Most cognitive scientists nowadays tend to think that at least some of the mind’s capacities are the product of biological evolution, yet important conceptual problems remain for all scientists in order to be able to speak coherently of mental or cognitive systems as having evolved naturally. Two of these important problems concern the articulation of adequate, interesting, and empirically useful concepts of homology and variation as applied to cognitive systems. However, systems in cognitive science are usually understood as (...) class='Hi'>functional systems of some sort. Thus, to be able to talk about functional systems being homologous requires having a solid, adequate, and empirically articulated concept of functional homology—and the same is true about functional variation. Here I construct an original concept of functional homology that, in my view, adequately systematizes a number of actual uses of the word “functional homology” in a variety of biological disciplines and in ethology. I also propose a number of criteria for the empirical application of the concept that are analogous to the criteria that are currently used in comparative biology, ethology, and molecular developmental genetics. Then I construct a concept of functional variation on the basis of this concept of homology. (shrink)

This paper commences from the critical observation that the Turing Test (TT) might not be best read as providing a definition or a genuine test of intelligence by proxy of a simulation of conversational behaviour. Firstly, the idea of a machine producing likenesses of this kind served a different purpose in Turing, namely providing a demonstrative simulation to elucidate the force and scope of his computational method, whose primary theoretical import lies within the realm of mathematics rather than cognitive modelling. (...) Secondly, it is argued that a certain bias in Turing’s computational reasoning towards formalism and methodological individualism contributed to systematically unwarranted interpretations of the role of the TT as a simulation of cognitive processes. On the basis of the conceptual distinction in biology between structural homology vs. functional analogy, a view towards alternate versions of the TT is presented that could function as investigative simulations into the emergence of communicative patterns oriented towards shared goals. Unlike the original TT, the purpose of these alternate versions would be co-ordinative rather than deceptive. On this level, genuine functional analogies between human and machine behaviour could arise in quasi-evolutionary fashion. (shrink)

This study examined variations in well-being as a function of the interaction between paranormal belief and psychopathology-related constructs. A United Kingdom-based, general sample of 4,402 respondents completed self-report measures assessing paranormal belief, psychopathology, and well-being. Latent profile analysis identified four distinct sub-groups: Profile 1, high Paranormal Belief and Psychopathology ; Profile 2, high Paranormal Belief and Unusual Experiences; moderate Psychopathology ; Profile 3, moderate Paranormal Belief and Psychopathology ; and Profile 4, low Paranormal Belief and Psychopathology. Multivariate analysis of variance (...) found that sub-groups with higher psychopathology scores reported lower well-being. Higher Paranormal Belief, however, was not necessarily associated with lower psychological adjustment and reduced well-being. These outcomes indicated that belief in the paranormal is not necessarily non-adaptive, and that further research is required to identify the conditions under which belief in the paranormal is maladaptive. (shrink)

There is a growing appreciation of the extent of transcriptome variation across individual cells of the same cell type. While expression variation may be a byproduct of, for example, dynamic or homeostatic processes, here we consider whether single‐cell molecular variation per se might be crucial for population‐level function. Under this hypothesis, molecular variation indicates a diversity of hidden functional capacities within an ensemble of “identical” cells, and this functional diversity facilitates collective behavior that would (...) be inaccessible to a homogenous population. In reviewing this topic, we explore possible functions that might be carried by a heterogeneous ensemble of cells; however, this question has proven difficult to test, both because methods to manipulate molecular variation are limited and because it is complicated to define, and measure, population‐level function. We consider several possible methods to further pursue the hypothesis that “variation is function” through the use of comparative analysis and novel experimental techniques. (shrink)

L'article met en valeur le fait que le système pronominal est un excellent indicateur en termes de valeurs véhiculées au sein des écrits argumentatifs des jeunes élèves. A partir d'une tâche rodée en psychologie cognitive, plusieurs thèmes contrastés et significativement testés pour être différents (pro- ou contre attitudes, ce, en lien avec les représentations croisées des enfants versus des parents) les écrits des élèves sont analysés. Le nombre de pronoms employés ne se distribue pas au hasard selon les thèmes. Chaque (...) pronom, je, tu, il(s), on, nous/vous est situé dans l'espace dialogique au regard de cette distribution. (shrink)

