The centromere is a specialized chromosomal structure that dictates kinetochore assembly and, thus, is essential for accurate chromosome segregation. Centromere identity is determined epigenetically by the presence of a centromere‐specific histone H3 variant, CENP‐A, that replaces canonical H3 in centromeric chromatin. Here, we discuss recent work by Roulland et al. that identifies structural elements of the nucleosome as essential determinants of centromere function. In particular, CENP‐A nucleosomes have flexible DNA ends due to the short αN helix of CENP‐A. The higher (...) flexibility of the DNA ends of centromeric nucleosomes impairs binding of linker histones H1, while it facilitates binding of other essential centromeric proteins, such as CENP‐C, and is required for mitotic fidelity. This work extends previous observations indicating that the differential structural properties of CENP‐A nucleosomes are on the basis of its contribution to centromere identity and function. Here, we discuss the implications of this work and the questions arising from it. (shrink)

La restauración borbónica en España se extendió entre el 29 de diciembre de 1874 (pronunciamiento de Martínez Campos) y el 14 de abril de 1931 (proclamación de la Segunda República española). José Ortega y Gasset nació en 1883 y vivió casi medio siglo, 48 años, en este periodo. Durante el mismo desarrolló parte de su trabajo. Sin embargo, la fragilidad del sistema político, social y económico que desembocó en la II República y más tarde en la Guerra Civil española motivó (...) una obra de Ortega que fue recibida desde unas tensiones que en gran medida la hicieron incomprensible en unos casos, enemiga en otros, pero también, al mismo tiempo, atractiva, genuina, cercana, universal y necesaria para gran parte del público. Estas líneas receptivas se agudizaron a partir de la Guerra Civil española. El presente estudio las recorre por las distintas generaciones de autores desde los marcos filosóficos, las líneas políticas, las posiciones hacia la religión y, especialmente, un sinfronismo que el propio Ortega toma gracias a la vida que magníficamente refleja Azorín en su libro Un pueblecito: Riofrío de Ávila. Ortega, filósofo in partibus infidelium, se constituyó así en una especie de figura paterna de un cuerpo frágil que, sin embargo, logró, a pesar de los grandes contratiempos, asimilar y valorar su obra hasta consolidar e influir en las nuevas generaciones de pensadores llegando a nuestros días. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Commentary on “Edmund Husserl’s Influence on Karl Jaspers’s Phenomenology”Jean Naudin (bio) and Jean-Michel Azorin (bio)Keywordsphenomenology, intentionality, intuition, empathy, ambiguitySchwartz and Wiggins’s paper clearly shows that Jaspers’s comprehensive psychiatry draws mainly from Husserl’s phenomenology. This thesis enters a current debate opened by Chris Walker and German Berrios about the influence of Husserlian philosophy on Jaspers’s work. This debate, which emerged at the end of the so-called decade of the brain, (...) could be considered perfectly obsolete. But its topicality relies on taking up the challenge of the scientific bases of comprehension in psychiatric experience. Wiggins and Schwartz perfectly achieve this aim by opposing a theory of seeing and a theory of thinking. Works such as Walker’s are grounded on thinking; they are works about theory. They are not works about experience, but rather epistemological or historical works. In contrast, Wiggins and Schwartz suggest to see, as Jaspers did, and not to think, following Husserl by grounding their psychopathology on intuition and presuppositionlessness. They emphasize Jaspers’s method of “making present” by doing a perfect analysis of the issues of translation of vergegenwärtigung as a co-experiencing of mental processes as if they were directly given. These main principles of direct-givenness, presuppositionlessness, and making present pull the Jaspersian concepts to the Husserlian phenomenological reduction and seem like the foremost principle in Husserlian phenomenology: the intuition of the thing in itself. Whereas Jaspers refuted the principle of eidetic reduction, Wiggins and Schwartz clearly show how much he grounded on the basis of the concept of intentionality, discovered and enlightened during Husserl’s life within the horizon of phenomenological reduction. Actually, it seems that the authors take the side of Jaspers to better support their own vision of psychiatric experience, which they more explicitly argued in Husserlian terms of the later period in some other papers (Schwartz and Wiggins 1985; Wiggins and Schwartz 1988, 1991; Wiggins, Schwartz, and Northoff 1990). However, they take care here to struggle exclusively with the epistemological field of their opponents, considering only Jaspers’s own writings and the Husserlian texts that were accessible to Jaspers when he wrote his psychopathology. There is no room for Kant in Jaspers’s main [End Page 37] principles, and this assumption must lead us to consider the horizon opened by Jaspers, that is, the horizon of a science of meaning essentially built on the lived experiences and the bracketing of any kind of a priori. In contrast to the slight influence of Kant, one idea that emerges is that of the straight impact of Dilthey on both Jaspers and Husserl. We perfectly agree with Wiggins and Schwartz that Jaspers, grounding both on Husserl and Dilthey, arrives at a methodological principle that is all his own, by considering both the connections of the life-stories and the objectivity of symptoms. In other words, we can find the originality and maybe the astonishing modernity of Jaspers in his perfect description of the balance between comprehension and observation, between empathy and its limits, that are obviously found in psychotic processes.We thus focused our comments on the following critiques to Jaspers, although they were already well argued in the brief conclusion of Wiggins and Schwartz: (a) the issue of empathy, (b) the limits of Jaspersian phenomenology, and (c) the merits of its genuine ambiguity.The Issue of Empathy. Indeed we have no reliable scientific mean to guarantee the correctness of our intuitions of the other’s mental life, and this problem might lead one to globally reject the method. The discussion of this problem, classical in the Continental literature since the twenties, led the Continental psychiatrists to unfortunately abandon their own traditions. And it is surprising for a Continental psychiatrist to see this debate coming back into the English-speaking literature. When we address the issue of empathy, we have no easy means to abandon folk psychology. Using philosophical slang weakens the attempt to enlighten its foundations instead of describing its values. The suspicion regarding empathy is partially legitimated by the prejudices of Jaspers himself. As psychiatrists, we have to carry on the Jaspersian research by progressively abandoning it and coming back... (shrink)

