NCG 4.0 is the latest update of the Network of Cancer Genes, a web-based repository of systems-level properties of cancer genes. In its current version, the database collects information on 537 known (i.e. experimentally supported) and 1463 candidate (i.e. inferred using statistical methods) cancer genes. Candidate cancer genes derive from the manual revision of 67 original publications describing the mutational screening of 3460 human exomes and genomes in 23 different cancer types. For all 2000 cancer genes, duplicability, evolutionary origin, expression, (...) functional annotation, interaction network with other human proteins and with microRNAs are reported. In addition to providing a substantial update of cancer-related information, NCG 4.0 also introduces two new features. The first is the annotation of possible false-positive cancer drivers, defined as candidate cancer genes inferred from large-scale screenings whose association with cancer is likely to be spurious. The second is the description of the systems-level properties of 64 human microRNAs that are causally involved in cancer progression (oncomiRs). Owing to the manual revision of all information, NCG 4.0 constitutes a complete and reliable resource on human coding and non-coding genes whose deregulation drives cancer onset and/or progression. NCG 4.0 can also be downloaded as a free application for Android smart phones. (shrink)

This paper describes the disorienting aesthetics of some environments that are characteristic of the Anthropocene. We refer to these environments as 'mashed-up' and present three dimensions - phenomenological, epistemological and narrative - of the aesthetic disorientation they can trigger. We then advance the suggestion that a rich, nuanced and meaningful aesthetic experience of mashed-up Anthropocene environments (MAEs) calls for a mode of appreciation grounded on performative practices of aesthetic familiarisation with particular MAEs and entities and processes thereof. Familiarisation with MAEs, (...) we further note, can have disorienting codas of its own. It can reveal and highlight, rather than eliminate or alleviate, the solid strangeness of Earth even in the systemically humanised world of the Anthropocene, and it can expose and tie at least some of our agency, identity and sources of meaning in life to the same unstable evolvability of particular MAEs. (shrink)

The global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or coronavirus disease 19 (COVID-19) has led to the imposition of severely restrictive measures by governments in the Western hemisphere. We feel a contrast between these measures and our freedom. This contrast, we argue, is a false perception. It only appears to us because we look at the issue through our contemporary moral philosophy of utilitarianism and an understanding of freedom as absence of constraints. Both these views can be (...) substituted with more sophisticated alternatives, namely an ethics of virtue and a notion of freedom of the will. These offer a fuller picture of morality and enable us to cooperate with the current restrictions by consciously choosing to adhere to them instead of perceiving them as draconian and immoral. We ask whether we should collaborate with the restrictions and argue that considerations of virtue will lead to an affirmative answer. More broadly, virtue ethics permits to deal with the practical concerns about how an individual should behave during this pandemic, given the current lockdown measures or lack thereof. -/- In section 1, we present how utilitarianism and a notion of freedom as negative liberty support the opposition to restrictive measures. In section 2, we outline an alternative based on an ethics of virtue and a more elaborated notion of free will. In the concluding section 3, we argue that considerations of virtue should guide the individual and public response to the emergency. (shrink)

What is a gene? Does it represent a natural kind, or is it just a tool for genomics? A clear answer to these questions has been challenged by postgenomic discoveries. In response, I will argue that the gene can be deemed a natural kind as it satisfies some requirements for genuine kindhood. Specifically, natural kinds are projectible categories in our best scientific theories, and they represent nodes in the causal network of the world (as in Khalidi. Natural Categories and Human (...) Kinds: Classification in the Natural and Social Sciences. Cambridge University Press, Cambridge, 2013; Khalidi. Synthese 195: 1379–1396, 2018; Khalidi. Are Sexes Natural Kinds, In: Dasgupta S, Weslake B (eds) Current Controversies in Philoso-phy of Science. Routledge, New York, 2020; Khalidi. Philos Sci 88:1–21, 2021). In Sect. 2, I will present a brief history of the gene and the controversy over its status. In Sect. 3, I will introduce the account of natural kinds considered in this paper. In Sect. 4, I will first present the relevant definition of genes and how they can be classified. Then, I will argue that the gene can be considered a natural kind as it satisfies the criteria for natural kindhood. Section 5 concludes. (shrink)