In our view, the ability to impose moral values which may be, to some extent, either shared or conflictual, influences the strategy adopted when writing argumentative texts. Our hypothesis is that the greater the socio-moral distance between the writers’ representations (the writers in this case being children) and those of the recipients (here the parents), the more likely it is that writing will be successful. Three topics derived from a preliminary experiment and corresponding to significant differences in opinion between children (...) and parents were tested in a population of 11-year-old pupils. The pupils had to write a letter designed to convince their parents about one of these topics. We analyzed the texts in order to identify the different configurations in the frequencies of use of the pronouns (frequencies of Je (I), Tu (You), Il (He), On (One/We)) and adverbs. These frequencies differed depending on the topic that was being written about (the moral context that is mobilized). (shrink)

Understanding the functional mechanisms underlying genetic signals associated with complex traits and common diseases, such as cancer, diabetes and Alzheimer's disease, is a formidable challenge. Many genetic signals discovered through genome‐wide association studies map to non‐protein coding sequences, where their molecular consequences are difficult to evaluate. This article summarizes concepts for the systematic interpretation of non‐coding genetic signals using genome annotation data sets in different cellular systems. We outline strategies for the global analysis of multiple association intervals and the (...) in‐depth molecular investigation of individual intervals. We highlight experimental techniques to validate candidate (potential causal) regulatory variants, with a focus on novel genome‐editing techniques including CRISPR/Cas9. These approaches are also applicable to low‐frequency and rare variants, which have become increasingly important in genomic studies of complex traits and diseases. There is a pressing need to translate genetic signals into biological mechanisms, leading to prognostic, diagnostic and therapeutic advances. (shrink)

A very weak omniscience principle is formulated, related omniscience principlesare considered, and the theorem that a function of bounded variation is the difference of two increasing functions is shown to be equivalent to the omniscience principle WLPO. It is a so shown that an arbitrary function with located variation on an interval is the difference of two increasing functions.

Cognitive flexibility, the adaptation of representations and responses to new task demands, improves dramatically in early childhood. It is unclear, however, whether flexibility is a coherent, unitary cognitive trait, or is an emergent dimension of task-specific performance that varies across populations with divergent experiences. Three-to 5-year-old English-speaking U.S. children and Tswana-speaking South African children completed two distinct language-processing cognitive flexibility tests: the FIM-Animates, a word-learning test, and the 3DCCS, a rule-switching test. U.S. and South African children did not differ in (...) word-learning flexibility but showed similar age-related increases. In contrast, U.S. preschoolers showed an age-related increase in rule-switching flexibility but South African children did not. Verbal recall explained additional variance in both tests but did not modulate the interaction between population sample (i.e., country) and task. We hypothesize that rule-switching flexibility might be more dependent upon particular kinds of cultural experiences, whereas word-learning flexibility is less cross-culturally variable. (shrink)

The centromere is a specialized chromosomal structure that dictates kinetochore assembly and, thus, is essential for accurate chromosome segregation. Centromere identity is determined epigenetically by the presence of a centromere‐specific histone H3 variant, CENP‐A, that replaces canonical H3 in centromeric chromatin. Here, we discuss recent work by Roulland et al. that identifies structural elements of the nucleosome as essential determinants of centromere function. In particular, CENP‐A nucleosomes have flexible DNA ends due to the short αN helix of CENP‐A. The higher (...) flexibility of the DNA ends of centromeric nucleosomes impairs binding of linker histones H1, while it facilitates binding of other essential centromeric proteins, such as CENP‐C, and is required for mitotic fidelity. This work extends previous observations indicating that the differential structural properties of CENP‐A nucleosomes are on the basis of its contribution to centromere identity and function. Here, we discuss the implications of this work and the questions arising from it. (shrink)

The process of antigenic variation in parasitic African trypanosomes is a remarkable mechanism for outwitting the immune system of the mammalian host, but it requires a delicate balancing act for the monoallelic expression, folding and transport of a single variant surface glycoprotein (VSG). Only one of hundreds of VSG genes is expressed at time, and this from just one of ≈15 dedicated expression sites. By switching expression of VSGs the parasite presents a continuously shifting antigenic facade leading to prolonged (...) chronic infections lasting months to years. The basics of VSG structure and switching have been known for several decades, but recent studies have brought higher resolution to many aspects this process. New VSG structures, in silico modeling of infections, studies of VSG codon usage, and experimental ablation of VSG expression provide insights that inform how this remarkable system may have evolved. (shrink)

Jones argues that extending Seneca kin terms to second cousins requires a revised version of Optimality Theoretic grammar. I extend Seneca terms using three constraints on expression of markers in nested binary classification trees. Multiple constraint rankings on a nested set coupled with local parity checking determines how a given kin classification grammar marks structural endogamy.

