Notch signaling plays an essential role in the processes of embryogenesis and cellular differentiation, and it is believed that the oncogenic effects of dysregulated Notch signaling are an anomalous reflection of the normal functions of this cascade. Nonetheless, the cellular events associated with oncogenic Notch signaling have thus far remained elusive. In a recent report, Ferres‐Marco et al.1 described how they used the Drosphila eye as a model system and found that elevated Notch signaling in combination with activation of components (...) of the Polycomb complex of transcriptional repressors led to metastatic growth of tumors through epigenetic silencing of the Rbf gene. Rbf is the Drosophila homologue of the retinoblastoma tumor‐suppressor gene (Rb), thus it represents a novel link between Notch signaling, tumor growth and metastasis. BioEssays 28: 692–695, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

This article analyses the first 20 years of the journal Philosophyof Management to provide insight into how the journal has developed and delineated the field of philosophy of management. Our content analysis uses an inductively developed combination of thematic and frequency analysis. We present our findings in a descriptive tone, inviting scholars to reflect upon how the journal has shaped the field over the past two decades, and to trigger a discussion on a more deliberately inclusive future shaping of the (...) field. (shrink)

If the condemnation and crucifixion of Christ is interpreted in the key of Lutheran divine omniscience and absence of alternative possibilities, an apparent contradiction regarding the moral responsibility and duties of the Israelite executioners of Christ would arise. This contradiction would be the following: How can we sustain the moral responsibility of the executioners if they did not have alternative possibilities and, according to Christ’s first Saying on the cross, they did not know what they were doing? How could it (...) be possible to attribute duties to the executioners if they were not able to fulfill them? These problems can be addressed from a semicompatibilistic perspective of moral responsibility. It could be argued that: 1) the absence of alternative possibilities does not exclude the fact that the executioners could be considered morally responsible for Christ’s crucifixion, and that 2) the impossibility of fulfilling certain duties does not imply that the executioners would not have had these duties and cannot be considered morally responsible for their breach. (shrink)

The present study investigates the association between mental health problems and criminal behavior among adolescents in Sweden. Community crime prevention in a Swedish context is also discussed. Every two years, pupils from schools in Stockholm answer the Stockholm School Survey with questions and statements about their social situation, alcohol and drug use, attitudes, school climate, school grades and criminal behavior. Data collected from pupils who answered the survey in 2014, 2018 and 2020 form the basis of this study. A significant (...) association between mental health problems and criminal behavior was shown, even after controlling for factors suggested in international literature. Mental health problems were shown to be a strong explanation for criminal behavior among adolescents. (shrink)

The purpose of this study was to examine how different inquiry experiences affect in-service science teachers’ performance in terms of their questions and classroom actions. Teachers in a workshop experience proceeded through structured, guided, and full inquiry stations where materials to make foam were provided. Participants were 26 in-service science teachers who were enrolled in an 8-day workshop learning about science-technology-society (STS) approaches to teaching. Those who experienced full inquiry first resulted in more curiosity, more questions, and more unique experiments (...) than at the other two stations. Success in guided inquiry was observed when the guidance was provided by more open-ended questions posed by the leader teachers. The study raises questions concerning the limitations on student thinking when in structured and guided laboratories that characterize traditional science teaching. An analysis of this study may contribute important direction and information for science teaching and learning and encourage more moves for STS successes. (shrink)

It seems odd that in such a densely theological text that Augustine would bring up something like the KK-thesis, which is so epistemological. Yet, as one progresses through the book it does begin to make sense. In this paper, I aim to try to come to some understanding of how and why Augustine uses something like the KK-thesis in Book 11 of The City of God. The paper will progress in the following way: First, I discuss Jaakko Hintikka's work on (...) the KK-thesis in order to have a clear idea of what the KK-thesis is, and some associated problems with it. Next, since Augustine most explicitly deals with the KK-thesis in De Trinitate, with the help of Gareth Matthews work, I discuss Augustine's use of the KK-thesis there. Finally, I return to The City of God, in order come to an understanding of Augustine's use of the KK-thesis there. (shrink)

Was sind Prozesse und Strukturen, die in der theoretischen Ausrichtung des einflussreichen franzosischen Philosophen Louis Althusser nichts weniger als die Gegenstande bzw. Objekte der Wissenschaften darstellen? Es ist diese eminente Fragestellung, die das vorliegende Buch anleitet, welches sich damit mehreren, spezifischen Aufgaben gleichzeitig stellt: Erklarung der komplizierten Philosophie Althussers (und wie sie sich von bestimmten anderen Philosophien unterscheidet) und Bestimmung von Prozess- und Strukturbegriffen in aus-gewahlten Wissenschaften bzw. wissenschaftlichen Forschungsgebieten (mit unterschiedlicher Gewichtung namentlich in der Okonomietheorie, Ideologietheorie, Theorie der Geschichte (...) theoretischer Formationen, Ethnologie und in der Theorie des psychischen Unbewussten). (shrink)