At Columbia University in 1906, William James gave a highly confrontational speech to the American Philosophical Association (APA). He ignored the technical philosophical questions the audience had gathered to discuss and instead addressed the topic of human energy. Tramping on the rules of academic decorum, James invoked the work of amateurs, read testimonials on the benefits of yoga and alcohol, and concluded by urging his listeners to take up this psychological and physiological problem. What was the goal of this unusual (...) speech? Rather than an oddity, Francesca Bordogna asserts that the APA address was emblematic—it was just one of many gestures that James employed as he plowed through the barriers between academic, popular, and pseudoscience, as well as the newly emergent borders between the study of philosophy, psychology, and the “science of man.” Bordogna reveals that James’s trespassing of boundaries was an essential element of a broader intellectual and social project. By crisscrossing divides, she argues, James imagined a new social configuration of knowledge, a better society, and a new vision of the human self. As the academy moves toward an increasingly interdisciplinary future, William James at the Boundaries reintroduces readers to a seminal influence on the way knowledge is pursued. (shrink)

In recent years, bioethical discourse around the topic of ‘genetic enhancement’ has become increasingly politicized. We fear there is too much focus on the semantic question of whether we should call particular practices and emerging bio-technologies such as CRISPR ‘eugenics’, rather than the more important question of how we should view them from the perspective of ethics and policy. Here, we address the question of whether ‘eugenics’ can be defended and how proponents and critics of enhancement should engage with each (...) other. (shrink)

Criminal liability for acts committed by AI systems has recently become a hot legal topic. This paper includes three different contributions. The first contribution is an analysis of the extent to which an AI system can satisfy the requirements for criminal liability: accomplishing an actus reus, having the corresponding mens rea, possessing the cognitive capacities needed for responsibility. The second contribution is a discussion of criminal activity accomplished by an AI entity, with reference to a recent case involving an online (...) bot, the Random Darknet Shopper. This discussion will provide the context for the analysis of commonalities and differences between criminal activities by humans and by artificial systems. The third contribution concerns the evaluation of different ways of addressing criminal activities by AI systems in a regulatory perspective. (shrink)

In this paper, I present two crucial problems for Wolff’s metaphysics of quantities: 1) The structural identification problem and 2) the Pythagorean problem. The former is the problem of uniquely defining a general algebraic structure for all quantities; the latter is the problem of distinguishing physical quantitative structure from mathematical quantities. While Wolff seems to have a consistent and elegant solution to the first problem, the second problem may put in jeopardy his metaphysical view on quantities as spaces. After drawing (...) a parallelism between Wolff’s treatment of quantitative structures and Frege’s conception of quantitative domain, I propose a solution to the Pythagorean problem based on the idea that mathematical structures are the result of applying an abstraction principle on physical quantitative structures. In particular, I propose the view that abstraction may be seen as the operation of structure determination which transforms concrete physical quantities (i.e. undetermined structures) into abstract mathematical quantities (fully determined structures of thin and shallow objects). Keywords: Metaphysics of Quantities, Abstraction Principles, Locationism. (shrink)

Dans cet article, je discute quatre contributions récentes sur Leo Strauss écrites par des chercheurs italiens : celles de M. Farnesi Camellone (1), de M. Menon (2), d’A. Ghibellini et la mienne (3). Il s’agit ici de clarifier les raisons pour lesquelles, dans plusieurs études italiennes des deux dernières décennies, Strauss a été étudié davantage comme philosophe que comme penseur politique au sens strict. La principale réside à mon avis dans la relation que Strauss lui-même a établie entre le « (...) problème de la possibilité de la philosophie », relatif à la séparation de l’épistémé d’avec la doxa, et la nécessité de « l’écriture réticente ». L’écriture réticente est un outil méthodologique permettant de contrôler le conflit généré par la question philosophique de la justice, un conflit aux conséquences potentiellement exorbitantes pour la philosophie en tant que mode de vie. (shrink)

In this article I offer an explicating interpretation of the procedure of content recarving as described by Frege in §64 of the Foundations of Arithmetic. I argue that the procedure of content recarving may be interpreted as an operation that while restricting the subject matter of a sentence, performs a generalization on what the sentence says about its subject matter. The characterization of the recarving operation is given in the setting of Yablo’s theory of subject matter and it is based (...) on the relation of determination between properties. The main advantage of the proposal is its generality, for it is applicable not just to the case of abstraction principles. (shrink)

Study of the thought of A. Palomes, Sicilian publisher and typographer, writer in Sicilian and Italian on significant historical events in Sicily and determined critic of the Unity of Italy.

