This case is about a study of burn patients that included a request to the IRB for a waiver of consent for perianal specimen collection–a request which ultimately was not approved by a reviewing IR...

ABSTRACT:Psychedelics, including psilocybin, and other consciousness-altering compounds such as 3,4-methylenedioxymethamphetamine (MDMA), currently are being scientifically investigated for their potential therapeutic uses, with a primary focus on measurable outcomes: for example, alleviation of symptoms or increases in self-reported well-being. Accordingly, much recent discussion about the possible value of these substances has turned on estimates of the magnitude and duration of persisting positive effects in comparison to harms. However, many have described the value of a psychedelic experience with little or no reference (...) to such therapeutic benefits, instead seeming to find the experience valuable in its own right. How can we make sense of such testimony? Could a psychedelic experience be valuable even if there were no persisting beneficial effects? If so, how? Using the concept of psychological richness, combined with insights from the philosophy of aesthetics and the enhancement literature, this essay explores potential sources of value in the acute subjective experience, apart from the value derived from persisting beneficial effects. (shrink)

Physicists use different theories to describe the world on different scales. In particular, they use the standard model of particle physics at very high energies, but move to various effective field theories, such as quantum electrodynamics, when modelling lower energy scattering processes. One way to explain this methodological fact is pragmatic in spirit. According to this view, physicists move to an effective field theory at lower energies in order to extract predictions and qualitative understanding which would be difficult or impossible (...) to extract directly from a more fundamental theory. By contrast, another way of accounting for the methodological data is metaphysical in spirit. On this view, the reason that physicists use different theories at different scales is that the world actually exhibits different nomic structure on different scales. These two positions have recently been thrown into sharp relief in a debate between Woodward (2016) and Batterman (2021), with Woodward taking the pragmatist line and Batterman the metaphysical line. One difficulty with the metaphysical answer is that its content is unclear: in what sense exactly could an effective field theory provide a better representation of the nomic structure of the world in its domain of applicability than our world’s fundamental theory? This talk attempts to provide an answer to this question by developing a simple metaphysical model. I start by assuming a set of possible worlds which are nomically possible according to some fundamental theory (I suggest that one is free to adopt either a Humean or Non-Humean view of these fundamental nomic necessities). I then introduce an equivalence relation between possible worlds: two worlds are scale-E equivalent if they assign the same values to physical quantities below energy scale E (up to some finite level of precision P). The key question now is whether this relation induces equivalence classes on the set of nomically possible worlds. I argue that in the case of current quantum field theories this does indeed occur, as evidenced by the possibility of “integrating out” high energy degrees of freedom in the renormalisation group framework. The formation of equivalence classes in the fundamental theory's possibility space indicates that some of its high energy features do not make a difference to its low energy dynamical behaviour. This suggests the following reading of the claim that an effective field theory provides a better representation of the nomic structure of the world in its domain of applicability: the solutions of the effective field theory stand in one-to-one correspondence with equivalence classes induced by the scale-E equivalence relation, whereas the fundamental theory overcounts the physical possibilities which are relevant at scale E. In this sense, the effective field theory provides a more natural representation of low energy physics than the fundamental theory. I conclude by explaining how this metaphysical model offers a reduction compatible understanding of multiple realisability, once again pointing to renormalisation group results in quantum field theory to support this. (shrink)

Résumé Alberto Voltolini préconise une analyse syncrétique des entités fictives, affirmant qu'elle satisfait tous les desiderata d'une analyse appropriée des entités fictives. Cet article présente une analyse des personnages fictifs qui réponde à ces critères, tout en évitant les problèmes que rencontre l'analyse de Voltolini. Selon mon analyse antiréaliste et leibnizienne, un personnage fictif peut être identifié par la collection de prédicats attribués à son nom. Cette analyse offre le bénéfice de la théorie des faisceaux, puisqu'elle écarte la question des (...) porteurs des noms fictifs, tout en expliquant pourquoi un personnage fictif est plus qu'une simple collection de prédicats. (shrink)

