Under certain conditions, the cell cycle can be arrested for a long period of time. Vertebrate oocytes are arrested at G2 phase, while somatic cells arrest at G0 phase. In both cells, nuclei have lost the ability to initiate DNA synthesis. In a pair of recently published papers,1,2 Méchali and colleagues and Coué and colleagues have clarified how frog oocytes prevent untimely DNA synthesis during the long G2 arrest. Intriguingly, they found only Cdc6 is responsible for the inability of immature (...) oocytes to replicate DNA. Cdc6 is a key component for replication licensing, and for G0 cells to re‐enter the proliferative stage. Strikingly similar strategies for preventing the untimely replication in both cells suggest that the suppression of replication licensing is a universal mechanism for securing the prolonged arrest of the cell cycle. BioEssays 25:313–316, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Background: Advocacy is an important role of psychiatric nurses because their patients are ethically, socially, and legally vulnerable. This study of Japanese expert psychiatric nurses’ judgments of interventions for patient advocacy will show effective strategies for ethical nursing practice and their relationship with Japanese culture. Objectives: This article explores Japanese psychiatric nurses’ decision to intervene as a patient advocate and examine their ethical, cultural, and social implications. Research design: Using semi-structured interviews verbatim, themes of the problems that required interventions were (...) inductively summarized by a qualitative analysis and their contexts and nursing judgments were examined. Participants and research context: The participants were 21 nurses with 5 or more years of experience in psychiatric nursing. Ethical considerations: The research was approved by Institutional Review Board of research site and study facilities. The participants gave written informed consent. Findings: Analysis of 45 cases showed that nurses decided to intervene when surrounding people’s opinions impeded patients’ safety, healthcare professionals’ policies impeded patients’ decision-making, own violent behaviors impeded treatment and welfare services for patients, own or families’ low acceptance of illness impeded patients’ self-actualization, inappropriate treatment or care impeded patients’ liberty, and their families abused patients’ property. Discussion: To solve conflicts between patients and their surrounding people, the nurses sought reconciliation between them, which is in accordance with Japanese cultural norms respecting harmony. When necessary, however, they protected patients’ rights against cultural norms. Therefore, their judgments cannot be explained by cultural norms alone. Conclusion: The findings indicate that the nurses’ judgments were based on respect for patients’ rights apart from cultural norms, and they first sought solutions fitting the cultural norms before other solutions. This seems to be an ethical, effective strategy if advocates know the culture in depth. (shrink)

This paper investigates the effects of group interaction in a storytelling situation for children using two robots: a reader robot and a listener robot as a side-participant. We developed a storytelling system that consists of a reader robot, a listener robot, a display, a gaze model, a depth sensor, and a human operator who responds and provides easily understandable answers to the children’s questions. We experimentally investigated the effects of using a listener robot and either one or two children during (...) a storytelling situation on the children’s preferences and their speech activities. Our experimental results showed that the children preferred storytelling with the listener robot. Although two children obviously produced more speech than one child, the listener robot discouraged the children’s speech regardless of whether one or two were listening. (shrink)

Research has documented the influence of ALS patients families’ attitudes on patients’ decision to accept or reject TIV, a treatment that in many cases will allow them to live long enough to experience locked-in syndrome ; under Japanese law the use of a ventilator cannot be terminated once it is essential to a patient’s survival, so to choose TIV means to choose the possibility of entering a locked-in state. Previous studies have not, however, elucidated the changes in family members’ attitudes (...) that take place after they receive pertinent information about the social systems and services available to them. This study aims to fill this gap by collecting and analyzing patients’ and family members’ narratives. In Japan, about 30% of ALS patients utilize TIV. This rate is much higher than in most other developed countries. Patients’ narratives illuminate the psychological and especially the contextual factors of their decision-making. Many Japanese patients who currently use a ventilator say that their family members encouraged them to prolong their lives through ventilation. These family members have done so because patients are able to use long-term ventilation for only ¥1000 per month, and can also access the latest communication devices and round the clock caregiver services in their homes at very low cost. Japanese caregivers who are supported by social systems and services including communication assistance, empowering factors such as patients’ associations, care provided by people outside the patient’s family, and a public nursing care system are able to encourage patients to decide to use longterm ventilation. (shrink)

