While philosophers of science have marginally discussed concepts such as ‘nutrient’, ‘naturalness’, ‘food’, or the ‘molecularization’ of nutrition, they have yet to seriously engage with the nutrition sciences. In this paper, I offer one way to begin this engagement by investigating conceptual challenges facing the burgeoning field of nutritional ecology and the question of how organisms construct a ‘balanced’ diet. To provide clarity, I propose the distinction between nutrient balance as a property of foods or dietary patterns and nutrient balancing (...) as an evolved capacity to regulate nutrient intake. This distinction raises conceptual and empirical issues, such as what properties constitute this capacity and whether they are the same in all organisms. Additionally, while scientists use the term ‘balancing’, its intension and extension need further clarification. Based on the literature, the properties of external nutrient detection, internal sensing of nutrient levels, and organismal regulation could provide a basic recipe for nutrient balancing. Next, using an evolutionary lens, I examine nutrient acquisition in some prokaryotes, slime molds, simple multicellular eukaryotes, and in the quirks of multicellular metabolism to raise questions about the origins and universality of balancing. Finally, I build on this explication of balance and balancing by considering how obesity and cancer might respectively elucidate problems of organismal nutrient imbalances versus disrupted cellular nutrient balancing. (shrink)

Overview The evolution of multicellularity raises questions regarding genomic and developmental commonalities and discordances, selective advantages and disadvantages, physical determinants of development, and the origins of morphological novelties. It also represents a change in the definition of individuality, because a new organism emerges from interactions among single cells. This volume considers these and other questions, with contributions that explore the origins and consequences of the evolution of multicellularity, addressing a range of topics, organisms, and experimental protocols. Each section focuses on (...) selected topics or particular lineages that present a significant insight or challenge. The contributors consider the fossil record of the paleontological circumstances in which animal multicellularity evolved; cooptation, recurrent patterns, modularity, and plausible pathways for multicellular evolution in plants; theoretical approaches to the amoebozoa and fungi (cellular slime molds having long provided a robust model system for exploring the evolution of multicellularity), plants, and animals; genomic toolkits of metazoan multicellularity; and philosophical aspects of the meaning of individuality in light of multicellular evolution. Contributors Maja Adamska, Argyris Arnellos, Juan A. Arias, Eugenio Azpeitia, Mariana Benítez, Adriano Bonforti, John Tyler Bonner, Peter L. Conlin, A. Keith Dunker, Salva Duran-Nebreda, Ana E. Escalante, Valeria Hernández-Hernández, Kunihiko Kaneko, Andrew H. Knoll, Stephan G. König, Daniel J. G. Lahr, Ottoline Leyser, Alan C. Love, Raul Montañez, Emilio Mora van Cauwelaert, Alvaro Moreno, Vidyanand Nanjundiah, Aurora M. Nedelcu, Stuart A. Newman, Karl J. Niklas, William C. Ratcliff, Iñaki Ruiz-Trillo, Ricard Solé . (shrink)

John Bonner managed a long and productive career that balanced specialized inquiry into cellular slime molds with general investigations of big questions in evolutionary biology, such as the origins of multicellular development and the evolution of complexity. This commentary engages with his final paper (“The evolution of evolution”), which argues that the evolutionary process has changed through the history of life. In particular, Bonner emphasizes the possibility that natural selection plays different roles at different size scales. I identify (...) some underlying assumptions in his argument and evaluate its cogency to both foster future discussion and emulate the intellectual example set by Bonner over a lifetime. This endeavor is important beyond Bonner's own theoretical disposition because similar issues are visible in controversies about the possibility of an extended evolutionary synthesis. (shrink)