Fernando Coni Campos é considerado um dos maiores roteiristas da nossa cinematografia, autor de filmes importantes como 'A Viagem Ao Fim do Mundo', 'Ladrões de Cinema' e 'O Mágico e o Delegado'. 'Cinema - Sonho e Lucidez' é uma reunião da reflexão sobre cinema do cineasta, morto em 1988, acrescida de alguns contos que mostram todo o seu domínio em contar histórias.

Nada hay más confortable para el hombre, ni más peligroso, que las certezas. Nuestra mejor defensa es la filosofía, que consiste engran medida en el arte de cuestionarlas, de atreverse a pensar, de interpelar las verdades establecidas y ver qué esconden. En estepaseo por la historia de la filosofía, Fernando Savater nos presenta a los grandes personajes que con sus preguntas, y en ocasiones con sus respuestas, han marcado el pensamiento occidental. Platón, Aristóteles, Hobbes, Tomás de Aquino, Nietzsche, Marx, (...) Ortega, Wittgenstein y hasta dieciocho filósofos más desfilan por estas páginas de la mano de Savater, que con su habitual estilo lúcido, ameno e inteligente explica sus ideas más importantes y resume sus trayectorias. Un canto al irrenunciable ejercicio de la libertad intelectual, este libro es en realidad una invitación a huir de los tópicos y a compartir con los grandes filósofos la maravillosa aventura de pensar. (shrink)

To begin with -- Genealogy of the cerebral subject -- Disciplines of the neuro -- Cerebralizing distress -- Brains on screen and paper -- Up for grabs.

Tradução para o português da obra "El Politico", de José Martínez Ruiz. Neste clássico de 1908, Azorín retoma uma antiga tradição espanhola: a dos tratados de aconselhamento aos políticos. Na esteira de autores como Saavedra Fajardo (1584-1648), ele usa a própria experiência nos negócios públicos como fonte para suas prescrições. O texto, em vários aspectos, é atual. Mas até o que nele já está ultrapassado é precioso, pois vale como testemunho de como era a política e das mudanças pelas (...) quais desde então ela passou. Tradução de Jaimir Conte. (shrink)