There is no consensus over the proper definition of ‘scientific misconduct.’ There are differences in opinion not only between countries but also between research institutions in the same country. This is unfortunate. Without a widely accepted definition it is difficult for scientists to adjust to new research milieux. This might hamper scientific innovation and make cooperation difficult. Furthermore, due to the potentially damaging consequences it is important to combat misconduct. But how frequent is it and what measures are efficient? Without (...) an appropriate definition there are no interesting answers to these questions. In order to achieve a high degree of consensus and to foster research integrity, the international dialogue over the proper definition of ‘scientific misconduct’ must be on going. Yet, the scientific community should not end up with the definition suggested by the Swedish Research Council. The definition the council advocates does not satisfy the ordinary language condition. That is, the definition is not consistent with how ‘scientific misconduct’ is used by scientists. I will show that this is due to the fact that it refers to false results. I generalise this and argue that no adequate definition of ‘scientific misconduct’ makes such a reference. (shrink)

This paper explores the role the Panhellenic centers played in facilitating the circulation of wisdom in ancient Greece. It argues that there are substantial thematic overlaps among practitioners of wisdom , who are typically understood as belonging to different categories . By focusing on the presence of σοφοί at the Panhellenic centers in general, and Delphi in particular, we can acquire a more accurate picture of the particular expertise they possessed, and of the range of meanings the Greeks attributed to (...) the word σοφία. This approach seeks to challenge the conventional categories of modern scholarship and to offer a broader and more inclusive interpretive framework in its stead. One such thematic overlap is the way in which many σοφοί are described as exerting an almost uncanny, yet highly conventional ability to attract listeners and enchant them with their verbal performances. There is plenty of material to support the view that σοφοό, through tapping into the repository of σοφία that Delphi constituted and by aligning themselves with its authority, were seen as themselves being a conduit for a similar type of charismatic speech. (shrink)

The aim of this study was to describe the experiences of undergoing a presymptomatic genetic test for the hereditary and fatal Huntington’s disease, using a case study approach. The study was based on 18 interviews with a young woman and her husband from the decision to undergo the test, to receiving the results and trying to adapt to them, which were analysed using a life history approach. The findings show that the process of undergoing a presymptomatic test involves several closely (...) connected ethical and medical questions, such as the reason for the test, the consequences of the test results and how health-care services can be developed to support people in this situation. (shrink)

Inspired by Koselleck’s approach to conceptual history, this essay presents a semantic analysis of management. Our inquiry into what management is, focuses on lingual and cognitive wholes of meaning and signification. The essay undertakes a periodization of management history, in an attempt to formulate expectations for a dystopian future management by artificial intelligence. Five periods are distinguished. Each period entails a specific characterisation for three questions: what is the activity of managing, what or who is managed, and who manages? Starting (...) from managing-by-hand, successive differentiation of meaning occurs with regard to different elements of the management relationship (object, activity, agent), followed by a rescaling of the whole relationship into an attitude that can be applied anywhere by anyone. The implication is a dissociation between manager and decision-maker. The essay also speculates how plausible this evolution makes non-human managers (i.e. artificial intelligence). Throughout these five periods, hierarchy is an immanent feature of management. For each period, the essay discusses differentiated meaning, corresponding social reality and characterizes its hierarchy and justification. (shrink)

The repugnant conclusion can be formulated as follows: For any population consisting of people with very high positive welfare, there is a better population in which everyone has a very low positive welfare, other things being equal. As the name indicates, this conclusion appears unacceptable. Yet it has proven to be surprisingly difficult to find a theory that avoids it without implying other very counterintuitive conclusions. Moreover, the conclusion is a problem not just for total utilitarians or those committed to (...) welfarism but for all moral theories according to which welfare matters at least when all other things are equal, which arguably is a minimal adequacy condition for any moral theory. And, not the least, how to deal with it has implications for the present generations’ duties to future generations and intergenerational justice. The question as to how the repugnant conclusion should be dealt with has thus become one of the cardinal challenges of modern ethics, and the inquiry into what it shows about the nature of ethics has opened up many new avenues for research. This chapter covers the different suggestions in the literature on how to do deal with the conclusion, both on the axiological and on the normative levels. Moreover, the conclusion and different ways of deriving it are explained in detail. (shrink)