Since the dawn of molecular biology, cancer therapy has focused on druggable targets. Despite some remarkable successes, cell‐level evolution remains a potent antagonist to this approach. We suggest that a deeper understanding of the breakdown of cooperation can synergize the evolutionary and druggable‐targets approaches. Complexity requires cooperation, whether between cells of different species (symbiosis) or between cells of the same organism (multicellularity). Both forms of cooperation may be associated with nutrient scarcity, which in turn may be associated with a chemiosmotic (...) metabolism. A variety of examples from modern organisms supports these generalities. Indeed, mammalian cancers—unicellular, glycolytic, and fast‐replicating—parallel these examples. Nutrient scarcity, chemiosmosis, and associated signaling may favor cooperation, while under conditions of nutrient abundance a fermentative metabolism may signal the breakdown of cooperation. Manipulating this metabolic milieu may potentiate the effects of targeted therapeutics. Specific opportunities are discussed in this regard, including avicins, a novel plant product. (shrink)

The hypothesis of extended cognition (HEC) claims that the cognitive processes that materially realise thinking are sometimes partially constituted by entities that are located external to an agent’s body in its local envi- ronment. We show how proponents of HEC need not claim that an agent must have a central nervous system, or physically instantiate processes organised in such a way as to play a causal role equivalent to that of the brain if that agent is to be capable of (...) cognition. Focusing on the case of spatial memory, we make our argument by taking a close look at the striking example of Physarum Polycephalum plasmodium (i.e., slime mould) which uses self- produced non-living extracellular slime trails to navigate its environment. We will argue that the use of exter- nalized spatial memory by basal organisms like Physarum is an example of extended cognition. Moreover, it is a possible evolutionary precursor to the use of internal spatial memory and recall in animals thus demonstrating how extended cognition may have emerged early in evolutionary history. (shrink)

[Erratum] At evening, with the sun no longer overhead, the air developed a kind of viscosity in which time seemed to stand very still and the labyrinth of the city, no longer bisected by light and shade and unstirred by the afternoon breezes, appeared suspended in a kind of dream, paused in an atmosphere of extraordinary pallor and thickness.Contemporary rhetorical theory is in the midst of a new materialist turn. Things, sensations, affects, and ambience are seen as collectively forming the (...) ground of what we mean by rhetoric. New materialist and affective theories attempt to transform our understanding of what rhetoric is, where rhetoric is, and how rhetoric emerges. Recent scholarship considers a host of... (shrink)

The genomes of the slime moulds are relatively small when compared with those of higher eukaryotes. They also contain far fewer families of repetitive sequences. Nevertheless, the general patterns of organization of their repetitive DNA are similar. The slime moulds can therefore help us to investigate the structure and evolution of repetitive DNA in “simple” eukaryotes and to understand how these sequences contribute to the architecture and function of the eukaryotic genome. Several questions remain, including perhaps the most (...) important: do repetitive sequences perform some definable function?. (shrink)

(1996). Molding democrats: American reeducation policy in Germany and Japan. The European Legacy: Vol. 1, Fourth International Conference of the International Society for the study of European Ideas, pp. 796-800.

This article presents a quantitative analysis of how different socio-cultural factors, including lifestyle, affect the extent to which different media are perceived as indispensable for maintaining close relations with family and friends. Through applying ‘indispensability’ as an indicator of the mediatization of social life, the study provides a concrete illustration of how mediatization is continuously molded through socio-cultural processes in everyday life. The results are based on a national survey conducted in Sweden and show that e-mail and video calls constitute (...) a culturally distinctive ensemble of communication, especially in comparison to online chat functions and Facebook. E-mail is valued especially among people with higher education who lead globally oriented lifestyles thus testifying to the enduring status of text-based communication in the longer format as a cultural marker. The study thus suggests that the modalities of communication that certain media make possible are important to how these media are perceived as cultural properties as well as social technics. (shrink)

Despite the exponential progress in computing power of digital computers, the development of lifelike cognitive systems appears has not yet reached the complexity of the simplest kinds of organisms. This may be explained by the lack of robustness of digital computers due to the requirements of structural programmability in the conventional computing architectures. In contrast, biological systems appear to operate in a different mode of information processing. In order to approach more lifelike artificial cognitive systems, the integration of natural and (...) unnatural systems may open a path to investigate the possibilities of the desired biological functions such as through the creation of hybrid architectures that interface nature's computing brains with artificial devices such as using the behaviour of the slime mould Physarum polycephalum to influence the behaviour of a mechanical robot. (shrink)

