Alzheimer's disease is the most common form of dementia that gradually disrupts the brain network to impair memory, language and cognition. While the amyloid hypothesis remains the leading proposed mechanism to explain AD pathophysiology, anti-amyloid therapeutic strategies have yet to translate into useful therapies, suggesting that amyloid β-protein and its precursor, the amyloid precursor protein are but a part of the disease cascade. Further, risk of AD can be modulated by a number of factors, the most impactful being the ɛ4 (...) isoform of apolipoprotein E. A recent study reported a novel isoform-dependent transcriptional regulation of APP by apoE. These interesting new results add to the myriad of mechanisms that have been proposed to explain how apoE4 enhances AD risk, highlighting the complexities of not only apoE and AD pathophysiology, but also of disease itself. Also see the video abstract here: https://youtu.be/yd14MBdPkCY APP transcription is differentially modulated by apoE and its isoforms: how does this novel mechanism fit with the existing hypotheses? (shrink)

The COVID-19 epidemic in the early 2020s is making a big difference for educators around the world. For the past 2 years, the curriculum and working patterns have been overturned in response to this epidemic, which has brought unprecedented challenges and physical and mental stress to preschool teachers. This situation can have a drastic impact on the acquisition of job well-being for preschool teachers. During this special time, the leader’s management style will also influence the psychological feelings of the organization’s (...) staff. For example, empowering leadership is an important management function that empowers subordinates, emphasizes the meaning of work, promotes participation in decision-making, and expresses confidence. Therefore, in the current COVID-19 pandemic context, it is worthwhile to explore the topic of empowering leadership to ensure preschool teachers’ well-being, by balancing work demands and work resources in a way that facilitates a sense of organizational support and reduces job stress, while relatively fewer studies have been conducted on the relationship between preschool teachers’ job well-being in the context of the COVID-19 pandemic. Based on this, this study proposed a research model from the theoretical perspective of the Job Demands-Resources Model to explore the influence of empowering leadership, sense of organizational support, and job stress on preschool teachers’ job well-being in the context of the COVID-19 pandemic. To achieve the purpose of this study, a convenience sampling method was used to invite 500 preschool teachers in China to complete a questionnaire survey, and after removing invalid samples and data with incomplete answers, reliability and validity analyses and model fit tests were conducted, followed by a structural equation modeling method for path analysis. The results of the study showed that in the kindergarten work context, empowering leadership showed a significant negative effect on job stress, but a significant positive effect on job well-being and a significant positive effect on sense of organizational support. Sense of organizational support had a significant negative effect on job stress but a significant positive effect on preschool teachers’ job well-being. Preschool teachers’ job stress and job well-being showed a significant negative effect. The contribution of this study was to explore the relationship between understanding leadership empowerment and preschool teachers’ job well-being in the context of the COVID-19 pandemic based on the Job Demands-Resources Model, which will facilitate educational organizational contexts to empower preschool teachers to work harder to reduce their job stress as well as enhance their sense of organizational support and promote the acquisition of job well-being. (shrink)

The role of psycho-emotional and social factors in determining teachers’ pedagogical success has been largely endorsed in the literature. This highlights the necessity of improving EFL teachers’ awareness and knowledge of various factors related to classroom interaction and interpersonal communication. Despite the existence of some L2 studies on interpersonal communication skills after the popularity of positive psychology, the interplay of variables that directly reflect classroom interactions and their linkage to one’s intelligence has been overlooked, to date. To fill this gap, (...) the present mini review presented the theoretical and empirical foundations of three significant teacher-related variables, namely open-mindedness, immediacy, and social intelligence. In so doing, their relevant definitions, conceptualizations, models, and correlates were provided. Finally, the study offered some practical implications and suggestions for EFL stakeholders and researchers who can improve their knowledge and use of social-based variables in second/foreign language education. (shrink)