How ought the historian to reconcile themselves philosophically with the fact of evental contingency and of its relationship to structural determination? Does the existence of contingent causation undermine the very concept of historical necessity, or do the two instead in dialectical entanglement? In this essay, I engage with the problem of historical contingency from a transcendental-materialist perspective informed by the work of Slavoj Žižek, tendering a philosophically serious response to the famous Pascalian conundrum of Cleopatra’s nose and its challenge to (...) structuralist accounts of historical causation. The position associated with Laplace – that is to say, that the course of history would be entirely predictable were one provided with a complete account of initial conditions – is firmly rejected. Instead, I revive Althusser’s attempt to craft a theory of ‘aleatory materialism’, in which the determinative power of structural forces nevertheless leave space for the radical and unpredictable transformation of a situation by the chance crystallisation of events and encounters. In this effort, I recruit conceptual architecture not only from the fields of historiography and philosophy, but also quantum physics, psychoanalysis, and mathematics. (shrink)

The thymus is a unique primary lymphoid organ that supports the production of self‐tolerant T‐cells essential for adaptive immunity. Intrathymic microenvironments are microanatomically compartmentalised, forming defined cortical, and medullary regions each differentially supporting critical aspects of thymus‐dependent T‐cell maturation. Importantly, the specific functional properties of thymic cortical and medullary compartments are defined by highly specialised thymic epithelial cells (TEC). For example, in the medulla heterogenous medullary TEC (mTEC) contribute to the enforcement of central tolerance by supporting deletion of autoreactive T‐cell (...) clones, thereby counterbalancing the potential for random T‐cell receptor generation to contribute to autoimmune disease. Recent advances have further shed light on the pathways and mechanisms that control heterogeneous mTEC development and how differential mTEC functionality contributes to control self‐tolerant T‐cell development. Here we discuss recent findings in relation to mTEC development and highlight examples of how mTEC diversity contribute to thymus medulla function. (shrink)

It is widely believed that Perelman and Olbrechts-Tyteca’s theory of argumentation is vulnerable to the charge of relativism. This paper provides a more charitable interpretation of Perelman and Olbrechts-Tyteca’s normative views, one that properly considers the historical trajectory of their work and a wider range of texts than existing interpretations. It is argued that their views are better characterized as a form of “contrastivism about arguments” than any kind relativism. This more accurate depiction contributes to ongoing efforts to revive interest (...) in Perelman and Olbrechts-Tyteca’s work as well as build bridges with trends in contemporary argumentation theory. (shrink)

What makes ethical accounts natural law ethical is, I argue, commonly misrepresented in teaching within much of the philosophical academy. Yet those immersed in the field of natural law and ethics rarely give definitions/brief characterisations of what makes ethical accounts natural law ethical. I suggest theoretical reasons for the lack. I argue that bringing natural law into ethics is best understood as leading to theoretically unitary accounts, not simply collections of positions detachable from each other: an overlooked and significant point (...) when defending natural law ethical accounts. My arguments throughout rely on the metaethical/normative ethical distinction, which is relatively little used in the natural law literature. I argue that the distinction helps clarify what is distinctive of natural law ethical accounts in general, especially to the secular contemporary philosophical academy, where appreciation of natural law ethical accounts is commonly appreciably lower than in philosophical contexts with a religious ethos. (shrink)

Variability in the emotion regulation (ER) strategies one uses throughout daily life has been suggested to reflect adaptive ER ability and to act as a protective factor in mental health. Moreover, psychological inflexibility and persistent negative affect (or affective inertia) are key features of depression and other forms of mental illness and are often further exacerbated by rigid or overly passive regulatory behaviours. The current study investigated the hypothesis that ER variability might serve as a protective factor against depressive symptoms (...) and affective inertia. Using experience-sampling (N = 213), we tested whether two indictors of ER variability (between- and within-strategy SDs) were related to depressive symptoms and affective inertia. We found that people with higher between-strategy variability and within-strategy variability (specifically for reappraisal and distraction) reported fewer depressive symptoms. Both within- and between-strategy variability were negatively related to negative affective inertia. Between-strategy variability and negative affective inertia had unique effects on depression, when used as simultaneous predictors. Altogether, this study provides further evidence for the utility of ER as a factor buffering against depressive symptoms and particularly for the use of variable ER strategies. (shrink)