This paper seeks to examine the putative growth of corporate social responsibility (CSR) in Singapore. A key impetus for the nascent CSR movement in twenty-first century Singapore is the economic imperative. As a trade-dependent industrializing economy, the economic development drive coupled with the need for international expansion has made it necessary for Singapore businesses to be cognizant of the growing CSR movement in the western, industrialized world. The government supports the CSR endeavour with an instrumental bent, where CSR ideas and (...) concepts are adapted, incorporated, and promoted in various sectors of the economy. This paper assesses the state’s active encouragement of CSR in various facets of economic life in Singapore. The government sees itself as a promoter and practitioner of CSR. For instance, Singapore’s unique tripartite labor relations have recently emphasized a CSR gloss while CSR is also touted as being beneficial for corporate governance as well as improving the competitiveness of companies and improving the quality of life. However, CSR is too often seen as another form of corporate governance. This paper argues that the CSR drive in Singapore coheres with the government’s pragmatic approach to governance broadly conceived. There are many intrinsic and tangible benefits in the government being seen as an active promoter of CSR in various facets of Singapore life. The close association with the various concerns of CSR ensures that the government is seen to be involved in issues, such as environmentalism, work–life balance, anti-corruption, and philanthropy, that concern and appeal to the younger generation of Singaporeans. The CSR endorsement by the state, while not taking a legislative framework and still very much a private sector-driven initiative, is in accord with Singapore’s political and cultural values where the promotion of social responsibility (individual and group), harmony, cohesion, and stability in a multi-racial, multi-religious, and multi-lingual society are very much valued. In studying the putative CSR movement in Singapore, a sense of the values that the state, in partnership with the business world, hopes to inculcate would be evident. (shrink)

Some evil actions are public. Maybe genocide is the most awful. Other evil actions are private, a matter of one person harming another or of self-inflicted injury. Child abuse, in our current reckoning, is the worst of private evils. We want to put a stop to it. We know we can’t do that, not entirely. Human wickedness won’t go away. But we must protect as many children as we can. We want also to discover and help those who have already (...) been hurt. Anyone who feels differently is already something of a monster.We are so sure of these moral truths that we seldom pause to wonder what child abuse is. We know we don’t understand it. We have little idea of what prompts people to harm children. But we do have the sense that what we mean by child abuse is something perfectly definite. So it comes as a surprise that the very idea of child abuse has been in constant flux the past thirty years. Previously our present conception of abusing a child did not even exist. People do many of the same vile things to children, for sure, that they did a century ago. But we’ve been almost unwittingly changing the very definitions of abuse and revising our values and our moral codes accordingly. Ian Hacking, a philosopher, teaches at the Institute for the History and Philosophy of Science and Technology in the University of Toronto. His latest book is entitled The Taming of Chance. (shrink)

The aim of this article is to contribute to the discussion surrounding mediatization by presenting some arguments on how we could include questions of media specificity in an appropriate way. The core argument is that we have to do this by integrating `media specificity' into a theory of communicative practice or action. In doing so, we can grasp media in their institutional and technological sense as `molding force' of communicative action and research them empirically as part of mediatization processes.

Vagueness is epistemic, according to some. Vagueness is ontological, according to others. This article deploys what I take to be a compromise position. Predicates are coined in specific contexts for specific purposes, but these limited practices do not automatically fix the extensions of predicates over the domain of all objects. The linguistic community using the predicate has rarely considered, much less decided, all questions that might arise about the predicate’s extension. To this extent, the ontological view is correct. But a (...) predicate that applies in some contexts can be reasonably extended to other contexts where it is initially vague. This process of development approximates the cognitive remedy for vagueness that the epistemic view prescribes. The process is piecemeal and inductive, akin to what von Wright described as the molding of concepts. Vagueness cannot be understood apart from the backdrop of classification, for vagueness is classification gone awry. Hence these pages explore the classification of particulars, both its clear successes and vague failures. How we classify unique particulars is the theme of Sections 2 and 3, which are primarily descriptive. Section 2 identifies a way of classifying particulars that pervades discourse of all sorts, and Section 3 illustrates its use in a field notorious for vagueness: ethics. Why a certain particular should (or should not) be classified in a certain way is a normative question, however, and it occupies Sections 4 and 5. Section 4 proposes a norm for strong arguments by analogy, and Section 5 illustrates how the norm might resolve vagueness in one kind of ethical dispute. This norm, which has a strong probabilistic component, is one way of affirming that probability is a guide to life. (shrink)

