The microstructures of cryogenically ball-milled Cu were investigated by high-resolution electron microscopy. It was found that the grain-size reduction is a dislocation-controlled continuous process which consists of the formation of small-angle grain boundaries , a gradual increase in misorientations as a result of accumulation of more dislocations and, finally, the formation of large-angle GBs. The GBs were generally curved, wavy or faceted, and heavily strained, which are typical characteristics of nanostructured materials. In addition, extrinsic dislocations were found in many GBs, (...) indicating that most are in a high-energy non-equilibrium configuration, which is consistent with observations in equal-channel angular pressing processed Cu, Ni, and Al-Mg, repetitive corrugation and straightening processed Cu and room-temperature ball-milled Cu. These results support a still-disputed concept that GBs in nanostructured metals processed by severe plastic deformation are mostly in non-equilibrium states. (shrink)

Catholic thinkers generally agree that artificial womb technology (AWT) would be permissible in cases of partial ectogenesis to assist severely premature infants, but there is substantially more debate concerning whether AWT could be used to save frozen embryos, which are the result of in vitro fertilization (IVF). In many cases, these embryos have been abandoned and left in a permanently cryogenic state, which is an affront to their human dignity. While AWT would allow people to adopt these embryos and give (...) them an opportunity to develop, it gives rise to serious concerns over the possibility of scandal and the potential for cooperation in evil. Therefore, the author argues that even though AWT may one day represent a solution to this tragedy, it is currently not a morally licit answer, given the widespread use and approval of IVF in our culture. (shrink)

Einstein's early thoughts about superconductivity are discussed as a case study of how theoretical physics reacts to experimental findings that are incompatible with established theoretical notions. One such notion that is discussed is the model of electric conductivity implied by Drude's electron theory of metals, and the derivation of the Wiedemann-Franz law within this framework. After summarizing the experimental knowledge on superconductivity around 1920, the topic is then discussed both on a phenomenological level in terms of implications of Maxwell's equations (...) for the case of infinite conductivity, and on a microscopic level in terms of suggested models for superconductive charge transport. Analyzing Einstein's manuscripts and correspondence as well as his own 1922 paper on the subject, it is shown that Einstein had a sustained interest in superconductivity and was well informed about the phenomenon. It is argued that his appointment as special professor in Leiden in 1920 was motivated to a considerable extent by his perception as a leading theoretician of quantum theory and condensed matter physics and the hope that he would contribute to the theoretical direction of the experiments done at Kamerlingh Onnes' cryogenic laboratory. Einstein tried to live up to these expectations by proposing at least three experiments on the phenomenon, one of which was carried out twice in Leiden. Compared to other theoretical proposals at the time, the prominent role of quantum concepts was characteristic of Einstein's understanding of the phenomenon. The paper concludes with comments on Einstein's epistemological reflections on the problem. (shrink)

Most definitions of death – whether cardiopulmonary, whole brain and brain stem, or just upper brain – include an irreversibility condition. Cessation of function is not enough to declare death. Irreversibility should be limited to an organism's ability to ‘restart’ itself after vital organs have ceased to function. However, this would mean that every hour people who cannot be revived without the intervention of medical personnel and their technology are coming back from the dead. However, the alternative of irreversibility being (...) dependent upon technology will lead to even more counterintuitive results such as: some people are dead at a particular time and place, but others in more technologically advanced eras and locations are alive despite their being in identical physical states; in the future, millions of cryogenically frozen human beings could spend centuries in a non–dead state because of the future technological breakthroughs; or large numbers of ‘frozen’ people are dead for aeons but coroners are not able to declare them so because they are unaware of what biological conditions science will never be able to reverse. So death should be defined only in non–relational biological terms with a self–starting condition similar to that once advocated by Lawrence Becker. (shrink)

From the Ninth Circle of hell in Dante’s Inferno to the idea of human cryogenic storage, cold has been an important part of human life and imagination. In History of Artificial Cold, Scientific, Technological and Cultural Issues, editor Kostas Gavroglu has brought together a well-balanced and very readable collection of essays on the history of the investigation and use of “cold.” There is something here for a broad range of readers, with articles ranging from fundamental physics to industrial refrigeration and (...) the international politics of frozen meat.Cold is a very relative term, and this book looks at a broad range of coldness. On the laboratory side, there was a competition starting in the late part of the nineteenth century to create the lowest temperature possible. The effort to transform gases into liquids and solids had serious implications for material science and laboratory practice, but it also contributed to the experimental understanding of quantum physics. At about the sa .. (shrink)