We contend that Ramsey et al.'s definition of animal innovation sensu process may be partially misleading when investigating mechanisms underlying animal innovation. By excluding social learning from the of innovation, they may be reproducing a dichotomous schema that does not accurately correspond to our knowledge of the acquisition of novel behavioral variants. This gives us some reason to doubt the functional specification of the defined process of innovation.

This study investigated relationships between inter-class variations in paranormal experience and executive functions. A sample of 516 adults completed self-report measures assessing personal encounter-based paranormal occurrences, executive functions together with Emotion Regulation and Belief in the Paranormal. Paranormal belief served as a measure of convergent validity for experience-based phenomena. Latent profile analysis combined experience-based indices into four classes based on sample subpopulation scores. Multivariate analysis of variance then examined interclass differences. Results revealed that breadth of paranormal experience was associated with (...) higher levels of executive functioning difficulties for General Executive Function, Working Memory, Decision Making, and Belief in the Paranormal. On the Everyday Memory Questionnaire, scores differed on Attention Tracking and Factor 3, but not Retrieval. In the case of the Emotion Regulation Scale, class scores varied on Expressive Suppression, however, no difference was evident on Cognitive Reappraisal. Overall, inter-class comparisons identified subtle differences in executive functions related to experience. Since the present study was exploratory, sampled only a limited subset of executive functions, and used subjective, self-report measures, further research is necessary to confirm these outcomes. This should employ objective tests and include a broader range of executive functions. (shrink)

The sound system of a language must be able to support a perceptual contrast between different words in order to signal communicatively relevant meaning distinctions. In this paper, we use a simple agent-based exemplar model in which the evolution of sound-category systems is understood as a co-evolutionary process, where the range of variation within sound categories is constrained by functional pressure to keep different words perceptually distinct. We show that this model can reproduce several observed effects on the (...) range of sound variation. We argue that phonological systems can be seen as finding a relative optimum of variation: Efficient communication is sustained while at the same time, hidden category variation provides pathways for future evolution. (shrink)

Edmund Husserl’s eidetic phenomenology seeks a priori knowledge of essences and eidetic laws pertaining to conscious experience and its objects. Husserl believes that such eidetic knowledge has a higher epistemic status than the inherently fallible empirical knowledge, but a closer reading of his work shows that even eidetic claims are subject to error and open to modification. In this article, I develop a self-correcting account of Husserl’s method of eidetic variation, arguing that eidetic variation plays a critical role (...) in both challenging and improving upon the eidetic results in phenomenology. More specifically, I argue that the self-correcting account of eidetic variation 1) is consistent with Husserl’s own formulations of his eidetic methodology and epistemic principles; 2) captures the dual epistemic function of eidetic variation as means for both testing and intuitively validating eidetic claims; and 3) offers methodological support for contemporary attempts to integrate eidetic variation with non-eidetic methods and resources. To substantiate these claims, I first contrast the self-correcting account with the falsificationist interpretations of eidetic variation. Then, I turn to three applications of eidetic variation in order to examine how eidetic phenomenology could draw from real-life deviations, artificial variations, and critical–historical reflection. The goal is to lay the methodological groundwork for a self-correcting and integrative account of eidetic variation and illustrate its usefulness in research practice. (shrink)

Emotive Interjections in British English: A corpus-based study on variation in acquisition, function and usage constitutes the first in-depth corpus-based study on the use of emotive interjections in Present Day British English. In a novel approach, it systematically distinguishes between child and adult speakers, providing new insights into how they use Ow!, Ouch!, Ugh!, Yuck!, Whoops!, Whoopsadaisy! and Wow! in everyday spoken language. It studies in detail their acquisition by children and pinpoints changes and developments in their use throughout (...) early childhood. The study highlights particularities displayed by child and adult speakers in general and identifies crucial differences regarding how adults use emotive interjections depending on whether they are interacting with children or other adults. This book thus offers an exhaustive overview on the functions of emotive interjections based on thorough empirical research and will appeal to linguists concerned with pragmatics, child language acquisition, the expression of emotion and interjections. (shrink)