Drawing on scientific accounts of Harmful Algal Blooms (HABs) and their detection technologies, this paper asks what conceptions of time and species presences enable a mapping of the biological productivity of microorganisms onto economic productivity or the loss thereof and how certain modes of technoscientific detection of specific algae materialize such a conception of time, circumscribing what counts as harmfulness and to whom. Moving beyond the mere affirmation of the activity of nonhuman nature, I seek to demonstrate how an epistemological (...) anthropocentrism in scientific knowledge production that opposes historically flexible and technologically enhanced human creativity to its atemporal object of study manifests itself as a political anthropocentrism that presupposes “our” time as the unalterable movement of Homo Economicus. Such a political conception of time is supported by a view of “life itself” as a teleological process toward ever increasing complexity, effacing the possibility of asking to whom the current ecological transformations matter. (shrink)

Drawing on scientific accounts of Harmful Algal Blooms (HABs) and their detection technologies, this paper asks what conceptions of time and species presences enable a mapping of the biological productivity of microorganisms onto economic productivity or the loss thereof and how certain modes of technoscientific detection of specific algae materialize such a conception of time, circumscribing what counts as harmfulness and to whom. Moving beyond the mere affirmation of the activity of nonhuman nature, I seek to demonstrate how an epistemological (...) anthropocentrism in scientific knowledge production that opposes historically flexible and technologically enhanced human creativity to its atemporal object of study manifests itself as a political anthropocentrism that presupposes “our” time as the unalterable movement of Homo Economicus. Such a political conception of time is supported by a view of “life itself” as a teleological process toward ever increasing complexity, effacing the possibility of asking to whom the current ecological transformations matter. (shrink)

In this paper, I provide an overview of today’s philosophical approaches to the problem of “intelligence” in the field of artificial intelligence by examining several important papers on phenomenology and the philosophy of biology such as those on Heideggerian AI, Jonas's metabolism model, and slime mold type intelligence.

The paper intends to analyze the philosophic, imaginative, and theological aspects of Islam, which give grounds to the integration, acceptance, and enhancement of the transhuman, through the analysis of core concepts such as ‘humanity’ and ‘body’ in Islamic tradition. While transhumanism is considered mainly from a lay or super-diverse perspective, Imams, fuquha, Muslim scholars and simple believers—be they in Western or non-Western contexts—are evermore challenged to question the relationship between technological innovation effecting human nature, and Islamic tradition with its specific (...) cultural framework. Considering that body-matter is what expresses the identity and the ‘anthropopoiesis’ of the Muslim believer, the intent of the paper is to investigate how—and through which spiritual meanings—can Islamic theology integrate the liminal bodies of the transhuman into the limited, defined, and purified human traditional models of Islamic belief. (shrink)

Photonic Crystals is the first book to address one of the newest and most exciting developments in physics--the discovery of photonic band-gap materials and their use in controlling the propagation of light. Recent discoveries show that many of the properties of an electron in a semiconductor crystal can apply to a particle of light in a photonic crystal. This has vast implications for physicists, materials scientists, and electrical engineers and suggests such possible developments as an entirely optical computer. Combining cutting-edge (...) research with the basic theoretical concepts behind photonic crystals, the authors present to undergraduates and researchers a concise, readable, and comprehensive text on these novel materials and their applications. The first chapters develop the theoretical tools of photonic crystals in a broad, intuitive fashion, starting from nothing more than Maxwell's equations and Fourier analysis, and include analogies to traditional solid-state physics and quantum theory. There follows an investigation of the unique phenomena that take place within photonic crystals, at defect sites, and at surfaces and interfaces. The authors offer a new treatment of the traditional multilayer film (a one-dimensional photonic crystal), which allows for the extension to higher dimensions and more complex geometries. After exploring the capabilities of photonic crystals to guide and localize light, the authors demonstrate how these notions can be put to work. (shrink)