The focus here is the question of the moral status of viable human embryos for the first few days of their existence. More precisely, my focus is the human embryo from its conception, through its becoming a mass of undifferentiated cells, to its first differentiation when the initial stem cell mass appears. Naturally, this would occur in the first week of the embryo’s existence, whether in vitro (in a laboratory) or in vivo (in the uterine tubes or uterus). With (...) class='Hi'>cryogenics, the process can be frozen at any stage. In this essay, I identify four categories of human embryos and argue that differences between these categories support the view that embryos are not all equal in terms of their moral status, which, in turn, supports the legitimacy of some medical and research procedures that put embryos at risk. (shrink)

The focus here is the question of the moral status of viable human embryos for the first few days of their existence. More precisely, my focus is the human embryo from its conception, through its becoming a mass of undifferentiated cells, to its first differentiation when the initial stem cell mass appears. Naturally, this would occur in the first week of the embryo’s existence, whether in vitro (in a laboratory) or in vivo (in the uterine tubes or uterus). With (...) class='Hi'>cryogenics, the process can be frozen at any stage. In this essay, I identify four categories of human embryos and argue that differences between these categories support the view that embryos are not all equal in terms of their moral status, which, in turn, supports the legitimacy of some medical and research procedures that put embryos at risk. (shrink)

Many of the thousands of human embryos currently in cryogenic storage will sooner or later be discarded, often after being experimented upon. Others will remain in storage indefinitely, left there by parents who have no plans either to bring them to term or to offer them for adoption. These facts, coupled with a commitment to the basic moral equality of all human beings at all stages of development, generate a pressing question: What should be done for these embryos whose vital (...) activities have been suspended and whose futures look so bleak? This paper offers a case that allows some of these cryogenically stored embryos to thaw and die, allows disposal of their remains in a manner that reflects their status, and is morally acceptable in that it is consistent with the principles that many accept as governing the removal of life-sustaining treatment in end-of-life cases. (shrink)

While some countries are moving toward legalization, euthanasia is still criticized on various fronts. Most importantly, it is considered a violation of the medical ethics principle of non-maleficence, because it actively seeks a patient’s death. But, medical ethicists should consider an ethical alternative to euthanasia. In this article, we defend cryocide as one such alternative. Under this procedure, with the consent of terminally-ill patients, their clinical death is induced, in order to prevent the further advance of their brain’s deterioration. Their (...) body is then cryogenically preserved, in the hope that in the future, there will be a technology to reanimate it. This prospect is ethically distinct from euthanasia if a different criterion of death is assumed. In the information-theoretic criterion of death, a person is not considered dead when brain and cardiopulmonary functions cease, but rather, when information constituting psychology and memory is lost. (shrink)

The purpose of this article is to analyse Adam Smith’s view of death in The Theory of Moral Sentiments for commercial society to determine whether the current commodification of goods (e.g. pharmaceuticals) and services (e.g. cryogenics) to assist people to deal with the fear of death was what Smith envisioned for meaningful existence and to find out what he proposed as a means to manage the fear of death in existence. The investigation revealed that Smith’s book contains many references (...) to death as a source of anxiety that negatively influences the lives of people, their happiness and meaning in life, and ignites fear and anxiety. The cultural measure of Smith’s time to manage the fear of death are magnanimity (e.g. war and suffering), the comfort of wealth, posthumous happiness (e.g. duty and sacrifice) and philosophy (e.g. Stoicism). The problem for Smith is that wealth and commodities, as is the case with the other means to deal with the fear of death, do not result in being-for-itself without the assistance of the impartial spectator which is a cognitive mechanism for self-awareness and socially located meaning-creation in the world with others. (shrink)

One of the first envatted brains, the most cyborgian element of J. D. Bernal’s 1929 futuristic manifesto, The world, the flesh and the the devil, proposed a technological solution to the dreary certainty of mortality. In Bernal’s scenario the brain is maintained in an ‘out of body’ but ‘like-body’ environment—in a bath of cerebral–spinal fluid held at constant body temperature. In reality, acquiring prospective immortality requires access to very different technologies—those that allow human organs and tissues to be preserved in (...) a quite ‘inhuman’ life-world—the cryogenic storage chamber. Like Bernal, today’s cryonicists consider that immortality can be secured through preservation of the brain alone. In this article I trace attempts to preserve or suspend life, and especially brain function, through the application of new ‘technologies of immortality’. Drawing together historical information on the development of refrigeration, cryopreservation, transplantation, and nanotechnologies, I explore the uneasy relationship between cryonics and the technology on which it depends for its success—cryogenics. In so doing, I argue that the ability to successfully realize the science fiction fantasy of human immortality will rest on a moral and scientific parasitism: the capacity to use the biotechnological artifacts or proxies—cryogenically preserved brains, archived brains, tissues, and immortalized cell lines—derived from the dead, in order to prolong life. (shrink)