This work offers an analysis of all the legal and moral issues surrounding humanitarian intervention: the deaths of innocent persons and the Doctrine of Double Effect Governmental legitimacy - The Doctrine of Effective Political Control; UN Charter and evaluation of the Nicaragua ruling; The Morality of not intervening; US-led invasion of Iraq; Humanitarian intervention authorised by the UN Security Council - Iraq, Somalia, Haiti, Rwanda, and Bosnia among others highlight NATO's intervention in Kosovo; The Nicaragua Decision; and The precedents of (...) Panama, Liberia and Sierra Leone. The book's features include: a new framework based on the doctrine of double effect; basic principles of international ethics; outline of the moral argument for humanitarian intervention; explores the morality and legality of military action to end tyranny or anarchy; arguments in a much more detailed and complete fashion than in previous editions; in-depth examination of philosophy of international law; the relationship between custom and moral theory; new discussion of the question of right authority; and a full analysis of recent interventions in Kosovo and Iraq. book addresses a broad interdisciplinary audience of international lawyers, philosophers, and political scientists. In this new edition, the author responds to critics while updating the discussion in the light of the momentous events that took place at the beginning of the new millennium. (shrink)

Why should sovereign states obey international law? What compels them to owe allegiance to a higher set of rules when each country is its own law of the land? What is the basis of their obligations to each other? Conventional wisdom suggests that countries are too different from one another culturally to follow laws out of mere loyalty to each other or a set of shared moral values. Surely, the prevailing view holds, countries act simply out of self-interest, and they (...) eventually consent to norms of international law to regulate matters of common interest.In this groundbreaking book, Fernando Tesón goes against this prevailing thought by arguing, in the Kantian tradition, that a shared respect for individual human rights underpins not just the obligation countries feel to follow international law but also international laws themselves and even the very legitimacy of nations in the eyes of the international community. Tesón, both a lawyer and a philosopher, proposes that an overlapping respect for human rights has created a moral common ground among the countries of the world; and moreover, that such an outlook is the only one that is rationally defensible. It is this common set of values rather than self-interest that ultimately provides legitimacy to international law. Using the tools of moral philosophy, Tesón analyzes the concepts of sovereignty, intervention, and national interest; the contributions of social contact theory, game theory, and feminist theory; and the puzzles of self-determination and group rights.More than simply outlining his theory, Tesón goes on to give detailed examples of international laws, international institutions, and their human rights foundations, putting his ideas to work and addressing legal reforms called for by the theory. He suggests that treaties, for example, should be considered binding if, and only if, the consent to the treaty was given by a genuinely representative government, one that acts out of interest for the human rights of its citizens. Although the theoretical achievement of this book is to challenge received wisdom on the foundation of international law, the practical ambition is a call to reform the international legal system for the post–Cold War era, to substitute for the old order one that gives primacy to human dignity and freedom over state power. (shrink)

Western philosophers have made significant contributions to the establishment of government around the world. Philosophers like Plato, Locke, Hobbes, and Machiavelli dramatically influenced the government system not just in foreign countries but also in the Philippines. Hence, this seminar paper explored the political notions of four Western philosophers and positioned them in Duterte’s six years of presidency. In pursuit of this study, the researcher employed a systematic literature review. A systematic review process is used to collect articles, and then a (...) qualitative approach is used to assess them. The researcher came up with four major themes in this study particularly (1) Duterte is a Dictator, not a Philosopher-King, (2) Violators of natural rights, (3) the Sea-monster of Davao, and lastly (4) Love, fear, cruelty, and Duterte. Thus, the researcher concurred that all of the philosophical ideas of the four Western philosophers did not fit or even violated during Duterte’s six years of presidency in the Philippines. (shrink)