As mariculture—the cultivation of aquatic organisms in marine environment—intensifies to meet the demands of sustainable blue growth and national policies, novel ethical challenges will arise. In the context of ethics, primary concerns over aquaculture and mariculture tend to stay within differing value-based perspectives focused on benefits to human and non-human subjects, specifically animal welfare and animal rights. Nonetheless, the burgeoning field of feminist blue humanities provides ethical considerations that extend beyond animal subjects (including humans), often because of its concerns with (...) new materialist, posthumanist, and other relations-based theories. This article examines feminist blue humanities and the contributions it may bring to understanding contemporary and future ethical challenges posed by mariculture and its intensification, especially the cultivation of low-trophic organisms. By offering an overview of feminist blue humanities, this article explores some of its particularities by drawing out three major ethical concerns facing contemporary mariculture, specifically material reconfigurations, radical alteration of the lives of low-trophic species through industrialization and increases in maricultural waste products. (shrink)

This book grew out of previously published papers of mine composed over a period of years; they have been reworked (sometimes beyond recognition) so as to form a reasonably coherent whole. Part One treats of informative inference. I argue (Chapter 2) that the traditional principle of induction in its clearest formulation (that laws are confirmed by their positive cases) is clearly false. Other formulations in terms of the 'uniformity of nature' or the 'resemblance of the future to the past' seem (...) to me hopelessly unclear. From a Bayesian point of view, 'learning from experience' goes by conditionalization (Bayes' rule). The traditional stum bling block for Bayesians has been to fmd objective probability inputs to conditionalize upon. Subjective Bayesians allow any probability inputs that do not violate the usual axioms of probability. Many subjectivists grant that this liberality seems prodigal but own themselves unable to think of additional constraints that might plausibly be imposed. To be sure, if we could agree on the correct probabilistic representation of 'ignorance' (or absence of pertinent data), then all probabilities obtained by applying Bayes' rule to an 'informationless' prior would be objective. But familiar contra dictions, like the Bertrand paradox, are thought to vitiate all attempts to objectify 'ignorance'. BuUding on the earlier work of Sir Harold Jeffreys, E. T. Jaynes, and the more recent work ofG. E. P. Box and G. E. Tiao, I have elected to bite this bullet. In Chapter 3, I develop and defend an objectivist Bayesian approach. (shrink)

