Fibroblast growth factors (FGFs) comprise a large family of developmental and physiological signaling molecules. All FGFs have a high affinity for the glycosaminoglycan heparin and for cell surface heparan sulfate proteoglycans. A large body of biochemical and cellular evidence points to a direct role for heparin/heparan sulfate in the formation of an active FGF/FGF receptor signaling complex. However, until recently there has been no direct demonstration that heparan is required for the biological activity of FGF in a developmental system in (...) vivo. A recent paper by Lin et al.(1) has broken through this barrier to demonstrate that heparan sulfate is essential for FGF function during Drosophila development. The establishment of a role for heparan sulfate in FGFR activation in vivo suggests that tissue-specific differences in the structure of heparan may modulate the activity of FGF. BioEssays 22:108–112, 2000. ©2000 John Wiley & Sons, Inc. (shrink)

The American Journal of Bioethics, Volume 12, Issue 10, Page 18-20, October 2012.

In this article we examine the sonic framing of place. Our theoretical approach combines Goffman’s microsociology (and its sociology of music/sound studies off-shoots) with an account of sound in the urban atmospheres literature. Drawing on the work of French urban sociologist Jean-Paul Thibaud and associated work on sound in urban environments by the CRESSON research centre, we propose that sound frames activity in particular ways, including by infusing self and space with a certain tone, and by rendering places more or (...) less hospitable. In the latter part of the article, we examine Quiet Hour shopping as a case study in the sonic constitution and transformation of places. We conclude by reflecting on whether the social and cultural theoretical analysis of sound has suffered from a ‘noise bias’, and whether the ‘resonances’ of public places is a new frontier in both sociological research and in the politics of cities. (shrink)

"Godard is the most contemporary of directors, one who has never set a film in the past. Yet since the 1990s he has produced a whole cycle of works whose tones are retrospective, memorial, elegaic. These include JLG/JLG:Auto-portrait du Décembre, the much-discussed Histoire du Cinèma 2 x 50 Years of French Cinema, The Old Place, On the Origin of the Twenty-First Century, Dans Le Noir du Temps, and the 2006 Centre Pompidou exhibition “Travels in Utopia.” This last was a retrospective (...) in the conventional sense, but was also retrospective as an installation, divided into three spaces identified as hier, l’avant-hier, and aujourd’hui, with tomorrow notable for its absence...". (shrink)

This introduction positions the special issue by highlighting the inherent relationality of place as well as how place is not just an object of analysis but something that shapes thinking, writing and experiences of the world. We reflect on why sociology has found it somewhat more difficult than its social science counterparts to give place the centrality it merits, and discuss whether this reflects a problem with dealing with questions of ‘scale’ and thinking the ‘in-betweenness’ of place. We assess important (...) formulations of place in recent place theories, including non-essentialist framings of place such as ‘progressive’ and as ‘assemblage’. We make a case for seeing the articles in this special issue (and Thesis Eleven’s own long history of publishing writing on the topic of place) as resonating with the themes of place as materiality, atmospheres and spaces of belonging. (shrink)

Introduction to Education provides pre-service teachers with an overview of the context, craft and practice of teaching in Australian schools as they commence the journey from learner to classroom teacher. Each chapter poses questions about the nature of teaching students, and guides readers though the Australian Professional Standards for Teachers. Incorporating recent research and theoretical literature, Introduction to Education presents a critical consideration of the professional, policy and curriculum contexts of teaching in Australia. The book covers theoretical topics in chapters (...) addressing assessment, planning, safe learning environments, and working with colleagues, families, carers and communities. More practical chapters discuss professional experience and building a career after graduation. Rigorous in conception and practical in scope, Introduction to Education welcomes new educators to the theory and practical elements of teaching, learning, and professional practice. (shrink)

In this working paper, we discuss why researchers and policymakers need to better understand how different theoretical accounts of stability lead to different frameworks of analysis. Though ubiquitously mentioned, stability remains an under-theorized notion in security studies. Expert accounts tend to present stability as a generic description, readily applicable to most political phenomena Ð a stabilized state, a stable region, an unstable society. While seemingly equivocal, such uses exhibit different conceptualizations, exhibiting different features and demanding multiple research programs. To date, (...) most accounts of stability tend to take stability to be an (unconstructed) natural phenomenon or a non-derivative social construction. In this introductory paper, we claim that there is a third way to account for stability that remains unexplored in security studies. Simply put, it involves taking stability to be a derivative social construction (i.e., systemic fallout). We then argue that this alternative account should serve as the theoretical basis for an independent research program within stability studies. (shrink)

The purpose of the present project is to show the manner in which Early Heidegger's notion authenticity is vague. We cannot, given the rest of Heidegger's ontology of Dasein in Being and Time, tell what counts as a case of authentic, rather than inauthentic existence. The first half of the present work is devoted to carefully explaining some relevant, general features of Dasein's ontology, followed by an explanation of the structures associated with authenticity. In the third chapter I defend Heidegger's (...) account of authenticity and, in the process, my own interpretation of his account. In the final chapter I argue in favor of my main claim that Heidegger's notion of authenticity is vague in nature and that a case of a particular, authentic Dasein cannot be definitively derived. (shrink)

Rat Man, a lucidly Lacanian rereading of Freud's famous case of obsessional neurosis, suggests at one point that an obsessional cannot establish any temporality of his or her, and is obliged to wait for what Lacan called "the hour of the Other" . As the authors preface makes clear, something similar is true of Rat Man itself; originally completed in 1977, this terse and instructive book took a full decade to find a publisher. I know nothing of the specific circumstances (...) involved in this delay, but hope that it is not an indication of the current status of Lacan and Lacanians in the English-speaking intellectual world. (shrink)

Sheldon Brivic has an immediately idealist and ultimately religious view of language and literature; he is devoted to Berkeley and Hegel, turns phenomenology into what he wittily calls "phonemonology" , and is much preoccupied with the individuality, personality, and god-like authority of the author. For Brivic, history is mainly important insofar as it passes through the mind of the author , and political criticism is readily construed as "narrowly political" , particularly if it seems insufficiently respectful of a favored character. (...) With the partial exception of phenonemology, these are not habits of thought with which I instinctively sympathize, though I do respect them and would certainly expect to learn something from them, especially when it comes to the practical criticism of Joyce, which is what I found most rewarding in the book; Brivic has a sensitive chapter on the consciousness of Stephen in the "Proteus" episode of Ulysses, as well as some noteworthy ideas on the echoing interactions between Stephen and Bloom and the more contentious relationship between Shem and Shaun in Finnegans Wake. Though he doesn't use the term, the homosocial bond would seem to be his long suit; since he does on page 160 use the phrase "between men," I think he could profitably have consulted Eve Kosofsky Sedgwick's l985 book of the same name. Requests for reprints should be sent to Michael Walsh, Ph.D., Department of English, University of Hartford, West Hartford, Connecticut 06117. (shrink)