The preschool education profession often faces many challenges and preschool teachers, as important members of the preschool education profession must respond to a variety of emergencies with young children, which also leads to high levels of job stress and can have a negative impact on their ongoing well-being. Past research has pointed out that a healthy lifestyle is one of the key factors in enhancing sustainable well-being in high-stress work situations and many studies have found that good leisure activity engagement (...) as a healthy lifestyle is associated with higher levels of well-being. However, the relationship between preschool teachers’ leisure engagement and sustainable well-being has been less explored. Therefore, this study proposed seven research hypotheses based on the engagement theory proposed by Fredricks et al. and developed a research model to explore the relationship between three types of leisure engagement, including behavioral, affective and cognitive, and preschool teachers’ job stress and sustainable well-being, using age as a control variable. This study used a cross-sectional web-based questionnaire with a convenience sample of 500 preschool teachers in China. The collected data were analyzed for reliability and validity, model fit testing and structural equation modeling for model validation after removing invalid data and incomplete responses. The results of the study showed that behavioral engagement was not related with either the job stress or sustainable well-being of preschool teachers; Emotional and cognitive engagement were negatively related to job stress but positively related to the sustainable well-being of preschool teachers; and Job stress was negatively related to the sustainable well-being of preschool teachers; Age is an effective control variable. From the above results, it is clear that not all three types of leisure engagement are effective in terms of reducing the work stress of preschool teachers. As well as being related to the sustainable well-being of preschool teachers emotional and cognitive engagement contributed more to sustainable well-being acquisition. (shrink)

Teacher education students, as an important reserve in the field of education, their growth and development are related to the future of science, economy, sustainable development of education. Through participation in the educational practice of STEAM, which integrates science, technology, engineering, art, and mathematics is more beneficial for them to acquire 21st century skills like communication, collaboration, learning innovation and critical thinking. However, little has been seen about the use and effectiveness of short videos in STEAM education activities and how (...) they can be used to support and promote teacher education students STEAM learning performance and sustainable inquiry behaviors. Therefore, this study combines the framework of triadic reciprocity determinism theory and technology acceptance theory to propose six research hypotheses and develop a research model to explore the relationship between collaborative self-efficacy, perceived usefulness of short videos, perceived ease of use, STEAM learning performance and teacher education students’ sustainable inquiry behavior. To achieve the purpose of this study, this study used purposive sampling and invited teacher education students from five classes of preschool education at a university in Guangxi Zhuang Autonomous Region, China, to participate in this study. A total of 8 h of instructional guidance was provided over a four-week period, in which participants used short videos for collaborative group learning and independent inquiry and applied STEAM concepts to kindergarten science activities. Participants’ STEAM performance was measured and surveyed during the fourth week. The results of the study validation showed that teacher education students CS-E had a positive effect on the PU and PEOU of short videos; Teacher’s education students PEOU of short videos had a positive effect on usefulness; Teacher’s education students PU and PEOU of short videos had a positive effect on STEAM learning performance; Teacher’s education students’ STEAM learning performance had a positive effect on sustainable inquiry behavior. (shrink)

The issue of how to identify the liability of subjects after a traffic accident takes place remains a puzzle regarding the SAE classification system. The SAE system is not good at dealing with the problem of responsibility evaluation; therefore, building a new classification system for self-driving cars from the perspective of the subject's liability is a possible way to solve this problem. This new system divides automated driving into three levels: i) assisted driving based on the will of drivers, ii) (...) automated driving based on the will of the manufacturers, and iii) fully automated driving based on social will. The corresponding responsible subjects for level one, level two, and level three are the drivers, the manufacturers, and society, respectively. (shrink)

The present study examined the behavioral effects of the first-person possessive pronoun. In each trial, a noun was presented to participants after visual presentation of a possessive pronoun “wo de” or “ta de” , which formed ownership. Half participants were assigned to contextual encoding condition in which they were required to judge whether they liked the item expressed by a noun from the first or third-person perspective. The rest were assigned to perceptual encoding condition in which they were asked to (...) judge what color the noun was. A subsequent recall test was performed. The results showed that there were significant memory and response advantages for nouns in “my” ownership under both conditions. The results were discussed with reference to self-specificity and other effects in the current study. (shrink)