Cryoethics is a new theme within bioethics (see bioethics) concerned with the ethics of cryonic storage. Cryonics, which is also erroneously referred to as “cryogenic” technology, offers people the option of having their bodies or brain-stems preserved at very low temperatures after death in order to be revived at some point in the future when technology is sufficiently advanced to enable reanimation, and possibly immortality. The main issues in cryoethics center around whether it is ethical to use this technology, and (...) whether it is prudent to do so. While there are several prudential and ethical arguments against cryonic storage, there is only one argument in favor, but it is quite powerful: the possibility of cheating death for a few years, or even forever if technology advances enough in the time before revival (Shaw 2009). (shrink)

I propose an experiment that may be performed, with present low temperature and cryogenic technology, to reveal Wheeler’s quantum foam. It involves coupling an optical photon’s momentum to the center of mass motion of a macroscopic transparent block with parameters such that the latter is displaced in space by approximately a Planck length. I argue that such displacement is sensitive to quantum foam and will react back on the photon’s probability of transiting the block. This might allow determination of the (...) precise scale at which quantum fluctuations of space–time become large, and so differentiate between the brane-world and the traditional scenarios of spacetime. (shrink)

Two posttranslational lipid modifications present on all Hedgehog (Hh) morphogens—an N‐terminal palmitate and a C‐terminal cholesterol—are established and essential regulators of Hh biofunction. Yet, for several decades, the question of exactly how both lipids contribute to Hh signaling remained obscure. Recently, cryogenic electron microscopy revealed different modes by which one or both lipids may contribute directly to Hh binding and signaling to its receptor Patched1 (Ptc). Some of these modes demand that the established release factor Dispatched1 (Disp) extracts dual‐lipidated Hh (...) from the cell surface, and that another known upstream signaling modulator called Scube2 chaperones the dual‐lipidated morphogen to Ptc. By mechanistically and biochemically aligning this concept with established in vivo and recent in vitro findings, this reflection identifies remaining questions in lipidated Hh transport and evaluates additional mechanisms of Disp‐ and Scube2‐regulated release of a second bioactive Hh fraction that has one or both lipids removed. (shrink)

Embryo adoption is a topic of considerable debate in the Church. Well over a million human embryos are currently being kept in cryogenic containers with little prospect of survival. The desire to rescue these vulnerable human beings is natural. However, the processes required to do so raise serious questions regarding the ethics of embryo adoptions. The violation of the unitive and procreative aspects of human intercourse and its ramifications on the moral status of heterologous embryo transfer are key to understanding (...) the reasoning behind some objections to human embryo adoption. (shrink)

Two years ago, astrophysicists studying Type Ia supernovas discovered that our universe is a much stranger place than we had imagined, with invisible vacuum energy accelerating its expansion. (See my column about this in the May-1999 Analog.) However, new astrophysical observations from the BOOMERanG experiment (Balloon Observations Of Millimetric Extragalactic Radiation and Geomagnetics), a balloon-borne cryogenic microwave telescope measurement that flew at an altitude of about 24 miles over the Antarctic, indicate that our universe is also rather ordinary, in that (...) its space is maximally flat. The term “flat” as used here means that the space of our universe is neither positively curved like a ball or negatively curved like a potato chip. It appears that in our universe, the tendencies of space toward positive curvature from gravitational attraction and towards negative curvature from expansion kinetic energy are precisely in balance, leaving space on the average completely free of curvature. (shrink)

The focus here is the question of the moral status of viable human embryos for the first few days of their existence. More precisely, my focus is the human embryo from its conception, through its becoming a mass of undifferentiated cells, to its first differentiation when the initial stem cell mass appears. Naturally, this would occur in the first week of the embryo’s existence, whether in vitro or in vivo. With cryogenics, the process can be frozen at any stage. (...) In this essay, I identify four categories of human embryos and argue that differences between these categories support the view that embryos are not all equal in terms of their moral status, which, in turn, supports the legitimacy of some medical and research procedures that put embryos at risk. (shrink)

IVF/PGS procedures require that all embryos produced for potential implantation be screened for genetic abnormalities: only embryos free of genetic defects may be implanted or cryogenically preserved for future implantation. In this paper, I argue that the standard practice of the reproductive technology clinic, according to which all abnormal embryos must be discarded, unjustly imposes certain biases and discriminatory social values upon persons for whom it may not be a significant concern that their offspring would be disabled. The “standard” practice (...) both reflects a bias against disability and imposes this bias upon those who seek reproductive assistance from RTCs. I argue, therefore, that insofar as consenting to the destruction of any abnormal embryos as a condition of IVF treatment, RTCs threaten the autonomy of women seeking medical assistance to overcome infertility. Finally, I examine recent empirical findings which suggest that genetic screening and destruction of abnormal embryos does not actually aid the overall objective of IVF, which is live birth, and may actually hinder it. (shrink)

This chapter contains section titled: Feeble Versions Robust Versions The Body View Who's Who? The Soul View The Reincarnation View Is There an Afterlife? Might I Live On?