In this paper we consider possibilities for applying p-adic valued logic BL to the task of designing an unconventional computer based on the medium of slime mould, the giant amoebozoa that looks for attractants and reaches them by means of propagating complex networks. If it is assumed that at any time step t of propagation the slime mould can discover and reach not more than attractants, then this behaviour can be coded in terms of p-adic numbers. As a (...) result, this behaviour implements some p-adic valued arithmetic circuits and can verify p-adic valued logical propositions. (shrink)

As one of the basic manufacturing industries in China, injection molding industry is faced with the problems of low degree of informatization and intelligence, resulting in low production efficiency and high costs. It is urgent to integrate deeply with new generation of information technology to achieve transformation and upgrade. In this paper, an integrative industrial Internet architecture of “integration of intelligent equipment, intelligent production lines, intelligent workshops, intelligent factories, and intelligent formats” was described. The injection molding intelligent control system, the (...) production management, control platform based on the MES system, and other key technologies were researched. Also, the smart factory architecture based on digital twin was established, and the implementation method of the smart factory digital twin system was elaborated. The feasibility and effectiveness of the method had been verified through the industrial application, which provided the technical supports for the injection molding industrial Internet system. Finally, the intelligent manufacturing industrial Internet cloud platform for injection molding industry was prospected. (shrink)

The two vegetative cell types of the acellular slime mould Physarum polycephalum ‐ amoebae and plasmodia ‐ differ greatly in cellular organisation and behaviour as a result of differences in gene expression. The development of uninucleate amoebae into multinucleate, syncytial plasmodia is under the control of the mating‐type locus matA, which is a complex, multi‐functional locus. A key period during plasmodium development is the extended cell cycle, which occurs in the developing uninucleate cell. During this long cell cycle, many (...) of the changes in cellular organisation that accompany development into the multinucleate stage are initiated including, for example, alterations in microtubule organisation. Genes have been identified that show cell‐type specific expression in either amoebae or plasmodia and many of these genes alter their pattern of expression during the extended cell cycle. With the introduction of a DNA transformation system for P. polycephalum, it is now possible to investigate the functions of genes in the vegetative cell types and their roles in the cellular reorganisations accompanying development. (shrink)

The private letter, one of the most representative expressions of mass literacy, was the product of improved postal services and epistolary manuals. In the nineteenth century, which also witnessed the new phenomenon of mass emigration, letter writing became one of the most common practices. This article discusses the correspondence of José Moldes, an Asturian who left Spain for Puerto Rico at the age of fourteen and settled shortly afterwards in Chile. He died in his native Asturias at the age of (...) sixty-one. Throughout these fifty or so years, José wrote letters to keep in contact with members of his family, to control them when he became head of the household or to manage his businesses and investments. About 120 of his letters survived in the Moldes-Barreras family archive, through which we can reconstruct his experiences. The essential characteristics of this epistolary corpus emerge from an analysis of its material and graphic aspects, suggesting the profound influence of immigration on personal writing. (shrink)

Recent investigations have revealed 1) that the isochores of the human genome group into two super‐families characterized by two different long‐range 3D structures, and 2) that these structures, essentially based on the distribution and topology of short sequences, mold primary chromatin domains (and define nucleosome binding). More specifically, GC‐poor, gene‐poor isochores are low‐heterogeneity sequences with oligo‐A spikes that mold the lamina‐associated domains (LADs), whereas GC‐rich, gene‐rich isochores are characterized by single or multiple GC peaks that mold the topologically associating domains (...) (TADs). The formation of these “primary TADs” may be followed by extrusion under the action of cohesin and CTCF. Finally, the genomic code, which is responsible for the pervasive encoding and molding of primary chromatin domains (LADs and primary TADs, namely the “gene spaces”/“spatial compartments”) resolves the longstanding problems of “non‐coding DNA,” “junk DNA,” and “selfish DNA” leading to a new vision of the genome as shaped by DNA sequences. (shrink)

