A special road sign bearing the legend of the title greeted visitors to the Stanford Artificial Intelligence Laboratory during the time it was housed in the starship that parked on a Stanford hill from the mid sixties to the mid eighties. The sign, near the periphery of SAIL's grounds, referred to the Stanford Cart, a guerrilla research project near the periphery of John McCarthy 's core interests, but motivated by his desire for autonomous vision-guided automatic cars. In a 1969 essay (...) \cite{JMC69} {\em Computer Controlled Cars}, John suggested that the power of a PDP-10 was adequate for the job. I think John still favors this estimate. John is guided by a strong and principled intuition that has proven itself correct in very many things. But in this paper I will present accumulating experimental evidence that hints that in this one opinion John's intuition misled him by more than a few orders of magnitude. (shrink)

The 1981 book Genes, Mind and Culture by Edward O. Wilson and Charles J. Lumsden attempts to offer a comprehensive theory of the linkage between biological and cultural evolution. In the following 21 May 1982 radio broadcast, produced by Julian Brown under the auspices of the British Broadcasting Corporation, Wilson is joined by a philosopher, a geneticist, and a religion scholar in a discussion of “gene culture co‐evolution” and of other issues raised by sociobiology. The discussion is introduced and chaired (...) by the editor of Nature, John Maddox. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Human Genome ProjectSharon J. Durfy (bio) and Amy E. Grotevant (bio)In recent years, scientists throughout the world have embarked upon a long-term biological investigation that promises to revolutionize the decisions people make about their lives and lifestyles, the way doctors practice medicine, how scientists study biology, and the way we think of ourselves as individuals and as a species. It is called the Human Genome Project, and its (...) ultimate goal is to map and determine the chemical sequence of the three billion nucleotide base pairs that comprise the human genome. The feat is expected to take about fifteen years (see General Surveys).These three billion base pairs include an estimated 50,000 to 100,000 genes. The rest of the genome—perhaps 95 percent of it—is nongenic sequences with unknown function, sometimes called "junk." Determining the order and organization of all this material has been likened to tearing six volumes of the Encyclopaedia Brittanica into pieces, then trying to put it all back together to read the information (Surveys: Hall 1990). The effort could be well worth it, many scientists say, because it is expected to yield major insights into many common and complex diseases, including cancer, cardiovascular disease, and Alzheimer's disease (Debate: Dulbecco 1986; Koshland 1989).The Human Genome Project is not without controversy, however (Debate: Davis 1990; Leder 1990; Rechsteiner 1990). Many scientists fear that funding for it will be diverted from other areas of research, rather than obtained from new funding sources. This has enlivened the debate about the relative value of "big" versus "small" science. Also, the value of undertaking a complete sequencing of the genome has been questioned, especially given the high proportion of non-genic sequences.Advocates of the effort converted many critics by making two alterations in the original plan. Plans were included to simultaneously determine the nucleotide sequence of the genomes of other organisms; this provides comparisons and points of reference for the human sequence (U.S.: NIH/DOE 1990). Second, in response to concerns about the high cost of developing technology to sequence the whole [End Page 347] genome, the focus moved from large-scale sequencing to mapping the genome, which would hasten the search for disease genes (U.S.: NIH/DOE 1990).The ideal map would be both genetic, locating DNA markers, or signposts, at closely spaced intervals along the chromosomes, and physical, indicating the exact distance between these markers (Map: McKusick 1991). Since 1973, Human Gene Mapping workshops (HGM) have been held at least every two years to locate, compare, and compile genetic markers. This information is published and is accessible through Genome Database at Johns Hopkins University (McKusick 1991). The most recent Human Genome Mapping workshop was held in August 1991, at which the Human Genome Organization (HUGO) began to assume increased responsibility for coordination of the international mapping effort (Surveys: Maddox 1991).Historical Background of the United States EffortThe first serious discussions about sequencing the entire human genome occurred at a workshop at the University of California at Santa Cruz in 1985 (U.S.: Sinsheimer 1989). A second workshop, organized by the U.S. Department of Energy (DOE) and held in March 1986, addressed the feasibility of an organized program (U.S.: DOE 1986). Shortly thereafter, DOE instituted its own genome project (U.S.: DOE 1987). Reports in early 1988 from both the National Research Council (NRC) of the National Academy of Sciences (NAS) and Congress' Office of Technology Assessment (OTA) (U.S.: NRC 1988; OTA 1988) served as catalysts, and in fiscal year 1988, the U.S. Congress officially launched the Human Genome Project by appropriating funds to both the Department of Energy and the National Institutes of Health (NIH).To avoid potential congressional "meddling" (U.S.: Roberts 1988), NIH and DOE drafted a memorandum of understanding for interagency coordination in October 1988 (U.S.: NIH/DOE 1990). The agencies then created both separate and joint committees, and working groups to administer the project. NIH established the Office of Human Genome Research in 1988 (directed by James D. Watson) to plan and coordinate NIH genome activities. That office has evolved into the National Center for Human Genome Research (NCHGR... (shrink)