Metaphor has been considered as a cognitive process, independent of the verbal versus visual mode, through which an unknown conceptual domain is understood in terms of another known conceptual domain. Metaphor might instead be viewed as a cognitive process, dependent on the mode, which leads to genuinely new knowledge via ignorance. First, I argue that there are two main senses of ignorance at stake when we understand a metaphor: we ignore some existing properties of the known domain in the sense (...) that we disregard or neglect them; we ignore some “non-existing” properties of the known domain in the sense that they are not a piece of information belonging to the known domain, but emerge in metaphor interpretation. Secondly, I consider a metaphor as a reasoning device, guiding the interpreters along a path of inferences to a conclusion, which attributes to the target some properties of the source. In this path, interpreters might discover the ignored existing properties of the known domain and/or recover the “non-existing” properties, inferring or imagining the missing piece of information. Finally, I argue that, especially in visual metaphors, this process is guided by a “sentiment of rationality”, tracking a disruption of existing familiar conceptualisations of objects and/or actions and a recovery of ignored properties. (shrink)

In this paper, we will explore the relation between molecular structure and functions displayed by biochemical molecules in complex physiological processes by using tools from the philosophy of science and the philosophy of scientific practice. We will argue that biochemical functions are weakly emergent from molecular structure by using an account of weak. In order to explore this thesis, we will consider the role of vitamin B12 in contributing to the process of erythropoiesis. The structure of the paper is the (...) following: First, we will consider biochemical functions and why they cannot be easily reduced to their chemical realisers. We will suggest weak emergence as an alternative while also accounting for the relevance of the context, in our case, systemic and organisational. The paper will conclude by considering (1) how the usage of tools from the philosophy of science, such as weak emergence, can aid our understanding of the relations between the components of complex phenomena, such as erythropoiesis, and (2) how the philosophy of scientific practice sheds light on the explanatory role of processes that are dynamically stabilised and the different levels of organisation implied. (shrink)

Many studies have highlighted a substantial "bureaucracy domination" in procedures relating to migrants’ access to territory. This form of domination is marked by highly discretionary and arbitrary practices, enacted by the administrative authorities of the state. Only minor attention, however, has been devoted to the arbitrariness of judicial decisions and to the judicial role in general in the numerous proceedings that increasingly affect the path of migrants. This path is the main object of this paper. The study focuses on Italian (...) case law in expulsion and detention proceedings of irregular third country national citizens and asylum seekers and presents qualitative empirical research on decisions issued by the competent national authorities. The results have been analysed using a selection of theoretical tools, all referable to the general concept of the rule of law. The judicial decisions on pre-removal detention proceedings in two case studies are examined: the jurisprudence on detention of irregular migrants, in different offices of the Justice of the Peace in Italy; and the case law on detention of asylum seekers in the Ordinary Tribunal of Rome. The assumption underlying the research is that various conceptions of the rule of law may have different explanatory power when it comes to explaining the empirical results. To verify this hypothesis, the study proposes an overview of the main rule of law doctrines in the Western tradition of political and legal thought and applies the method of historical-conceptual analysis. As a result, the explanatory power of six theoretical models of the rule of law was verified against the data with the view to highlight the virtues and vices of the respective explanatory frameworks. This article reaches a two-fold conclusion. First, as far as the explanatory frameworks are concerned: the results of the two case studies cannot be fully explained by any of the models considered in this study. This fact alone casts doubts on the explanatory power of these theories and calls for further research on judicial decision-making more generally. Secondly, a key finding of the study regarding the notions of discretion and arbitrariness is that the judicial approach which assures the highest protection of rights is also the one that is most easily influenced by arbitrariness. The author argues that this paradox can be easily dissolved by paying attention to the plural dimensions of arbitrariness. If we consider arbitrariness from a legal point of view, i.e. as an illegal decision, it is unsurprising that the authority that most uses its discretionary powers is also the one most at risk of abusing these discretionary powers and hence of exercising arbitrary power. However, if we consider arbitrariness from the point of view of philosophical-political theory, i.e. as a form of domination characterised by the absence of sufficient justification, it is unsurprising that the judicial approach which assures the highest protection of rights is also the one that takes its own role as guarantor of these rights and of the constitutional democratic legal order as such most seriously. This judicial approach thus most often risks exercising its power in criticisable ways, as compared to an authority much more in line with the requirements of law enforcement agencies. Keywords: migration, discretion, justice, arbitrariness, civil rights, Rechtsstaat, expulsion, mixed constitution. (shrink)