Public reason liberalism demands that political decisions be publicly justified to the citizens who are subjected to them. Much recent literature emphasises the differences between the two main interpretations of this requirement, justificatory and political liberalism. In this paper, I show that both views share structural democratic deficits. They fail to guarantee political autonomy, the expressive quality of law, and the justification to citizens, because they allow collective decisions made by incompletely theorised agreements. I argue that the result can only (...) be avoided by changing public reason’s role in collective decision-making. Instead of incompletely theorised agreements, we should demand agreement both on the public reasons themselves and on the other premises that justify political decisions. In this way, it is always possible to point to a procedure-independent reason that justifies democratic decisions, and the reasoning of the state is public and contestable. Finally, I explain how this, in turn, implies that only political liberalism can be rescued—by accepting what I will call strong political liberalism. Modifying justificatory liberalism in the necessary way will inevitably open the door to an objectionable form of perfectionism. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BUDDHISM AND MIMETIC THEORY: A RESPONSE TO CHRISTOPHER IVES Leo D. Lefebure Fordham University ChristopherIves offers avery clearandthoughtful exploration ofthe relation between Dharma and Destruction. His discussion helps us to understand the historical relation between institutions and violence in various Buddhist traditions. His overview of the historical record is quite compelling, offering us an important counterpoint and corrective to the widespread images of Buddhist peacemakers in the popular media. (...) From the beginning, the Buddhist tradition has had a mixed record in its understanding and practice of the first moral precept, nonviolence. The encounter between Buddhist perspectives and mimetic theory poses interesting challenges for both partners to the discussion. Mimetic theory offers Buddhists an analysis ofthe construction ofdesire and the self that in many ways complements traditional Buddhist perspectives. It also offers a naming ofthe mechanisms of violence in the formation of societies that may be helpful for Buddhists' social analyses. Buddhism for its part offers mimetic theory a centuries-old tradition of reflection on the role of desire in the construction of an illusory self as well as a body of practical wisdom on non-violence that, even if it has not always been put into practice, challenges and instructs the human community today. The popular images of Buddhist peacemakers are, after all, deeply rooted in the early Buddhist tradition and powerfully represented by contemporary figures such as the Dalai Lama, Mahaghosananda (the Patriarch of Cambodian Buddhism and Thich Nhat Hanh (a Vietnamese Zen Buddhist leader who has been nominated for the Nobel Peace Prize). 176Leo D. Lefebure I approach this discussion not as a professional scholar of Buddhism but as a Christian theologian who has been involved in Buddhist-Christian dialogue and who is interested in both Buddhism and mimetic theory, as well as in the relations between these two trajectories today. One model for further discussion would be to take the historical data that Ives has set forth and then apply mimetic theory, asking to what degree mimetic theory can illumine the dynamics and developments of Buddhist history. Using Bernard Lonergan's image of the scissors, which Charles Heflingmentionedin his discussion inthis conference, this approach would cast Buddhism in the role of providing the lower blade of the scissors, the data to be understood, and mimetic theory would provide the upper blade of the scissors, the analytic concepts to understand the data and to make judgments and decisions. In this method, Buddhism would be relatively passive and mimetic theory would be more active. I am sure that there is ample material in Buddhist history that lends itselfto mimetic analysis (one can think ofthe traditional treatment ofthe so-called "outcasts" in Japanese society). One could, as James Alison noted in his opening address, go on endlessly, even obsessively applyingmimetic concepts to different areas of human experience. I am not sure this qualifies as true dialogue, however. It risks continuing the older Orientalist assumption that only Western concepts are capable of understanding Asia's experience and that Asians themselves have relatively little to contribute.1 For a true dialogue, the voices ofboth traditions must play a rather more active role. Both traditions can furnish material for both the upper and the lower blades of the scissors. In Lonergan's terminology, we aremovingbeyondinterpretation, which seeks understanding, and beyond history, which for Lonergan asks what is going forward in history, to the distinct functional specialization of dialectic (Lonergan 125?30). This discipline reflects upon the underlying values at work in historical processes and the assumptions behind these values. In this inquiry we ask about the status of differences of perspective: to what degree are they complementary and where are they contradictory? I would like to organize the discussion between Buddhist perspectives and mimetic theory around the three central points of mimetic theory, which René Girard himself has described as his three most important discoveries: (1) the mimetic construction of desire as the source of human identity, (2) the surrogate victim mechanism as the central dynamic of 1 On Orientalism, see Edward W. Said, Orientalism (New York: Vintage Books, 1979). A Response to Christopher Ives177 primal religion and culture, and (3) biblical revelation as the unique, unparalleled unmasking of the surrogate victim mechanism... (shrink)