The article shows how merit has been used to highlight pensioners as a special population in the claims-making activities of the senior rights movement in Sweden, as well as in debates about issues concerning old age. Simply put, merit refers to the claim that pensioners have built the society and they are entitled to special treatment – for instance welfare, reverence – for this reason. Merit is concluded to be a rhetorical tool with the potential of countering images of older (...) people as a burden to the young. It portrays seniors as a population worthy of welfare and reverence. Social movements that emphasize merit among seniors will however risk isolation, since such claims to some extent have become associated with populist attacks on immigrants, politicians and other groups labeled as non-merited. (shrink)

We consider the expressive power of second - order generalized quantifiers on finite structures, especially with respect to the types of the quantifiers. We show that on finite structures with at most binary relations, there are very powerful second - order generalized quantifiers, even of the simplest possible type. More precisely, if a logic is countable and satisfies some weak closure conditions, then there is a generalized second - order quantifier which is monadic, unary and simple, and a uniformly obtained (...) sublogic of which is equivalent to. We show some other results of the above kind, relating other classes of quantifiers to other classes of structures. For example, if the quantifiers are of the simplest non-monadic type, then the result extends to finite structures of any arity. We further show that there are second - order generalized quantifiers which do not increase expressive power of first- order logic but do increase the power significantly when added to stronger logics. (shrink)

In the first of these two studies it is argued that the discrepancy between the predicted and actual outcome of the Michelson-Morley experiment is due to the use of Newton's velocity addition theorem in conjunction with an electromagnetic theory of light. The ether hypothesis is not directly affected at all. The second study is a case study of the removal of a clash in physics generated from the outcome of an experiment. The clash due to the Michelson-Morley experiment gave rise (...) to a program of revision. In the process of implementation of this program Newtonian mechanics was remolded. It is argued that the Riemannian space-time in Einstein's general theory of relativity may be regarded as a successor of the classical ether. (shrink)

Technological developments in recent years have brought about a rapid increase in the number and variety of organ transplants, leading to problems in finding enough organs to meet the need. Organ transplantation has also become a particularly significant issue in medical ethics, especially regarding the question of how and from whom organs are procured. Many methods have been tried in order to solve these problems and discussed from an ethical perspective. This study investigates the Spanish, Belgian and Iranian approaches to (...) solving the organ procurement problem. The Spanish model, which is based on persuading patients and their relatives, is ethically less problematic and is also an improved version of the model applied in Turkey. This study argues that an ideal solution can be found without disregarding ethical rules. In particular, nurses can contribute by helping to run the system more efficiently. The principal aim of this article is to demonstrate the contribution of nurses to solving the current organ procurement problem in Turkey and offer some reflections on what can be done to improve the efficiency of the system. (shrink)

Siyasal sistemler, kitlelerin duyguları ile bilgilerini mobilize etmek, etkilemek ve yönlendirmek için çeşitli yol ve yöntemlere başvurur. Bunların belki de en etkilisi renk sembolizmidir. Zira renkler, hafızada kalıcı iz bırakan ve anlam zenginliği olan kültür sembolleridir. Bu sebeple bazen bir bayrakta, bazen bir afişte, bazen de bir sloganda siyasi bir araç olarak kullanılmaktadır. Hâl böyle olunca siyaset alanında gerçek niteliklerinden uzaklaşan renkler, simgesel anlam ve işlevler kazanmaktadır. Bu yolla siyasiler ile halk arasında hem hızlı bir iletişim hem de güçlü bir (...) dayanışma sağlanabilmektedir. Bu yüzden siyasiler, ideolojik söylemlerini güçlü kılmak adına deyim, özlü söz, vecize gibi dilin söz varlıklarından faydalanmaktadır. Söz konusu ifadelerde geçen renklerin (siyah, beyaz ve kırmızı vb.) siyasi ideoloji ve kavramların yerini tuttukları varsayılmaktadır. Buradan hareketle bu çalışmada, Sovyetlerden beri Rus siyasetinde gelişen sosyo-politik olaylarda sembol değer olarak kullanılan renkler analiz edilmiştir. Bu incelemede siyaset dilinde zikredilen ve aynı zamanda medya ve halkın diline yansıyan “renkli” ifadelere başvurulmuştur. Bu siyasi söylemlerin betimsel yöntemle tanımları yapılmış, renklerin taşıdıkları metaforik ile metonimik anlamları belirlenmiş ve kullanım alanları örneklerle gösterilmiştir. Böylelikle, Rus siyasetinde renklerin anlam, imaj ve fonksiyonları belirlenmeye çalışılmıştır. İnceleme neticesinde, beyazın geçtiğimiz asrın başında demokrasinin, düzenin ve meşrutiyetin simgesi; günümüzde ise hükümet karşıtı sergilenen yasadışı eylemlerin sembol ifadesi olduğu saptanmıştır. Sovyetler zamanında direnişin, isyanın, devrimin simgesi kızıl renk iken eski Sovyet coğrafyasında batı destekli gerçekleşen devrim hareketlerinde kızılın yerini turuncuya bıraktığı anlaşılmıştır. Çarlık rejimi yanlısı ve devrim karşıtı Ortodoks, muhafazakâr, milliyetçi örgütlerin temsil renginin ise siyah olduğu tespit edilmiştir. Çalışmanın sonunda ise araştırmadan elde edilen bilgi ve bulgular derlenerek kısaca değerlendirilmiştir. (shrink)