In Book One of the Treatise of Human Nature, Hume seems to acknowledge the existence of both internal and external worlds, in which perceptions, objects, and bodies, exist. In particular, Hume seems directly to affirm the existence of extra-mental bodies, when he says at the beginning of the section "Of scepticism with regard to the senses," "We may well ask, What causes induce us to believe in theexistence of body? but 'tis in vain to ask, whether there be body or (...) not? That is a point, which we must take for granted in all our reasonings" (T 1.4.2.1; SBN 187).1 Furthermore, he thinks that the existence of body must be taken for granted because it is "an affair of too great importance to be trusted to our .. (shrink)

William James criticizes Hume for failing to adhere to the strictly empiricist method when he postulates discrete constituents of experience—which Hume calls perceptions—thereby making our experience a train of disconnected pieces. James argues that the discontinuity of experience in Hume results in part from his failure to recognize the immediate presence of relations in experience.1 Emphasizing a continuity and unity of experience, James thus differentiates his empiricism from Hume's as being radical in the sense that it recognizes relations as 'real' (...) parts of experience just as are things that are experienced to be so related.2 This raises a question concerning the experiential status of relations in Hume: is .. (shrink)

In A Treatise of Human Nature, Hume seems to use the term "object" to refer to different things in different contexts, including impressions, ideas, perceptions, and bodies. Does he ever use the term "external bodies" to refer to things in the extra-mental world? I argue that what Hume means by external bodies when he affirms their existence is not externally existing, material objects that are somehow presented to the mind or presented in impressions. Rather, the bodies that Hume affirms are, (...) at bottom, no different from perceptions, but they can be distinguished from merely internal perceptions like pain or pleasure in terms of their "different relations, connexions, and durations" (T 1.2.6.9; SBN 68). I conclude that in order to be consistent, given the various statements he makes throughout Book One of the Treatise, Hume must reject the philosopher's doctrine of double existence of perceptions and objects and affirm only the existence of perceptions, sometimes conceived as internally existing and mind-dependent and sometimes conceived as existing outside and independent of the mind. (shrink)

William James criticizes Hume for failing to adhere to the strictly empiricist method when he postulates discrete constituents of experience — which Hume calls perceptions — thereby making our experience a train of disconnected pieces. James argues that the discontinuity of experience in Hume results in part from his failure to recognize the immediate presence of relations in experience. Emphasizing a continuity and unity of experience, James thus differentiates his empiricism from Hume's as being radical in the sense that it (...) recognizes relations as ‘real’ parts of experience just as are things that are experienced to be so related. This raises a question concerning the experiential status of relations in Hume: is James correct in accusing Hume of failing to notice the experiential reality of relations? Does Hume deny the experiential reality of relations entirely? Or does Hume downplay the experiential reality of relations and come to take them merely as products of the imagination, hence not ‘real,’ for certain theoretical reasons? (shrink)

Categorial grammar is well-known for its elegant analysis of coordination enabled by the flexible notion of constituency it entertains. However, to date, no systematic study exists that examines whether this analysis has any obvious empirical advantage over alternative analyses of nonconstituent coordination available in phrase structure-based theories of syntax. This paper attempts precisely such a comparison. We compare the direct constituent coordination analysis of non-canonical coordinations in categorial grammar with an ellipsis-based analysis of the same phenomena in the recent HPSG (...) literature. We provide a set of empirical evidence, consisting of cases in which non-canonical coordinations interact with scopal operators of various sorts, which systematically falsifies the predictions of the latter, ‘linearization-based’ ellipsis approach to coordination. We propose an alternative analysis in a variant of categorial grammar called Hybrid Type-Logical Categorial Grammar. The proposed framework builds on both the Lambek-inspired variants of categorial grammar and a more recent line of work modelling word order via a lambda calculus for the prosodic component. The flexible syntax–semantics interface of this framework straightforwardly captures the interactions between non-canonical coordinations and scopal expressions, demonstrating the broader empirical payoff of the direct constituent coordination analysis of non-canonical coordinations pioneered by Steedman :523–568, 1985; Linguist Philos 13:207–263, 1990) and Dowty hitherto not explicitly recognized in the literature. (shrink)