Theory of Mind (ToM) or mentalization is the ability to understand and foresee the behavior referring to one's own and others' mental states (Premack & Woodruff, 1978; Wimmer & Perner, 1983). This capacity, which is considered the most representative mechanism of social cognition, is a multifaceted set of competences liable to influence--and be influenced by--a manifold of psychosocial aspects. Studies on typical and atypical/clinical development during life showed that ToM is frequently delayed (e.g. in deafness) or impaired in many clinical (...) conditions (e.g. Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, Schizophrenia, Borderline Personality Disorder, Parkinson's Disease, Alzheimer's Disease) and, on the other hand, may not be unequivocally a positive experience. It is therefore possible to consider the existence of multiple kinds of Theory of Mind. In fact, ToM may vary along a quantitative and a qualitative continuum. As for the quantitative dimension, the continuum is constituted by the fluctuation between high and low levels of ToM ability in different clinical conditions. Along this continuum, impairment can mean "not enough" ToM (for example in Autism Spectrum Disorder) as well as "too much" ToM (for example in Schizophrenia and Borderline Personality Disorder). The qualitative dimension--highly interrelated with the quantitative one--regards the shift between adaptive (e.g. prosocial, nice ToM) vs. unadaptive (e.g. antisocial, nasty ToM) mental states content. The issue is discussed in light of recent evidence from outstanding researchers working on typical and atypical/clinical populations along the life-span. Findings from the fields of psychology, neuropsychology and neuroscience enrich the research topic argumentation"--Page 2. (shrink)

Desde el campo de las Neurociencias, las emociones implican cambios fisiológicos, comportamentales y cognitivos. En dichas respuestas interviene el sistema nervioso. El abuso infantil, bullying y adicciones en niños, niñas y adolescentes impactan negativamente sobre su sistema neuroendócrino e inmunitario. La vulnerabilidad fisiológica que esto implica produce alteraciones en la funciones cognitivas que impactan desfavorablemente sobre el desarrollo escolar.

Sociopolitical attitudes are often the root cause of conflicts between individuals, groups, and even nations, but little is known about the origin of individual differences in sociopolitical orientation. We test a combination of economic and evolutionary ideas about the degree to which the mating market, sex, age, and income affect sociopolitical orientation. We collected data online through Amazon’s Mechanical Turk from 1108 US participants who were between 18 and 60, fluent in English, and single. While ostensibly testing a new online (...) dating website, participants created an online dating profile and described people they would like to date. We manipulated the participants’ popularity in the mating market and the size of the market and then measured participants’ sociopolitical attitudes. The sociopolitical attitudes were reduced to five dimensions via Principal Components Analysis. Both manipulations affected attitudes toward wealth redistribution but were largely not significant predictors of the other dimensions. Men reported more unrestricted sociosexual attitudes, and more support for benevolent sexism and traditional family values, than women did, and women supported wealth redistribution more than men did. There was no sex difference in accepting nonconforming behaviors. Younger people and people with lower incomes were more liberal than older people and people with higher incomes, respectively, regardless of sex. Overall, effects were largely not interactive, suggesting that individual differences in sociopolitical orientation may reflect strategic self-interest and be more straightforward than previously predicted. (shrink)