Para la reproducción escultórica de una obra tallada en piedra de Sierra Elvira mediante la realización de un molde de silicona se ha necesitado el estudio de un agente desmoldeante que mejore la liberación de la obra de la silicona y que esta no manche el material pétreo. Probados varios agentes desmoldeantes en probetas pétreas, el más adecuado ha sido el espray fijador de carboncillo, que ha ayudado a liberar el molde, además de proteger la obra y de aplicar una (...) capa tan fina que no ha hecho perder el registro del acabado pétreo, siendo eliminado con lavado y cepillado. (shrink)

Fluid-phase endocytosis (pinocytosis) kinetics were studied inDictyostelium discoideum amoebae from the axenic strain Ax-2 that exhibits high rates of fluid-phase endocytosis when cultured in liquid nutrient media. Fluorescein-labelled dextran (FITC-dextran) was used as a marker in continuous uptake- and in pulse-chase exocytosis experiments. In the latter case, efflux of the marker was monitored on cells loaded for short periods of time and resuspended in marker-free medium. A multicompartmental model was developed which describes satisfactorily fluid-phase endocytosis kinetics. In particular, it accounts (...) correctly for the extended latency period before exocytosis in pulse-chase experiments and it suggests the existence of some sorts of maturation stages in the pathway. (shrink)

This paper addresses the role of specification tests in the selection of a statistically admissible model used to evaluate economic hypotheses. The issue is formulated in the context of recent philosophical accounts on the nature of models and related to some results in the literature on specification search. In contrast to enumerative induction and a priori theory, powerful search methodologies are often adequate substitutes for experimental methods. They underwrite and support, rather than distort, statistical hypothesis tests. Their success is grounded (...) in a systematic effort to mold appropriate models to, and test them against, constraints of the data. (shrink)

A widely cited roadblock to bridging ecological psychology and enactivism is that the former identifies with realism and the latter identifies with constructivism, which critics charge is subjectivist. A pragmatic reading, however, suggests non-mental forms of constructivism that simultaneously fit core tenets of enactivism and ecological realism. After advancing a pragmatic version of enactive constructivism that does not obviate realism, I reinforce the position with an empirical illustration: Physarum polycephalum (a slime mold), a communal unicellular organism that leaves (...) class='Hi'>slime trails that form chemical barriers that it avoids in foraging explorations. Here, environmental building and sensorimotor engagement are part of the same process with P. polycephalum coordinating around self-created, affordance-bearing geographies, which nonetheless exist independently in ways described by ecological realists. For ecological psychologists, affordances are values, meaning values are external to the perceiver. I argue that agent-enacted values have the same status and thus do not obviate ecological realism or generate subjectivism. The constructivist-realist debate organizes around the emphasis that enactivists and ecological theorists respectively place on the inner constitution of organisms vs. the structure of environments. Building on alimentary themes introduced in the P. polycephalum example and also in Gibson’s work, I go on to consider how environment, brain, visceral systems, and even bacteria within them enter perceptual loops. This highlights almost unfathomable degrees of mutually modulating internal and external synchronization. It also shows instances in which internal conditions alter worldly configurations and invert values, in Gibson’s sense of the term, albeit without implying subjectivism. My aim is to cut across the somatic focus of enactive constructivism and the external environment-oriented emphasis of ecological realism and show that enactivism can enrich ecological accounts of value. (shrink)

Children are not simply molded by the environment; through constant inference and interpretation, they actively shape their own social world. This book is about that process. Elliot Turiel's work focuses on the development of moral judgment in children and adolescents and, more generally, on their evolving understanding of the conventions of social systems. His research suggests that social judgements are ordered, systematic, subtly discriminative, and related to behavior. His theory of the ways in which children generate social knowledge through their (...) social experiences will be of interest to a wide range of researchers and students in child development and education. (shrink)