Representations are not only used in our folk-psychological explanations of behaviour, but are also fruitfully postulated, for example, in cognitive science. The mainstream view in cognitive science maintains that our mind is a representational system. This popular view requires an understanding of the nature of the entities they are postulating. Teleosemantic theories face this challenge, unpacking the normativity in the relation of representation by appealing to the teleological function of the representing state. It has been argued that, if intentionality is (...) to be explained in teleological terms, then the function of a state cannot depend on its phylogenetical history, given the metaphysical possibility of a duplicate of an intentional being that lacks an evolutionary history. In this paper, I present a method to produce, according to our current knowledge in genetic engineering, human-like individuals who are not the product of natural selection in the required sense. This variation will be used to shed light on the main replies that have been offered in the literature to the Swampman thought experiment. I argue that these replies are not satisfactory: representations should better not depend on natural selection. I conclude that a non-etiological notion of function is to be preferred for characterizing the relation of representation. (shrink)

The ABO histo‐blood group, first discovered over a century ago, is found not only in humans but also in many other primate species, with the same genetic variants maintained for at least 20 million years. Polymorphisms in ABO have been associated with susceptibility to a large number of human diseases, from gastric cancers to immune or artery diseases, but the adaptive phenotypes to which the polymorphism contributes remain unclear. We suggest that variation in ABO has been maintained by frequency‐dependent (...) or fluctuating selection pressures, potentially arising from co‐evolution with gut pathogens. We further hypothesize that the histo‐blood group labels A, B, AB, and O do not offer a full description of variants maintained by natural selection, implying that there are unrecognized, functionally important, antigens beyond the ABO group in humans and other primates. (shrink)

BackgroundPrevious studies suggested a circadian variation of migraine attack onset, although, with contradictory results – possibly because of the existence of migraine subgroups with different circadian attack onset peaks. Migraine is primarily a brain disorder, and if the diversity in daily distribution of migraine attack onset reflects an important aspect of migraine, it may also associate with interictal brain activity. Our goal was to assess brain activity differences in episodic migraine subgroups who were classified according to their typical circadian (...) peak of attack onset.MethodsTwo fMRI studies were conducted with migraine without aura patients (n= 31 in Study 1,n= 48 in Study 2). Among them, three subgroups emerged with typical Morning, Evening, and Varying start of attack onset. Whole brain activity was compared between the groups in an implicit emotional processing fMRI task, comparing fearful, sad, and happy facial stimuli to neutral ones.ResultsIn both studies, significantly increased neural activation was detected to fearful (but not sad or happy) faces. In Study 1, the Evening start group showed increased activation compared to the Morning start group in regions involved in emotional, self-referential (left posterior cingulate gyrus, right precuneus), pain (including left middle cingulate, left postcentral, left supramarginal gyri, right Rolandic operculum) and sensory (including bilateral superior temporal gyrus, right Heschl’s gyrus) processing. While in Study 2, the Morning start group showed increased activation compared to the Varying start group at a nominally significant level in regions with pain (right precentral gyrus, right supplementary motor area) and sensory processing (bilateral paracentral lobule) functions.ConclusionOur fMRI studies suggest that different circadian attack onset peaks are associated with interictal brain activity differences indicating heterogeneity within migraine patients and alterations in sensitivity to threatening fearful stimuli. Circadian variation of migraine attack onset may be an important characteristic to address in future studies and migraine prophylaxis. (shrink)

It is shown constructively that a strongly extensional function of bounded variation on an interval is regulated, in a sequential sense that is classically equivalent to the usual one.