The article examines the modalities of social development. Reconsidering the history of the evolution of ideas, it can be noted that the development of countries was usually interpreted only in two modalities – evolution and revolution. But the concepts of revolution and evolution – qua states of progress – cannot explain the whole variety of real but unique processes and events, cannot reflect the specifics of the development process in countries of different regions of the world. In the humanities, there (...) is a domination of formal pragmatic ideas that social well-being is determined by the level of the economic and technical base of society, by the total volume of the benefits consumed. However, the state of public consciousness, being a form of the internal state of society, directly affects social well-being. For this reason, the concept of “trauma” is proposed as a term for a specific state, different from a revolutionary or evolutionary one, a state that draws society away from the logic of development and progress. Thus, we should talk about the “trauma society,” which should be understood as the third modality of social development along with evolution and revolution. The trauma state primarily manifests itself in the forms of social self-awareness. Trauma society lacks a clear strategy and understanding of its own prospects. The actions of society are inconsistent in nature and are not able to mobilize resources to overcome destructive processes. Due to that, the traumatic conditions have economic and political consequences. In a trauma society, national specificity is usually either ignored or, contrarily, exaggerated. The degradation of economic and government institutions leads to a merger of power and property. Therefore, the harmonization of public consciousness should be considered as one of the conditions for overcoming the institutional crisis. (shrink)

本书分教化的源流和内涵、教化的基础和旨归、教化的现状和使命三篇。记录了作者从前辈大师那里所受到的教诲,对学业上的开示和道德人格上的感召等。.

Residual useful lifetime prediction plays a key role of failure prediction and health management in equipment. Aiming at the problems of residual life prediction without comprehensively considering multistage and individual differences in equipment performance degradation at present, we explore a prediction model that can fit the multistage random performance degradation. Degradation modeling is based on the random Wiener process. Moreover, according to the degradation monitoring data of the same batch of equipment, we apply the expectation maximization algorithm to estimate the (...) prior distribution of the model. The real-time remaining life distribution of the equipment is acquired by merging prior information of real-time degradation data and historical degradation monitoring data. The accuracy of the proposed model is demonstrated by analyzing a practical case of metalized film capacitors, and the result shows that a better RUL estimation accuracy can be provided by our model compared with existing models. (shrink)

The authors explore the changing dynamics of gendered familial caregiving in urban China within the context of economic reforms and the continued cultural influence of xiao. Data collected in China through interviews with 110 familial caregivers were used to examine cultural and structural influences on the caregiving behavior of adult children. Results from multiple regression analyses provide evidence of a gendered division of parental care tasks, a decline in the patrilocal tradition of caregiving, and a strong social pressure that influences (...) caregiving behavior. Structural factors linked to caregiving performance included family size, lack of pensions for elders, and caregivers’ employment status and income. Findings portend deleterious effects for the women who are now caregivers as they are likely to live longer but be more financially dependent and have fewer children available to help them. (shrink)

本书展示了哲学大师冯友兰的学术思想和精神魅力，全书共分十四章，内容包括：祁仪少年、随父就读、公学读书、求学北大、留学美国、安身清华、南渡岁月等。.

Mismatch negativity of event-related potentials is a biomarker reflecting the preattentional change detection under non-attentional conditions. This study was performed to explore whether high self-related information could elicit MMN in the visual channel, indicating the automatic processing of self-related information at the preattentional stage. Thirty-five participants were recruited and asked to list 25 city names including the birthplace. According to the difference of relevance reported from the participants, we divided names of the different cities into high, medium, and low self-related (...) information. Visual MMN was elicited by high self-related information but not by medium self-related information, with an occipital–temporal scalp distribution, indicating that, under non-attentional condition, high self-related information can be effectively processed automatically in the preattentional stage compared with low self-related information. These data provided new electrophysiological evidence for self-related information processing. (shrink)