Six case studies on nursing home staff attitudes to patient autonomy have been analysed. The case studies are based on six polarities within autonomy, as developed by Collopy. In total, 189 professional caregivers, comprising the staff of 13 nursing homes in the county of Stockholm, Sweden, responded to questions based on the case studies. Results show that the attitudes within each professional category had a high level of internal correspondence. Nurses consistently supported patient preferences to the highest degree, followed by (...) assistant nurses and auxiliary staff. Nurses' aides ranked lowest in supporting patient preferences. In only one of the cases were background variables of significance. (shrink)

The aim of this research is to examine the relationships between authenticity, subjective happiness, and life satisfaction. The participants were 347 university students. In this study, the Authenticity Scale, the Subjective Happiness Scale, and Satisfaction with Life Scale were used. The relationships between authenticity, subjective happiness and life satisfaction were examined using correlation analysis and Structural Equation Model. In correlation analysis, authentic living was found positively related to subjective happiness. On the other hand, self-alienation, accepting external influence was found negatively (...) correlated to subjective happiness. Besides subjective happiness and life satisfaction have positive relation. Structural Equation Model showed that self-alienation, accepting external influence results in a decrease subjective happiness on life satisfaction whereas rise in authentic living lead to subjective happiness, so subjective happiness also brings life satisfaction. According to standardized beta coefficients, the most significant predictor of subjective happiness was self-alienation. Results were discussed in the light of the related literature. (shrink)

Evolutionary Transitions in Individuality have been responsible for the major transitions in levels of selection and individuality in natural history, such as the origins of prokaryotic and eukaryotic cells, multicellular organisms, and eusocial insects. The integrated hierarchical organization of life thereby emerged as groups of individuals repeatedly evolved into new and more complex kinds of individuals. The Social Protocell Hypothesis proposes that the integrated hierarchical organization of human culture can also be understood as the outcome of an ETI—one that produced (...) a “cultural organism” from a substrate of socially learned traditions that were contained in growing and dividing social communities. The SPH predicts that a threshold degree of evolutionary individuality would have been achieved by 2.0–2.5 Mya, followed by an increasing degree of evolutionary individuality as the ETI unfolded. We here assess the SPH by applying a battery of criteria—developed to assess evolutionary individuality in biological units—to cultural units across the evolutionary history of Homo. We find an increasing agreement with these criteria, which buttresses the claim that an ETI occurred in the cultural realm. (shrink)

How should one understand comparisons in which neither of two alternatives is at least as good as the other? Much recent literature on comparability problems focuses on what the appropriate explanation of the phenomenon is. Is it due to vagueness or the possibility of non-conventional comparative relations such as parity? This paper argues that the discussions on how to best explain comparability problems has reached an impasse at which it is hard to make any progress. To advance the discussion we (...) suggest a new classification of comparability problems that focuses on the problems they cause for practical reasoning. (shrink)

The internet, either as a tool or as an area of research, adds moral worries to an already complicated research ethical backdrop. Agencies, professional associations and philosophers have formulated research ethical norms designed to help scientists to arrive at responsible solutions to the problems. Yet, many criticize this reliance on norms. Somewhat more precisely, many claim that research ethical norms do not offer guidance. In the literature at least three arguments to that effect can be found. First, the research ethical (...) norms fail to guide since they are inconsistent. Second, they fail to guide since they are too opaque. Third, they fail to guide since they cannot handle the moral complexity of issues scientists doing e-research face. In this paper I argue that these arguments are weak. The arguments are, in their original formulations, rather unclear. I try to improve the situation by spelling out the arguments with reference to a certain set of research ethical norms, to a certain account of action-guidance and with reference to certain important distinctions. It then turns out that the arguments’ premises are either untenable or suffers from lack of relevance. The arguments do not force us to conclude that research ethical norms fail to guide. (shrink)

Aldo Leopold, the modern father of ethical holism, embraced the moral principle that the deontic status of an action is determined by its effect on the integrity, stability, and beauty of the bioti...