The study aimed to comprehensively overview the experiences encountered by public school employees during the recruitment, selection, and placement (RSP) process within the DepEd Bohol Division. Employing a qualitative-descriptive research design, the researchers utilized a phenomenological approach to delve deeply into these experiences, shedding light on the nuances and intricacies of the division's RSP process. As Lambert et al. (2013) described, qualitative- descriptive studies aim to provide a comprehensive and detailed summary of specific events experienced by individuals or groups in (...) everyday terms. To achieve this, Colaizzi's (1978) data analysis method was applied, meticulously gathering, transcribing, and analyzing recorded participant responses. The rigorous analysis revealed that an overwhelming 81% of the participants recognized significant challenges within the current RSP system of the division, underscoring the pressing need for a renewed approach to address these identified challenges. This highlighted the necessity for an RSP policy that is responsive and innovative, tailored to meet the evolving needs and expectations of applicants, schools, and the division. By implementing improvements to the RSP process, a more efficient and timely filling of vacated and newly available positions is anticipated, contributing to the seamless functioning of the educational system and ultimately enhancing the prospects of success. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 8.4 (2001) 291-293 [Access article in PDF] Schizophrenia and the Void Jean Naudin and Jean-Michel Azorin It was Eugene Minkowski who, from the 1920s on, introduced the French to the work of Eugen Bleuler, whose student he had been. In the introduction to his first book, Schizophrenia: Psychopathology of Schizoids and Schizophrenics (Minkowski 1927), Minkowski nevertheless notes with regard to Bleuler that he could not (...) allow himself "to be restricted to this student's task." For Minkowski, Bleuler certainly enjoys the great merit of having substituted the notion of schizophrenia for that of dementia praecox and of having described autism with precision. But—Minkowski says—autism is badly defined when, relying upon the concept of Spaltung, Bleuler fails to break free of associationist psychology. Minkowski justifies his critical attitude by appealing, as does Binswanger, to Husserl and above all to Bergson. For Bergson, dissociation is a normal feature of thought. If, for Minkowski, it is important to pay attention to autism, it is because it attests not to a certain fragmentation of consciousness, but rather to an attitude whereby the subject seeks to preserve the precarious equilibrium of a personality that is threatened by a void.The article translated into English for this special issue of Philosophy, Psychiatry, & Psychology prefigures Schizophrenia and, like an earlier article on the theme of "morbid rationalism," already announces certain key concepts. Here these concepts are, so to speak, caught in their embryonic state, and one is forced to recognize with Tatossian (1993) how radically Minkowski differs from his master, Bleuler, in the choice of specific cases. By according exemplary significance to cases of "poor autism," Minkowski focuses on the reflexivity of the subjective experience of the patient rather than on the proliferation of the delusional state, which lends itself more readily to clinical observation. We must remember that Minkowski is above all a healer. If, like Bleuler, he is interested in the problem that generates the illness, it is only in order to be able to heal the patient. It is therefore not so much the isolated problem that interests him as the way the person tries to deal with it. So it should not come as a surprise that one of the essential themes of this article is what Minkowski calls "compensation." Like the psychoanalytical concepts to which Bleuler refers, compensation is a dynamic concept. But Minkowski takes care to distinguish the compensation that characterizes the interrogative attitude from motives of a more psychological kind aimed at meeting a lack by symbolically satisfying a desire. In the purely phenomenological sense in which Minkowski takes it, compensation does not refer to a hidden motive. It represents a way of getting around the void or sense of emptiness that results from the schizophrenic person's inability to project himself into the future by pursuing the practical goals of normal, daily life. In this case, the dynamic does not feed off the vicissitudes of drive but off the élan vital—or rather, off the decline of élan vital that such persons suffer. [End Page 291]Minkowski particularly insists upon the fact that Paul's interrogative attitude is not simple curiosity, even if Paul's questioning began with sexual curiosity. Confronted with incessant questioning reminiscent of a child, a psychoanalyst would be likely to invoke infantile curiosity concerning procreation and sexual difference. Minkowski, however, seeks to show that the prevailing motive in Paul's case is not so much desire for knowledge as the vital necessity of finding a way of—can one put it this way?—playing for time. In other words, the interrogatory attitude is a way of avoiding confrontation with the realm of practical concerns that, at bottom, makes the patient suffer. If this realm makes him suffer, it is because the absence of any vital attachment leaves him floating in a kind of void. The fundamental problem of schizophrenia is therefore identified as the loss of meaning going along with a deficiency in the individual's attachment to practical reality. Practical reality, or to put it otherwise, an orientation toward practical activity... (shrink)

We present an experiment designed to investigate three different mechanisms to achieve impartiality in distributive justice. We consider a first-person procedure, inspired by the Rawlsian veil of ignorance, and two third-party procedures, an involved spectator and a detached observer. First-person veiled stakeholders and involved spectators are affected by an initially unfair distribution that, in the stakeholders’ case, is to be redressed. We find substantial differences in the redressing task. Detached observers propose significantly fairer redistributions than veiled stakeholders or involved spectators. (...) Risk preferences partly explain why veiled stakeholders propose less egalitarian redistributions. Surprisingly, involved spectators, who are informed about their position in society, tend to favour stakeholders holding the same position as they do after the initial distribution. (shrink)

This electronic document serves as a guide on how to get a LAMP stack running on a Google Compute Engine virtual machine instance running Debian.