In the Appendix to A Treatise of Human Nature, Hume famously retracts his account of personal identity by confessing that it involves a profound problem he cannot solve, which I have elsewhere identified and called the Bundling Problem. Neither of the two possible solutions that Hume himself considers in the Appendix is a viable option for him by his own lights, which might suggest that any successful account of a unified self must go beyond the empirical framework. In this paper, (...) I argue that we can find a strictly empiricist solution to Hume's problem in William James. I attempt to show that James's descriptions of our experience are phenomenologically more detailed and faithful to how experience is undergone from the first-person perspective, which allows him to explain our belief in an identical, unified self solely on empirical grounds. James finds unity and continuity right in the content of the stream of experience itself. A detailed investigation of James's accounts reveals that Hume's fundamental problem does not stem merely from his lack of empirical resources but, more importantly, from his tacit abandonment of the professed empiricist methodology. (shrink)

There are remarkable parallels between Hume and Nagarjuna in their denial of substantiality and independence in objects and their subsequent attitude toward our ordinary world. Acknowledging a deep-rooted human tendency to take objects as independent entities, they both argue that there is nothing intrinsic in those objects that make them unitary and independent, and that those characters are, strictly speaking, merely fictitious, mental constructs. They nonetheless affirm the existence of our ordinary world as real. Although their main purposes of the (...) philosophical inquiry are different (epistemological for Hume, and soteriological for Nagarjuna), their accounts of the nature of our world allow us to accept it in the way we ordinarily believe with the deeper understanding of it. It is only in this world where we think, act, and interact with others that an epistemology grounded in human sentiment and experience (for Hume) or humans liberation (for Nagarjuna) is possible. (shrink)

This study examined potential sources of grammatical gender variability in heritage speakers of Italian with a focus on morphological markedness. Fifty-four adult Italian HSs living in Germany and 40 homeland Italian speakers completed an online Self-Paced Reading Task and an offline Grammaticality Judgment Task. Both tasks involved sentences with grammatical and ungrammatical noun-adjective agreement, manipulating markedness. In grammatical sentences, both groups showed a markedness effect: shorter reading times and higher accuracy for sentences containing masculine nouns as compared to sentences with (...) feminine nouns. In ungrammatical sentences, although both groups were sensitive to ungrammaticality, only HSs showed a markedness effect, that is, they had significantly longer RTs and higher accuracy when violations were realized on feminine adjectives. Proficiency in the HL was a significant predictor of accuracy and RTs at the individual level. Taken together, results indicate that HSs acquire and process gender in a qualitatively similar way to homeland native speakers. However, RT evidence seems to suggest that at least under particular experimental methods, markedness considerations are more prevalent for HSs resulting in a speed-accuracy tradeoff. (shrink)

In 1997, the Japanese Diet revised the Bank of Japan law thereby granting the central bank greater independence in monetary policy making. The revision was an attempt by Japan's political class to weaken the authority of the powerful Ministry of Finance over the central bank and augment its own influence. The Bank of Japan, however, gained more autonomy than politicians ever intended, leading to frequent confrontations between the government and the central bank over monetary policy. This paper explores the new (...) strategic relationship that emerged between the Bank of Japan and government and the nature of monetary policy implemented in the post-reform period. We demonstrate that several factors contributed to the Bank's unexpected ability to enhance its independence: the astute leadership of the first post-reform governor Hayami Masaru; the Bank's ability to turn politicization of monetary policy to its advantage; and its pursuit of a strategy achieved by augmenting its own research capacity. On a theoretical level, our findings show that the passage of a new legal framework only marks the completion of one stage of institutional change and the start of the next; post-enactment politics have as much importance as pre-enactment politics in shaping outcomes. In the post-enactment phase, various factors, including the state of the economy and informal institutions or processes, matter greatly and may shift the direction of institutional change away from the intended path. (shrink)