Ethnomethodology research has systematically investigated discursive practices of categorisation, looking at the various ways by which social actors ascribe both themselves and others to identity categories to accomplish various kinds of social actions. Drawing on a data corpus of oncological visits collected in an Italian hospital, involving both native and non-native patients, the present work analyses how participants in these intercultural medical encounters invoke and make relevant social identity categories by the marking of collective pronouns in their talk. Our results (...) showed that whilst institutional identities prevailed, categorial formulations related to cultural or linguistic identities were rarely displayed in interactions with non-native patients. Conversational participants made very little of their linguistical or cultural background and when they did so, their cultural and linguistic identities were deployed for rhetorical and pragmatical aims, such as testing and negotiating common knowledge and epistemic authority. This study shows how even speakers’ minimal lexical choices, such as marked pronouns, impact the negotiation of meanings and activities in life-saving sites such as oncological visits. (shrink)

Grammar as a discipline devoted to the study of language was greatly advanced by the Alexandrian philologists, and especially by Aristarchus, as demonstrated by Stephanos Matthaios. In order to edit Homer and other literary authors, whose texts were often written in archaic Greek and presented many linguistic problems, the Alexandrians had to recognize linguistic grammatical categories and declensional patterns. In particular, to determine the correct orthography or accentuation of debated morphological forms they often employed analogy, which is generally defined as (...) the doctrine that grammatical forms must follow strict rules of declension. Modern scholars have often opposed the Alexandrian doctrine of analogy to the Pergamene doctrine of ‘anomaly’, which favoured spoken usage to determine debated forms. Detlev Fehling and David Blank, however, have shown that this strong opposition never really existed and it is mostly due to Varro. More correctly, ancient grammarians identified inflectional rules as well as forms derived from spoken usage or otherwise aberrant forms—however, respect for spoken usage in the latter case was not labelled ‘anomaly’, which was never a technical term of ancient grammar. Rather, and especially in the Roman period, grammarians used the term ‘pathology’ to account for and explain irregular forms. (shrink)

The aim of this paper is to investigate Nishida Kitarō’s way of philosophizing in the light of the concept of “transition” in order to deepen our understanding of both Nishida’s philosophy and our thinking about and in transitions, using the concept of “boundary” or “border” (Grenze) as a catalyst. For that purpose, we focus on Nishida’s essay “Place” (「場所」), passing through different parts of the text as if through successive gates on a path of transition between one place and the (...) next, until we reach the final place of “absolute nothingness.” Dwelling on this place, we turn our attention to its internal structure and try to depict it along the outlines of a boundary, following the movements taking place in Nishida’s essay. The second part proposes an interpretation of the place of nothingness as an interminable practice of boundary-crossing that doesn’t come to a halt in a final, all-encompassing place, but dynamically situates itself on countless intersecting planes. After a more or less abstract analysis of the concept of “boundary,” we will apply and concretize this approach by using the example of the skin. To this end, we expose five main features of the skin as boundary: permeability, enclosure, excessiveness, interstitiality and reciprocal self-formation. (shrink)

In this article I offer an explicating interpretation of the procedure of content recarving as described by Frege in §64 of the Foundations of Arithmetic. I argue that the procedure of content recarving may be interpreted as an operation that while restricting the subject matter of a sentence, performs a generalization on what the sentence says about its subject matter. The characterization of the recarving operation is given in the setting of Yablo’s theory of subject matter and it is based (...) on the relation of determination between properties. The main advantage of the proposal is its generality, for it is applicable not just to the case of abstraction principles. (shrink)

An inquiry drawing on the presence of Hellenistic philosophy in Philo provides a better knowledge of the diffusion of Hellenistic philosophy since the late ...

_Aristotle on Prescription_ explores Aristotle’s deep reflections on rule-making as a process that is both distinct from that of particular deliberation and decision-making and fundamental to it, operating at the level both of the individual and of society as a whole.