The article deals with the chances of illustration of Mohammed: is it forbidden to depict Mohammed in the Islam? What the history or the religion say about it? The following sentences try to get a brief but deep approaching to that issue, underlying the importance that just a few time ago when several problems related to misunderstanding and hatred set the Muslim world in front of the Western people as violent in a behavior that no one could share. Through the (...) article we will see the lack of respect there was in some images that were published provoking all kind of reactions in the world. (shrink)

El autor expone las dimensiones y circunstancias de una investigación cualitativa realizada en un prestigioso instituto de docentes en Uruguay. Indagando en los rituales de interacción aplicados en el ámbito educativo, se observan los modelos de relación, la construcción de la identidad de docente y demás elementos propios de la institución educativa. En ese contexto, se identifican distintos contextos y situaciones cotidianas que reproducen procesos sociales en los que la finalidad está clara: la enseñanza y el aprendizaje.

The emigration is an arduous and complex process that includes practically all the aspects of the life of a human being. One is a sociological phenomenon: the challenging of the emigrant, the decision making, the election of the destination place, and so on; they are determined by the social issue, by the family, the friends and social networks. Normally the studies on the subject are of a quantitative type, as a matter of fact, the topic has a so deep meaning (...) and it affects so much the human being and its surroundings that seemed essential to me a qualitative approach to respond to the question: what desires, anxieties, fears and frustrations move the people to leave their homes and get themselves to a distant and practically unknown country? (shrink)

The war in Iraq has reignited the passionate humanitarian intervention debate. President George W. Bush surprised many observers in his second inaugural address when he promised to oppose tyranny and oppression, and this in a world not always willing or ready to join in that fight. Humanitarian intervention is again on the forefront of world politics.

La palabra alegría es muy importante para Fernando Savater... Y es el tema central en tomo al que se articula el libro "Misterios gozosos", una antología de textos, a cargo de Héctor Subirats, que recorre 25 años de la producción filosófica y literaria de Savater. El escritor definió la palabra alegría como "afirmación del presente, no nostalgia del pasado ni del futuro". Misterios gozosos se divide, en cinco capítulos en los que se recogen las razones para la (su) alegría: (...) el solo hecho de vivir, el gusto por la comida, el buen vino, el regocijo por la polémica, el entusiasmo por lo admirado, desde figuras históricas como Voltaire o Spinoza a personajes míticos como Groucho Marx o King Kong. De hecho, Savater aparece en la portada, del libro con un pequeño King Kong en las manos. El escritor, siempre vitalista, reflexiona también en su libro sobre cuestiones de primordial interés como las drogas, la salud, los derechos humanos, el amor, la muerte o la soledad.Subirats explicó que seleccionó los textos con "mala leche, para mostar la evolución o involución de Savater". Preguntado sobre cómo ha sido la involución del escritor, Subirats respondió que "Savater permanece en su sitio. Ha sido el mundo el que se ha echado para atrás". Y Savater precisó: "Las ideas no entran en uno como en la religión. A los 20 años se piensa de una manera y a los 50, de otra. Si uno lee, va al cine, sigue atento la marcha del país... y sigue pensando invariablemente lo mismo es que no ha pensado nunca". "El resultado del pensamiento no es siempre gozoso: lo gozoso es pensar", añadió. (En "Fernando Savater defiende la alegría de vivir en "Misterios gozosos"". Madrid : El País. 28 de febrero de 1995). (shrink)