Disagreement has garnered attention in a variety of academic disciplines, but its counterpart agreement is deserving of much more attention than it has received. This paper begins by reviewing some of the existing literature directly discussing agreement. Inspired by these conversations, I then provide a typology of basic types of agreement followed by a more general discussion of its nature. The aim of the paper is to provide conceptual clarifications and a framework for discussing and analyzing agreement wherever it may (...) be found. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:An Appreciation of Arvind Mandair's Sikh Philosophy:Exploring Gurmat Concepts in a Decolonizing WorldJeffery D. Long (bio)"Sikhism," the Colonial Project, and Modernity1I do not use this adjective lightly, but in his brilliant volume Sikh Philosophy: Exploring Gurmat Concepts in a Decolonizing World (Bloomsbury, 2022) Arvind-Pal Singh Mandair goes a considerable distance toward liberating sikhī—known more widely in the academic world as Sikhism—from the conceptual constraints that have kept it from (...) engaging with and informing global issues. In so doing, he does a service not only to the Sikh community and to sikhī itself, but to the world, for there is indeed much in Sikh thought from which the wider human community can benefit. By liberating sikhī from the constraining concept of religion, Mandair facilitates a process by which persons of any background can engage with gurmat ideas—that is, ideas drawn from the system of thought based upon the teachings of the Gurus of the Sikh tradition—and learn from their wisdom.Mandair skillfully deconstructs the concept of religion, building upon earlier work in which he demonstrates the colonial functionalities of this concept.2 When, through colonial knowledge-production processes, sikhī came to be conceived as a religion, Sikh thought was relegated to the realm of theology. This was a relegation, not an elevation, because under the dominant paradigm of modernity, theology is seen as a discourse that is relevant only to a specific religious community. It is thus perceived as lacking the universality [End Page 353] that is taken to inhere in the discourses of philosophy or science. When combined with the colonial situation of Sikhs under British rule, this relegation of Sikh thought to the realm of theology becomes a way of exerting power over the community. As Mandair explains,Once theology had become the primary regime of cultural translation, Sikh thinking was inevitably tethered to the social and political project of religious identification which was required primarily to facilitate governance of cultural differences or heterogeneity that characterized the indigenous populations [of India]. By doing so, it effectively locked Sikh activity within the confines of identity politics.(p. 10)Integral to British colonial policy in India was a project of defining communities, primarily on the basis of religion, but also deploying concepts such as caste and tribe. Through these definitions, the identities of Indians could be essentialized, and policies applied to them in ways that facilitated British dominance over Indian society.3Much has been written about the ways in which language is used to promote ideologies that serve to advance the power interests of some groups of people over others.4 No less an ideological mechanism than the Oxford English Dictionary has been brought to bear in the process of constraining sikhī and depriving it of the universal relevance that it ought naturally to possess. In Mandair's words, "By defining 'Sikhism' as the beliefs and practices of Sikhs, or as an Indian monotheistic religion founded in fifteenth-century India, the OED turns the Sikh aspect into a cliché—a religious type (monotheism), an ethnic type tied to a geographical location (Punjabi/North India) and a historical type (medieval India)" (p. 11).The damage that has been wrought by the modern colonial concept of religion globally is, of course, not limited exclusively to the Sikh community. It has been integral to the construction of a secular order in which what is regarded as religious thought is, again, relegated to a parochial realm of relevance only to members of specific communities. It further serves to marginalize these same communities, whose discourses come to be seen as lacking the universality of secular thought, which is presented as objective truth. As Mandair continues,The purpose of creating the modern category of 'religion' was to help authorize and naturalize secular rationality as the dominant form of modern consciousness, and as the essential language of conventional thinking, or 'common sense.' It is precisely this common sense which persuades us of the apparent naturalness of oppositions such as religion versus politics or materiality versus ideality, to give two well-known examples.(p. 11)To these two examples, one could add the opposition of religion and... (shrink)

Recent research has highlighted the character and importance of the study of agreement. This paper, paralleling work on the more familiar concept of deep disagreement, will provide a first articulation of the character and implications of deep agreements, that is, agreements so deep that disagreement cannot overcome them. To do so, I start by outlining the main features of deep disagreement. I then provide a brief characterization of agreement in general to ground the discussion of the unique characteristics of deep (...) agreements and compare them to deep disagreements. After distinguishing the concept from other more familiar ones, I then point to a few of the major social and theoretical issues the existence of deep agreements poses before concluding with some remarks pointing to valuable areas for future research. (shrink)

In this essay, I revisit and extend my arguments for a view of science that is pluralistic, perspectival and pragmatist. I attempt to resolve mismatches between metaphysical assumptions, epistemological desiderata, and scientific practice. I consider long-held views about unity of science and reductionism, emergent properties and physicalism, exceptionless necessity in explanatory laws, and in the justification for realism. My solutions appeal to the partiality of representation, the perspectivism of theories and data, and the interactive co-construction of warranted claims for realism.

Part One of the ERDs addresses the balance Catholic health care institutions must strike between their mission to carry out the healing ministry of Christ and the demands of the US health care system. Divided into two sections, the commentary begins by proposing revisions to the Part One introduction focusing on enhanced application of Catholic social teaching principles and a renewed call for robust conscience and religious liberty protections. It then proposes additions to the Part One directives designed to help (...) Catholic health care respond with integrity to the many contemporarychallenges it faces, and to more full live out its mission and identity. (shrink)

This book constitutes the refereed proceedings of the International Conference on Spatial Information Theory, COSIT 2005, held in Elliottville, NY, USA in September 2005. The 30 revised full papers presented were carefully reviewed and selected from 82 submissions. The papers are organized in topical sections on vagueness, uncertainty, and gradation; paths and routes; ontologies and semantics; ontologies and spatial relations; spatial reasoning: cognitive maps and spatial reasoning; time, change, and dynamics; landmarks and navigation; geographic information, and spatial behaviour.