In recent years a number of important studies have explored the new international division of reproductive labor, but those works have concentrated, for the most part, on one end of the life cycle: nannies and childcare. This article focuses on the other end of it, home eldercare work. Jobs falling under this label encompass a variety of work situations but the title suggests a job that is more homogeneous than the occupation actually is. This article explores, through the narratives of (...) the workers and the exploration of this 24-hour job, what it means to work as a home eldercare assistant. (shrink)

Despite the remarkable advances in behavioral and brain sciences over the last decades, the mind/body (brain) problem is still an open debate and one of the most intriguing questions for both cognitive neuroscience and philosophy of mind. Traditional approaches have conceived this problem in terms of a contrast between physicalist monism and Cartesian dualism. However, since the late sixties, the landscape of philosophical views on the problem has become more varied and complex. The Multiple Realization Thesis (MRT) claims that mental (...) properties can be (or are) realized, and mental processes can be (or are) implemented by neural correlates of different kinds. Thus, MRT challenges the psychoneural type-identity theory and the corresponding reductionism. Many philosophers have acknowledged the a priori plausibility of MRT. However, the existence of empirical evidence in favor of intraspecific, human multiple realizations of mental processes and properties is still controversial. Here we illustrate some cases that provide empirical evidence in support of MRT. Recently, it has been proposed that foveal agnosic vision, like peripheral vision, can be restored by increasing object parts’ spacing (Strappini et al., 2017a; Crutch and Warrington, 2007). Agnosic fovea and normal periphery are both limited by crowding, that impairs object recognition, and provides the signature of visual integration. Here we define a psychological property of restored object identification and we cross-reference the data of visually-impaired patients with different etiologies. In particular, we compare the data of two stroke patients, two patients with posterior cortical atrophy (PCA), six cases of strabismic amblyopia, and one case with restored sight. We also compare these patients with unimpaired subjects tested in the periphery. We show that integration (i.e. restored recognition) seems to describe quite accurately the visual performance in all these cases. While the patients have different etiologies and different neural correlates, the unimpaired subjects have no neural damage. Thus similarity in the psychological property given the differences in the neural substrate can be interpreted in relation to MRT and provide evidence in its support. Finally, we will frame our contribution within the current debate concerning MRT providing new and compelling empirical evidence. (shrink)

Axel Honneth is internationally renowned for being one of the leading political and social philosophers of our time, and is highly regarded for his work on recognition and the struggles for recognition. In this interview, he discusses his work over the past four decades, starting from the rise of his intellectual vocation to his most recent book on the sovereignty of work. The text is a transcript, revised by the author, of the dialogue Honneth had with his interviewers and the (...) audience at the masterclass held on 24 May 2023 at the University of Trento, as part of the first series of lectures “Voices from Contemporary Philosophy”. (shrink)

Way-finding (WF) is the ability to move around efficiently and find the way from a starting point to a destination. It is a component of spatial navigation, a coordinate and goal-directed movement of one’s self through the environment. In the present study, the relationship between WF tasks (route tracing and shortcut finding) and individual factors were explored with the hypothesis that WF tasks would be predicted by different types of cognitive, affective, motivational variables and personality factors. A group of 116 (...) university students (88 F.) was conducted along a route in a virtual environment and then asked first to trace the same route again, and then to find a shortcut between the start and end points. Several instruments assessing visuospatial working memory, mental rotation ability, self-efficacy, spatial anxiety, positive attitude to exploring, and personality traits were administered. The results showed that a latent spatial ability factor (measured with the visuospatial working memory and mental rotations tests) - controlled for gender - predicted route-tracing performance, while self-report measures of anxiety, efficacy, and pleasure in exploring, and some personality traits were more likely to predict shortcut-finding performance. We concluded that both personality and cognitive abilities affect WF performance, but differently, depending on the requirements of the task. (shrink)

Cryonics—also known as cryopreservation or cryosuspension—is the preservation of legally dead individuals at ultra-low temperatures. Those who undergo this procedure hope that future technology will not only succeed in reviving them, but also cure them of the condition that led to their demise. In this sense, some hope that cryopreservation will allow people to continue living indefinitely. This book discusses the moral concerns of cryonics, both as a medical procedure and as an intermediate step toward life extension. In particular, Minerva (...) analyses the moral issues surrounding cryonics-related techniques by focusing on how they might impact the individuals who undergo cryosuspension, as well as society at large. (shrink)