University students having high entrepreneurial intention while not transferring into actual entrepreneurial behavior is a contradictory issue in need of in-depth research. To explore the successive development mechanism of the entrepreneurial process, this study constructed a moderated mediation model to examine whether entrepreneurial commitment from three dimensions mediated the relationship between entrepreneurial intention and behavior, and whether this mediating process was moderated by family support. A survey was conducted among university students from six major universities in south China using the (...) snowball sampling approach. A total of 469 valid responses were obtained. Structural equation modeling was adopted for data analysis. According to the results of the confirmatory factor analysis, it was found that entrepreneurial intention had both direct and indirect positive effects on entrepreneurial behavior, while entrepreneurial commitment worked as the mediator, and family support moderated the relationship between entrepreneurial intention and behavior. Results indicated that entrepreneurial commitment bridged the path from entrepreneurial intention to behavior, and family support created the boundary effect. This finding highlights the importance of guiding students through entrepreneurial commitment toward entrepreneurial behavior, and pays special attention to the crucial role of family support under the national strategy. (shrink)

Analytic philosophy has been developing in China for over a century, and philosophers shaped by the analytic tradition have grown into an important philosophical community in China. The views of contemporary analytic philosophers in China on central philosophical issues and their similarities and differences with analytic philosophers in English-speaking countries have not been systematically investigated. Bourget and Chalmers have conducted two large-scale online questionnaire surveys on analytic philosophers in English-speaking countries. Inspired by their studies, a survey on analytic philosophers in (...) China was performed. It is found that philosophers in China had no agreement on most issues. According to the comparative analysis with the results of Bourget and Chalmers’ second survey, there were significant differences in views as well as thinking styles between analytic philosophers in China and English-speaking countries. And these differences may be partially explained by cultural factors and academic environments. (shrink)

Taking the increasing implementation and practice of ‘quality‐oriented education’ as the background to the current reform, the paper outlines moral education in the Chinese junior high school over the last 25 years. It offers a brief review of a few theoretical and empirical research projects which have had some influence on the 2003 reform of the course of Ideology and Morality. It describes: three basic principles behind this new curriculum, focusing on the developing lives of students; curriculum characteristics with ideological, (...) humanistic, practical and integrative dimensions; and the objectives of developing feelings, attitudes and value orientations, competencies and knowledge. The curriculum is illustrated by four textbook and class‐based examples of respect for parents, self‐esteem, environmental awareness and being a responsible citizen, which offer some insights into contemporary moral education with distinctive Chinese characteristics. Finally, the paper gives an overview of the significance of the moral education curriculum reform and of its ongoing challenges. (shrink)

Travel route preferences can strongly interact with the events that happened in networked traveling, and this coevolving phenomena are essential in providing theoretical foundations for travel route recommendation and predicting collective behaviour in social systems. While most literature puts the focus on route recommendation of individual scenic spots instead of city travel, we propose a novel approach named City Travel Route Recommendation based on Sequential Events Similarity by applying the coevolving spreading dynamics of the city tour networks and mine the (...) travel spatiotemporal patterns in the networks. First, we present the Event Sequence Similarity Measurement Method based on modelling tourists’ travel sequences. The method can help measure similarities in various city travel routes, which combine different scenic types, time slots, and relative locations. Second, by applying the user preference learning method based on scenic type, we learn from the user’s city travel historical data and compute the personalized travel preference. Finally, we verify our algorithm by collecting data of 54 city travellers of their historical spatiotemporal routes in the ten most popular cities from Mafeng.com. CTRR-SES shows better performance in predicting the user’s new city travel sequence fitting the user’s individual preference. (shrink)

The results of our research, obtained from a survey of 50 Western managers working in Romania, show that differences exist between Western managers' ethics and those of their Romanian counterparts, especially with regard to bribery. Different backgrounds are at the basis of such divergence. Beyond the communist era and its heritage, the cultural aspect of bribery has been analyzed. Nevertheless, the results of our research suggest that culture may play a double role and the influence could come from both the (...) home environment of Western managers and their new environment. Some Western managers who adapt to the Romanian environment appear to have been already conditioned to bribery from their home environment. (shrink)

This open access book sheds light on the term gongsheng/kyōsei, which is used in Chinese and Japanese to not only translate “symbiosis” in biology but also broadly deployed in philosophical, social and political contexts. It is a cross-contextual attempt to study the foundation of gongsheng/kyōsei as a philosophy of co-becoming, with exploration of its significance for thinking about the planetary challenges of our times.

