM. This study showed that the activity of the glymphatic system could be evaluated by diffusion tensor image analysis. (shrink)

Immersive 360-degree video has become a new learning resource because of its immersive sensory experience. This study examined the effects of textual and visual cues on learning and attention in immersive 360-degree video by using eye-tracking equipment integrated in a virtual reality head-mounted display. Participants were randomly assigned to one of four conditions: no cues, textual cues in the initial field of view, textual cues outside the initial FOV, and textual cues outside the initial FOV + visual cues. The results (...) showed that the cues helped learners achieve better learning outcomes and spend more time focusing on the areas with cues. In addition, the study found a serious imbalance in the distribution of learners’ attention in each region of the video. The attention directed to textual cues in the initial FOV is much higher than the attention directed to textual cues outside the initial FOV. Adding visual cues can effectively direct attention to textual cues outside the initial FOV and alleviate the imbalance of attention distribution. Consequently, adding cues to immersive 360-degree video can be an appropriate approach to promote learning and guide attention in immersive 360-degree video learning environments. This study provided new insights into the design and development of immersive 360-degree video instructional resources. (shrink)

IntroductionDuring the COVID-19 outbreak, many citizens were asked to stay at home in self-quarantine, which can pose a significant challenge with respect to remaining physically active and maintaining mental health. This study aimed to evaluate the prevalence of inadequate physical activity, anxiety, and depression and to explore the relationship of physical activity with anxiety and depression symptoms among Chinese college students during quarantine.MethodUsing a web-based cross-sectional survey, we collected data from 1,396 Chinese college students. Anxiety and depression were assessed with (...) the Self-Rating Anxiety Scale and the Self-Rating Depression Scale, respectively. The data on physical activity were collected by types of physical activity and the International Physical Activity Questionnaire.ResultsDuring the COVID-19 outbreak, about 52.3% of Chinese college students had inadequate physical activity. The rates of anxiety and depression symptoms were 31.0 and 41.8%, respectively. A high level of physical activity was significantly closely associated with low anxiety, while a moderate, or high level of physical activity was significantly closely associated with reduced depression after adjusting confounding demographic factors. Moreover, specific types of physical activity, such as stretching and resistance training, were negatively correlated with both anxiety and depression; doing household chores was negatively correlated with depression.ConclusionOur findings highlight specific levels and types of home-based physical activities that need to be taken into consideration to protect the mental health of college students during the COVID-19 epidemic. (shrink)

Although the relationship between stressors and thriving at work has been established, the linkage between them is still in the early stages of theory development. This study proposed a two-path model, based on Lepine’s stressors-performance model, to analyze the effects of the stressors on the thriving at work. Two complementary mediating paths were proposed, i.e., affective strain and motivation, which were explained using affective events theory and expectancy theory, respectively. Based on the empirical data from 233 employees, the results show (...) that challenge stressors could enhance employees’ positive affect and self-efficacy, thus leading to thriving at work; on the contrary, hindrance stressors would result in negative influences. In addition, it is also found that the effect of affective path tend to be greater than that of motivation path, which could provide a practical guide for organizations to effectively apply stress management and to promote employees thriving at work. (shrink)

The pressure control for a liquid nature gas ship is vital for the cargo handling system which is a nonlinear, unstable, and controllable complex system accompanied by the dynamics of time delay. To improve the control effect, this article proposed a robust controller based on closed-loop gain shaping algorithm by mirror-mapping approach. In addition, the complete mechanism models for the system are established to predict the changes of temperature, pressure, and liquid inventory in the cargo tank. The heat exchanges and (...) evaporation of liquid are also considered. By collecting the data from the LNG ship “Dapeng,” the system models are validated. At the same time, the comparative experiment is introduced to verify the reliability and effectiveness. The scheme has been compared with the 2-DOF structure control law of modified Smith predictor. The comparative experimental results show that the scheme proposed in this note has a strong disturbance rejection ability and steady-state performance. The controller designed in this note has advantages of simplified construction method, satisfactory control effect and robustness. (shrink)

In the present study, we use a training design in two experiments to examine whether bilingual language switching facilitates two components of cognitive control, namely monitoring and inhibitory control. The results of Experiment 1 showed that training in language switching reduced mixing costs and the anti-saccade effect among bilinguals. In Experiment 2, the findings revealed a greater decrease of mixing costs and a smaller decrease of the anti-saccade effect from pre- to post-training for the language switching training group compared to (...) the L2 training group. Overall, the results suggest that extensive exercise in monitoring and inhibitory control among languages in an experimental setting may enhance the corresponding components of cognitive control. We discuss these findings in the context of the relationship between bilingual language control and executive control. (shrink)

Customized bus services are conducive to improving urban traffic and environment, and have attracted widespread attention. However, the problems encountered in the new customized bus mode include the large difference between the basis of customized bus passenger flow data analysis and the basis of the traditional bus passenger flow data analysis, and the difficulty in different vehicle scheduling caused by the combination of traditional and customized bus modes. We propose a customized bus passenger flow analysis algorithm and multi-destination customized bus (...) line capacity scheduling algorithm, and display them in an intuitive way. The experimental results show that the algorithm model established in this paper can basically meet the data requirements of operation and management, and can provide decision support for customized bus line planning. (shrink)

Kawasaki disease (KD) is an acute self‐limiting vasculitis with coronary complications, usually occurring in children. The incidence of KD in children is increasing year by year, mainly in East Asian countries, but relatively stably in Europe and America. Although studies on KD have been reported, the pathogenesis of KD is unknown. With the development of high‐throughput sequencing technology, growing number of regulatory noncoding RNAs (ncRNAs) including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) have been identified to involved (...) in KD. However, the role of ncRNAs in KD has not been comprehensively elucidated. Therefore, it is significative to study the regulatory role of ncRNA in KD, which might help to uncover new and effective therapeutic strategies for KD. In this review, we summarize recent studies on ncRNA in KD from the perspectives of immune disorders, inflammatory disorders, and endothelial dysfunction, and highlight the potential of ncRNAs as therapeutic targets for KD. (shrink)