This research tackled the challenges public secondary schools in Sagbayan District, Bohol, faced regarding records management. The study employed a mixed research design, combining both descriptive-qualitative and descriptive- quantitative methods. The qualitative phase involved conducting in-depth interviews and focus group discussions with relevant stakeholders involved in records management. On the other hand, the quantitative phase utilized survey questionnaires to gather data from relevant stakeholders to determine the acceptability of the proposed MIS among end-users. The first phase findings revealed various challenges (...) in records management faced by the schools, such as inefficient manual record-keeping systems, difficulties in data retrieval, and the risk of data loss due to inadequate backup procedures. These challenges highlighted the need for a comprehensive, technology-driven solution to streamline records management processes and ensure data security. The evaluation results in the second phase showed that the developed Management Information System (MIS) was well-accepted among the end users. The absence of any significant difference in the level of acceptability among the participants further validated the system's suitability for addressing their specific needs. The successful implementation of the MIS proved to be an effective solution to the records management challenges faced by the public secondary schools in Sagbayan District, Bohol. (shrink)

Abstract The article addresses three aspects of the humanitarian intervention doctrine. It argues, first, that the value of sovereignty rests on the justified social processes of the target state ? the horizontal contract. Foreign interventions, even when otherwise justified, must respect the horizontal contract. In contrast, morally objectionable social processes (such as the subjection of women) are not protected by sovereignty (intervention, of course, may be banned for other reasons). In addition, tyrants have no moral protection against interventions directed at (...) them. Second, the article addresses the internal legitimacy of humanitarian intervention. It concludes that the liberal state may only use voluntary soldiers (either the voluntary army or mercenaries) to conduct humanitarian intervention. Conscription for that purpose is not permissible. The article shows that the long-standing criticism of mercenaries stems from a romantic prejudice and is thus unfair. Third, the article makes a distinction between intention (the determination to perform an action) and motive (a further goal that the agent seeks with that action) and shows that only intention is relevant for humanitarian intervention. A justified humanitarian intervention requires the intention to liberate the victims, but not necessarily a good further motive. It shows how mainstream doctrine has impermissibly confused the two concepts. (shrink)

El texto de Martin Heidegger Was ist das - die Philosophie? es una de las obras claves para hacer una hermenéutica de su pensamiento. En ella se explica como lo que pretendía la filosofía en su origen no tiene un correlato con sus conquistas a lo largo de la tradición, que están más bien teñidas de un tinte racionalista que obvia los estados afectivos, tan necesarios para entender el pensar filosófico. De este modo, volvemos con Heidegger a remontarnos al inicio (...) de la filosofía, hasta Heráclito, para así poder establecer unas pautas que nos ayuden en nuestras disquisiciones dentro del filosofar. Para ello será necesario retomar el verdadero sentido griego de λὀγος tal y como fue planteado por Heráclito: como fluir y como lucha. (shrink)

ResumenEl Senado Federal de Brasil creó una Comisión Parlamentaria de Investigación (CPI) para investigar las irregularidades del gobierno de Bolsonaro en la gestión de la pandemia de COVID‐19. Uno de los casos que llamó la atención fue la investigación llevada a cabo por Prevent Senior, una empresa privada de seguros de salud, sobre el tratamiento temprano de COVID‐19. Este artículo analiza la validez científica de la investigación y los problemas éticos relacionados con su implementación. Se basa en un análisis del (...) informe del estudio clínico de Prevent Senior, de los registros de ensayos clínicos de Brasil y Estados Unidos, del informe de la CPI del Senado y de información difundida por los medios de comunicación. Este caso de fraude científico y sesgo político‐ideológico ejemplifica cómo Prevent Senior, utilizando un protocolo cuestionable para mejorar su reputación y obtener el apoyo del gobierno, contribuyó a la construcción de la narrativa de “tratamiento temprano” para COVID‐19, y muestra cómo sirvió de base para una política pública del gobierno que promovió el uso de medicamentos ineficaces. (shrink)

En el terreno de la moral, el contraste entre lo ¿que el filósofo Wilfrid Sellars denominó «la ¿imagen manifiesta» y la «imagen científica» es enorme y tiene unas consecuencias prácticas ineludibles. Este libro reduce la distancia entre esa imagen manifiesta y la imagen científica, dotando al lector de referencias fundamentales, enfoques diversos y un amplio abanico de temáticas a partir de investigaciones experimentales sobre nuestra conducta moral.