In this paper, we introduce the notions of -fuzzy filters and -fuzzy Boolean filters in R0-algebras and investigate some of their related properties. Some characterization theorems of these generalized fuzzy filters are derived. In particular, we prove that a fuzzy set in R0-algebras is an -fuzzy Boolean filter if and only if it is an -fuzzy implicative filter. Finally, we consider the concepts of implication-based fuzzy Boolean filters of R0-algebras.

In this paper, we introduce the notions of -fuzzy filters and -fuzzy Boolean filters in R0-algebras and investigate some of their related properties. Some characterization theorems of these generalized fuzzy filters are derived. In particular, we prove that a fuzzy set in R0-algebras is an -fuzzy Boolean filter if and only if it is an -fuzzy implicative filter. Finally, we consider the concepts of implication-based fuzzy Boolean filters of R0-algebras.

Emotion Review, Volume 14, Issue 1, Page 66-83, January 2022. To better define the boundaries of conceptually overlapping constructs of intrapersonal emotion knowledge, we examined meta-analytic correlations among five intrapersonal EK-related constructs and attention to emotion. Affect labelling, alexithymia, and emotional clarity were strongly associated, and they were moderately associated with attention to emotion. Alexithymia and emotional awareness were weakly associated, and emotion differentiation was unrelated with emotional clarity. Sample characteristics and measures moderated some of the associations. Publication bias was (...) not found, except for the alexithymia-emotional awareness association. This study helped to clarify the extent to which similarly defined constructs overlap or are distinct, which can inform our decision to adequately label important constructs and employ corresponding measures. (shrink)

Emotion Review, Volume 14, Issue 1, Page 66-83, January 2022. To better define the boundaries of conceptually overlapping constructs of intrapersonal emotion knowledge, we examined meta-analytic correlations among five intrapersonal EK-related constructs and attention to emotion. Affect labelling, alexithymia, and emotional clarity were strongly associated, and they were moderately associated with attention to emotion. Alexithymia and emotional awareness were weakly associated, and emotion differentiation was unrelated with emotional clarity. Sample characteristics and measures moderated some of the associations. Publication bias was (...) not found, except for the alexithymia-emotional awareness association. This study helped to clarify the extent to which similarly defined constructs overlap or are distinct, which can inform our decision to adequately label important constructs and employ corresponding measures. (shrink)

The idea of fragmentalism has been proposed by Kit Fine as a non-standard view of tense realism. This paper examines a modal version of the view, called modal fragmentalism, which combines genuine realism and realism of modality. Modal fragmentalism has been recently discussed by Iaquinto. But unlike Iaquinto, who primarily focused on possibilities de re, in this paper, we focus on expressions of possibilities de dicto. We argue that the chief idea of modal realism should be that different worlds are (...) distinguished not just in terms of how things are differently with respect to each world, but also in terms of how things could have been differently with respect to each world. This demands a realism-oriented semantics for suppositional contents, and more specifically, for conditionals. By deploying a multidimensional semantics for conditionals, we show that there are good reasons to consider modal fragmentalism as a serious approach in metaphysics, which shares many similarities with the fragmentalism of tense. (shrink)

Rosenkranz (2021) offered a logic and a detailed account of justification, according to which justification that p can be analyzed as a form of second-level ignorance: ¬K¬Kp. An intuition behind the analysis is that the justified subject has the potential, at least in a nearby world, to either come to know p or come to know ¬Kp. However, given Rosenkranz’s hyperintensional semantics for modeling knowledge states, we can always construct, out of an ¬K¬K-agent’s knowledge state, epistemic possibilities that prohibit the (...) agent from having that potential. This shows that Rosenkranz’s analysis is still insufficient for carrying all the epistemic weight underlying the notion of justification. A better analysis would require a deeper look into an agent’s knowledge structure and its involved modalities, which could be a lot more complex than what the ¬K¬K rule tells us. (shrink)

本书主要内容包括:自我问题的由来及其同一性、科学思维与主体的实践精神、个人自我与意志、“意志”的必然性及其分化、个人意志及其虚无主义的价值取向等。.

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