Behavioral evidence for the COVIS dual‐process model of category learning has been widely reported in over a hundred publications (Ashby & Valentin, ). It is generally accepted that the validity of such evidence depends on the accurate identification of individual participants' categorization strategies, a task that usually falls to Decision Bound analysis (Maddox & Ashby, ). Here, we examine the accuracy of this analysis in a series of model‐recovery simulations. In Simulation 1, over a third of simulated participants using (...) an Explicit (conjunctive) strategy were misidentified as using a Procedural strategy. In Simulation 2, nearly all simulated participants using a Procedural strategy were misidentified as using an Explicit strategy. In Simulation 3, we re‐examined a recently reported COVIS‐supporting dissociation (Smith et al., ) and found that these misidentification errors permit an alternative, single‐process, explanation of the results. Implications for due process in the future evaluation of dual‐process theories, including recommendations for future practice, are discussed. (shrink)

The article “Consciousness in a Bioreactor? Science and Ethics of Potentially Conscious Human Cerebral Organoids” (Zillo and Lavazza 2023) presents a thoughtful discussion on the potential ethical...

Explores the nature and significance of Petrarch’s indebtedness to Dante in the Rime sparse.

This paper investigates relationships between procedural-memory, declarative-memory, and working-memory skills and adult native English speakers’ novel sound-category learning. Participants completed a sound-categorization task that required integrating two dimensions: one native (vowel quality), one non-native (pitch). Similar information-integration category structures in the visual and auditory domains have been shown to be best learned implicitly (e.g., Maddox, Ing, & Lauritzen, 2006). Thus, we predicted that individuals with greater procedural-memory capacity would better learn sound categories, because procedural memory appears to support implicit (...) learning of new information and integration of dimensions. Seventy undergraduates were tested across two experiments. Procedural memory was assessed using a linguistic adaptation of the serial-reaction-time task (Misyak, Christiansen, & Tomblin, 2010a, 2010b). Declarative memory was assessed using the logical-memory subtest of the Wechsler Memory Scale-4th edition (WMS-IV; Wechsler, 2009). Working memory was assessed using an auditory version of the reading-span task (Kane et al., 2004). Experiment 1 revealed contributions of only declarative memory to dimensional integration, which might indicate not enough time or motivation to shift over to a procedural/integrative strategy. Experiment 2 gave twice the speech-sound training, distributed over two days, and also attempted to train at the category boundary. As predicted, effects of declarative memory were removed and effects of procedural memory emerged, but, unexpectedly, new effects of working memory surfaced. The results may be compatible with a multiple-systems account in which declarative and working memory facilitate transfer of control to the procedural system. (shrink)

Recent studies indicate that mammalian chromosomes contain discretecis‐acting loci that control replication timing, mitotic condensation, and stability of entire chromosomes. Disruption of the large non‐coding RNA gene ASAR6 results in late replication, an under‐condensed appearance during mitosis, and structural instability of human chromosome 6. Similarly, disruption of the mouse Xist gene in adult somatic cells results in a late replication and instability phenotype on the X chromosome. ASAR6 shares many characteristics with Xist, including random mono‐allelic expression and asynchronous replication timing. (...) Additional “chromosome engineering” studies indicate that certain chromosome rearrangements affecting many different chromosomes display this abnormal replication and instability phenotype. These observations suggest that all mammalian chromosomes contain “inactivation/stability centers” that control proper replication, condensation, and stability of individual chromosomes. Therefore, mammalian chromosomes contain four types ofcis‐acting elements, origins, telomeres, centromeres, and “inactivation/stability centers”, all functioning to ensure proper replication, condensation, segregation, and stability of individual chromosomes. (shrink)

The book is not a history of photography, but a history of the theories of photography.

In this paper, we explore the methodologies underpinning two participatory research collaborations with Australian non-profit organisations that aimed to build data capability and social benefit in data use. We suggest that studying and intervening in data practices in situ, that is, in organisational data settings expands opportunities for improving the social value of data. These situated and collaborative approaches not only address the ‘expertise lag’ for non-profits but also help to realign the potential social value of organisational data use. We (...) explore the relationship between data literacy, data expertise and data capability to test the idea that collaborative work with non-profit organisations can be a practical step towards addressing data equity and generating data-driven social outcomes. Rather than adopting approaches to data literacy that focus on individuals – or ideal ‘data citizens’ – we target the organisation-wide data settings, goals and practices of the non-profit sector. We conclude that participatory methods can embed social value-generating data capability where it can be sustained at an organisational level, aligning with community needs to promote collaborative data action. (shrink)