This study aims to unveil the process of whistleblowing. Two nursing staff members who worked in a psychiatric hospital convicted of large-scale wrongdoing were interviewed. Data were analyzed using a modified grounded theory approach. Analysis of the interviews demonstrated that they did not decide to whistleblow when they were suspicious or had an awareness of wrongdoing. They continued to work, driven by appreciation, affection, and a sense of duty. Their decision to whistleblow was ultimately motivated by firm conviction. Shortly after (...) whistleblowing, wavering emotions were observed, consisting of a guilty conscience, fear of retribution, and pride, which subsequently transformed to stable emotions containing a sense of relief and regret for delayed action. It is necessary for nurses to recognize that their professional responsibility is primarily to patients, not to organizations. Nurses should also have professional judgment about appropriate allegiance and actions. (shrink)

This article proposes an alternative approach in sustainability assessment. The conceptual framework was developed by modifying Ken Wilber's All Quadrants, All Levels (AQAL) approach, and focuses on the inter-relatedness/inter-connection of various perspectives inherent to the concept of sustainability. To look at how our framework can facilitate the practice of sustainability assessment, we apply the framework to examine the relationships between social systems and the environmental changes in the Ili River basin across the period 1900?2008. This approach enables us to investigate (...) the environmental problems of the Ili River basin in a four-quadrant framework, and combine the empirics of quadrants obtained from traditional disciplinary methodologies. The four-quadrant framework adopted in this study illustrates the interlocking relationships among various perspectives of environmental issues in the Ili River basin, namely, physical perspective, personal perspective, cultural perspective, and social perspective. In particular, the protruding development (evolution) of the lower right dimension is the fundamental cause of the environmental degradation and its related social problems in the Ili River basin. Compared to other established approaches in literature that emphasize on the tradeoffs of various perspectives of sustainability, our findings indicate the potential contributions of four-quadrant framework to sustainability assessment through its focus on the inter-relatedness/inter-connection of different perspectives. (shrink)

1-3. [without special titles] -- 4. "Kogaku" no shisō.

This study investigates the choice of genitive forms (the woman’s book vs. the book of the woman) in the English of Japanese-English bilingual returnees (i.e. children who returned from a second language dominant environment to their first language environment). The specific aim was to examine whether change in language dominance/exposure influences choice of genitive form in the bilingual children; the more general question was the extent to which observed behaviour can be explained by cross linguistic influence (CLI). First, we compared (...) the choice of genitive form between monolingual Japanese speakers and bilinguals who had recently returned to Japan from an English monolingual environment. Second, we tracked changes in genitive preference within bilingual children, comparing their performances upon return to Japan to those of one year later. Results show that CLI alone is insufficient to explain the difference in genitive evaluation between bilinguals and monolinguals, as well as the intra-group bilingual variation over time. We suggest that both CLI and general processing considerations couple together to influence the changes in genitive preference. (shrink)

Literature expects that an attitude toward nuclear power is in direct proportion to the perceived risk of accidents at an operational nuclear power plant; that is, the oppositional attitude is based on the view that nuclear technology is risky and support for nuclear power is related to a perceived low risk and/or potential benefit. However, it is misleading to assume that individuals’ risk perception alone can linearly explain their position after such an accident. The association between risk perception and attitude (...) toward nuclear power varies significantly according to country but, until now, has been largely unexamined. This article takes into consideration the effects of structural factors on that relationship by examining public attitudes toward nuclear energy after the Fukushima nuclear accident in March 2011 and reveals that the need for the efficient production of electricity (i.e., nuclear energy) outweighs concern for the potential danger of a nuclear incident. Although a country's dependence on nuclear power for the production of electricity engenders anti-nuclear attitudes, it is evident that a level of economic development largely alleviates any negativity relative to that energy source. (shrink)