The Hubbard model is studied at half filling, using two complementary variational wave functions, the Gutzwiller ansatz for the metallic phase at small values of the interaction parameter U and its analog for the insulating phase at large values of U. The metallic phase is characterized by the Drude weight, which exhibits a jump at the critical point Uc. In the insulating phase the system behaves as a collection of dipoles which increase both in number and in size as U (...) gets smaller. The two wave functions are able to describe the two asymptotic regimes (small and large values of U, respectively), but they can no longer be trusted in the region of the Mott transition (U≈Uc). More powerful methods are needed to study, for instance, the divergence of the electric susceptibility for U→Uc. (shrink)

This book explores a key issue in linguistic theory, the systematic variation in form between semantic equivalents across languages. Two contrasting views of the role of lexical meaning in the analysis of such variation can be found in the literature: (i) uniformity, whereby lexical meaning is universal, and variation arises from idiosyncratic differences in the inventory and phonological shape of language-particular functional material, and (ii) transparency, whereby systematic variation in form arises from systematic variation (...) in the meaning of basic lexical items. (shrink)

Working memory--the ability to keep important information in mind while comprehending, thinking, and acting--varies considerably from person to person and changes dramatically during each person's life. Understanding such individual and developmental differences is crucial because working memory is a major contributor to general intellectual functioning. This volume offers a state-of-the-art, integrative, and comprehensive approach to understanding variation in working memory by presenting explicit, detailed comparisons of the leading theories. It incorporates views from the different research groups that operate on (...) each side of the Atlantic, and covers working-memory research on a wide variety of populations, including healthy adults, children with and without learning difficulties, older adults, and adults and children with neurological disorders. A particular strength of this volume is that each research group explicitly addresses the same set of theoretical questions, from the perspective of both their own theoretical and experimental work and from the perspective of relevant alternative approaches. Through these questions, each research group considers their overarching theory of working memory, specifies the critical sources of working memory variation according to their theory, reflects on the compatibility of their approach with other approaches, and assesses their contribution to general working memory theory. This shared focus across chapters unifies the volume and highlights the similarities and differences among the various theories. Each chapter includes both a summary of research positions and a detailed discussion of each position. Variation in Working Memory achieves coherence across its chapters, while presenting the entire range of current theoretical and experimental approaches to variation in working memory. (shrink)

It is shown constructively that a strongly extensional function of bounded variation on an interval is regulated, in a sequential sense that is classically equivalent to the usual one.

After an introduction to set the stage, we consider some variations on the reasoning behind Curry's Paradox arising against the background of classical propositional logic and of BCI logic and one of its extensions, in the latter case treating the "paradoxicality" as a matter of nonconservative extension rather than outright inconsistency. A question about the relation of this extension and a differently described (though possibly identical) logic intermediate between BCI and BCK is raised in a final section, which closes with (...) a handful of questions left unanswered by our discussion. (shrink)

Weiermann [18] introduces a new method to generate fast growing functions in order to get an elegant and perspicuous proof of a bounding theorem for provably total recursive functions in a formal theory, e.g., in PA. His fast growing function θαn is described as follows. For each ordinal α and natural number n let T α n denote a finitely branching, primitive recursive tree of ordinals, i.e., an ordinal as a label is attached to each node in the tree so (...) that the labelling is compatible with the tree ordering. Then the tree T α n is well founded and hence finite by Konig's lemma. Define θαn=the depth of the tree T α n =the length of the longest branch in T α n . We introduce new fast and slow growing functions in this mode of definitions and show that each of these majorizes provably total recursive functions in PA. (shrink)

This paper aims to clarify the consequences of new scientific and philosophical approaches for the practical-theoretical framework of modern developmental biology. I highlight normal development, and the instructive-permissive distinction, as key parts of this framework which shape how variation is conceptualised and managed. Furthermore, I establish the different dimensions of biological variation: the units, temporality and mode of variation. Using the analytical frame established by this, I interpret a selection of examples as challenges to the instructive-permissive distinction. (...) These examples include the phenomena of developmental plasticity and transdifferentiation, the role of the microbiome in development, and new methodological approaches to standardisation and the assessment of causes. Furthermore, I argue that investigations into organismal development should investigate the effects of a wider range of kinds of variation including variation in the units, modes and temporalities of development. I close by examining various possible opportunities for producing and using normal development free of the assumptions of the instructive-permissive distinction. These opportunities are afforded by recent developments, which include new ways of producing standards incorporating more natural variation and being based on function rather than structure, and the ability to produce, store, and process large quantities of data. (shrink)