While writers of the English Civil War abstracted from Roman sources a theory of liberty, the original res publica, always under the control of a unified and entrenched oligarchy, presents a threadbare fabric of liberty. Yet an impressive strand of modern republicanism follows this example: Philip Pettit's 'liberty as non-domination' appears to be inimical to notions of government power, overlooking that power is sometimes necessary to protect freedoms. Quentin Skinner sharpens this classical focus on a 'neo-Roman' theory. In Pettit a (...) republican suspicion of popular government underplays contributions to the history of freedom from the Athenian democracy. (shrink)

Calvin approached every question that confronted him by turning to the Scriptures. His spiritual heirs were the makers of modern medicine. However, the fruit borne by his theology has become rotten, through secularization and the excess of its success. By returning to the Scriptures, and particularly Calvin's understanding of the role of the deacon, we can begin again to do the work Christ has for us in the world, building the true City and reversing the curse.

Vaesen infers unique properties of mind from the appearance of specific cultural innovation – a correlation without causal direction. Shifts in habitat, population density, and group dynamics are the only independently verifiable incentives for changes in cultural practices. The transition from Acheulean to Late Stone Age technologies requires that we consider how population and social dynamics affect cultural innovation and mental function.

I thank Michael Symons and Dr Paul Rule for comments on this paper; and Channel 10’s Chris Kenny and Grant Heading for access to the uncut tape of Mr Kenny’s interview with Mr Milera.

This essay examines Newman’s approach to the age-old skeptical “problem of the criterion” in his An Essay in Aid of a Grammar of Assent. By examining Newman’s accent on the illative sense as right judgment in rationation, especially in the justification of first principles of knowledge, this essay depicts Newman as offering a proceduralist approach to answering “the problem of the criterion.”.

The aim of Pyrrhonism is deceptively simple: to achieve a state of ataraxia, of tranquility and relief from perturbation. But what is the extent of the ataraxia envisioned? Must the Skeptic admit a hard distinction between disturbances apparently related to belief and there­fore subject to suspension of judgement, and extra-doxastic disturbanc­es that are beyond the scope of the Skeptical method? In this paper I examine passages from Sextus’s Outlines of Pyrrhonism that indicate that such a distinction may not stand up (...) to Skeptical scrutiny and that the Skepti­cal method does not only apply to “philosophical” speculative dogma or to “intellectual” perturbation, contra Barnes’s claim that the person who perceives the fewest anomalies may make “the perfect Pyrrhonist”. But I also, following Massie’s critique of unwarranted causal inferences regarding the relation between equipollence and ataraxia, distinguish cases where tarache presents itself as anomalous and thus lends itself to inquiry from cases where it presents itself with an appar­ent cause and does not provoke inquiry. Thus, though an apparently extra-doxastic disturbance may actually be rooted in unconsciously-held dogma, the Skeptic cannot demarcate a special class of potentially doxastic disturbances without employing a dogmatic psychology of her own. She must instead suspend judgment regarding the entire scope of her method, entertaining the possibility that any disturbance could be relieved through the Skeptical method. In the process, ataraxia is divested of definite parameters and the Skeptical method becomes effectively endless. (shrink)

A Sydney-based megachurch with global reach, well-known for its “prosperity gospel” of financial acquisition, has developed an additional strand: a detailed theology of consumption. The affinity between a theology of guilt-free—indeed, obligatory—consumption and late capitalism goes some way towards explaining the attraction this minority strand of Christianity holds for politicians, including those without personal religious commitments, in a secular electorate.

Given the dominance of the United States' constitutional tradition, the modern world has inherited a widespread conservatism that holds constitutional 'reform' to be risky and change to mean decline. This attitude has ancient roots. Atavism in politics may be traced to movements that draw (however remotely) upon the legacy of the presocratic philosopher, Parmenides, who promoted a monist view of the world and graphically represented a radical rejection of all change as mere illusion. As one of the forerunners of the (...) immeasurably influential Plato and Aristotle, he helped to shape a philosophical worldview in which the ultimate reality was locked in a realm of disembodied and unchanging Forms. Despite his 'new modes and orders', archaism is apparent in Machiavelli's constitutional inheritance from Polybius, who sought to arrest change through a blending of the 'given' forms of government. This mixed constitution is inherently not conducive to democratic development. (shrink)

Orthologic is defined by weakening the axioms and rules of inference of the classical propositional calculus. The resulting Lindenbaum-Tarski quotient algebra is an orthoimplication algebra which generalizes the author's implication algebra. The associated order structure is a semi-orthomodular lattice. The theory of orthomodular lattices is obtained by adjoining a falsity symbol to the underlying orthologic or a least element to the orthoimplication algebra.

The first English translation of Fichte’s second set of 1804 lectures on the Wissenschaftslehre.